Publications by authors named "Li Peipei"
Article Synopsis
- - The study introduces a new method called antibody recognition profile-aided hapten design (ARPHD) to improve the creation of haptens for generating broad-specific antibodies, addressing limitations in current designs by using insights from existing antibodies and chemical structures.
- - Researchers found that certain chemical groups, like the fluorine atom, positively influenced antibody production, while others, such as the -COCHCl group, hindered it; this led to the development of four new haptens designed to enhance antibody responses.
- - An indirect competitive ELISA (icELISA) was successfully created for detecting the compounds fluorfenicol (FF) and fluorfenicol amine (FFA) in environmental and food samples, achieving detection limits previously
Porous liquids (PLs) are a novel class of flowing liquid systems that possess accessible permanent porosity, exhibiting great prospects in gas capture and separation. Nevertheless, the further development of PLs lies in the facile synthesis and regulation of PLs with low viscosities. Herein, a novel strategy of preparing type I PLs with super-low viscosity is proposed through a simple one-step covalent linkage reaction using UiO-66-NH as the pore generator and monoglycidyl ether terminated polydimethylsiloxane (E-PDMS) as the sterically hindered solvent, respectively.
View Article and Find Full Text PDFHuman immunoglobulin (HIgG) has gained recognition as a crucial biomarker diagnosing and treating various diseases, particularly in identifying elevated serum levels in conditions like measles and pneumococcal disease. Traditional detection methods, however, are often hindered by inefficiencies, high costs, and potential inaccuracies, underscoring the urgent need for more sensitive, efficient, accurate, and self-calibration methods for HIgG. Here, a novel ZnInS/SnO composites was synthesized, featuring uniformly dispersed SnO nanoparticles on the flower-like ZnInS structure, resulting in a type II heterojunction that promotes the separation and transfer of photogenerated carriers.
View Article and Find Full Text PDFArticle Synopsis
- This study identified a new short-type peptidoglycan recognition protein (PGRP), termed AjPGRP-S2, from the sea cucumber Apostichopus japonicus, which plays a role in innate immunity.
- AjPGRP-S2 is an extracellular protein with a signal peptide, a zinc binding site, and was shown to exhibit amidase activity while being highly expressed in coelomocytes and tube feet.
- The research suggests that AjPGRP-S2 binds to various pathogen-associated molecular patterns (PAMPs) and is involved in signaling immune responses, potentially linking to broader immune functions like cell adhesion and apoptosis.
Interface-Engineering-Induced C-C Coupling for CH Photosynthesis from Atmospheric-Concentration CO Reduction.
Angew Chem Int Ed Engl
November 2024
Article Synopsis
- Producing ethylene from carbon dioxide through photoreduction has been challenging due to the difficulty of C-C coupling, but this study introduces a new solution using metal atom clusters on semiconductor nanosheets.
- The research highlights the use of Pd nanoclusters on ZnO nanosheets, demonstrating that they can facilitate the C-C coupling process needed to convert CO2 into ethylene (C2H4) in pure water.
- Results show that the Pd-ZnO system achieved a significant formation rate of 1.03 μmol g-1 h-1 for ethylene production from atmospheric CO2, while just using ZnO alone only yielded carbon monoxide.
Article Synopsis
- * Researchers analyzed the expression of m7G regulators in DLBCL compared to normal tissue, developed a risk model based on patient clustering and identified significant prognosis-associated genes through statistical methods.
- * Findings suggest that m7G modification correlates with immune cell infiltration and plays a critical role in determining the prognosis of DLBCL patients, aiding in better stratification and immunotherapy strategies.
Article Synopsis
- Myoglobin from engineered fermentation is used as a color additive in meat alternatives, but its allergy potential is not well understood.
- A study found no allergy-related proteins in porcine myoglobin, and simulated digestion indicated it was not very resilient to digestive processes.
- Sensitization was observed in mice with specific antibodies showing allergic reactions, suggesting that the non-myoglobin protein part may cause these allergies, emphasizing the need for better purification methods.
Article Synopsis
- Ferroptosis is a unique type of regulated cell death that differs from apoptosis, necrosis, and autophagy, and is gaining attention for its involvement in skin diseases.
