The relationship between fractional amplitude of low-frequency fluctuations (fALFF) and the severity of neglect in patients with unilateral spatial neglect (USN) after stroke: A functional near-infrared spectroscopy study.

Objective: Unilateral spatial neglect (USN) following right hemisphere stroke is more pronounced, severe, and persistent than in the left hemisphere. However, the pathophysiological mechanisms underlying USN remain largely unknown. This study aims to investigate the relationship between the fractional amplitude of low-frequency fluctuations (fALFF) in the right hemisphere of patients with post-stroke USN and the severity of neglect using resting-state functional near-infrared spectroscopy (fNIRS) technology.

Study on the detoxification and toxic effects of clam Ruditapes philippinarum exposed to 2,6-ditert-butyl-4-methylphenol (BHT): Oxidative stress, neurotoxicity, respiratory toxicity, and immunotoxicity.

The bioaccumulation and toxic effects of synthetic phenolic antioxidants (SPAs) in aquatic ecosystems are of growing concern due to their widespread use and potential environmental persistence. This study investigated the detoxification and toxicological impacts of 2,6-ditert-butyl-4-methylphenol (BHT), a representative SPAs, on clams Ruditapes philippinarum using environmentally relevant exposure concentrations. BHT bioaccumulation was observed in both gills and digestive glands, with higher levels in the latter.

CT Predictors of Angiolymphatic Invasion in Non-Small Cell Lung Cancer 30 mm or Smaller.

Background Angiolymphatic invasion (ALI) is an important prognostic indicator in non-small cell lung cancer (NSCLC). However, few studies focus on radiologic features for predicting ALI in patients with early-stage NSCLCs 30 mm or smaller. Purpose To identify radiologic features for predicting ALI in NSCLCs 30 mm or smaller in maximum diameter.

Targeted Activation of OGG1 Inhibits Paraptosis in Lens Epithelial Cells of Early Age-Related Cortical Cataract.

Purpose: To investigate potential modes of programmed cell death in the lens epithelial cells (LECs) of patients with early age-related cortical cataract (ARCC) and to explore early-stage intervention strategies.

Methods: Anterior lens capsules were collected from early ARCC patients for comprehensive analysis. Ultrastructural examination of LECs was performed using transmission electron microscopy.

Assessing the impact of residual film on agriculture: A meta-analysis of soil moisture, salinity, and crop yield.

Residual films (RFs) disrupt the normal migration and distribution of water, salts and nutrients in soil, posing a significant threat to the sustainable development of agriculture and food security. The effect complexity of RF on soil water-salt distribution and crop growth result in conflicting findings in previous studies. Systematic and quantitative exploration of RF thresholds is of great significanse.

Predictive Value of Systemic Immune Inflammation Index, Aggregate Index of Systemic Inflammation, and Systemic Inflammation Response Index in Lower Extremity Deep Venous Thrombosis Following Severe Trauma.

Objectives: Venous thromboembolism is a highly prevalent condition after polytrauma, and recognized as an important factor contributing to poor prognosis. The aim of this study was to investigate the risk factors for lower extremity deep venous thrombosis (LEDVT) in a severely traumatized population and to evaluate their predictive value for LEDVT.

Methods: This was a retrospective, single-center observational study.

Li Quasi-Grotthuss Topochemistry Transport Enables Direct Regeneration of Spent Lithium-Ion Battery Cathodes.

Direct regeneration of spent lithium-ion batteries offers economic benefits and a reduced CO footprint. Surface prelithiation, particularly through the molten salt method, is critical in enhancing spent cathode repair during high-temperature annealing. However, the sluggish Li transport kinetics, which predominantly relies on thermally driven processes in the traditional molten salt methods, limit the prelithiation efficiency and regeneration of spent cathodes.

Effect of low-dose radiation pre-irradiation on postoperative local chest wall recurrence of breast cancer-A retrospective study.

Purpose: The purpose of this study was to determine the efficacy and safety of low-dose radiotherapy (LDR) for postoperative local chest wall recurrence of breast cancer.

Methods: The records of 52 patients with postoperative local chest wall recurrent breast cancer treated at our cancer center from January 2019 to December 2022. The t-test was used to compare the means of the LDR group and non LDR group.

