An Investigation of the Saccharides Profile and Metabolic Gene Expression in Muskrat Scented Glands in Different Secretion Seasons.

The adult male muskrat has a pair of scented glands, which show clear seasonal changes in their developmental status between the secretion season and non-secretion season. During the secretion season, the scented glands are much larger than in the non-secretion season, with the metabolism of glandular cells increasing and a large amount of musk being produced. In this work, the blood, musk, and scented gland tissue were collected from three healthy adult male muskrats during secretion season (September).

Clinical features and prognostic risk factors of different sex with acute exacerbations of chronic obstructive pulmonary disease.

The aim of this retrospective cohort study was to investigate the clinical characteristics and the outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients between different sex. We aimed to collect the first hospitalization patients who were diagnosed as AECOPD between 1 January 2019 to 31 December 2021 from the general ward and intensive care unit in the hole hospital, Shanghai the Fifth People's Hospital, Fudan University. Demographic data, initial clinical symptoms, on-admission vital signs, comorbidities, laboratory tests and imaging examination, treatment, and follow-up were compared between the two groups.

Bifunctional Electrospun Nanocomposite Dressing: Integrating Antibacterial Efficacy and Controllable Antioxidant Properties for Expedited Wound Healing.

Current wound dressings are insufficient in simultaneously addressing bacterial infections and oxidative stress, which severely affects wound healing outcomes. To solve this problem, we introduced poly(ionic liquid) (PIL) with strong antibacterial properties and cerium oxide nanoparticles (CeONPs) with excellent antioxidant capabilities into polyacrylonitrile (PAN) nanofiber membranes to prepare a novel composite dressing. The PIL-CeONPs-PAN nanofiber membrane provides sustained antibacterial activity through stably embedded PIL, while the uniformly distributed CeONPs achieve controlled release, avoiding safety issues caused by the rapid release of active substances.

Mental Health in Early Pregnancy and Spontaneous Abortion Risk: A Prospective Cohort Study.

Objective: This study aims to explore the relationship between maternal mental health during early pregnancy and the risk of spontaneous abortion (SA), especially in the context of the Coronavirus disease 2019 pandemic.

Methods: We conducted a prospective cohort study involving 4088 pregnant women at a maternal-child health hospital in China from January to December 2022. During the first trimester, we assessed depression, anxiety, and stress levels using the Depression, Anxiety, and Stress Scale (DASS-21).

A Connected Convolutional Neutral Network Protocol for Design of Two-Dimensional Materials Based on Modified Graphdiyne.

In materials science, doping plays a crucial role in manipulating the electronic properties of materials. Conventional screening via a trial-and-error strategy is challenging owing to the enormous chemical space. We proposed a connected convolutional neutral network (CCNN) for quick screening of boron nitrogen (B-N) codoped graphdiyne in terms of band gap.

Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis.

Background: Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms and airflow limitation. The involvement of C-C motif chemokine ligand 2 (CCL2) in COPD pathogenesis, particularly in macrophage regulation and activation, is poorly understood despite its recognized role in chronic inflammation. Our study aims to elucidate the regulatory role and molecular mechanisms of CCL2 in the pathogenesis of COPD, providing new insights for therapeutic strategies.

A thermodynamic model of the surface hydroxylation of γ-AlO.

Rational design of γ-alumina-based catalysts relies on an extensive understanding of the distribution of hydroxyl groups on the surface of γ-alumina and their physicochemical properties, which remain unclear and challenging to determine experimentally due to the structural complexity. In this work, by means of DFT and thermodynamic calculations, various hydroxylation modes of γ-alumina (110) and (100) surfaces at different OH coverages were evaluated, based on which a thermodynamic model to reflect the relationship between temperature and the surface structure was established and the stable hydroxylation modes under experimental conditions were predicted. This enables us to identify the experimentally measured IR spectra.

Superhydrophilic PANI/Ag/TA@PVDF Composite Membrane with Antifouling Property for Oil-Water Separation.

The current membrane materials used for oil-water separation suffer from low separation efficiency and poor durability, and membrane contamination is also a key issue that must be addressed urgently. In this paper, a superhydrophilic PANI/Ag/TA@PVDF composite membrane with PANI-Ag NPs heterojunction structure was prepared via chelation and reduction of Ag by tannic acid (TA) and in situ growth of hydrochloric acid-doped polyaniline (PANI). TA endows the prepared composite membrane with excellent superhydrophilicity and underwater oleophobicity, remarkable oil-water separation capacity (the separation efficiency of more than 97% for soybean oil), and extraordinary antifouling properties.

