Publications by authors named "Li Wen Hu"

Background: Evidence on the influence of outdoor artificial light at night (ALAN) on hypothyroidism in pregnant women is scarce. We aimed to investigate the association between outdoor ALAN exposure and hypothyroidism in pregnancy.

Methods: 81,120 pregnant women from the China Birth Cohort Study (CBCS) were analyzed, which recruited from 18 provinces and autonomous regions in China between February 2018 and December 2020.

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This research aimed to systematically uncover the metastatic characteristics and survival rates of lung cancer subtypes and to evaluate the impact of surgery at the primary tumor site on cancer-specific survival in DM lung cancer. We used the Surveillance, Epidemiology, and End Results (SEER) database (2010-2019) to identify primary lung cancers with DM at presentation (M1). Kaplan-Meier (KM) survival curves were generated and compared utilizing log-rank tests.

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  • Metabolic syndrome (MetS) is a growing global health issue, with environmental factors like outdoor artificial light at night (LAN) potentially influencing it.
  • A study involving 15,477 adults examined the impact of LAN on MetS and its components, finding that increased LAN exposure correlated with higher odds of MetS and issues like elevated blood pressure and triglycerides.
  • Notably, individuals who didn't engage in regular exercise were more significantly affected by LAN exposure, indicating that lifestyle factors may modify the risk associated with MetS.
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  • A study with 48,502 Chinese children aged 5-12 explored the link between outdoor Light at Night (LAN) exposure and executive function, using satellite images to assess exposure levels.
  • The results indicated that higher outdoor LAN exposure correlated with poorer executive function and increased risks of executive dysfunction, particularly in older children (ages 10-12).
  • The researchers conclude that reducing outdoor LAN exposure could potentially improve executive function, suggesting the need for further studies on this topic.
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Cardiovascular diseases (CVDs) become a major public health concern. Evidence concerning the effects of outdoor artificial light at night (ALAN) on CVD in adults is scarce. We aimed to investigate the extent to which outdoor ALAN could affect the risk of CVD over a exposure range.

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  • The study investigated the link between home renovations and sleep problems in children aged 6-18, using data from over 186,000 participants in the National Chinese Children Health Study.
  • Results showed that about 48% of the children had been exposed to recent home renovations, and these children had significantly higher odds (30% more likely) of experiencing sleep disorders compared to those not exposed.
  • The impact on sleep problems varied based on the types of renovation materials used and was influenced by the children's age and sex, indicating that these factors play a role in how renovations affect sleep health.
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  • Estrogens are important in childbirth, and poly- and perfluoroalkyl substances (PFAS) with estrogen-like effects are linked to preterm birth, but how estrogens influence this relationship is unclear.
  • The study aimed to explore whether estrogens modify the connection between PFAS exposure and preterm birth using data from a cohort of 371 preterm births and 508 control births in China.
  • Results indicate that higher levels of certain PFAS are associated with increased odds of preterm birth, and significant interactions between cord estradiol levels and PFAS exposure suggest estrogens could play a role in this association.
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  • This study investigates the neurotoxic effects of F-53B on children and mice, linking higher levels of F-53B to poorer cognitive performance in the Wisconsin Card Sorting Test (WCST).
  • Experimental findings indicated that mice exposed to F-53B showed impaired learning and decreased levels of key proteins and dopamine related to brain development and function.
  • The results suggest early life exposure to F-53B may negatively impact neurodevelopment, warranting further research on its health implications.
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Anthropogenic heat has been reported to have significant health impacts, but research on its association with childhood adiposity is still lacking. In this study, we matched the 2008-2012 average anthropogenic heat flux, as simulated by a grid estimation model using inventory methods, with questionnaire and measurement data of 49,938 children randomly recruited from seven cities in Northeast China in 2012. After adjusting for social demographic and behavioral factors, we used generalized linear mixed-effect models to assess the association between anthropogenic heat flux and adiposity among children.

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Backgrounds: Trimodal therapy (neoadjuvant chemoradiotherapy followed by esophagectomy) for locally advanced esophageal squamous cell carcinoma (ESCC) is associated with a significant survival benefit. Modified Ryan score is an effective tool to evaluated the tumor regression grade (TRG) after neoadjuvant therapy. The aim of this study was to evaluate the prognostic value of TRG for overall survival (OS) and disease-free survival (DFS) in ESCC patients undergoing neoadjuvant chemoradiation.

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Previous studies have linked exposure to light at night (LAN) with various health outcomes, but evidence is limited for the LAN-obesity association. Thestudy analysed data from 24,845 participants of the 33 Communities Chinese Health Study and obesity (BMI ≥28 kg/m) was defined according to the Working Group on Obesity in China. The Global Radiance Calibrated Nighttime Lights data were used to estimate participants' LAN exposure.

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  • This study investigates the sources and toxicological effects of particulate matter (PM) collected in Guangzhou during a high air pollution season, focusing on the relationships between PM size, its chemical components, and how they affect cellular health.
  • The research shows that smaller PM contains more water-soluble ions and PAHs, while larger PM includes more metallic elements, with traffic exhaust, soil dust, and biomass burning being significant sources of pollution.
  • Findings reveal exposure to PM causes cell damage, including reduced mitochondrial activity and increased oxidative stress, with coarse PM also causing notable inflammatory effects, underscoring the importance of considering all PM sizes in health assessments.
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Little evidence exists concerning the associations of greenspace with childhood lipid profiles and dyslipidemias, especially in developing countries and regions. We aimed to investigate the associations of greenspace surrounding schools with lipid levels and dyslipidemia prevalence among Chinese children and teenagers. We obtained baseline information and health data of 10,408 children and teenagers (aged 6-18 years) who studied from 94 schools in China.

