Safety and efficacy of endoscopic resection for gastric gastrointestinal stromal tumors: a retrospective cohort study.

Background: The aim of this study was to verify the safety and efficacy of endoscopic resection (ER) for gastric gastrointestinal stromal tumors (GISTs).

Methods: Among a consecutive series of resections for gastric GISTs performed in a single center, the outcomes of patients who had ER were compared to standard surgical resection (SR).

Results: In the cohort, 329 consecutive primary localized gastric GISTs patients (, ER/SR = 251/78) were enrolled.

OTUD4-mediated inhibition of YAP1 signaling pathway in ovarian cancer: Implications for macrophage polarization and recruitment.

Ovarian cancer is a malignancy gynecologic oncology with high incidence and high mortality rate. M2-like tumor-associated macrophages promote cancer cell migration and metastasis. Ovarian tumor family deubiquitinase 4 (OTUD4) belongs to deubiquitinating enzyme family.

Quaternized Nanofiber-Based Anion-Exchange Chromatography Membrane with Periodic Diagonal Surface Structure for Efficient Protein Separation.

Constructing a nanofibrous membrane with high flow rate surface pore structure and high-density ligand chemical structure is a promising strategy to balance the trade-off between high flow rates and high adsorption capacity for protein separation and purification. Herein, a nanofiber-based ion-exchange chromatography membrane with a periodic diagonal surface structure and high ionic strength ligands was fabricated using dispersion cross-linking, wet coating, and template printing with a three-wire diagonal woven mesh. For this membrane, EVOH nanofibers were used as skeleton, glutaraldehyde (GA) as cross-linking agent, and quaternized chitosan (QCS) as binder and functional ligand.

Renoprotective effects of remote ischemic preconditioning on acute kidney injury induced by repeated tourniquet application in patients undergoing extremity surgery.

Objective: Limb ischemia-reperfusion injury caused by repeated tourniquet application usually leads to acute kidney injury, adversely affecting patient prognosis. This study aimed to investigate the renoprotective effect of remote ischemic preconditioning (RIPC) in patients undergoing extremity surgery with repeated tourniquet application.

Methods: 64 patients were enrolled and randomly divided into an RIPC group and a control group, with 32 patients in each.

Community Assembly Mechanisms of nirK- and nirS-type Denitrifying Bacteria in Sediments of Eutrophic Lake Taihu, China.

Denitrifying bacteria, particularly nirK- and nirS-type, are functionally equivalent and could occupy different niches, but their community assembly mechanisms and responses to environmental heterogeneity are poorly understood in eutrophic lakes. In this study, we investigated the community assembly mechanisms of nirK- and nirS-type denitrifying bacteria and clarified their responses to sediments environmental factors in Lake Taihu, China. The quantitative real-time PCR and Illumina HiSeq-based sequencing revealed that the abundance and composition of two types of denitrifying bacterial communities varied among different sites in the sediments of Lake Taihu.

Mollugin Derivatives as Anti-Inflammatory Agents: Design, Synthesis, and NF-κB Inhibition.

Nuclear factor κB (NF-κB) is a key inducible transcription factor that controls a large number of genes involved in inflammatory and immune processes. The entire inflammation-mediated process uses NF-κB as a hub, and inflammatory gene transcription and expression can be decreased by blocking the NF-κB signaling pathway, thereby reducing inflammatory damage. Therefore, the inhibition of this pathway is an important therapeutic target for the treatment of various types of inflammation.

Baihui-Penetrating-Qubin Acupuncture Attenuates Neurological Deficits Through SIRT1/FOXO1 Reducing Oxidative Stress and Neuronal Apoptosis in Intracerebral Hemorrhage Rats.

Background: Intracerebral hemorrhage (ICH) is a significant global disease with high mortality and disability. As of now, there is no effective therapy available. Oxidative stress and neuronal apoptosis play essential roles in ICH, determining neuronal survival.

