[Gene cloning and expression analysis of an inducible heat shock protein 70 gene from the polychaete Perinereis aibuhitensis under Cu stress].

The objective of this study was to evaluate the molecular characteristics of heat shock protein 70 (HSP70) gene, and document changes in HSP70 gene expression upon exposure of Perinereis aibuhitensis to aqueous Cu. Full length cDNA of HSP70 was sequenced and the characteristics of the translated protein were determined and compared both with other ragworms species and other invertebrates. The results showed that the cDNA was 2161 bp and consisted of a 5'-terminal untranslated region (UTR) of 48 bp, a 3'-termianl UTR of 142 bp with a canonical polyadenylation signal sequence AATAAA and a poly A tail, and an open reading frame (ORF) of 1971 bp.

[Impact of antihypertensive medication timing on degree and stability of blood pressure lowering in patients with essential hypertension].

Objective: To investigate the impact of antihypertensive medication timing on degree and stability of blood pressure (BP) lowering in patients with moderate and severe essential hypertension.

Methods: Ninety patients were randomly assigned to take Valsartan and Felodiping together in the morning (group A), Valsartan in the morning and Felodiping in the evening (group B) or Felodiping in the morning and Valsartan in the evening (group C, n = 30 each). The morning dosage was titrated if the goal blood pressure was not achieved.