Mitigation of Polysulfide Shuttling in Lithium-Sulfur Batteries Utilizing Vanadium Pentoxide/Polypyrrole Nanocomposite Separators.

Lithium-sulfur (Li-S) batteries are promising energy storage devices due to their high theoretical energy density and cost-effectiveness. However, the shuttle effect of polysulfides during the charging and discharging processes leads to a rapid decline in capacity, thereby restricting their application in energy storage. The separator, a crucial component of Li-S batteries, facilitates the transport of Li+ ions.

PD-like pathogenesis induced by intestinal exposure to microplastics: An in vivo study of animal models to a public health survey.

With the increasing incidence of non-hereditary Parkinson's disease (PD), research into the involvement of specific environmental factors, in addition to aging, has become more prominent. The effects of microplastic exposure on public health have gained increased attention as it is known to cause a range of neurotoxic changes, some of which are similar to the pathological features of PD. We carried out low-dose microplastic exposure experiments on mice and Caenorhabditis elegans models and implemented a survey regarding the utilization of plastic products in the population.

Clostridium Scindens Protects Against Vancomycin-Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR-FGF15/19 Signaling.

Primary sclerosing cholangitis (PSC) is characterized by abnormal bile acid metabolites and altered gut microbiota, with no effective treatments available. Vancomycin, a glycopeptide antibiotic, has emerged as a promising candidate. However, the mechanism by which vancomycin impacts the progression of PSC remains unknown.

Spatial transcriptomics analysis identifies therapeutic targets in diffuse high-grade gliomas.

Introduction: Diffuse high-grade gliomas are the most common malignant adult neuroepithelial tumors in humans and a leading cause of cancer-related death worldwide. The advancement of high throughput transcriptome sequencing technology enables rapid and comprehensive acquisition of transcriptome data from target cells or tissues. This technology aids researchers in understanding and identifying critical therapeutic targets for the prognosis and treatment of diffuse high-grade glioma.

Synergistic Effect of P Doping and Mo-Ni-Based Heterostructure Electrocatalyst for Overall Water Splitting.

Heterostructure construction and heteroatom doping are powerful strategies for enhancing the electrolytic efficiency of electrocatalysts for overall water splitting. Herein, we present a P-doped MoS/NiS electrocatalyst on nickel foam (NF) prepared using a one-step hydrothermal method. The optimized P-MoS/NiS@NF exhibits a cluster nanoflower-like morphology, which promotes the synergistic electrocatalytic effect of the heterostructures with abundant active centers, resulting in high catalytic activity for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in alkaline electrolyte.

Exosomes: A new option for osteoporosis treatment.

Osteoporosis is a systemic bone disease characterized by reduced bone mass and destruction of bone microarchitecture, leading to increased bone fragility and susceptibility to fracture. However, the pathogenesis and molecular mechanisms of this disease remain unclear. Extracellular vesicles, structures originating from the plasma membrane and ranging from 30 nm to 5 µm in diameter, play an important role in intercellular communication in the bone microenvironment.

Comprehensive analysis of mA/mC/mA-related gene expression, immune infiltration, and sensitivity of antineoplastic drugs in glioma.

This research aims to develop a prognostic glioma marker based on mA/mC/mA genes and investigate the potential role in the tumor immune microenvironment. Data for patients with glioma were downloaded from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA). The expression of genes related to mA/mC/mA was compared for normal and glioma groups.

Stability Analysis and Construction Parameter Optimization of Tunnels in the Fractured Zone of Faults.

In order to improve the construction method of highway tunnel fault, improve the excavation level, improve the construction efficiency, reduce the project cost, and shorten the construction period, so as to find a specific road, this paper puts forward the research method of tunnel stability analysis and construction parameter optimization in the fault fracture zone. First, this paper analyzes the specific geographical and geological environment of the construction site. Second, this paper compares and analyzes the effects of the drilling and blasting method and full-face tunnel boring machine (TBM) in construction and further analyzes the surrounding rock deformation, over excavation, and under excavation, as well as the range of loose circles when the surrounding rock is stable.

Long non-coding RNA Gm37494 alleviates osteoarthritis chondrocyte injury via the microRNA-181a-5p/GABRA1 axis.