- The review explores how ferroptosis, characterized by iron buildup and lipid damage, affects several skin conditions like psoriasis, dermatitis, and melanoma, while also comparing it to other cell death processes.
- It discusses the role of ferroptosis in five skin diseases and examines potential therapies targeting ferroptosis to improve skin disease management and treatment.
Article Synopsis
- Graft failure and poor graft function present significant challenges in haploidentical hematopoietic stem cell transplantation, particularly for patients with HLA antibodies, and this study explores the role of unrelated umbilical cord blood stem cells as a potential treatment option.
- A total of 90 patients were assessed, divided into three groups based on the presence of HLA antibodies and the use of UCB infusion, with all groups achieving similar recovery times for granulocytes post-transplantation.
- The findings suggest that UCB infusion in HLA antibody-positive patients may lead to better outcomes regarding graft-versus-host disease and overall survival rates compared to those who did not receive UCB support.
Article Synopsis
- Cisplatin is an effective chemotherapy drug for solid tumors but can lead to kidney damage, particularly acute kidney injury (AKI), limiting its use.
- The study explored the effects of GSTM1 and GSTT1 genes, which are linked to kidney health, by creating knockout mice to assess their role in cisplatin-induced AKI.
- Results indicated that the absence of these genes worsened kidney dysfunction and increased oxidative stress, suggesting their protective role against nephrotoxicity from cisplatin, and highlighting the potential for genetic screening to optimize treatment dosages in cancer patients.
Recent advances in scanning electrochemical microscopy for energy applications.
Nanotechnology
October 2024
Article Synopsis
- Scanning Electrochemical Microscopy (SECM) is a technique used to map surface topography and measure local electrochemical activity, developed by Allen J. Bard in 1989.
- SECM employs an ultra-microelectrode to detect redox currents as it scans across surfaces, enabling insights into nanomaterial characterization and various fields like energy and biology.
- The text reviews SECM's principles, recent applications in energy science from 2019-2023, and its potential for advancing understanding of reaction mechanisms in energy devices.
Highly Active Photoreduction of Atmospheric-Concentration CO into CHCOOH over Palladium Particles on NbO Nanosheets.
Angew Chem Int Ed Engl
September 2024
Article Synopsis
- The challenge in converting CO into carbon products stems from a significant energy barrier associated with C-C coupling.
- Researchers employed active metal particles on metal oxide nanosheets to create dual metal pair sites that facilitate this coupling process.
- The study demonstrates that Pd particles on NbO nanosheets lower the energy barrier for C-C coupling, leading to a highly efficient CHCOOH production rate that surpasses existing photocatalysts.
Article Synopsis
- A polysaccharide named CZS-0-1 was extracted from the marine green algae Codium fragile using specific chromatography techniques, revealing it to be a sulfated galactoarabinan with an arabinose, galactose, and glucose ratio of 9:2:1 and 21% sulfate content.
- Structural analysis showed that the backbone consisted mainly of (1 → 3)-β-L-Arap, with branches and sulfate modifications enhancing its complex configuration.
- CZS-0-1 displayed significant anticoagulant effects similar to heparin by inhibiting specific blood factors (FIIa and FXa), with its activity closely linked to its molecular weight, suggesting potential as a source for bioactive polys
Smartphone-integrated visual inspection for enhancing agricultural product quality and safety: a review.
Crit Rev Food Sci Nutr
September 2024
Article Synopsis
- The rising focus on agricultural product quality and safety has led to the development of innovative, affordable smart detection technologies, particularly utilizing smartphones.
- Smartphones have transformed into portable analytical tools with advanced features, including high-resolution cameras and sensors, aiding in the inspection and analysis of agriculture products.
- The review discusses the improvements in agricultural product inspection over the last decade, assesses current smart inspection methods, and projects future advancements in this field.
Article Synopsis
- Epoxy resins are great materials, but their brittleness limits how they can be used, leading researchers to explore ways to improve their properties.
- This study focuses on creating functionalized graphene by modifying graphene oxide, which enhances its compatibility with epoxy resin.
