Precooling storage of bone cement in percutaneous vertebroplasty for osteoporotic vertebral compression fracture.

Purpose: This study aimed to investigate the effect of precooling storage of bone cement in percutaneous vertebroplasty(PVP) for the patients with osteoporotic vertebral compression fracture (OVCF).

Methods: A total of 207 OVCF patients who underwent PVP were included in this study. Two different storage methods for the bone cement were randomly utilized: an operating room (NT group, 23 °C) and a refrigerator (PC group, 4 °C).

The combination of hydrogen evolution, nitric oxide oxidation and Zn-nitrate battery for energy conversion and storage by an efficient nitrogen-dopped CoO electrocatalyst with Turing structure.

We tuned the morphology from the needle-like Co(CO)(OH)·0.11HO to the unique Turing-structured CoCO through controlling the amount of glycerol in the solvothermal system, and then synthesized the Turing structure consisting of N-50 %-CoO hollow nanoparticles though the Kirkendall effect during nitriding process, which was applied as a novel bifunctional self-supporting electrode for efficient electrocatalytic hydrogen evolution reaction (HER) and electrocatalytic NO oxidation reaction (eNOOR). The eNOOR can be not only used as a substitution anode reaction of oxygen evolution reaction (OER) to couple with HER for efficient water splitting, but the production of nitrate from eNOOR also provides a strategy for the development of Zn-nitrate battery.

Investigation of pre-crash avoidance kinematics in pedestrians of different ages through volunteer experiment and scaling methodology.

Objective: Understanding pedestrians' pre-crash avoidance kinematics is crucial for improving the identification of potential collision areas in interactions with highly automated vehicles (HAVs). Age significantly influences pedestrian avoidance velocity and the subsequent crash risks. However, current active safety systems in HAVs often overlook the influence of pedestrians' avoidance velocity and age on imminent accidents.

Integrated network pharmacology and brain metabolomics to analyze the mechanism of Dihuang Yinzi intervention in Alzheimer's disease.

Ethnopharmacological Relevance: Alzheimer's disease (AD) is an incurable neurodegenerative disease that has become one of the most important diseases threatening global public health security. Dihuang Yinzi (DHYZ) is a traditional Chinese medicine that has been widely used for the treatment of AD and has significant therapeutic effects, but its specific mechanism of action is still unclear.The aim of the study is to investigate the specific mechanism of DHYZ in treating AD based on brain metabolomics and network pharmacology.

Antioxidant activity of herbal medicine evaluated by electron paramagnetic resonance spectroscopy.

The hydroxyl radical (˙OH) is one of the most reactive and harmful reactive oxygen species in living organisms. In this study, we used electron paramagnetic resonance (EPR) spectroscopy to evaluate the antioxidant activity of herbal medicine (PL) by measuring its scavenging activity against ˙OH radicals. Using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical as a scavenging model, the PL extract (0.

Developmental Trajectory of Autistic-Like Behaviors in a Prenatal Valproic Acid Rat Model of Autism.

Autism spectrum disorders (ASDs) are characterized by deficits in social functioning, stereotyped patterns of behaviors, narrowed interests, and elevated anxiety. Certain ASD symptoms can persist, whereas others may improve throughout the lifespan, but the specific patterns of changes have not been clearly delineated. Using a valproic acid (VPA) rat model of ASD, the present study took a developmental approach and examined how autistic-like behaviors, including anxiety-like behavior, object obsession, and social functioning deficits, manifested differently in three critical periods representing preadolescent (postnatal day [PND] 25), adolescent (PND 45), and adulthood life stage (PND 75) in a sex-dependent manner.

Activation strategies and effectiveness of Intelligent safety systems for reducing pedestrian injuries in autonomous vehicles.