[Development of Non-Invasive Continuous Blood Pressure Measurement System Based on Multiple Feature Parameters].

To address the issue of the difficulty in implementing non-invasive continuous blood pressure measurement technology in China, this study developed a high-performance synchronous electrocardiogram (ECG) and photoplethysmography (PPG) signal acquisition system. A PC-based human-computer interaction software platform was constructed, and continuous blood pressure measurement-related algorithms were integrated. Multiple feature parameters such as pulse wave transit time based on synchronous ECG and PPG signals were extracted, enabling non-invasive continuous blood pressure measurement.

Removal of sulfonamides by persulfate-based advanced oxidation: A mini review.

Sulfonamides (SAs) are known for their persistence and have become one of the most frequently detected pharmaceuticals and personal care products (PPCPs) in the environments. The widespread presence of SAs in natural waters, wastewater, soil, and sediment has prompted growing concern due to their potential threats to both human health and ecological systems. Persulfate-based advanced oxidation processes (PS-AOPs) have emerged as a promising technology for effectively mitigating the presence of these pollutants in the environment.

Experiencing chronic cough symptoms for 3 years is associated with increased rates of healthcare resource use and higher healthcare costs in the United States compared to resolved chronic cough.

Objective: Chronic cough (CC) symptoms can persist as refractory or unexplained CC (RCC). We sought to characterize the clinical and economic burden of RCC.

Methods: In this retrospective US cohort study using data from Optum's de-identified CDM Database (01/2015-03/2022), CC was identified as ≥1 CC diagnosis or ≥3 cough events (with ≥8 weeks and ≤120 days between the first and third events and ≥3 weeks between any 2 events).

The antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway.

Unlabelled: The type I interferon signaling pathway constitutes a pivotal component of the innate immune response, encompassing the cGAS/STING and JAK/STAT pathways. Drugs that affect the body's innate immune response could potentially be used as broad-spectrum antivirals. In this study, the antiviral activities of 25 flavonoids against pseudorabies virus (PRV) were tested in PK-15 cells.

Transplantation of human neural stem cells repairs neural circuits and restores neurological function in the stroke-injured brain.

Exogenous neural stem cell (NSC) transplantation has become one of the most promising treatment methods for chronic stroke. Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury, which limits the ability to observe long-term behavioral recovery. Here, we used a severe stroke rat model with 150 minutes of ischemia, which produced severe behavioral deficiencies that persisted at 12 weeks, to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.

EfficientNet-resDDSC: A Hybrid Deep Learning Model Integrating Residual Blocks and Dilated Convolutions for Inferring Gene Causality in Single-Cell Data.

Gene Regulatory Networks (GRNs) reveal complex interactions between genes in organisms, crucial for understanding the life system's operation. The rapid development of biotechnology, especially single-cell RNA sequencing (scRNA-seq), has generated a large amount of scRNA-seq data, which can be analyzed to explore the regulatory relationships between genes at the single-cell level. Previous models used to construct GRNs mainly aim at constructing associative relationships between genes, but usually fail to accurately reveal the causality between genes.

Double-crosslinked hydrogels and hydrogel beads formed by garlic protein hydrolysates for bioactive encapsulation and gastrointestinal delivery.

Background: Garlic protein is one of the main components of garlic. It has several beneficial characteristics. This study aimed to characterize a double crosslinked hydrogel formed with alginate, calcium ions (Ca), and garlic protein hydrolysates (GPH), and to develop hydrogel beads for targeted delivery of bioactive constituents to the gastrointestinal tract.

USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM.

Background: Radiation-induced intestinal injury (RIII) interrupts the scheduled processes of abdominal and pelvic radiotherapy (RT) and compromises the quality of life of cancer survivors. However, the specific regulators and mechanisms underlying the effects of RIII remain unknown. The biological effects of RT are caused primarily by DNA damage, and ataxia telangiectasia mutated (ATM) is a core protein of the DNA damage response (DDR).

