Publications by authors named "Li Li Peng"
Objective: To evaluate the feasibility, safety, and efficacy of microwave ablation (MWA) for the treatment of patients with Bethesda IV follicular neoplasms (FNs) (≤3 cm).
Methods: In the retrospective study, patients who underwent MWA for Bethesda IV follicular neoplasms (≤3 cm) were included. Technical success, volume reduction, disease progression, and adverse event (AE) rates were analyzed postablation.
Background: Thyroid nodule rupture (TNR) is a rare and severe complication after thermal ablation (TA), mostly from benign thyroid nodules (BTN).
Objective: To summarize the incidence of TNR after TA and analyze the causes and prevention strategies.
Materials And Methods: This retrospective study enrolled 3971 patients who underwent TA for BTN from January 2014 to March 2024.
Article Synopsis
- The study aimed to assess how different levels of thyroid-stimulating hormone (TSH) affect tumor progression and survival in patients with early-stage papillary thyroid cancer treated with microwave ablation (MWA).
- It analyzed the medical records of 525 patients, categorizing them into uni-focal (U-PTC) and multifocal (M-PTC) groups based on TSH levels after treatment, and observed the rates of tumor progression and survival outcomes.
- Results indicated that lower TSH levels in U-PTC patients correlated with higher tumor progression rates and reduced progression-free survival compared to medium and high TSH levels, whereas M-PTC patients showed no significant relationship between TSH levels and progression.
Objectives: This study aimed to evaluate the long-term efficacy and safety of microwave ablation (MWA) for solitary T1N0M0 papillary thyroid carcinoma (PTC) and compare them between T1a and T1b disease.
Materials And Methods: This retrospective study included 136 patients with solitary T1N0M0 PTC who were treated with MWA and followed up for more than 5 years. Outcomes were compared between patients with T1a and T1b disease.
Article Synopsis
- Thermal ablation (TA) is an effective treatment for benign thyroid nodules (BTNs), but the study seeks to determine the optimal maximum diameter (MD) for effective results.
- Analyzing data from 639 BTNs, the study finds that the complete disappearance rate is significantly linked to the MD, with an optimal threshold identified at 25.0 mm.
- Results show that BTNs larger than 25.0 mm have a lower chance of complete disappearance and a higher rate of complications compared to smaller nodules.
Article Synopsis
- The study aimed to evaluate the feasibility, efficacy, and safety of microwave ablation for treating follicular thyroid neoplasms.
- It involved 74 patients, achieving a 100% technical success rate and significant reduction in nodule size and volume over 24 months, with no adverse changes in thyroid function.
- Results indicate that microwave ablation is an effective and safe treatment option, with low rates of recurrence and complications.
Objective: To evaluate the efficacy and safety of thermal ablation in treating solitary low-risk T2N0M0 papillary thyroid cancer (PTC) and compare the outcomes of microwave ablation (MWA) and radiofrequency ablation (RFA).
Materials And Methods: This retrospective, single center study involved 34 patients (age: 40.0 ± 13.
Article Synopsis
- * A retrospective analysis of 280 TR5 nodules revealed that larger nodules (MD ≥ 6.2 mm) were more likely to yield probably malignant (PM) outcomes compared to smaller ones, with a significant difference in MD between PM and probably benign (PB) groups.
- * The findings suggest that an MD threshold of 6.2 mm is optimal for deciding when to perform FNA in TR5 nodules, as larger nodules have a higher probability
Article Synopsis
- Heart failure and cardiac remodeling involve mitochondrial dysfunction, which is crucial for heart muscle's contractile activity and cell survival.
- The study found that hypertension leads to abnormal mitochondria and contributes to cardiac hypertrophy, while metformin treatment improved mitochondrial structure and function, indicating a protective effect.
- Metformin enhances the mitochondrial unfolded protein response (UPRmt) and activates heat shock factor 1 (HSF1), suggesting that targeting these pathways could offer new therapeutic strategies for heart conditions.
Background Microwave ablation (MWA) is currently under preliminary investigation for the treatment of multifocal papillary thyroid carcinoma (PTC) and has shown promising treatment efficacy. Compared with surgical resection (SR), MWA is minimally invasive and could preserve thyroid function. However, a comparative analysis between MWA and SR is warranted to draw definitive conclusions.
View Article and Find Full Text PDFHeterochronous multiple primary prostate cancer and lymphoma: A case report.
World J Clin Cases
March 2024
Article Synopsis
- * The patient, a 77-year-old male, was initially treated for prostate cancer with radiation and endocrine therapy, but later developed rectal DLBCL with lung metastases seven years after the prostate cancer diagnosis.
- * The case highlights the importance of recognizing the possibility of coexisting cancers, even though it is uncommon, which can enhance understanding of cancer progression and treatment.
RAD21: A Key Transcriptional Regulator in the Development of Residual Liver Cancer.
J Hepatocell Carcinoma
February 2024
Article Synopsis
- - The study investigates the role of RAD21 in the rapid progression of residual hepatocellular carcinoma (HCC) following inadequate thermal ablation therapy, particularly focusing on the molecular mechanisms at play.
