Publications by authors named "Li Q"

Indium phosphide (InP)-based quantum dot light-emitting diodes (QLEDs) are promising for future lighting and display applications due to their high color purity and brightness. However, their efficiency and stability are often limited by the disordered structure of the widely used poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS), which impairs charge transport. Herein, we present a strategy to enhance the performance of InP-based QLEDs by modifying PEDOT:PSS through interfacial dipole modulation using molybdenum oxide (MoO) nanoparticles.

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Manganese-based oxides are be regarded as one of the most promising cathode materials for aqueous zinc ion batteries (AZIBs). A major restriction of manganese-based oxides in practical applications is their unsatisfied structural stability due to the irreversible manganese dissolution. Additionally, the poor electrical conductivity also limits the rate capability.

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Constructing hemostats capable of effectively controlling severe hemorrhage from irregular wounds presents significant challenges and imperatives. In this study, a novel approach is introduced using nanofibrous chitin microspheres (NCM) that are compressed to 60% strain (NCM-60%) to amplify their water-initiated expansion performance. This unique capacity allows NCM-60% to efficiently conform to and fill irregular bleeding cavities, even those of varying depths and curvatures, thereby promoting rapid blood coagulation at deep hemorrhage sites.

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The unusual properties of superconductivity in magic-angle twisted bilayer graphene (MATBG) have sparked considerable research interest. However, despite the dedication of intensive experimental efforts and the proposal of several possible pairing mechanisms, the origin of its superconductivity remains elusive. Here, by utilizing angle-resolved photoemission spectroscopy with micrometre spatial resolution, we reveal flat-band replicas in superconducting MATBG, where MATBG is unaligned with its hexagonal boron nitride substrate.

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In patients with recurrent pregnancy loss (RPL), excessive activation of decidual natural killer (dNK) cells has been widely observed, yet the precise underlying mechanisms remain to be elucidated. We collected decidual specimens from RPL patients and controls to assess GRIM19 expression, activation phenotype, cytotoxic function, inflammatory cytokine secretion, and mitochondrial homeostasis in dNK cells. Furthermore, we established a GRIM19-knockout NK-92MI cell line and a GRIM19 ± C57BL/6J mouse model to investigate the relationship between GRIM19 downregulation and dNK immune dysregulation, ultimately contributing to pregnancy loss.

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Metal oxides-catalyzed peroxymonosulfate (PMS) activation systems show promise in decomposing organic pollutants, whereas the critical challenges such as catalyst aggregation and metal ion leaching significantly impact the stability and reusability of catalysts and thus limit widespread application. To address these issues, an effective self-supported three-dimensional PMS activator consisted of spinel cobalt molybdate (CoMoO) and nickel foam (NF) (CoMoO/NF) is fabricated through hydrothermal and annealing processes. The cooperative redox interaction between Co and Mo metal sites in CoMoO/NF play a crucial role in efficiently activating PMS to degrade 4-nitrophenol (4-NP).

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Schizophrenia, a mental disorder characterized by delayed onset, high relapse rates, and significant disability, ranks among the top 20 contributors to the global burden of disease and poses a substantial public health challenge. Effective self-management is crucial for the recovery of individuals with schizophrenia, with medication experience playing a vital role. However, the underlying mechanisms and logical relationships remain elusive, hindering the development of effective self-management and enhancement strategies from the perspective of medication experience.

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Circular RNAs are a single-stranded non-coding RNAs and play an important role in the development of many diseases. Alternative polyadenylation (APA) regulates the gene 3'UTR length for controlling gene expressions. Although the APA mechanism has been widely studied in the development of diseases, there is no data on its role in the burned intestinal mucosa.

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Endotoxins are found in the outer membrane of all gram-negative bacteria and are a primary cause of endotoxemia, organ failure, and significant harm to human health. Limulus reagent as traditional detection method has certain limitations for the rapid and accurate detection of endotoxin due to the high costs associated with the horseshoe crab used in the sensing process. Herein, a fluorometric and colorimetric dual-mode biosensor was prepared for the rapid and sensitive detection of endotoxin.

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Membrane-based electrodeposition (MED) has emerged as a promising approach for reversible removal-recovery of toxic but valuable Pb. However, limited by the low specificity of membrane deposition toward various heavy metal ions in MED, the selective removal of Pb remains an obstacle. Inspired by the soft-hard acid-base theory, here we developed a Pb-affinity electroactive membrane by incorporating MoS with the cation exchange membrane (CEM) to achieve a tandem Pb selective adsorption-deposition process.

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Purpose: This study aimed to assess the feasibility and acceptability of a couple-based self-efficacy (SE) intervention, and to examine the effects of the intervention on health outcomes for CRC couples.

Methods: An assessor-blinded, two-armed, randomized controlled design was used. The study randomly assigned 144 patients hospitalized for colorectal cancer to receive either the SE intervention or the usual care.

