Publications by authors named "Li Ping Zhou"

Article Synopsis
  • The study aimed to analyze the failure patterns and prognostic factors for patients with nonmetastatic nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT) from 2012 to 2016.
  • Among 847 patients, survival rates were high with 5-year local relapse-free survival at 94.3% and overall survival at 85.7%, although distant metastasis was identified as a major failure pattern.
  • The most significant prognostic factor was the TNM stage, with common complications being acute events like leukopenia and ongoing issues like xerostomia and hearing impairment.
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Background And Purpose: Icariin, an 8-prenylated flavonoid glycoside, is an anabolic agent that could exert rapid estrogenic actions via ligand-independent activation of estrogen receptor alpha (ERα) in osteoblastic cells to promote osteogenesis. However, relatively little is known about its direct cellular target, its protective effects, and cell adhesion activities in bone marrow stromal cells (BMSCs) against microgravity. In the present study, the effects of icariin on osteogenesis and cell adhesion under microgravity were examined with the involvement of integrin receptor α5β1, connexin 43, and CAMs.

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Oleanolic acid (OA) is previously shown to exert bone protective effects in aged animals. However, its role in regulating osteoblastic vitamin D bioactivation, which is one of major causes of age-related bone loss, remains unclear. Our results revealed that treatment of OA significantly increased skeletal CYP27B1 expression and circulating 1,25(OH)D in ovariectomized mice (p <0.

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  • Melittin and its derivatives are being explored to enhance gene delivery systems, particularly in improving the efficiency of recombinant adeno-associated virus (rAAV) vectors for liver cancer treatment.
  • Various melittin-derived peptides were tested for their effects on rAAV vector performance, revealing that the p5RHH-rAAV2 vector was notably effective in transducing resistant cell lines and showed promise in both in vitro and in vivo settings.
  • The study identified several mechanisms through which melittin analogs enhance gene delivery, particularly emphasizing the role of endosome acidification in facilitating transgene expression.
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  • Homo sapiens began expanding into southeastern Europe around 47,000 years ago, using Initial Upper Palaeolithic (IUP) tools, and reached western Siberia by approximately 45,000 years ago.
  • H. sapiens also appeared in northeastern Asia around 40,000 years ago, with evidence of their presence at a site in China dating back to 43-41,000 years ago.
  • The site of Shiyu in northern China, dated to about 45,000 years ago, showcases advanced cultural behaviors through its stone tools, long-distance trade of obsidian, enhanced hunting techniques, and the discovery of a human cranial bone.
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  • The study investigates how blocking adenosine A receptors (AR) might help protect against memory problems in Alzheimer's disease (AD), especially in a specific type of mouse with AD.
  • Researchers looked at whether blocking AR could improve spatial memory deficits and found that these mice had problems with certain brain functions early on.
  • After treating the mice with a special drug that blocks AR, they showed improvements in memory and brain connections, suggesting that AR blockade could be a possible treatment for early cognitive issues in AD.
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To screen environment-friendly seedling cultivation substrates which could replace peat and with less cost, we compared the effects of different agricultural and forestry residue mixed substrates on cutting propagation of , in an experiment following randomized block design. There were five types of mixed substrates, including peat + vermiculite + perlite (T), edible mushroom residue (EMR) + vermiculite + perlite (T), carbo-nized rice husk (CRH) + vermiculite + perlite (T), EMR + slag + sawdust (T) and CRH + EMR + slag (T). The results showed that the bulk density of T was the lowest, followed by T, which significantly differed from other mixed substrates.

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Secoisolariciresinol (SECO) is one of the major lignans occurring in various grains, seeds, fruits, and vegetables. The gut microbiota plays an important role in the biotransformation of dietary lignans into enterolignans, which might exhibit more potent bioactivities than the precursor lignans. This study aimed to identify, synthesize, and evaluate the microbial metabolites of SECO and to develop efficient lead compounds from the metabolites for the treatment of osteoporosis.

