Ultralow Power Optoelectronic Memtransistors Based on Vertical WS/InSe van der Waals Heterostructures.

Memtransistors composed of 2D van der Waals (vdW) heterostructures are crucial for constructing artificial synaptic devices and realizing neuromorphic computing. The functional integration containing ultralow power, nonvolatile memory, and biomimetic synaptic behavior endows such devices with broad prospects. Here, we develop an optoelectronic memtransistor based on the WS/InSe vdW heterostructure and realize significant optical and electrical synaptic properties, which can simulate both short-range plasticity (STP) and long-range plasticity (LTP) of biological synapses.

Strategies for Improving Contact-Electro-Catalytic Efficiency: A Review.

Contact-electro-catalysis (CEC) has emerged as a promising catalytic methodology, integrating principles from solid-liquid triboelectric nanogenerators (SL-TENGs) into catalysis. Unlike conventional approaches, CEC harnesses various forms of mechanical energy, including wind and water, along with other renewable sources, enabling reactions under natural conditions without reliance on specific energy inputs like light or electricity. This review presents the basic principles of CEC and discusses its applications, including the degradation of organic molecules, synthesis of chemical substances, and reduction of metals.

Co-occurrence of mcr-9 and bla in Multidrug-Resistant Enterobacter hormaechei Strain Isolated from a Patient with Bloodstream Infection.

Enterobacter hormaechei (E. hormaechei), a member of the Enterobacter cloacae complex, has emerged as an important pathogen in healthcare-associated infections. In this study, a multidrug-resistant E.

Distinct effects of sevoflurane and propofol on vascular permeability in vitro and in a mouse model.

Background: General anesthetics may substantially influence endothelium function, potentially affecting outcomes of surgical patients, but their effects are unclear. Here, we studied a commonly used inhaled anesthetic, sevoflurane, and an intravenous anesthetic, propofol, on vascular endothelial permeability using multiple in vitro assays and a mouse model.

Methods: Human umbilical vein endothelial cells (HUVECs) and mouse pulmonary endothelial cells (MPECs) were used for in vitro models to test the effect of anesthetics on endothelial permeability.

Physiological and Transcriptome Analysis Reveal the Underlying Mechanism of Salicylic Acid-Alleviated Drought Stress in Kenaf ( L.).

Salicylic acid (SA) plays a crucial role in alleviating drought stress in plants. However, little is known about the molecular mechanisms underlying exogenous SA on the drought tolerance of kenaf. In this study, the kenaf seedlings were subjected to physiological and transcriptomic analysis under control (CK), moderate drought stress (D), and moderate drought stress with 1 mM SA (D_SA).

Plasma Treatment Induced Oxygen Vacancies and N Doping in the BiVO Photoanode toward Improved Charge Transfer and Facilitated Water Oxidation.

BiVO is a promising material candidate for photoelectrochemical (PEC) water splitting. However, the BiVO photoanode commonly suffers from poor charge carrier transport and sluggish water oxidation kinetics, which limits its PEC performance. Nitrogen (N) doping has been proven as an effective approach to improve electric conductivity and accelerate the water oxidation kinetics of the BiVO photoanode.

An unusual transfusion-dependent hemoglobin H disease caused by a novel complex inverted duplication involving the α-globin regulatory elements and α-thalassemia--SEA deletion.

Four multi-species conserved sequences (MCSs) are important enhancers which affect α-globin expression. Deletions of MCS can cause α-thalassemia. So far, duplication of MCS has never been reported to account for thalassemia.

A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study.

Alterations in intestinal microbiota have been identified as a key risk factor in rheumatoid arthritis (RA). This study presents a multidimensional gut microbiota profile from a large cohort of RA patients, stratified by disease stage and treatment regimens, and compared to healthy controls. Our dataset comprises gut microbiota profiles from 2,238 individuals, including 1,034 RA patients (Ascia Pacific RA cohort, APRAC) and 1,204 healthy controls.

Behavior as a window to the mind - objective daily life assessment of attention and hyperactivity/impulsivity.

Background: For decades, researchers have been searching for objective laboratory markers to measure and define attention deficit and hyperactivity disorder. However, in clinical practice, the most commonly used tools are still psychological scales, which are neither objective nor laboratory-based. This reliance on scales may stem from the fact that they are currently the only available method in this field for collecting daily-life data, and such data plays an irreplaceable role in defining mental disorders.

Functional Remediation Improves Serum BDNF and TrkB Levels in Euthymic Patients with Bipolar Disorder: A Randomized Trial Study.

Purpose: We aimed to verify the impact of functional remediation (FR) on serum brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) levels, to explore the biomechanism of FR intervention in patients with euthymic bipolar disorder (BD).

Patients And Methods: This is a randomized controlled, 12-week intervention study with participants randomized into the FR group (n=39) and the treatment as usual group (TAU, n=42) at the 1∶1 ratio. 17-Hamilton Depression Rating Scale-17 (HDRS-17), Young Mania Rating Scale (YMRS), and Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) were used to assess affective symptoms and cognitive functioning both at baseline and week 12, respectively.

Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection.

With the rapid increase in the number of implant operations, the incidence of bone infections has increased. Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make the management of bone infections even more challenging.

Fasting enhances the efficacy of Sorafenib in breast cancer via mitophagy mediated ROS-driven p53 pathway.

The multi-kinase inhibitor sorafenib has shown potential to inhibit tumor cell growth and intra-tumoral angiogenesis by targeting several kinases, including VEGFR2 and RAF. Abnormal activation of the Ras/Raf/MAPK/ERK kinase cascade and the VEGF pathway is a common feature in breast cancer. However, the efficacy of sorafenib in breast cancer treatment remains limited.

Bifunctional poly(1,3-dioxolane)-graphitic CN composite interlayers enable stable and compatible anode interfaces in solid lithium batteries.

Polyacrylonitrile (PAN)-based composite solid electrolytes (CSEs) hold great promise in the practical deployment of solid lithium batteries (SLBs) owing to their high voltage stability but suffer from poor stability against Li-metal. Herein, a poly(1,3-dioxolane) (PDOL)-graphitic CN (g-CN, i.e.

Preparation of pH-Responsive Tanshinone IIA-Loaded Calcium Alginate Nanoparticles and Their Anticancer Mechanisms.

Tanshinone IIA (Tan IIA) is a lipophilic active constituent derived from the rhizomes and roots of (Danshen), a common Chinese medicinal herb. However, clinical applications of Tan IIA are limited due to its poor solubility in water. : To overcome this limitation, we developed a calcium alginate hydrogel (CA) as a hydrophilic carrier for Tan IIA, which significantly improved its solubility.

Study on the Effect of Radish Sprouts on Short-Chain Fatty Acids and Gut Microbial Diversity in Healthy Individuals.

This study aimed to assess the impact of radish sprouts on the gut microbiota of healthy individuals. Radish sprout additives, subjected to short-term storage and steam treatment, were used to intervene in an in vitro culture of human gut microbiota. The influence of radish sprouts on the gut microbiota was evaluated by monitoring short-chain fatty acid (SCFA) content and proportion in the fermentation broth, and microbial diversity was assessed using 16S rDNA amplicon sequencing.

A clinical analysis and literature review of eleven cases with primary pulmonary angiosarcoma.

Objective: The aim of this study is to explore the clinicopathological features, radiographic manifestations, treatment options, and prognosis of primary pulmonary angiosarcoma (PPAS).

Method: We summarized and analyzed the clinical data of 11 patients with primary pulmonary angiosarcoma treated at the First Affiliated Hospital of Guangzhou Medical University between January 2018 and January 2024. A retrospective analysis was conducted in conjunction with a review of the relevant literature.

RPO film effectively promotes fruit quality and yield of cucumber through adjusting greenhouse environment and hormone contents.

Light conversion films are crucial for optimizing vegetable crop production in greenhouses, particularly during winter and spring seasons. This study investigated the effects of a europium-based light conversion film (RPO) compared to traditional polyolefin film (PO film, control) on cucumber (Cucumis sativus L.) cultivation, focusing on handle length, yield, and fruit quality in a randomized complete block design with three replications.

Systematic free energy insights into the enhanced dispersibility of myofibrillar protein in low-salt solutions through ultrasound-assisted enzymatic deamidation.

This work aimed to investigate the effects of ultrasound assisted enzymatic deamidation by protein-glutaminase (PG) on the dispersion of myofibrillar protein (MP) in low-salt solutions. The solubility, structural characteristics, transmission electron microscopy, asymmetric-flow field-flow fractionation, steady shear rheological property and multiple light scattering of MP deamidated by PG (MP-PG) and MP pretreated with ultrasound followed by PG deamidation (MP-U-PG) were determined. Molecular docking and molecular dynamics (MD) simulations were used to estimate the interaction between PG and MP.

mA demethylase CpALKBH regulates mRNA stability to modulate the development and virulence of chestnut blight fungus.

Unlabelled: As the most abundant eukaryotic mRNA modification, N-methyladenosine (mA) plays a crucial role in regulating multiple biological processes. This methylation is regulated by methyltransferases and demethylases. However, the regulatory role and mode of action of mA demethylases in fungi remain poorly understood.

Cyclosporine successfully treats steroid-resistant checkpoint inhibitor-related pneumonitis: a case report.

Background: Immune checkpoint inhibitor-related pneumonitis (CIP) stands out as a particularly severe adverse event caused by immune checkpoint inhibitors, with a substantial real-world incidence ranging from 13 to 19%. While systemic corticosteroids represent the standard treatment for CIP, therapeutic options become limited in cases where patients do not respond to corticosteroid therapy. Such patients are classified as having steroid-resistant CIP, often associated with a poor prognosis.

Effect and mechanisms of shikonin on breast cancer cells in vitro and in vivo.

Background: Breast cancer seriously affects physical and mental health of women. Despite advances in the clinical use of different treatments, breast cancer remains a major cause of mortality. Therefore, it is imperative to identify promising treatment options.