Basic Considerations for the Consistency Evaluation Based on ICH E17 Guideline.

In the International Council for Harmonisation (ICH) guidance on General Principles for Planning and Design of Multi-Regional Clinical Trials (E17), it is important to evaluate the consistency of treatment effect across regions in a multi-regional clinical trial (MRCT). In this paper, we elaborated on some basic considerations to evaluate consistency. We first list the design considerations, and then provide consistency evaluation and interpretation on pharmacokinetics, pharmacodynamics, efficacy, safety, and benefit-risk.

Detection and analysis of enzootic nasal tumor virus 2 in China.

Enzootic nasal tumor virus 2 (ENTV2), the etiologic agent of enzootic nasal adenocarcinoma (ENA) in goats, is highly prevalent in China and causes significant economic losses to the goat industry. Here we describe the occurrence of ENA on a Dazu black goat farm in Chongqing City. At autopsy, nasal cavity masses were observed within the nose of an affected goat; histologically, the tumor was a nasal adenocarcinoma.

Weighted Echo State Graph Neural Networks Based on Robust and Epitaxial Film Memristors.

Hardware system customized toward the demands of graph neural network learning would promote efficiency and strong temporal processing for graph-structured data. However, most amorphous/polycrystalline oxides-based memristors commonly have unstable conductance regulation due to random growth of conductive filaments. And graph neural networks based on robust and epitaxial film memristors can especially improve energy efficiency due to their high endurance and ultra-low power consumption.

Rigid, α-Helical Polypeptide Nanoprobes with Thermally Activated Delayed Fluorescence for Time-Resolved, High-Contrast Bioimaging.

Thermally activated delayed fluorescence (TADF)-based nanoprobes are promising candidates as bioimaging agents, yet the fine-tuning of their photophysical properties through the modulation of the surrounding matrices remains largely unexplored. Herein, we report the development of polypeptide-TADF nanoprobes, where the rigid, α-helical polypeptide scaffold plays a critical role in enhancing the emission intensity and lifetime of the TADF fluorophore for bioimaging. The α-helical scaffolds not only spatially separated TADF molecules to avoid self-quenching but also anchored the dyes with minimized rotation and vibration.

Associations between short-term exposure to air pollution and acute exacerbation of chronic bronchitis: A time-stratified case-crossover study.

Objective: This study aimed to explore the associations between short-term air pollution exposure and acute exacerbation of chronic bronchitis (AECB).

Methods: AECB data were collected from hospital surveillance systems in Shanghai, China, during 2018-2022. Exposure pollution data were obtained from China high resolution high quality near-surface air pollution datasets and assigned to individuals based on their residential addresses.

Systemic inflammatory regulators and age-related macular degeneration: a bidirectional Mendelian randomization study.

Introduction: We investigated the relationship between systematic regulators of inflammation and the risk of age-related macular degeneration (AMD), both wet and dry forms, by using bidirectional, two-sample Mendelian randomization (MR).

Methods: We performed bidirectional two-sample Mendelian randomization analysis using genome-wide study (GWAS) data for 91 plasma proteins from 14,824 individuals of European descent across 11 study groups. Next, we utilized data from the FinnGen consortium to study AMD using the inverse- variance-weighted approach for Mendelian randomization.

Interfacial functionalization and capillary force welding of enhanced silver nanowire-cellulose nanofiber composite electrodes for electroluminescent devices.

The development of flexible, intelligent, and lightweight optoelectronic devices based on flexible transparent conductive electrodes (FTCEs) utilizing silver nanowires (AgNWs) has garnered increasing attention. However, achieving low surface resistance, strong adhesion to the flexible substrate, low surface roughness, and green degradability remains a challenge. Here, a composite electrode combining natural polymer cellulose nanofibers (TCNFs) with AgNWs was prepared.

[Screening and identification of key miRNAs in post-transcriptional regulation of CART in the bovine hypothalamus].