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Background: Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of hepatocellular carcinoma (HCC). However, long-term survival outcomes and treatment response of HCC patients undergoing immunotherapy is unpredictable. The study aimed to evaluate the role of alpha-fetoprotein (AFP) combined with neutrophil-to-lymphocyte ratio (NLR) to predict the prognosis and treatment response of HCC patients receiving ICIs.

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Background: The aim of this study was to determine the clinical characteristics and outcome of patients with aortic dissection (AD) who present with an initial manifestation of cerebral infarction.

Methods: We retrospectively analyzed patients who were diagnosed with AD and admitted to the emergency department from May 1, 2017 to May 1, 2022. Data was collected for variables including age, sex, clinical manifestation, past medical history, and laboratory test results.

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Background: Anti-programmed cell death ligand 1/vascular endothelial growth factor inhibition, coupled with chemotherapy, may potentiate antitumor immunity leading to enhanced clinical benefit, but it has not been investigated in advanced biliary tract cancer (BTC).

Objectives: We investigated the efficacy and safety of atezolizumab, bevacizumab, and gemcitabine plus oxaliplatin (GEMOX) in advanced BTC and explore the potential biomarkers related to the response.

Design: Multicenter, single-arm, retrospective study.

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Article Synopsis
  • A study was conducted to compare the effectiveness and safety of three treatment options for unresectable recurrent hepatocellular carcinoma (HCC): transarterial chemoembolization combined with lenvatinib and PD-1 inhibitors (T-L-P), TACE with lenvatinib (T-L), and TACE alone.
  • Among 204 patients analyzed, those in the T-L-P group had the best survival outcomes and disease control rates compared to the other two groups.
  • The study concluded that the T-L-P regimen is both safe and significantly better in enhancing survival for patients dealing with unresectable recurrent HCC.
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Article Synopsis
  • - The study evaluated a combined treatment approach for patients with unresectable hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT), using transarterial chemoembolization (TACE), antiangiogenic therapy, and PD-1 inhibitors.
  • - Results from 39 patients showed an objective response rate of 35.9% and a disease control rate of 74.4%, with median overall survival at 14 months and progression-free survival at 9.2 months.
  • - Most patients (87.2%) experienced treatment-related adverse events, primarily hypertension and decreased albumin levels, but there were no treatment-related deaths in this cohort.
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This study investigated the effect of Maxing Shigan Decoction(MXSGD) and its disassembled prescriptions against the airway inflammation in respiratory syncytial virus(RSV)-aggravated asthma and the regulation of transient receptor potential vanilloid-1(TRPV1). To be specific, ovalbumin(OVA) and RSV were used to induce aggravated asthma in mice(female, C57BL/6). Then the model mice were intervened by MXSGD and the disassembled prescriptions.

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Our previous study revealed that the bone anabolic effects of the lignan-rich fraction (SWCA) from Hance was involved in modulating the metabolism of tryptophan in vivo and inhibiting serotonin (5-HT) synthesis in vitro. This study aimed to determine how SWCA modulates bone metabolism via serotonin in vivo. The effects of SWCA were evaluated by using 4-month-old Sprague-Dawley (SD) ovariectomized rats.

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  • Organic dyes are commonly utilized in various industries like textiles and medicine, but they pose significant environmental challenges due to their presence in wastewater.
  • This study focuses on effectively degrading the organic dye gentian violet using a specific iron-based catalyst, [Fe(TCPP)], and the oxidant iodosylbenzene (PhIO) at room temperature.
  • Results indicated that over 90% of gentian violet could be degraded in just one hour, showcasing the high efficiency of the proposed treatment method for dye-laden industrial wastewater.
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Objectives: Our goal in this study was to determine 1) whether there are any differences in clinical characteristics between Chinese and Western patients with aortic dissection (AD), and 2) the mortality rate of AD patients in the emergency department (ED) and identify the risk predictors for death.