Objective: This study was conducted to investigate the effect of long non-coding RNA (lncRNA) Gm37494 on osteoarthritis (OA) and its related molecular mechanism.

Methods: The cartilage tissues were obtained from OA patients, and an OA mouse model was induced by the destabilization of the medial meniscus, followed by measurement of Gm37494, microRNA (miR)-181a-5p, GABRA1 mRNA, and the encoded GABAR protein expression. Thereafter, a cellular model was induced by interleukin-1β (IL-1β) treatment in chondrocytes, followed by ectopic and silencing experiments.

Feasibility of bionanocomposite films fabricated using capsicum leaf protein and cellulose nanofibers.

In this study, the feasibility of fabricating protein-based bionanocomposite films (PBBFs) was analysed by applying capsicum leaf protein (CLP) and cellulose nanofiber (CNF) as raw materials. The effects of different amounts of CNF (solid content 2%) on physicochemical and material properties of PBBFs were investigated. The results showed nanoscale CNFs exhibited good interfacial compatibility with CLP.

Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis.

Circular RNAs (circRNAs) are a type of non-coding RNAs generated from back splicing to enhance or inhibit the progression of multiple human cancers including osteosarcoma (OS). Although circ_0102049 has been found to be highly expressed in OS cell lines, the role and specific mechanism of circ_0102049 in OS remains unclear. Here, we found that silence of circ_0102049 could significantly exacerbate the tumorigenesis of OS through sponging microRNA-520g-3p.

Enrichment of Wee1/CDC2 and NF-κB Signaling Pathway Constituents Mutually Contributes to CDDP Resistance in Human Osteosarcoma.

Purpose: Osteosarcoma (OS) universally exhibits heterogeneity and cisplatin (CDDP) resistance. Although the Wee1/CDC2 and nuclear factor кB (NF-κB) pathways were reported to show abnormal activation in some tumor cells with CDDP resistance, whether there is any concrete connection is currently unclear. We explored it in human OS cells.

Application of Magnetic Resonance Diffusion Tensor Imaging in the Clinical Diagnosis of Disc Herniation after Lumbar Spine Injury.

Magnetic resonance diffusion-weighted imaging (DTI) provides a unique perspective on the pathophysiological and microstructural changes during spinal cord injury, with high spatial specificity; meanwhile, NM reflects the conduction and integrity of neuroelectrical signals in spinal cord fiber tracts, with time-specific and dynamic evaluation effects. The fractional anisotropy (FA) value, SEP amplitude, and neurological function score or improvement rate are correlated. The combination of DTI and NM can more reliably quantify the spinal cord function, evaluate the effectiveness of treatment, and determine the patient's prognosis, which can provide reference for clinical decision making and future research for SCI patients.

Agarose-resolvable InDel markers based on whole genome re-sequencing in cucumber.

Insertion and Deletion (InDel) are common features in genomes and are associated with genetic variation. The whole-genome re-sequencing data from two parents (X1 and X2) of the elite cucumber (Cucumis sativus) hybrid variety Lvmei No.1 was used for genome-wide InDel polymorphisms analysis.

MicroRNA-15a-5p promotes the proliferation and invasion of T98G glioblastoma cells via targeting cell adhesion molecule 1.

Glioblastoma (GBM) is a type of malignant tumor occurring in the brain that severely influences the life of affected individuals. GBM cells are highly infiltrative, which is one of the main obstacles in the treatment of the disease. Numerous microRNAs (miRNAs/miRs) are associated with the development of GBM.

PLK2 modulation of enriched TAp73 affects osteogenic differentiation and prognosis in human osteosarcoma.

There are three subtypes of undifferentiated human conventional osteosarcoma (HCOS): osteoblastic osteosarcoma (OOS), chondroblastic osteosarcoma (COS), and fibroblastic osteosarcoma (FOS). HCOS also exhibits heterogeneous pathological maldifferentiation in individual patients. Currently, the mechanism regulating HCOS differentiation remains unclear, and therapies are ineffective.

Tribological Properties of Mo-Si-B Alloys Doped with LaO and Tested at 293-1173 K.

According to the stoichiometric ratios of Mo-10Si-7B, Mo-12Si-8.5B, Mo-14Si-9.8B, and Mo-25Si-8.