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Glucose electrocatalytic-conversion reaction (GCR) is a promising anode reaction to replace the slow oxygen evolution reaction (OER), thus promoting the development of hydrogen production by electrochemical water splitting. Herein, NiFe-based metal-organic framework (MOF) is used as a precursor to prepare W-doped nickel-iron phosphide (W-NiFeP) nanosheet arrays by ion exchange and phosphorylation, which exhibit a high electrocatalytic activity toward the hydrogen evolution reaction (HER), featuring an overpotential of only -179 mV to achieve the current density of 100 mA cm in alkaline media. Notably, electrochemical activation of W-NiFeP facilitates the in situ formation of phosphate groups producing W,P-NiFeOOH, which, in conjunction with the W co-doped amorphous layers, leads to a high electrocatalytic performance toward GCR, due to enhanced proton transfer and adsorption of reaction intermediates, as confirmed in experimental and theoretical studies.

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Unintentional, early pregnancy alcohol consumption affects embryonic development. During the peri-implantation stage, coinciding with the transition from naive to primed pluripotency, the long isoform of KDM2B (KDM2BLF) underlies the de novo establishment of polycomb repressive complex (PRC) functions at promoters after fertilization. However, it remains unclear whether and how ethanol exposure affects this spatiotemporal chromatin setting.

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Article Synopsis
  • Psoriasis is a chronic skin disease that currently lacks effective biologic treatment options, prompting the study of QX004N.
  • This study was a two-part clinical trial in China, with part 1 focusing on healthy individuals and part 2 involving patients with moderate to severe plaque psoriasis.
  • The trials assessed the safety, pharmacokinetics, and efficacy of QX004N, measuring outcomes like the improvement in psoriasis severity by week 12.
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  • Control measures are needed for disinfectant pollution, especially regarding benzalkonium chloride (BAC), a common ingredient in hand sanitizers.
  • A survey of 703 medical students found that while most have used BAC products, knowledge about their environmental impact was low, with an average test score of 1.90 out of 5.
  • Despite poor knowledge, students showed positive attitudes towards reducing BAC pollution and a desire to learn more about environmentally friendly practices.
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We report a general chemoselective strategy for amide bond formation with poorly nucleophilic amines in the presence of reactive primary alcohols or amines as the competing nucleophiles. The selectivity for less reactive amines over competing alcohols was achieved using TCFH and catalytic Oxyma as a highly reactive, inexpensive, and safe reagent combination. By temporarily masking more reactive amines as imines through the use of electron-deficient aldehydes, the hindered amines could be similarly coupled with high efficiency and selectivity.

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Mangroves are dominant flora of intertidal zones along tropical and subtropical coastline around the world that offer important ecological and economic value. Recently, the genomes of mangroves have been decoded, and massive omics data were generated and deposited in the public databases. Reanalysis of multi-omics data can provide new biological insights excluded in the original studies.

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  • A study evaluated a new long-lasting pain relief medication called QP001, compared to a placebo, to determine its effectiveness and safety for patients after abdominal surgery.
  • Conducted across 23 centers, 255 patients were administered either QP001 or placebo, and the results showed QP001 significantly reduced pain intensity for up to 24 hours post-surgery.
  • The trial indicated that QP001 also reduced the need for morphine and increased patient satisfaction, with no significant difference in adverse events compared to placebo.
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Cage-like and ladder-like polysilsesquioxane, named EPOSS and ELPSQ, were synthesized and employed as precursors to develop a UV-curable membrane exhibiting remarkable hardness, superior flexibility, exceptional transparency and excellent friction resistance. Nanoindentation analysis demonstrates that the precise control of the Silicane molecular frameworks by adding a small quantity of EPOSS to ELPSQ can significantly enhance the hardness of the membranes. The resulting hardness value reaches a record 1.

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Purpose: To explore the clinical efficacy of perforated Kirschner wire tension band in the treatment of Mayo IIA olecranon fracture.

Method: A retrospective study was conducted to analyze the clinical data of 96 adult patients with olecranon fractures of the ulna. Thirty-four cases underwent perforated Kirschner wire tension band fixation(group A), which included 21 males and 13 females, with an average age of 49.

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Dichloromethane is widely used as an organic solvent in aerospace, electronics, and medicine. Cases of poisoning caused by this substance are rare. Recently, we successfully treated a patient with an acute dichloromethane poisoning.

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Purpose: To evaluate and compare the effects of ciprofol and propofol on postoperative nausea and vomiting (PONV) in patients undergoing outpatient hysteroscopy.

Design: Double-blind randomized controlled trial.

Methods: This study included 1104 patients scheduled for elective outpatient hysteroscopy.

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Introduction: Benign multinodular goiter (BMNG) can grow very large and cause compression symptoms, making the operation procedure difficult. However, the recurrence rate of BMNG ranges from 3% to 43%. Reoperative thyroid surgery for BMNG is uncommon and can result in a high rate of complications, including hypoparathyroidism and recurrent laryngeal nerve palsy.

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The family is essential for cell proliferation, differentiation, and metabolism, particularly in embryonic development and stem cell functions. However, the specific role of in porcine early embryonic development is not fully understood. This study observed high expression during the four-cell stage of porcine embryos.

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