Angew Chem Int Ed Engl
November 2024
Sentinel lymph node (SLN) biopsy is currently the standard procedure for clinical cancer diagnosis and treatment, but still faces the risks of false negatives and tumor metastasis, as well as time-consuming pathological evaluation procedure. Herein, we proposed a near-infrared-II (NIR-II, 1000-1700 nm) theranostic nanosystem (FLAGC) for rapid, non-invasive, accurate diagnosis and efficient clearance of metastatic lymph nodes in breast cancer. Initialized by chlorin e6 (Ce6), a pH-sensitive amphiphilic amino acid fluorenylmethoxycarbonyl-L-histidine (Fmoc-His) was assembled with Gd, luminol, and AgAuSe quantum dots (AAS QDs) to form FLAGC.
View Article and Find Full Text PDFIntroduction: This study aimed to investigate the relationship between the serum albumin-to-serum creatinine ratio (sACR) and readmission in elderly heart failure patients.
Methods: We conducted a retrospective cohort study using data from the PhysioNet Restricted Health Data database. The exposure variable was sACR and the outcome variable readmission.
Colloids Surf B Biointerfaces
February 2025
Red blood cell (RBC)-based carriers have emerged as promising vehicles for drug delivery due to their inherent biocompatibility and biodegradability. Traditional methods for loading nanoparticles (NPs) onto RBC surfaces often involve labor-intensive processes like incubation and multiple centrifugation steps, limiting their practicality and controllability. In this study, we introduce a fully integrated acoustofluidic platform that enables one-step preparation of NP-loaded RBC carriers with controlled modification and on-site purification.
View Article and Find Full Text PDFIn wheat (Triticum aestivum), early maturity is desired to avoid the hot and dry summer season, especially in view of climate change. Here, we report that TaE3V1, a C3H2C3 RING-type E3 ligase that interacts with TaVRN1, is associated with early development. Aside from its RING domain, TaE3V1 does not harbor any domains that are conserved in other RING-type or other E3 ligase proteins.
View Article and Find Full Text PDFThe study presents a transcriptomics-based liquid biopsy approach for early recurrence detection in locally advanced gastric cancer (LAGC). Four mRNA biomarkers (AGTR1, DNER, EPHA7, and SUSD5) linked to recurrence are identified through transcriptomic data analysis. A Risk Stratification Assessment (RSA) model combining these biomarkers with clinical features showed superior predictive accuracy for postoperative recurrence, with AUCs of 0.
View Article and Find Full Text PDFThe time-resolved scRNA-seq (tscRNA-seq) provides the possibility to infer physically meaningful kinetic parameters, e.g., the transcription, splicing or RNA degradation rate constants with correct magnitudes, and RNA velocities by incorporating temporal information.
View Article and Find Full Text PDFObjective: To differentiate glioma grading and determine isocitrate dehydrogenase (IDH) mutation status, which are crucial for prognosis assessment and treatment planning in glioma patients.
Methods: This retrospective study included patients diagnosed with adult diffuse glioma from 1 January, 2018 to 31 July, 2023 in two independent institutions. It documented and analysed clinical and radiographic features.
The increasing frequency and intensity of low-temperature events in temperate and cold rice production regions threaten rice yields under climate change. While process-based crop models can project climate impacts on rice yield, their accuracy under low-temperature conditions has not been well-evaluated. Our six-year chamber experiments revealed that low temperatures reduce spikelet fertility from panicle initiation to flowering, grain number per spike during panicle development, and grain weight during grain filling.
View Article and Find Full Text PDFJ Phys Chem A
November 2024
In natural aquatic environments, the fate of arsenic (As) is significantly influenced by redox processes involving iron (Fe) species. Understanding the mechanisms governing As transformation in the presence of Fe species is crucial for comprehending its environmental impact and advancing remediation strategies. In this work, the oxidation of As(III) in oxygenated Fe(II) solutions was investigated.
View Article and Find Full Text PDFBackground: Effective targets for systolic blood-pressure control in patients with type 2 diabetes are unclear.
Methods: We enrolled patients 50 years of age or older with type 2 diabetes, elevated systolic blood pressure, and an increased risk of cardiovascular disease at 145 clinical sites across China. Patients were randomly assigned to receive intensive treatment that targeted a systolic blood pressure of less than 120 mm Hg or standard treatment that targeted a systolic blood pressure of less than 140 mm Hg for up to 5 years.