Identification of high-efficiency SSR markers for assessing watermelon genetic purity.

Genomic simple sequence repeat (SSR) markers were used to fingerprint and determine genetic similarity (GS) of the watermelon breeding lines, as well as the purity of their hybrid derivatives. Cluster analysis and Jaccard's distance coefficients using the unweighted pair group method with arithmetic mean (UPGMA) have classified these lines into three major groups. Notwithstanding,the genetic background of these lines is narrow as revealed by the restricted GS coefficients.

Development of a New Molecular Marker for the Resistance to Tomato Yellow Leaf Curl Virus.

(TYLCV) responsible for tomato yellow leaf curl disease (TYLCD) causes a substantial decrease in tomato ( L.) yield worldwide. The use of resistant variety as a sustainable management strategy has been advocated.

The Flexural Strength and Fracture Toughness of TC4-Based Laminated Composites Reinforced with Ti Aluminide and Carbide.

TiC-Ti-Al mixed powders and TC4 titanium alloy foils were overlapped layer-by-layer in the graphite die. The TC4-based laminated composite sheets reinforced by Ti aluminide and carbide were successfully fabricated via spark plasma sintering (SPS) at 1100 °C with a well-bonded interface. The composite layers were mainly composed of TiAl, Ti₃Al, Ti₂AlC, and Ti₃AlC₂ phases.

Influence of nutrient signals and carbon allocation on the expression of phosphate and nitrogen transporter genes in winter wheat (Triticum aestivum L.) roots colonized by arbuscular mycorrhizal fungi.

Arbuscular mycorrhizal (AM) colonization of plant roots causes the down-regulation of expression of phosphate (Pi) or nitrogen (N) transporter genes involved in direct nutrient uptake pathways. The mechanism of this effect remains unknown. In the present study, we sought to determine whether the expression of Pi or N transporter genes in roots of winter wheat colonized by AM fungus responded to (1) Pi or N nutrient signals transferred from the AM extra-radical hyphae, or (2) carbon allocation changes in the AM association.

Comparison of cell proliferation, apoptosis, cellular morphology and ultrastructure between human umbilical cord and placenta-derived mesenchymal stem cells.

Research in mesenchymal stem cells (MSCs) is mainly focused on applications for treatments of brain and spinal cord injury as well as mechanisms underlying effects of MSCs. However, due to numerous limitations, there is little information on selection of appropriate sources of MSCs for transplantation in clinical applications. Therefore, in this study we compared various properties of human umbilical cord-derived MSCs (HUCMSCs) with human placenta-derived MSCs (HPDMSCs), including cell proliferation, apoptosis, cellular morphology, ultrastructure, and their ability to secrete various growth factors (i.

Potential of placenta-derived mesenchymal stem cells as seed cells for bone tissue engineering: preliminary study of osteoblastic differentiation and immunogenicity.

Mesenchymal stem cells (MSCs) have been isolated from a variety of human tissues (eg, bone marrow, peripheral blood, muscle, fat, umbilical blood, amniotic fluid, embryonic tissues, and placenta). Placenta-derived MSCs (PDMSCs) have received considerable interest because of their wide availability and absence of ethical concerns. The authors characterized the biological properties, ultrastructure, growth factor production, and osteoblastic differentiation of PDMSCs and investigated their potential as seed cells for bone tissue engineering.

The Glu727 Allele of Thyroid Stimulating Hormone Receptor Gene is Associated with Osteoporosis.

Background: Published data indicate that thyroid stimulating hormone receptor (TSHR) activities are associated with osteoporosis in some patients.

Aim: This study aimed to elucidate whether a given polymorphism of the TSHR gene is associated with osteoporosis.

Materials And Methods: One hundred and fifty subjects with osteoporosis were recruited in this study.

Mental health, duration of unemployment, and coping strategy: a cross-sectional study of unemployed migrant workers in eastern China during the economic crisis.

Background: 20 million migrant workers in China lost their jobs during the economic crisis of 2008. Both urban migration and unemployment have long been documented to be associated with vulnerability to mental problems. This study aims to examine the mental health of unemployed migrant workers in Eastern China and its relation to duration of unemployment and coping strategy during the recent economic crisis.