Intelligent safety systems (ISS) for autonomous vehicles, integrating advanced perception capabilities and passive protection devices, are expected to reshape traditional pedestrian safety systems and play a key role in reducing the risk of pedestrian injuries in traffic accidents. However, traditional active control and passive protection modules remain disconnected due to insufficient evidence supporting the effectiveness of collaborative strategies in integrated systems, particularly concerning activation criteria and timing. This study aims to address this gap by developing a comprehensive ISS that incorporates advanced perception systems, a vehicle dynamic control module, and controllable passive safety devices.

The investigation of an inspired type toroidal dipole flexible metasurfaces at terahertz frequencies.

We theoretically and experimentally carried out an inspired type of toroidal dipole (TD) metasurfaces, which composed of a metamolecule of symmetric aluminium semicircles with a bar in the middle fabricated on polyimide substrate in the terahertz (THz) regime. It was found that the three resonances show red-shift tendency due to the increase of inductance and capacitance with the increase of semicircle's outer radius. Meanwhile, both the TD resonances and the current flowing in the metallic bar can generate the head-to-tail magnetic field distribution, which is the most prominent feature of TD phenomenon.

Liang-Ge-San Decoction Ameliorates Acute Respiratory Distress Syndrome via Suppressing p38MAPK-NF-κ B Signaling Pathway.

Objective: To explore the potential effects and mechanisms of Liang-Ge-San (LGS) for the treatment of acute respiratory distress syndrome (ARDS) through network pharmacology analysis and to verify LGS activity through biological experiments.

Methods: The key ingredients of LGS and related targets were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. ARDS-related targets were selected from GeneCards and DisGeNET databases.

Snapshot computational spectroscopy enabled by deep learning.

Spectroscopy is a technique that analyzes the interaction between matter and light as a function of wavelength. It is the most convenient method for obtaining qualitative and quantitative information about an unknown sample with reasonable accuracy. However, traditional spectroscopy is reliant on bulky and expensive spectrometers, while emerging applications of portable, low-cost and lightweight sensing and imaging necessitate the development of miniaturized spectrometers.

The mechanisms of Pin1 as targets for cancer therapy.

Targeted therapy has considerable promise for the effective eradication of cancer at the primary tumor site prior to subsequent metastasis. Using this therapeutic approach, gaining an understanding of mechanistic cancer models is essential for facilitating the inhibition or suppression of tumor growth. Among different oncogenes and proteins, the protein interacting with never-in-mitosis kinase-1 (Pin1) is particularly important.

Pseudomonas chlororaphis ZH2: Evaluation of the Biocontrol Potential of Continuous Cropping Obstacles on the Basis of Genome Analysis, Autotoxic Substance Degradation and In Vitro Antifungal Activity.

The accumulation of autotoxic substances and fungal pathogens in soil are the two leading causes of continuous cropping obstacles. In this context, the use of beneficial strains for the biological control of continuous cropping obstacles is a promising research direction. In this work, the functions of Pseudomonas chlororaphis ZH2 in antagonizing pathogenic fungi and degrading autotoxic substances during continuous cropping were studied via genome-wide sequence analysis, antifungal activity in vitro, and autotoxic substances degrading tests.

Modulation format identification in elastic optical networks using integrated photonic reservoir computing and untrained K-nearest neighbors algorithm.

In the next generation of Elastic Optical Networks, various modulation formats exhibit varying degrees of sensitivity to channel impairments during transmission. To adopt appropriate channel equalization schemes at the receiver, it is essential to perform modulation format identification prior to the receiver, followed by the adjustment of receiver parameters and types based on the recognition results. A system based on a 52-node integrated photonic reservoir chip and untrained K-nearest neighbors (KNN) algorithm is proposed for the recognition of OOK, PAM4, QPSK, and BPSK modulation formats in optical channel transmission.

Theoretical insights on potential-dependent oxidation behaviors and antioxidant strategies of MXenes.