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Thallium (Tl) is a cumulative high toxicant in the environment, but few studies have investigated the comprehensive health effects underlying chronic Tl exposure at trace levels. This study aims to evaluate the liver, kidney, lung and other potential health effects associated with chronic Tl exposure at trace levels in rural areas of China. Urinary Tl concentrations of 2883 adults from rural areas of 12 provinces in China were measured and 2363 participants were involved in the final analysis.

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  • The study investigates how vitamin D levels affect the relationship between particulate matter (PM) exposure and blood lipid levels in young, healthy adults.
  • Conducted in Guangzhou, China, the research included 88 participants and analyzed various sizes of PM alongside serum lipids and vitamin D concentrations over five weeks.
  • Findings reveal that lower vitamin D levels (under 15 ng/mL) were linked to significant increases in triglycerides and low-density lipoprotein cholesterol with higher PM exposure, while these associations were not significant in those with higher vitamin D levels (15 ng/mL or more).
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Background: Although ozone exposure has neurological toxicity, it remains unclear whether it was associated with an increased risk of attention-deficit/hyperactivity disorders (ADHD) among childhood.

Methods: We matched the four-year average ozone concentration with questionnaire data for 35,103 children aged 3-12 years from seven cities in Liaoning, China, 2012-2013. Using mixed-effect logistic regression models, we assessed the association of ozone concentration with multiple ADHD indicators using the Conners Abbreviated Symptom Questionnaire (C-ASQ), including explicit attention-deficit/hyperactivity symptoms (ADHD; score ≥15), attention-deficit/hyperactivity disorder tendencies (ADHD-T; 11 ≤ score ≤14), and attention-deficit/hyperactivity problems (ADHP; score ≥11).

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Objective: A SVM predictive model consisting of preoperative tumor markers and inflammatory factors was established to explore its significance in evaluating the prognosis of patients with ESCC.

Methods: Clinical data of 311 patients with ESCC who underwent surgery were collected and followed up until October 2019. Statistical software SPSS version 22.

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The perfluorooctane sulfonate alternative, F-53B, induces multiple physiological defects but whether it can disrupt eye development is unknown. We exposed zebrafish to F-53B at four different concentrations (0, 0.15, 1.

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Introduction: Home enteral nutrition (HEN) is a relatively new nutritional intervention that provides patients with EN support at home through jejunostomy or nasogastric feeding tubes. We conducted this systematic review and meta-analysis to explore the safety and effect of HEN compared with normal oral diet (NOD) in postoperative patients with esophageal cancer (EC).

Methods: EMBASE, Medline, Web of Science, and the Cochrane Library were used to search articles in English-language journals.

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Background: Studies on the obesogenic effect of air pollution on children have been mixed and sparse. Moreover, due to insufficient air monitoring, few studies have investigated the role of more tiny but unregulated particles (ambient particles with a diameter of 0.1 μm or less, ultrafine particles).

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The sources and chemical components of urban air particles exhibit seasonal variations that may affect their hazardousness to human health. Our aims were to investigate winter and spring variation in particulate matter (PM) sources, components and toxicological responses of different PM size fractions from samples collected in Guangzhou, China. Four size-segregated PM samples (PM, PM, PM, and PM) were collected separately during winter (December 2017 and January 2018) and spring (March 2018).

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Studies have investigated associations between maternal exposure to PFAS and preterm birth, but the impact of paternal and overall family exposure to PFAS mixtures on preterm birth remains unknown. To address this knowledge gap, a total of 355 preterm births and 481 controls were selected for a family-based birth cohort study in a coastal area of China, between 2016 and 2018. Seven PFAS, including perfluorobutanoic acid (PFBA), perfluorohexanoic acid (PFHxA), perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), were quantified in maternal, paternal and neonatal sera.

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Importance: Healthy sleep has an important role in the physical and mental health of children. However, few studies have investigated the association between outdoor artificial light at night (ALAN) and sleep disorders in children.

Objective: To explore the associations between outdoor ALAN exposure and sleep disorders in children.

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Backgrounds: High level of anion gap (AG) was associated with organic acidosis. This study aimed to explore the relationship between delta AG (ΔAG = AG - AG) during first 3 days after intensive care unit (ICU) admission and hospital mortality for patients admitted in the cardiothoracic surgery recovery unit (CSRU).

Methods: In this retrospective cohort study, we identified patients from the open access database called Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC III).

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Little evidence is available regarding the impact of different sizes of inhaled particulate matter (PM) on inflammatory responses in healthy young adults in connection with toxicological responses. We conducted a five-time repeated measurement panel study on 88 healthy young college students in Guangzhou, China from December 2017 to January 2018. Blood samples were collected from each participant and tested for tumor necrosis factor alpha (TNF-α) levels every week for 5 consecutive weeks.

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