Publications by authors named "Li Ruiqi"

Pyroptosis is a type of programmed cell death that induces proinflammatory cytokine release and is closely related to inflammatory diseases. Pulpitis and apical periodontitis are common inflammatory diseases that lead to alveolar bone destruction and tooth loss. Recent studies have revealed that pyroptosis is crucial in the progression of pulpitis and apical periodontitis, which involves various cell types and leads to different results.

View Article and Find Full Text PDF

Circular RNAs (circRNAs) are closely associated with human tumorigenesis; however, whether hsa_circ_0004846 serves a role in the progression of papillary thyroid carcinoma (PTC) remains unclear. Therefore, the present study aimed to investigate the effect of hsa_circ_0004846 on PTC. The results demonstrated that circ_0004846 was abnormally upregulated in PTC tissues and thyroid cancer cell lines (BCPAP, TPC-1 and IHH-4).

View Article and Find Full Text PDF

Objective: This retrospective study aimed to conduct a comparative analysis of the impact of high tibial osteotomy (HTO) and supramalleolar osteotomy (SMOT) on lower limb alignment and ankle function after surgery.

Methods: A cohort of patients who underwent either HTO (n = 63) or SMOT (n = 51) for lower limb alignment issues was included in the study. Inclusion criteria comprised individuals who underwent the surgical procedures between June 2018 and June 2021; exclusion criteria encompassed incomplete medical records and inadequate follow-up data.

View Article and Find Full Text PDF

Chicken anemia virus (CAV), when primarily transmitted through the vertical route, could result in a significant global prevalence. Specifically, vertical CAV transmission, especially in newly-hatched chicks, may cause anemia and immunosuppression, leading to significant losses in the global poultry industry. Although CAV infection of chick embryos is critical in its vertical transmission, the pathogenicity of CAV in these embryos remains unclear.

View Article and Find Full Text PDF

Pressure transmitters are widely used in the process industry for pressure measurement. The sensing line, a core component of the pressure sensor in the pressure transmitter, significantly impacts the accuracy of the pressure transmitter's output. The reliability of pressure transmitters is critical in the nuclear power industry.

View Article and Find Full Text PDF

Introduction: Fusarium verticillioides (F. verticillioides) is a prevalent phytopathogen that incites severe diseases in maize, resulting in substantial reductions in grain yield and quality. Despite its widespread impact, the genetic mechanisms underlying resistance to this pathogen remain elusive, with only a limited of resistant genes having been identified to date.

View Article and Find Full Text PDF

Principal component analysis (PCA) is indispensable for processing high-throughput omics datasets, as it can extract meaningful biological variability while minimizing the influence of noise. However, the suitability of PCA is contingent on appropriate normalization and transformation of count data, and accurate selection of the number of principal components; improper choices can result in the loss of biological information or corruption of the signal due to excessive noise. Typical approaches to these challenges rely on heuristics that lack theoretical foundations.

View Article and Find Full Text PDF

HIV infection exerts profound and long-lasting neurodegenerative effects on the central nervous system (CNS) that can persist despite antiretroviral therapy (ART). Here, we used single-nucleus multiome sequencing to map the transcriptomic and epigenetic landscapes of postmortem human brains from 13 healthy individuals and 20 individuals with HIV who have a history of treatment with ART. Our study spanned three distinct regions-the prefrontal cortex, insular cortex, and ventral striatum-enabling a comprehensive exploration of region-specific and cross-regional perturbations.

View Article and Find Full Text PDF

Introduction: Mitochondria and angiogenesis play key roles in multiple myeloma (MM) development, but their interrelated genes affecting MM prognosis are under-studied.

Methods: We analyzed TCGA_MMRF and GSE4581 datasets to identify four genes - CCNB1, CDC25C, HSP90AA1, and PARP1 - that significantly correlate with MM prognosis, with high expression indicating poor outcomes.

Results: A prognostic signature based on these genes stratified patients into high- and low-risk groups, with the latter showing better survival.

View Article and Find Full Text PDF

The readiness potential (RP) is an important neural characteristic in motor preparation-based brain-computer interface. In our previous research, we observed a significant decrease of the RP amplitude in some cases, which severely affects the pre-movement patterns detection. In this paper, we aimed to improve the accuracy (Acc) of pre-movement patterns detection in the condition of RP decrease.

View Article and Find Full Text PDF

Objectives: Chitosan is widely used in medicine to regulate immune responses in T cells and dendritic cells. However, research on the regulation of mast cells (MCs) is scarce. Mas-related G-protein-coupled receptor X2 (MRGPRX2) is a key receptor that mediates MC activation.

View Article and Find Full Text PDF

Background: Presently, colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. We provided global, regional, and national estimates of the burden of CRC and their attributable risks from 1990 to 2021, aiming to guide screening, early detection, and treatment strategies, optimize healthcare resource allocation, and facilitate the rational management of burden of CRC.