Methods: We retrospectively analyzed patients who were diagnosed with AD and admitted to our ED between September 1, 2017-August 31, 2020. Data on age, gender, clinical manifestation, medical history, routine blood tests, liver and kidney function, coagulation, myocardial enzymology, and mortality were collected.

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Liver fibrosis is characterized by the abnormal deposition of the extracellular matrix with a severe inflammatory response and/or metabolic disorder. Asiatic acid (AA), a natural compound derived from Centella asiatica, exhibited potent anti-fibrosis effects. This investigation first confirmed the anti-fibrosis effects of AA in TGF-β-LX-2 cells and CCl-induced liver fibrosis mice, and then sought to elucidate a novel mechanism of action by integrating network pharmacology and lipidomics.

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Aim: Surgical treatment is the first-line treatment for patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 or A1 hepatocellular carcinoma (HCC), and postoperative monitoring improves long-term survival. We aimed to establish a reasonable short-interval follow-up duration for patients with HCC.

Methods: The cohort for this retrospective study included 1396 HCC patients with BCLC stage 0 or A1 disease who underwent curative resection from 2013 to 2016 at five centers in China.

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Article Synopsis
  • The study compares the efficacy of two treatments for hepatocellular carcinoma (HCC): transarterial chemoembolization (TACE) combined with a PD-1 inhibitor versus TACE combined with a PD-1 inhibitor and lenvatinib.
  • Results indicated that patients receiving the triple therapy had significantly better progression-free survival (PFS) and overall survival (OS) compared to those on the double therapy.
  • While the triple therapy showed better clinical outcomes, it also had common treatment-related adverse events like decreased albumin and platelet count, but these were manageable.
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  • The introduction of neurotrophic factors can aid in peripheral nerve regeneration, but their rapid degradation and high doses limit their effectiveness in clinical settings.
  • Bioactive mimetic peptides have been developed as more stable alternatives, maintaining similar actions to neurotrophic factors with simpler structures.
  • The study created special conduits (Chi/PDA-Ps) that showed lower toxicity, sustained peptide release, and improved nerve regeneration in rat models, enhancing motor function and nerve structure.
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Background And Aims: Patients with intermediate-stage hepatocellular carcinoma (HCC) who are refractory to transarterial chemoembolization (TACE) have a poor prognosis. This study aimed to explore whether stereotactic body radiation therapy (SBRT) combined with PD-1 inhibitors could improve the clinical outcomes of such patients.

Methods: This retrospective cohort study included patients with intermediate-stage HCC who were diagnosed with TACE refractoriness between January 2019 and December 2020 in the Eastern Hepatobiliary Surgery Hospital and the First Affiliated Hospital of Wenzhou Medical University.

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Ethnopharmacological Relevance: Cigarette smoke (CS) is a common environmental irritant and a risk factor for asthma, as it induces as well as aggravates asthmatic attacks. The injured airway epithelial tight junctions (TJs) aggravate asthma. CS can aggravate asthma by activating the transient receptor potential ankyrin A1 (TRPA1) channel and enhancing TJs destruction.

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Article Synopsis
  • A new staging system for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) was created by improving upon existing classifications, incorporating factors like liver function and tumor resectability.
  • The research involved a training cohort of 2,179 patients and a validation cohort of 1,550 patients from major liver centers in China, demonstrating the system's effectiveness in predicting overall survival based on identified clinical factors.
  • The new staging system showed strong ability to classify patients into distinct stages, significantly impacting median overall survival rates, thus serving as a valuable supplement to current HCC staging systems.
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Aims: Peripheral nerve injury is a significant clinical problem with a substantial impact on quality of life, for which no optimal treatment has been found. This study aimed to analyze the effect and mechanism of Wnt5a-loaded fibrin hydrogel on a 10-mm rat sciatic nerve defect.

Methods: The Wnt5a-loaded fibrin hydrogel was synthesized by mixing a Wnt5a solution with thrombin and fibrinogen solutions.

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