- Tests showed that adding just 0.1 wt% of this functionalized graphene to epoxy significantly improved mechanical and thermal properties, like a 77% increase in tensile strength and a 56% increase in flexural strength, making epoxy resins more versatile for various applications.
Article Synopsis
- * Experiments with porous anodized nickel foam (ANF) show that nickel sites capture Fe ions, forming active FeNi-based intermediates that boost OER performance and maintain long-term stability.
- * The findings indicate that the system achieves notable overpotentials (242 and 343 mV at different current densities) and impressive stability over 360 hours, suggesting potential for practical, cost-effective applications in the industry.
Kombo knife combined with sorafenib in liver cancer treatment: Efficacy and safety under immune function influence.
World J Gastrointest Oncol
July 2024
Article Synopsis
- Researchers are adopting a holistic approach to treat hepatocellular carcinoma (HCC) by combining data analytics with innovative therapies, using resources like the cancer genome atlas (TCGA).
- The study aims to understand how the combined treatment of Kombo knife and sorafenib affects immune genes and their mechanisms, using TCGA data and machine learning techniques.
- Key findings reveal that specific immune genes serve as important prognostic markers, and the combined treatment leads to better patient outcomes, supporting its efficacy as an immune-focused therapy for HCC.
Article Synopsis
- - The study aimed to assess the effectiveness of combining contrast-enhanced ultrasound (CEUS) with microflow imaging (MFI) to predict microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC).
- - 80 HCC patients were analyzed, divided into MVI-positive (39) and MVI-negative (41) groups, revealing a 48.8% MVI positivity rate; significant independent risk factors for MVI were identified.
- - The findings suggest that using CEUS and MFI together is effective for predicting MVI preoperatively, offering valuable insights for tailored clinical treatment options.
Article Synopsis
- Discarded circuit boards are a growing source of non-biodegradable waste in the electronics industry, prompting research into recycling methods.
- This study focuses on converting discarded epoxy resin into activated carbon (AC) using carbonization and activation techniques, resulting in carbon materials with oxygen-containing groups and specific adsorption properties.
- The research shows that activated carbon effectively adsorbs methyl orange, aligning with the quasi-secondary kinetic model and Langmuir isotherm, indicating potential for recycling waste and reducing environmental pollution while also offering economic benefits.
Article Synopsis
- Scientists are using special tests called immunoassays to find tiny amounts of chemicals, like pesticides, in food and the environment.
- They created new types of antibodies specifically for a pesticide called atrazine, which helps make more accurate tests and reduces mistakes.
- The new test showed good results in spotting atrazine in fruits, veggies, and tea, proving it can help keep our food safer from harmful chemicals.
Article Synopsis
- - High-performance photodetectors for linearly polarized light have important applications in military and civilian sectors, and ZrS is a promising emerging material despite its low responsivity.
- - The study introduces a new photodetector using a ZrS/MoS heterostructure that significantly improves performance, achieving high responsivity (up to 212 A/W), a remarkable external quantum efficiency, and rapid response times.
- - Enhanced properties like birefringence and dichroism in ZrS, combined with effective interlayer interactions, result in strong polarization sensitivity, showcasing the potential for ZrS-based devices in high-performance and ultrafast photodetection applications.
Article Synopsis
- Diabetic nephropathy (DN) is a serious kidney problem caused by long-term diabetes, affecting many people around the world.
- The study looked at a protein called TRIB3, which might worsen DN, by testing it in special lab mice and cells.
- Results showed that blocking TRIB3 reduced inflammation and damage in kidneys, which could help doctors find new ways to treat diabetes-related kidney issues.
Article Synopsis
- Rheumatoid arthritis (RA) is a long-lasting autoimmune disease that leads to inflammation and damage in joints, with key characteristics including inflammation of the synovial membrane and destruction of cartilage and bone.
- The study found that an enzyme called lysine-specific demethylase 1 (LSD1) is more active in RA tissues and plays a role in inflammation and cell movement related to RA.
- The drug SP2509, which blocks LSD1, showed promise in reducing inflammation and joint damage in RA models by lowering pro-inflammatory proteins and inhibiting the migration of cells involved in RA progression.