CSTF2 Supports Hypoxia Tolerance in Hepatocellular Carcinoma by Enabling m6A Modification Evasion of PGK1 to Enhance Glycolysis.

Cleavage stimulation factor subunit 2 (CSTF2) is a fundamental factor in the regulation of 3'-end cleavage and alternative polyadenylation of pre-mRNAs. Previous work has identified a tumor-promoting role of CSTF2, suggesting that it may represent a potential therapeutic target. Here, we aimed to elucidate the mechanistic function of CSTF2 in hepatocellular carcinoma (HCC).

Identification of volatile and flavor metabolites in three varieties of broccoli sprouts.

Broccoli sprouts are promising functional food sources and their taste and flavor play a pivotal role in the acceptance of consumers. In this study, the flavor profiles of three varieties of broccoli sprouts, namely Bi Lv, You Xiu, and Lv Hua, were comprehensively characterized using HS-SPME-GC/MS analysis. A total of 364 volatile and flavor components across 15 chemical classes were successfully identified.

EGCG protects intestines of mice and pelvic cancer patients against radiation injury via the gut microbiota/D-tagatose/AMPK axis.

Background And Purpose: Radiation-induced intestinal injury (RIII) compromises the clinical utility of pelvic radiotherapy (RT). We aimed to explore the protective effect and underlying mechanism of (-)-epigallocatechin-3-gallate (EGCG) on RIII.

Materials And Methods: We evaluated the protective effect of EGCG on intestine in RIII mouse model and pelvic cancer patients, while explored the underlying mechanism through (1) 16S rRNA sequencing, (2) metabolomic profiles, (3) fresh sterile fecal filtrate (SFF) transplantation, and (4) transcriptome sequencing.

Long-term trends and response of wet ammonia deposition to changes in anthropogenic emissions in the Pearl River delta of China.

The Pearl River Delta (PRD) region has been identified as a significant hotspot of wet ammonium deposition. However, the absence of long-term monitoring data in the area hinders the comprehension of the historical trends and changes in wet NH-N deposition in response to emissions, which interferes with the ability to make effective decisions. This study has analyzed the long-term trends of wet NH-N deposition flux and has quantified the effect of anthropogenic emissions and meteorological factors at a typical urban site and a typical forest site in the PRD region from 2009 to 2020.

V-Shaped Heterostructure Nanocavities Array with CM and EM Coupled Enhancement for Ultra-Sensitive SERS Substrate.

The field of semiconductor surface-enhanced Raman scattering (SERS) substrates has experienced significant advancements, leading to a wide range of applications in several fields. However, the quest for new ultra-sensitive semiconductor SERS materials is still of utmost importance. In this regard, an efficient and novel substrate, FTCNQ/MoS heterostructure is introduced, assisted by V-shaped aluminum anodic oxide (AAO) nanocavities with different depths.

A glutathione S-transferase PcGSTMu2 involved in the detoxification of bifenazate in Panonychus citri.

Background: The citri red mite, Panonychus citri (McGregor), is an important citrus pest worldwide, causing enormous economic losses to citrus production. Bifenazate is a widely used acaricide for controlling P. citri.

Impact of Chromosomal Fusion and Transposable Elements on the Genomic Evolution and Genetic Diversity of Species.

The genus belongs to the sole family and is the single genus within the order Aquifoliales, exhibiting significant phenotypic diversity. However, the genetic differences underlying these phenotypic variations have rarely been studied. In this study, collinearity analyses of three genomes, Thunb.

Co-analysis of total suspended particles and discharge reveals the dynamic of mercury input into glacier meltwater runoff in the northern Tibetan Plateau.

Climate warming has accelerated glacier melting, releasing legacy pollutants such as mercury (Hg) into aquatic ecosystems. While the relationship between Hg in glacier meltwater runoff, total suspended particles (TSP), and runoff discharges has been established, the underlying inter-relationships and governing factors remain poorly understood. To address this knowledge gap, we conducted a continuous fixed-point sampling at Laohugou No.