Development of a PANoptosis-related LncRNAs for prognosis predicting and immune infiltration characterization of gastric Cancer.

PANoptosis is a newly discovered form of programmed cell death (PCD), involving the interaction of cellular pyroptosis, apoptosis, and necroptosis. Although PANoptosis plays a significant role in carcinogenesis process, the impact of PANoptosis-related lncRNAs (PANlncRNAs) on the prognostic value and mechanism of immune infiltration of gastric cancer have not been studied. All information of gastric cancer (GC) patients was downloaded from the TCGA database.

Comprehensive analysis and experimental validation of disulfidptosis-associated prognostic signature and immune microenvironment characterization of gastric cancer.

Background: Gastric cancer (GC) is one of the most common causes of cancer-related death worldwide. As a novel form of programmed cell death, disulfidptosis is characterized by excessive cysteine accumulation, disulfide stress and actin destruction. There is evidence that targeting disulfidptosis is a promising anticancer strategy.

Association between triglyceride-glucose index and carotid atherosclerosis in Chinese steelworkers: a cross-sectional study.

This study aims to explore the association between the triglyceride-glucose (TyG) index and the risk of carotid atherosclerosis (CAS) among Chinese steelworkers. This is a cross-sectional study involving a total of 4,203 Chinese steelworkers. The TyG index was calculated using the formula: TyG = Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL) / 2].

Modulation of the Second-Beyond Coordination Structure in Single-Atom Electrocatalysts for Confirmed Promotion of Ammonia Synthesis.

Although microenvironments surrounding single-atom catalysts (SACs) have been widely demonstrated to have a remarkable effect on their catalytic performances, it remains unclear whether the local structure beyond the secondary coordination shells works as well or not. Herein, we employed a series of metal-organic frameworks (MOFs) with well-defined and tunable second-beyond coordination spheres as model SAC electrocatalysts to discuss the influence of long-distance structure on the ammonia synthesis from nitrate, which were synthesized and denoted as Cu-NDI-X (X = NMe, H, F). It is first experimentally confirmed that the remote substitution of function groups beyond the secondary coordination sphere can remarkably affect the activity of ammonia synthesis.

Study on the Properties of Basalt Fiber-Calcined Gangue-Silty Clay Foam Concrete for Filling Undermined Goaf Areas of Highways.

The collapse of surface goaf beneath highways can result in instability and damage to roadbeds. However, filling the goaf areas with foam concrete can significantly enhance the stability of the roadbeds while considerably reducing the costs of filling materials. This study analyzes the effects on destructive characteristics, mechanical properties, stress-strain curve features, and relevant metrics, while also observing the microstructure of basalt fiber-calcined gangue-silty clay foam concrete (BF-CCG-SCFC).

Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway.

Background: With extended gefitinib treatment, the therapeutic effect in some non-small cell lung cancer (NSCLC) patients declined with the development of drug resistance. Aidi injection (ADI) is utilized in various cancers as a traditional Chinese medicine prescription. This study explores the molecular mechanism by which ADI, when combined with gefitinib, attenuates gefitinib resistance in PC9GR NSCLC cells.

[Nutritional status and height development of rural children aged 10-12 years in Linxia Hui Autonomous Prefecture, Gansu Province, and the relationship with intelligence quotient in 2019].

Objective: To investigate the nutritional status, height development and intellectual development level of rural children aged 10-12 years in Linxia Hui Autonomous Prefecture, Gansu Province, and to analyze the relationship between the nutritional status and height development of local schoolchildren and their intellectual development.

Methods: In 2019, a total of 1721 students were selected from 8 counties(cities) under the jurisdiction of Linxia Prefecture in Gansu Province, with 1 township selected from each county in 5 directions: east, west, south, north, and central. One primary school was randomly selected from each township, and 45 students aged 10-12 were selected from each primary school.

Multifunctional Phase Change Films with High Mechanical Strength, Thermally Induced Switchable Adhesion, and Shape Recoverability for Infrared Stealth.

The application of organic solid-liquid phase change materials (PCMs) is limited for the leakage problem after phase change and high rigidity. In this work, a novel flexible solid-solid PCM (DXPCM) was synthesized using a block copolymerization process with polyethylene glycol (PEG) as the energy storage segment. The phase transition temperature (from 36.

Acute kidney injury in elderly patients receiving invasive mechanical ventilation: early versus late onset.

Background: Acute kidney injury (AKI) is a severe complication in critical patients receiving invasive mechanical ventilation (MV). However, AKI which occurs in the first 48 h after MV (early AKI) and thus likely associated with the MV settings is probably different from AKI occurring following 48 h (late AKI). This study is aimed at exploring the incidence of early and late AKI in elderly patients receiving MV and identifying their different risk factors and outcomes.

The PRL2 Phosphatase Upregulates miR-21 through Activation of the JAK2/STAT3 Pathway to Downregulate the PTEN Tumor Suppressor.