Methods: Using data derived from the Global Burden of Disease database, we estimated the incidence, mortality, and disability-adjusted life years (DALYs) of CRC.

View Article and Find Full Text PDF

Background: Gestational diabetes mellitus (GDM) is a complex metabolic disease that has short-term and long-term adverse effects on mothers and infants. However, the specific pathogenic mechanism has not been elucidated.

Objective: The aim of this study was to confirm the associations between candidate genetic variants (rs4134819, rs720918, rs2034410, rs11109509, and rs12524768) and GDM risk and prediction in a southern Chinese population.

View Article and Find Full Text PDF

Background: Chronic graft-versus-host disease (cGVHD) manifests with characteristics of autoimmune disease with organs attacked by pathogenic helper T cells. Recent studies have highlighted the role of T cells in cGVHD pathogenesis. Due to limited understanding of underlying mechanisms, preventing cGVHD after allogenic hematopoietic cell transplantation (HCT) has become a major challenge.

View Article and Find Full Text PDF

Symbioses are major drivers of organismal diversification and phenotypic innovation. However, how long-term symbioses shape whole genome evolution in metazoans is still underexplored. Here, we use a giant clam (Tridacna maxima) genome to demonstrate how symbiosis has left complex signatures in an animal's genome.

View Article and Find Full Text PDF

As marine equipment advances from shallow to deep-sea environments, the demand for high-performance antifouling materials continues to increase. The lionfish, a species inhabiting both deep-sea and shallow coral reefs, prevents fouling organism adhesion via its smooth, mucus-covered skin, which contains antimicrobial peptides. Inspired by lionfish skin, this work integrates zwitterionic segments with hydration-based fouling-release properties and the furan oxime ester structure with intrinsic antibacterial activity to develop a silicone-based antifouling coating capable of operating from shallow to deep-sea environments.

View Article and Find Full Text PDF

Silicone coatings are widely employed in marine antifouling applications due to their low surface energy. However, in static marine environments, pure silicone coatings are ineffective in preventing the adhesion of marine biofilms, which consist of proteins, marine bacteria, and extracellular matrices, ultimately promoting the attachment of macrofouling organisms. To address the limitations in antifouling performance under static conditions, this study introduces a silicone-based antifouling coating modified with zwitterionic polymers.

View Article and Find Full Text PDF

Aiming at predefined-time synchronization for chaotic systems, a new predefined-time sliding mode control method is proposed. First, based on the definition of predefined-time stability, a novel predefined-time inequality is proposed, along with a detailed mathematical proof. This inequality differs from existing Lyapunov inequalities and offers greater flexibility.

View Article and Find Full Text PDF

Sarcopenia is more common in elderly individuals and is often associated with functional limitations, which can affect postoperative clinical efficacy and mortality rates in cancer surgery. Yet, the precise effects of sarcopenia on individuals receiving robotic colorectal cancer surgery (RCRC) remain insufficiently explored. Our objective was to evaluate the value of preoperative skeletal muscle status on patients receiving RCRC about postoperative complications and long-term prognosis.

View Article and Find Full Text PDF

D-amino acids, found in excess in a minority of organisms and crucial for marine invertebrates, contrast with the more common L-amino acids in most life forms. The local prebiotic origin of D-amino acid enantiomeric excess in natural systems remains an unsolved conundrum. Herein, we demonstrate the formation of enantiomeric excess (ee) D-amino acids through photocatalytic reductive amination of α-keto acids on natural pyrite.

View Article and Find Full Text PDF

The manipulation of oxygen vacancies is regarded as a viable approach to enhance the electrochemical properties of electrode materials. Herein, NiAl-LDH nanosheets with rich oxygen vacancies were successfully synthesized on the surface of nickel foam a conventional hydrothermal and chemical reduction strategy. The oxygen vacancies were introduced and modulated NaBH treatment, significantly enhancing the electrochemical properties.

View Article and Find Full Text PDF

In this study, solid composite electrolytes (SCEs) comprising UIO-66-F(Zr) were obtained by using a simple solution casting method. By introducing fluorinated groups, the interaction between the MOF and the polymer was significantly improved, which not only stabilizes the SEI layer but also improves the ionic conductivity of the SCEs, thus advancing the practical application of solid composite electrolytes in lithium metal batteries.

View Article and Find Full Text PDF

Background: Gastric cancer can lead to excessive catabolism in patients. After undergoing gastric surgery, patients may experience additional unintended weight loss, resulting in severe malnutrition and potentially cachexia.

Methods: We selected and incorporated patients from two centers.

View Article and Find Full Text PDF
Article Synopsis
  • * Granulosa cells from patients with endometrioma showed significant differences in chromatin accessibility and gene expression compared to women without the condition, with many genes being downregulated.
  • * Key downregulated genes (PPIF and VEGFA) were linked to the number of retrieved oocytes, suggesting that disruptions in granulosa cell functions may hinder egg quality and fertility in endometrioma patients.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session5cgfnu2pr61jg2o9a92e2pokd0cd6p2n): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once