Further investigation of the lateral approach for the resection of Knosp grade 4 pituitary adenomas in endoscopic endonasal surgery.

Objective: The authors performed a further in-depth study of the lateral compartment of the cavernous sinus (LCCS) by the endoscopic endonasal approach to improve the safety and efficacy of the lateral approach for the removal of Knosp grade 4 pituitary adenomas (KG4PAs).

Methods: Twenty-three cadaveric specimens were used for endoscopic endonasal dissection, and the LCCS was exposed to observe the neurovascular and fibrous structures within. A subclassification of the lateral approach based on further knowledge of the LCCS was proposed and used to resect 86 KG4PAs, and the surgical outcomes of these cases were reviewed.

Pituitary adenoma with oculomotor cistern extension: membranous anatomy and clinical application.

Background: The anatomical basis of pituitary adenomas (PAs) with oculomotor cistern (OC) extension as a growth corridor is overlooked in the literature. In this paper, the authors use the technique of epoxy sheet plastination to study the membranous structure of the OC and validate the results by retrospective analysis of patients with OC extension.

Methods: Eighteen specimens were used to study the membranous anatomy surrounding the OC using the epoxy sheet plastination technique.

Endoscopic Endonasal Approach for Trigeminal Schwannomas: Tailored Approaches Based on Lesion Traits.

Objectives: To describe four endoscopic endonasal subapproaches, namely, the trans-lamina papyracea, trans-prelacrimal recess, trans-Meckel's cave, and transclival approaches for trigeminal schwannomas (TSs).

Methods: This retrospective study reviewed the medical records and intraoperative videos of 38 patients with TSs who underwent endoscopic endonasal approach (EEA) between Jan 2013 and Dec 2021.

Results: According to Jeong's classification, for TS equally in middle and posterior fossae (MP), a purely trans-Meckel's cave approach was carried out in 2 cases, and a combined transclival approach was carried out in 4 cases.

Extracellular Vesicles Derived from Bone Mesenchymal Stem Cells Carrying circ_0000075 Relieves Cerebral Ischemic Injury by Competitively Inhibiting miR-218-5p and Up-regulating E3 Ubiquitin Ligase SMURF2.

Extracellular vesicle (EV)-encapsulated circRNAs have the potential role in affecting brain disorders. However, the role of circ_0000075 in cerebral ischemic injury remains unclear. Here, we tried to investigate the mechanism of bone marrow mesenchymal stem cell (BMSC)-derived EVs carrying circ_0000075 in the control of cerebral ischemic injury.

How I do it: a purely endoscopic endonasal approach for anterior clinoidal meningioma.

Background: Surgery for anterior clinoid meningiomas (ACMs) remains challenging due to their tight adhesion to vital neurovascular and has been traditionally performed through a transcranial approach.

Method: We present the key steps of the endoscopic endonasal approach (EEA) for ACMs with a video illustration and figures. The relevant surgical anatomy is described along with the indications and limitations of this approach.

Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1/AGR2/HIF-1α axis.

Gliomas are the most common primary intracranial tumor, accounting for more than 70% of brain malignancies. Studies indicate that highly upregulated in liver cancer (HULC), a long noncoding RNA (lncRNA), functions as an oncogene in gliomas. However, the underlying mechanism of HULC in gliomas remains under-studied and was subsequently investigated in the current study.

Analysis of the Mediating Effect of Risk Perception on the Relationship Between Time Perception and Mental Health of College Students During the COVID-19 Epidemic.

COVID-19 has had a wide impact on the mental health of college students. This study aims to explore the relationship between time perception, risk perception, and the mental health of college students during COVID-19 through a questionnaire survey. One thousand two hundred and eighteen college students, 449 male and 769 female, who studied online during the COVID-19 epidemic were selected.

Robust Heterogeneous Photocatalyst for Visible-Light-Driven Hydrogen Evolution Promotion: Immobilization of a Fluorescein Dye-Encapsulated Metal-Organic Cage on TiO.

The design of artificial photocatalytic devices that simulates the ingenious and efficient photosynthetic systems in nature is promising. Herein, a metal-organic cage [Pd(NPyCzPF)] (MOC-PC6) integrating 12 organic ligands NPyCzBP and 6 Pd catalytic centers is designed, which is well defined to include organic dye fluorescein (FL) for constructing a supramolecular photochemical molecular device (SPMD) FL@MOC-PC6. Photoinduced electron transfer (PET) between MOC-PC6 and the encapsulated FL has been observed by steady-state and time-resolved emission spectroscopy.

Erratum: MicroRNA-181 inhibits the proliferation, drug sensitivity and invasion of human glioma cells by targeting Selenoprotein K (SELK).

[This corrects the article on p. 6632 in vol. 11, PMID: 31737213.

A Robust Photocatalytic Hybrid Material Composed of Metal-Organic Cages and TiO for Efficient Visible-Light-Driven Hydrogen Evolution.

The design of photochemical molecular devices (PMDs) for photocatalytic H production from water is a meaningful but challenging subject currently. Herein, a Pd L type metal-organic cage (denoted as MOC-Q2) is designed as a PMD, which consists of two catalytic centers (Pd ) and four photosensitive ligands (L-2) with four pyridine anchoring groups. Subsequently, the MOC-Q2 is combined with TiO to form TiO -MOC-Q2 hybrid materials with different MOC-Q2 contents by a facile sol-gel method, which have micro/mesoporous structures and large surface areas.

Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis.