Significant efforts have been devoted to investigating the oxidation of MXenes in various environments. However, the underlying mechanism of MXene oxidation and its dependence on the electrode potential remain poorly understood. Here we show the oxidation behavior of MXenes under the working conditions of electrochemical processes in terms of kinetics and thermodynamics by using constant-potential ab initio simulations.

Umbilical Cord-Derived Mesenchymal Stem Cells Improve Ornidazole-Induced Asthenozoospermia in Rats via Activation of the AKT/mTOR Pathway.

Mesenchymal stem cells (MSCs) have been highly confirmed for their critical role in the treatment of different diseases. This study focuses on the mechanism of umbilical cord-derived MSCs (UC-MSCs) in the treatment of ornidazole (ORN)-induced asthenozoospermia (AS) in rats via the AKT/mTOR pathway. An animal model of AS was established in ORN-induced rats, followed by treatment of UC-MSCs and rapamycin (autophagy activator) or MK-2206 (AKT inhibitor).

Targeted antimicrobial self-assembly peptide hydrogel with in situ bio-mimic remineralization for caries management.

The single-function agents with wide-spectrum activity which tend to disturb the ecological balance of oral cavity cannot satisfy dental treatment need. A multi-functional agent with specifically targeted killing property and in situ remineralization is warranted for caries management. A novel multi-functional agent (8DSS-C8-P-113) consisting of three domains, i.

Ketogenesis promotes triple-negative breast cancer metastasis via calpastatin β-hydroxybutyrylation.

Triple-negative breast cancer (TNBC) continues to pose a significant obstacle in the field of oncology. Dysregulation of lipid metabolism, notably upregulated ketogenesis, has emerged as a hallmark of TNBC, yet its role in metastasis has been elusive. Here, by utilizing clinical specimens and experimental models, the study demonstrates that increased ketogenesis fosters TNBC metastasis by promoting the up-regulation of β-hydroxybutyrate (β-OHB), a key ketone body.

Quantum Coherence Control at Temperatures up to 1400 K.

Coherent quantum control at high temperatures is important for expanding the quantum world and is useful for applying quantum technologies to realistic environments. Quantum control of spins in diamond has been demonstrated near 1000 K, with the spins polarized and read out at room temperature and controlled at elevated temperatures by rapid heating and cooling. Further increase of the working temperature is challenging due to fast spin relaxation in comparison with the heating and cooling rates.

Design and Synthesis of BODIPY and Its Application in Inhibiting Intestinal Flora.

BODIPY-based photosensitizers were synthesized and tested for antimicrobial photodynamic therapy, revealing structural modifications enhancing the photodynamic therapy (PDT) effects. This research may lead to new PDT strategies for treating bacterial infections, including those resistant to traditional antibiotics, and offers insights into the prevention and treatment of Alzheimer's disease through gut microbiota regulation.

Huaxian formula prevents the progression of radiation-induced pulmonary fibrosis by inhibiting the pro-fibrotic effects of macrophages.

Ethnopharmacological Relevance: The Huaxian formula (HXF), a traditional Chinese medicine (TCM) remedy, specifically targets the pathological factors of "heat toxicity" and "phlegm stasis" induced by radiation in radiation-induced pulmonary fibrosis (RIPF). It works by clearing heat and invigorating the blood, addressing these key factors in the development of RIPF.

Aim Of The Study: The HXF has demonstrated potential in preventing RIPF, although its underlying mechanisms remain unclear.

FoxK1 and FoxK2 cooperate with ORF45 to promote late lytic replication of Kaposi's sarcoma-associated herpesvirus.

Lytic replication is essential for persistent infection of Kaposi's sarcoma-associated herpesvirus (KSHV) and the pathogenesis of related diseases, and many cellular pathways are hijacked by KSHV proteins to initiate and control the lytic replication of this virus. However, the mechanism involved in KSHV lytic replication from the early to the late phases remains largely undetermined. We previously revealed that KSHV open reading frame 45 (ORF45) plays important roles in late transcription and translation.