Publications by authors named "Li Ka Man"
Article Synopsis
- The study investigates how hepatocellular carcinoma (HCC) adapts to resistance against anti-PD-L1 immunotherapies, revealing the importance of tumour microenvironment remodelling.
- Researchers created resistant HCC models and used advanced techniques like single-cell RNA sequencing to explore the mechanisms of resistance, finding that certain immune cells (MDSCs) grow alongside tumours and suppress the immune response.
- The research identified a specific pathway involving PPARγ, which enhances VEGF-A production, leading to immune dysfunction and poor patient outcomes, suggesting that targeting this pathway could potentially enhance the effectiveness of immunotherapies.