- - Using an animal model, researchers found that high levels of RAD21 correlate with poor tumor differentiation and aggressive tumor behavior, while silencing RAD21 significantly reduces cancer cell migration, invasion, and proliferation.
- - The research also indicates that elevated RAD21 levels enhance HCC malignancy after heat treatment and that RAD21 regulates several key signaling pathways associated with tumor growth and metastasis.
Objective: To evaluate the complications associated with microwave ablation (MWA) in treating persistent/recurrent hyperparathyroidism (HPT) post-surgical or ablative treatments.
Materials And Methods: From January 2015 to December 2022, 87 persistent/recurrent HPT patients (primary HPT [PHPT]: secondary HPT [SHPT] = 13:74) who underwent MWA after surgical or ablative treatment were studied. Grouping was based on ablation order (initial vs.
Article Synopsis
- - High levels or mutations of SHP2 are linked to cancer, prompting researchers to target it as a potential treatment strategy, leading to the development of a new SHP2 inhibitor.
- - The synthesized compound 4b showed impressive selectivity and potency as an allosteric inhibitor of SHP2, significantly outperforming the previous standard, IACS-13909, in reducing cancer cell proliferation.
- - Compound 4b demonstrated strong effectiveness against KRAS-mutant lung cancer cells when combined with the KRAS inhibitor sotorasib, suggesting a promising synergy in cancer treatment approaches.
Targeting SHP2 has become a potential cancer treatment strategy. In this study, ellagic acid was first reported as a competitive inhibitor of SHP2, with an IC value of 0.69 ± 0.
View Article and Find Full Text PDFArticle Synopsis
- - The study aims to compare the health-related quality of life (HRQoL) between patients with T1N0M0 papillary thyroid carcinoma who underwent microwave ablation (MWA) and those who had total thyroidectomy (TT).
- - Researchers analyzed 180 patients, equally divided into two groups, using quality of life questionnaires (EORTC QLQ-C30 and THYCA-QoL) to assess HRQoL scores.
- - Results showed that the MWA group had significantly better quality of life scores in multiple areas compared to the TT group, suggesting MWA could be a favorable alternative to TT for these patients.
Article Synopsis
- The study aimed to evaluate the safety of a new hydrodissection technique during microwave ablation (MWA) for secondary hyperparathyroidism (SHPT) by comparing improved hydrodissection to traditional methods.
- Data from 337 patients revealed that the risk of hoarseness, a common complication from nerve injury, was significantly lower in the improved hydrodissection group (6.9%) versus the traditional group (13.0%).
- Additionally, patients in the improved group recovered from hoarseness in a median time of 2 months compared to 6 months for those in the traditional group, suggesting the improved technique is safer without compromising technical effectiveness.
Article Synopsis
- The study investigates the safety and efficacy of microwave ablation (MWA) in patients with multifocal papillary thyroid carcinoma (M-PTC) compared to those with unifocal papillary thyroid carcinoma (U-PTC), using data from 504 patients over five years.
- Results showed that while the complete ablation was achieved in all cases, the tumour disappearance rate was significantly lower and slower for M-PTC patients compared to U-PTC, but the overall safety and complication rates were comparable between the two groups.
- In conclusion, MWA is an effective and safe treatment for selected M-PTC patients, with clinical outcomes similar to those with U-PTC
Article Synopsis
- The study aimed to evaluate the safety and effectiveness of a new hydrodissection technique during microwave ablation for treating papillary thyroid carcinoma (PTC).
- Data from 341 patients were analyzed, comparing traditional hydrodissection with an improved method targeting perithyroidal fascial spaces, focusing on complications and recovery outcomes.
- The improved technique resulted in fewer cases of hoarseness due to nerve injury and a quicker recovery time, while both methods showed no significant difference in tumor disappearance rates or local recurrence during follow-up.
Purpose: To study the feasibility, safety, and effectiveness of microwave ablation (MWA) in patients with multifocal papillary thyroid microcarcinoma (PTMC).
Materials And Methods: This retrospective study included patients who underwent MWA for multifocal PTMC (number of nodules ≤3). A total of 44 patients were included, and the mean age was 43 years (SD ± 11).
CDC25B belongs to the CDC25 family, and it plays an important part in regulating the activity of CDK/CyclinA. Studies have shown that CDC25B is closely related to cancer development. When CYS473 on CDC25B is mutated into ASP, the affinity between CDC25B and CDK2/CyclinA weakens, and their dissociation speed is greatly improved.
View Article and Find Full Text PDFChanges in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules.
Int J Endocrinol
September 2022
Purpose: Microwave ablation (MWA) is a minimally invasive method for the thermal ablation of benign thyroid nodules and papillary thyroid cancer (PTC) and has shown promising results. The aim of this study was to investigate the impact of MWA on thyroid antibodies and associated influencing factors.
Materials And Methods: A total of 119 patients, including 69 with benign thyroid nodules and 50 with PTC, underwent MWA between June 2019 and June 2021.