The Phosphatases of Regenerating Liver (PRLs) are members of the protein tyrosine phosphatase (PTP) superfamily that play pro-oncogenic roles in cell proliferation, migration, and survival. We previously demonstrated that PRLs can post-translationally downregulate PTEN, a tumor suppressor frequently inactivated in human cancers, by dephosphorylating PTEN at Tyr336, which promotes the NEDD4-mediated PTEN ubiquitination and proteasomal degradation. Here we report that PRLs can also reduce PTEN expression by upregulating MicroRNA-21 (miR-21), which is one of the most frequently overexpressed miRNAs in solid tumors.

Nitrogen metabolic responses of non-rhizosphere and rhizosphere microbial communities in constructed wetlands under nanoplastics disturbance.

Constructed wetlands (CWs) serve as crucial sinks for nanoplastics, making them a significant research hotspot regarding the impacts of nanoplastics on the nitrogen metabolism within microbial communities. However, there has been a lack of comparative analysis between rhizosphere and non-rhizosphere microbial communities under nanoplastics disturbance. This study analyzes the nitrogen metabolic responses of these microbial communities in CWs following repeated nanoplastics disturbance.

Cinobufagin modulates vasculogenic mimicry and tumor-associated macrophages to inhibit ovarian cancer progression.

Background: Ovarian cancer is among the most prevalent malignant tumors affecting women. While conventional therapies like surgery do provide some measure of disease control, they are accompanied by evident side effects that may readily result in drug resistance. Cinobufagin (HCS) is a water-soluble active component extracted from the dried skin of the Bufo gargarizans.

Dysmagnesemia with acute kidney injury among older adults: clinical characteristics and prognostic importance.

Purpose: The relationship between dysmagnesemia and all-cause mortality probability in individuals with acute kidney injury (AKI) have not been investigated. In this study, we evaluated the correlation of varying magnesium levels with mortality in older adults undergoing AKI.

Patients And Methods: Older adults receiving treatment at the Chinese PLA General Hospital between 2007 and 2018 were retrospectively recruited.

Exploring the mechanism of tetramethylpyrazine in the treatment of osteoarthritis based on network pharmacology.

Background: Osteoarthritis (OA) is the most common joint disease, which mainly damages articular cartilage and involves the whole joint tissue. It has the characteristics of long course, repeated symptoms and high disability rate, and the incidence trend is gradually increasing. Tetramethylpyrazine (TMP) is the main alkaloid active substance in Ligusticum wallichii, a traditional Chinese medicine, which has the effect of promoting blood circulation and dredging collaterals, and has a good effect on the treatment of early OA, but its molecular mechanism has not been fully clarified so far.

Predicting Health-Related Quality of Life Among Chinese Residents: Latent Class Analysis Based on Panel Survey Data.

Purpose: This study aimed to identify distinct trends among Chinese residents based on their health-related quality of life (HR-QoL) outcomes and to analyze the demographic characteristics that contribute to these trends.

Materials And Methods: The study conducted latent class analysis using baseline data obtained from a survey of health service utilization behaviors (from July to December 2016) among residents of Hubei Province, China (N = 1517). Latent classes were used to implement the HR-QoL grouping of different trends among the respondents.

[Characteristics of Vegetation and Soil of Degraded Grasslands and Their Relationships in Xizang].

To investigate the characteristics of grassland degradation on a regional scale in Xizang, data on grassland degradation from the second grassland survey of Xizang and 12 vegetation and soil indicators from the National Tibetan Plateau Data Center were collected. Using ArcMap, 10 000 random sample points were selected on raster data （excluding non-grassland, desertification, and salinization data, leaving 7 949 valid sample points）. The multi-value extraction to-point method was applied to extract degradation and indicator data for each sample point.

Screening of PDSS1 as a Potential Biomarker for Hepatocellular Carcinoma Based on a Copper-Related Prognostic Signature through Bulk and Single-cell RNA-sequencing Analysis.

Currently, there is few literature comprehensively analyzing landscape of cuproptosis-related genes (CRGs) in liver hepatocellular carcinoma (LIHC) with multiple omics approaches. Using comprehensive analysis, we aim to find out how CRGs works on LIHC. With data from The Cancer Genome Atlas (TCGA) database, we constructed a prognostic prediction model for CGRs using LASSO regression analysis and performed immune infiltration analysis using the same dataset.

Recovery capacity of constructed wetlands in response to multiple disturbances: Microbial interaction perspective.

Previous studies have predominantly explored the response mechanisms of constructed wetlands (CWs) to singular disturbances. In practical applications, CWs are frequently subject to multiple disturbances, resulting in complex interference mechanisms. Therefore, this study aims to select harmful algal blooms and microalga ZM-5 as disturbances to investigate the response mechanisms of CWs.

Early and minimal changes in serum creatinine can predict prognosis in elderly patients receiving invasive mechanical ventilation: A retrospective observational study.

Background: Emerging evidence suggests that minimal acute kidney injury (stage 1 AKI) is associated with increased hospital mortality rates. However, for those who do not meet the AKI diagnostic criteria, whether a small increase in serum creatinine (SCr) levels is associated with an increased mortality rate in elderly patients is not known. Therefore, we aimed to investigate small elevations in SCr of <26.