Accumulating evidences have suggested that extracellular vesicles (EVs) are crucial players in the pathogenesis of ischemic brain injury. This study was designed to explore the specific functions of M2 phenotype microglia-derived EVs in ischemic brain injury progression. The expression of microRNA-135a-5p (miR-135a-5p) in M2 microglia-derived EVs was determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), followed by the identification of expression relationship among miR-135a-5p, thioredoxin-interacting protein (TXNIP), and nod-like receptor protein 3 (NLRP3) by dual luciferase reporter gene assay.

Single-stage endoscopic endonasal approach for the complete removal of trigeminal schwannomas occupying both the middle and posterior fossae.

To introduce a purely endoscopic endonasal trans-Meckel's cave approach or a transclival approach for trigeminal schwannomas (TSs) involving both the middle and posterior fossae. This retrospective study reviewed the medical records and intraoperative videos of 8 patients with TSs occupying both the middle and posterior fossae who underwent an endoscopic endonasal approach (EEA) between January 2017 and October 2019. All 8 patients received total resection under a single-stage EEA.

Photocatalysts for H Generation from Starburst Triphenylamine/Carbazole Donor-Based Metal-Free Dyes and Porous Anatase TiO Cube.

A series of novel triphenylamine/carbazole-based D-D-π-π-A dyes DH1-4 and a mesoporous anatase cubic "microcage" TiO material (denoted as MC-TiO ) were synthesized and combined to obtain dye-sensitized photocatalysts (denoted as DHn/Pt/MC-TiO , n=1-4). These catalysts showed better performances in visible-light-driven H evolution from water than DHn/Pt/P25-TiO catalysts based on commercial P25-TiO bulk semiconductor under similar conditions. Compared with P25-TiO particles, the porous MC-TiO had a large Brunauer-Emmett-Teller surface area, porosity, and exposed {0 0 1} crystal plane, which greatly contributed to the photocatalytic activity.

A novel endoscopic classification for craniopharyngioma based on its origin.

Endoscopic endonasal approach for craniopharyngioma (CP) resection provides a wide view and direct observation of hypothalamus and origin of tumor. Under endoscopy, 92 CPs were classified into 2 types: Peripheral and Central, according to its relation to pituitary stalk. Peripheral type was further divided into 3 subtypes: Hypothalamic stalk, Suprasellar stalk and Intrasellar stalk CP, according to the different origin site along hypothalamus-pituitary axis.

Endoscopic Endonasal Clipping of Anterior Circulation Aneurysm: Surgical Techniques and Results.

Background: Endoscopic endonasal clipping of intracranial aneurysms may use microsurgical techniques as an alternative to the transcranial approach. Here we report a series of patients who underwent microsurgical clipping of anterior circulation aneurysms via an endoscopic endonasal approach (EEA).

Methods: This retrospective chart review included all the patients who underwent standard binostril EEA for aneurysm clipping.

Regio- and Enantioselective Photodimerization within the Confined Space of a Homochiral Ruthenium/Palladium Heterometallic Coordination Cage.

The photoinduced regio- and enantioselective coupling of naphthols and derivatives thereof is achieved in the confined chiral coordination space of a Ru metalloligand based cage. The racemic or enantiopure cages encapsulate naphthol guests, which then undergo a regiospecific 1,4-coupling, rather than the normal 1,1-coupling, to form 4-(2-hydroxy-1-naphthyl)-1,2-napthoquinones; moderate stereochemical control is achieved with homochiral cages. The photoreactions proceed under both aerobic and anaerobic conditions but through distinct pathways that nevertheless involve the same radical intermediates.

Dye-sensitized solar cells with improved performance using cone-calix[4]arene based dyes.

Three cone-calix[4]arene-based sensitizers (Calix-1-Calix-3) with multiple donor-π-acceptor (D-π-A) moieties are designed, synthesized, and applied in dye-sensitized solar cells (DSSCs). Their photophysical and electrochemical properties are characterized by measuring UV/Vis absorption and emission spectra, cyclic voltammetry, and density functional theory (DFT) calculations. Calix-3 has excellent thermo- and photostability, as illustrated by thermogravimetric analysis (TGA) and dye-aging tests, respectively.

Starburst triarylamine based dyes bearing a 3,4-ethylenedioxythiophene linker for efficient dye-sensitized solar cells.

Starburst triarylamine-based organic dyes (D1, D2, and D3) have been synthesized. For the three designed dyes, the starburst triarylamine group, thiophene (or 3,4-ethylenedioxythiophene), and cyanoacetic acid take the role of electron donor, π-conjugation bridge, and electron acceptor, respectively. These compounds are characterized by photophysical, electrochemical, and theoretical computational methods.

[Meta analysis of association between TNF-α-308 polymorphism and periodontitis in Chinese Han population].

Purpose: To assess the association between TNF-α-308 polymorphism and periodontitis in Chinese Han population.

Methods: Articles published between 1994 and 2011 were searched in the fulltext database of CNKI, Chinese Biomedical Literature Database, Wanfang Database and PubMed. Case-control studies on TNF-α-308 polymorphism and periodontitis were searched up to Feb.

[Research based on 3MRA model about the risk assessment methods and applications of the landfill waste].

Seven major contaminations of the landfill were selected from northeast of China, and the migration and transformation of contaminations environmental medias were studied by using the multimedia multipathway and multireceptor risk assessment (3MRA) model. The results show, the order of the radical concentration of the seven contaminations is Ni2+ > Benzene > Cd > Pb > Cr6+ > As > Hg. The radical concentration of benzene, As and Hg in human is similar to that of ecology, respectively.