Publications by authors named "Li Shiyue"

Purpose: Chronic obstructive pulmonary disease (COPD) is a common disease with high prevalence, high mortality and high costs across the globe. Small airways are major sites contributing to airway resistance and the small airway disorder (SAD) is frequently implicated in early-stage COPD. Smoking is recognized as the leading cause of COPD and SAD.

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Background: Mixed granulocytic asthma (MGA) is usually associated with poor response to corticosteroid therapy and a high risk of severe asthma. Cathepsin S (CTSS) has been found to play an important role in various inflammatory diseases. This study was aimed to investigate the role of CTSS in MGA.

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  • This study focused on creating machine learning models to identify predictive features of dementia in older adults who initially showed normal cognition.
  • Four models were developed and tested, with the random forest model showing the highest accuracy (93%) using factors like memory test results, education, and follow-up time.
  • The findings suggest that this machine learning approach can effectively predict dementia in primary healthcare settings, helping to track cognitive changes and enable early intervention.
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  • The study enhances a model to predict infection risks of respiratory diseases in large public spaces by analyzing factors like pathogen release and airflow.
  • The findings indicate that infection probabilities vary greatly within a shelter hospital, with some areas facing risks 4 to 14 times higher than average.
  • It also reveals concerning statistics, such as a 1.72% infection probability for medical staff, suggesting that patients in specific wards could infect healthcare workers every four days.
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Detecting green fruits presents significant challenges due to their close resemblance in color to the leaves in an orchard environment. We designed GreenFruitDetector, a lightweight model based on an improved YOLO v8 architecture, specifically for green fruit detection. In the Backbone network, we replace ordinary convolution with Deformable Convolution to enhance the extraction of geometric features.

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Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a large class of toxic contaminants. Nutrients are closely related to the ecological health of aquatic systems. Both have received widespread global attention.

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Background: Post-intubation subglottic stenosis (PI-SGS) is a fatal disease which could result in partial or complete narrowing of the airway. Although airway stenting is commonly used as an alternative treatment for PI-SGS patients unsuitable for surgery, complications including stent migration and excessive granulation tissue formation are frequently encountered. Additionally, tracheotomy is necessary in patients undergoing T-tube placement.

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Unlabelled: Although the Omicron variant has been associated with greater transmissibility and tropism of the upper respiratory tract, the clinical and pathogenic features of patients infected with the Omicron variant during an outbreak in China have been unclear. Adults with COVID-19 were retrospectively enrolled from seven medical centers in Guangzhou, China, and clinical information and specimens ( BALF, sputum, and throat swabs) from participants were collected. Conventional detection methods, metagenomics next-generation sequencing (mNGS), and other methods were used to detect pathogens in lower respiratory tract samples.

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Introduction: Bronchopleural fistula (BPF) is associated with high morbidity and mortality rates in patients undergoing pulmonary resections. Surgery, bronchoscopy, and conservative management have their limitations for small fistulas. Platelet-rich plasma (PRP) has regenerative properties, which might be efficient in enhancing tissue recovery and repairing small BPF.

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Background: Gastroesophageal reflux disease (GERD) is a prevalent condition that manifests a spectrum of symptoms, including gastroesophageal-related cough (GERC). Anti-reflux procedures have been employed to alleviate these symptoms, yet their efficacy varies. This systematic review and meta-analysis aim to evaluate the improvement in gastroesophageal-related cough and other reflux symptoms following anti-reflux procedures.

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Background And Objective: Radiofrequency ablation (RFA) is an emerging treatment of lung cancer, yet it is accompanied by certain safety concerns and operational limitations. This first multi-centre, large-scale clinical trial aimed to investigate the technical performance, efficacy and safety of an innovative transbronchial RFA system for lung tumours.

Methods: The study enrolled patients with malignant lung tumours who underwent transbronchial RFA using an automatic saline microperfusion system between January 2021 and December 2021 across 16 medical centres.

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  • Severe asthma has problems with its airway barrier, and a key protein called E-cadherin can be turned into a different form that might cause issues.
  • Researchers studied how this new form, called sE-cadherin, affects asthma by using samples from healthy people and asthma patients, and testing in mice.
  • They found that high levels of sE-cadherin in asthma patients are linked to worse symptoms, and blocking it in mice helped reduce inflammation and problems in their airways.
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Despite the success of various cancer therapies on patient survival, these treatments can have negative side effects, particularly severe damage to the respiratory system. Given the rise in respiratory-associated illnesses in response to cancer treatment, we urge the field to consider a new discipline referred to as 'oncology-respirology' (or onco-respirology).