This study aimed to explore the roles of microRNAs (miRNAs) in the post-transcriptional regulation of cocaine- and amphetamine-regulated transcript (CART) peptide in the bovine hypothalamus and to screen key regulatory miRNAs. Targetscan was used to predict the potential miRNAs binding to 3' untranslated regions (3'UTR). Bioinformatics analysis predicted 7 miRNA binding sites in the bovine 3'UTR, which were bta-miR-377, bta-miR-331-3p, bta-miR-491, bta-miR-493, bta-miR-758, bta-miR-877, and bta-miR-381, respectively.

[Characteristics, Risk Assessment of Microplastics, and Heavy Metal Pollution in Farmland Soils in the Upper Hanjiang River].

To investigate the pollution of microplastics and heavy metals from farmland soils in the upper Han River, the pollution status and distribution characteristics of pollutants were systematically analyzed. The risk level of pollutants was evaluated using methods such as the potential ecological risk index （RI）. Source apportionment was identified using correlation analysis and cluster analysis.

Effects of drinking water supplemented with essential oils and organic acids mixtures on growth performance and intestinal health of broilers challenged with necrotic enteritis.

It is urgent to develop effective antibiotic alternatives for the control of subclinical necrotic enteritis (NE) in chickens after in-feed antibiotics have been banned. The current study investigated the efficacy of drinking water supplemented with essential oils and organic acids mixtures (EOA) on growth performance and intestinal health of broilers challenged with necrotic enteritis (NE). A total of 360 one-day-old Arbor Acres male broilers were randomly divided into 5 treatment groups, including non-challenged control group (T0), challenged NE group (T1), and challenged NE chickens treated with 0.

Diverse Synthesis of Arene-Fused [n.1.1]-Bridged Molecules via Catalytic Cycloaddition and Rearrangement Reactions.

Although great advancement has been made in synthesis of 3D bridged bicyclic[n.1.1]-bioisosteres, facile construction of 2D/3D merged molecules incorporating bridged rings, as novel chemical space in drug discovery, remains a significant challenge.

Synthesis of fluorine-containing bicyclo[4.1.1]octenes photocatalyzed defluorinative (4 + 3) annulation of bicyclo[1.1.0]butanes with -difluoroalkenes.

Although bicyclo[4.1.1] systems are privileged scaffolds in many natural products and drug molecules, efficient synthetic approaches to these systems remain underdeveloped.

The impact of physical exercise with additional visual tasks on UDVA and accommodation sensitivity in children: the mediating role of kinetic visual acuity.

Purpose: This study investigates the impact of physical exercise supplemented with visual tasks on children's uncorrected distance visual acuity (UDVA), kinetic visual acuity (KVA), and accommodative sensitivity, with an analysis of the mediating role of KVA.

Methods: A total of 168 third-grade students from four natural classes in a primary school in Suzhou City were randomly assigned to either an experimental group ( = 86) or a control group ( = 82). The experimental group engaged in 30 cycles of ciliary muscle training tasks with visual targets presented for 3 s during physical exercises, while the control group participated in regular physical exercises.

Interaction between ischemia-reperfusion injury and intestinal microecology in organ transplantation and its therapeutic prospects.

Organ transplantation is a vital intervention for end-stage organ failure; however, ischemia-reperfusion injury is a complication of transplantation, affecting the prognosis and survival of transplant recipients. As a complex ecosystem, recent research has highlighted the role of the intestinal microecology in transplantation, revealing its significant interplay with ischemia-reperfusion injury. This review explores the interaction between ischemia-reperfusion injury and intestinal microecology, with a special focus on how ischemia-reperfusion injury affects intestinal microecology and how these microecological changes contribute to complications after organ transplantation, such as infection and rejection.

Wnt5a alleviates the symptoms of PCOS by modulating PI3K/AKT/mTOR pathway-mediated autophagy in granulosa cells.

Objective: Polycystic ovary syndrome (PCOS) is a metabolic and endocrine disease that entails dysregulated ovulation, hyperandrogenism, and polycystic ovaries. While Wnt5a has been suggested to play key roles in follicular development and female fertility under normal conditions, its functions in the context of PCOS have yet to be established. This study was thus designed to explore the impact of Wnt5a on ovarian granulosa cell autophagy in PCOS, providing in vitro evidence in support of its role in this setting.