J Extracell Biol
November 2024
Exosomes are cell-derived nanovesicles that play a crucial role in intercellular communication, presenting promising potential as biomarkers and therapeutic agents. Bovine milk exosomes (MK-Exo) show production scalability and cost-effectiveness, offering distinct advantages over cell-derived exosomes. However, exosome storage and transportation are challenging owing to their unstable nature, necessitating preservation at ultralow temperatures.
View Article and Find Full Text PDFIn this study, we present a pump-free SERS microfluidic chip capable of detecting liver cancer-related miR-21 and miR-155 concurrently with ultra-sensitivity and high efficiency. We employed a FeO@cDNA-AuNPs@Raman reporter@H composite structure and a recognition competition strategy. When the target miRNAs (miR-21 and miR-155) are present in the test liquid, they specifically compete with the nucleic acid complementary strand(H) of FeO@cDNA-AuNPs@Raman reporter@H, causing AuNPs to competitively detach from the surface of FeO, resulting in a decrease in the SERS signal.
View Article and Find Full Text PDFBreast Cancer (Dove Med Press)
November 2024
Background: Aneuploid circulating endothelial cells (CECs) are an indicator in breast cancer (BC). Significant changes of aneuploid CECs occurred during neoadjuvant chemotherapy (NCT). This study aimed to explore the predictive and prognostic values of aneuploid CECs in locally advanced breast cancer (LABC) patients with different NCT responses.
View Article and Find Full Text PDFBackground: Psychological distress, including anxiety and depression, is not only prevalent in patients with coronary heart disease (CHD) but can actually predict adverse clinical events. Therefore, the necessity of addressing psychological problems among patients with CHD to improve their treatment results is increasingly acknowledged. This study's objective was to examine the prognostic impact of anxiety and depression on major adverse cardiovascular events (MACEs) and physical function among patients with acute coronary syndrome (ACS).
View Article and Find Full Text PDFThe present study aimed to investigate the therapeutic potential of Osmundacetone (Osu), a natural plant product, for the treatment of rheumatoid arthritis (RA). The study revealed that Osu effectively reduced arthritis-induced swelling and bone destruction, as well as alleviating inflammation-related factors and oxidative stress in animal models. We focused the mechanism exploration on its regulatory mechanism on osteoclastogenesis in the next investigation.
View Article and Find Full Text PDFObjective: Some patients with pheochromocytoma and paraganglioma (PPGL) suffer from glucose metabolic disorders. The aim was to investigate the relationship between glucose metabolic disorders and catecholamine levels in 705 patients with PPGL.
Methods: A retrospective analysis was conducted on the clinical data of 705 patients diagnosed with PPGL at Peking Union Medical College Hospital from 2018 to 2023.
Colloids Surf B Biointerfaces
February 2025
Conventional chemotherapy drugs are difficult to effectively target tumor tissue, leading to poor treatment outcomes and side effects. Actively targeted and stimuli-responsive nanomedicine greatly improves this situation, allowing for more precise drug accumulation at tumor sites. Herein, carboxymethyl-β-cyclodextrin (CMCD) - based host-guest nanocomposites (NPs) encapsulating hydroxycamptothecin (HCPT) were fabricated, which responded to esterase and had the function of targeting CD 44 receptors and the nucleus.
View Article and Find Full Text PDFAim: This study aimed to explore the trajectory and predictors of subjective well-being (SWB).
Methods: Elderly in Ma'anshan were followed up for 5 years. SWB was measured using the Memorial University of Newfoundland Scale of Happiness (MUNSH).
Skin ageing results in wrinkling. In this study, we discuss four types of facial wrinkles: Crow's Feet wrinkles, forehead wrinkles, glabellar frown wrinkles, and nasolabial folds. These four phenotypes can be assessed either with a photo-numeric scale developed and validated on Caucasian skin (i.
View Article and Find Full Text PDFAims: Diabetes mellitus (DM) links the risk of cardiovascular diseases. Inverse to the enhanced expression of matrix metalloproteinases (MMPs), the development of aortic aneurysm is lower in diabetic population. We examined the hypothesis that DM-induced alteration of metal ion levels declines the activity of MMPs to decrease aortic aneurysm risk.
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