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Background: To explore the impact of diabetes on the clinical features and prognosis of COVID-19 and assess the influence of glucocorticoid use on the prognosis of patients with COVID-19 and diabetes.

Methods: This retrospective multicenter cohort study included patients admitted between December 2022 and January 2023. The patients were grouped according to diabetes and glucocorticoid use.

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MnO has attracted much attention as the anode for Li-ion batteries (LIBs) owing to its high specific capacity. However, the low conductivity limited its large application. An effective solution to solve this problem is carbon coating.

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Biosafety laboratories are critical in many fields. However, experimenters associated the infection risk from biological aerosols. In this study, by conducting experiments on the release and collection of bioaerosols within a typical BSL-2 + laboratory, the spatial distribution of bioaerosols was tracked.

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  • The study addresses the challenge of diagnosing tracheobronchopathia osteochondroplastica (TO), a rare disease, since many young doctors may struggle to identify it through bronchoscopy.
  • Researchers developed an artificial intelligence (AI) model using bronchoscopic images to accurately distinguish TO from other similar airway diseases such as amyloidosis and tumors.
  • Results showed the AI model achieved a high accuracy of 89.2% in detecting TO among multinodular lesions, and an external validation confirmed the model's effectiveness with an accuracy of 89.8% in diagnosing patients with TO.
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BACKGROUND While many studies have been conducted on sugammadex sodium and neostigmine in patients undergoing general anesthesia, few have explored their effects in patients with interstitial lung diseases (ILDs). MATERIAL AND METHODS Sixty-three patients who underwent transbronchial cryobiopsy under general anesthesia were enrolled in a prospective randomized study. The patients were randomly divided into 2 groups: neostigmine combined with atropine group (group C, n=32) and sugammadex group (group S, n=31).

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Fine particulate matter (PM2.5) has been extensively implicated in the pathogenesis of neurodevelopmental disorders, but the underlying mechanism remains unclear. Recent studies have revealed that PM2.

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  • The study explores the role of ferroptosis, a regulated cell death process, in disrupting E-cadherin expression in asthma, particularly in mixed granulocyte asthma (MGA).
  • Using murine models induced by toluene diisocyanate and ovalbumin, researchers found that allergen exposure led to mitochondrial shrinkage, ferroptosis markers changes, and a significant reduction in E-cadherin levels in airway epithelia.
  • Treatment with ferroptosis antagonists improved lung function, reduced inflammation, and restored E-cadherin expression, suggesting that ferroptosis plays a crucial role in the cellular dysfunction associated with asthma.
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Introduction: Postoperative nausea and vomiting (PONV) is one of the most common adverse events following orthognathic surgery. It's a distressing feeling for patients and continues to be the cause of postoperative complications such as bleeding, delayed healing, and wound infection. This scoping review aims to identify effective PONV prophylaxis strategies during orthognathic surgery that have emerged in the past 15 years.

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  • Endoscopic lung volume reduction using endobronchial valves is a promising treatment for patients with advanced COPD and emphysema, but challenges remain with valve placement and quantity.
  • This study tested the new PulmValve model PV-13 in six healthy pigs, focusing on valve implantation time and safety through various follow-up examinations.
  • Results showed successful deployment and removal of the valves, effective lung volume reduction, and no severe complications, but some minor issues like coughing and granulation tissue were noted, indicating need for further human studies.
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  • Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor, difficult to diagnose early, prompting a study to analyze and predict its imaging characteristics.
  • The research involved assessing 96 cases (25 from a center and 71 published) and created a deep learning model using CT images for accurate PEH identification.
  • Findings revealed diverse imaging features, with specific patterns and a deep learning model showing a promising accuracy, indicating potential clinical application for future use.
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  • The Omicron variant of COVID-19 spreads easily but usually causes milder illness than other variants, and researchers wanted to see how it relates to sepsis in hospitalized patients.
  • In a study of 299 hospitalized adults in China, they checked for sepsis using the Sepsis 3.0 definition and looked at how it affected patients' health and need for intensive care.
  • They found that 64% of patients had sepsis, with a higher number of serious cases among older men and those with other health problems, showing that Omicron can still lead to serious complications.
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