Publications by authors named "Li Sha Chi"
Fibroblast migration is a central process in skin wound healing, which requires the coordination of several types of growth factors. bFGF, a well-known fibroblast growth factor (FGF), is able to accelerate fibroblast migration; however, the underlying mechanism of bFGF regulation fibroblast migration remains unclear. Through the RNA-seq analysis, we had identified that the hedgehog (Hh) canonical pathway genes including Smoothened (Smo) and Gli1, were regulated by bFGF.
View Article and Find Full Text PDFHigh blood sugar is a symptom of diabetes mellitus (DM). Vascular endothelial cells (VECs) directly contact the blood and are damaged when blood sugar levels are high. However, the molecular mechanism underlying this process remains elusive.
View Article and Find Full Text PDFArticle Synopsis
- Delayed wound healing is a key symptom of diabetes mellitus (DM), affecting many patients globally, and the study investigates how high glucose (HG) conditions impact fibroblast cell migration.
- Findings show that while 30 mM HG impedes cell migration, it does not hinder cell proliferation, and bFGF can partially restore normal migration rates by promoting cell movement.
- Mechanistically, the research reveals that HG increases reactive oxygen species (ROS) production and represses JNK phosphorylation, which is crucial for bFGF-regulated migration, demonstrating a link between HG-induced migration delay and bFGF signaling suppression.