Apple Fruit Edge Detection Model Using a Rough Set and Convolutional Neural Network.

Accurately and effectively detecting the growth position and contour size of apple fruits is crucial for achieving intelligent picking and yield predictions. Thus, an effective fruit edge detection algorithm is necessary. In this study, a fusion edge detection model (RED) based on a convolutional neural network and rough sets was proposed.

Proteomic analysis of DEN and CCl-induced hepatocellular carcinoma mouse model.

Hepatocellular carcinoma (HCC) seriously threatens human health, mostly developed from liver fibrosis or cirrhosis. Since diethylnitrosamine (DEN) and carbon tetrachloride (CCl)-induced HCC mouse model almost recapitulates the characteristic of HCC with fibrosis and inflammation, it is taken as an essential tool to investigate the pathogenesis of HCC. However, a comprehensive understanding of the protein expression profile of this model is little.

Mechanistic Study of Glycyrrhizic Acid Improving Alcoholic Fatty Liver Disease by Modulating the SHP1/SYK Signaling Pathway in Macrophages.

Objective: To investigate glycyrrhizin's effects and molecular mechanisms on the progression of alcoholic fatty liver.

Methods: An alcoholic fatty liver model was established, followed by the administration of glycyrrhizin ammonium (20 mg/kg). Liver tissue pathological changes were observed using oil red O staining, and pyroptotic bodies were observed using transmission electron microscopy.

Synthesis of the AgS/PANI@PES Composite Membrane and Its Antipollution Properties.

Membrane separation technology offers a sustainable and efficient solution to wastewater management; however, membrane fouling significantly impedes its application. Photocatalytic membranes, integrating photocatalytic and membrane separation technologies, enhance membrane separation efficacy while effectively mitigating organic and biological contaminations. In this work, AgS/PANI@PES composite membranes were prepared via a facile in situ polymerization and successive layer adsorption technique.

Nonreciprocal toroidal dipole resonance and one-way quasi-bound state in the continuum.

Bound states in the continuum (BICs) provide an alternative way of trapping light at nanoscale. Although the last 10 years have witnessed tremendous progress on BICs from fundamentals to applications, nonreciprocal BICs and their potential applications have not been fully exploited yet. In this study, we demonstrated a one-way quasi-BIC by leveraging an all-dielectric magneto-optical (MO) metasurface.

Thermal-Adaptation-Behavior-Based Thermal Sensation Evaluation Model with Surveillance Cameras.

The construction sector is responsible for almost 30% of the world's total energy consumption, with a significant portion of this energy being used by heating, ventilation and air-conditioning (HVAC) systems to ensure people's thermal comfort. In practical applications, the conventional approach to HVAC management in buildings typically involves the manual control of temperature setpoints by facility operators. Nevertheless, the implementation of real-time alterations that are based on the thermal comfort levels of humans inside a building has the potential to dramatically improve the energy efficiency of the structure.

Music combined with dexmedetomidine relieves preoperative anxiety and promotes postoperative recovery in patients undergoing gynecologic laparoscopic surgery: a randomized clinical trial.

Objectives: To investigate the effects of music combined with dexmedetomidine on perioperative anxiety and postoperative recovery in gynecologic laparoscopic patients.

Methods: A total of 82 female patients were enrolled in this study. Patients were randomized to the patient-preferred Music+Dexmedetomidine group (M+DEX group, n=41) and the Dexmedetomidine group (DEX group, n=41).

Unconventional luminescent CS-PEC-based composite hemostasis sponge with antibacterial activity and visual monitoring for wound healing.

Multifunctional wound dressings are promising medical materials for various applications. Among them, dressings with antimicrobial activity, high biosafety, and real-time monitoring have attracted considerable research interest. Herein, a biodegradable hemostatic sponge comprising a chitosan skeleton and polyelectrolyte-surfactant complex (CS-PEC) was developed as a versatile wound dressing for wound pH monitoring and inhibition of bacterial infection.

Positive Synergy between the Helical Poly(phenylacetylene) Backbones and the Helical -Proline Oligopeptide Pendants for Enhanced Enantioseparation Properties.

A series of optically active helical poly(phenylacetylene)s (, , , , and ) bearing different chain lengths of -proline oligopeptide in the side chains were obtained by polymerizing the corresponding novel phenylacetylene monomers. The monomer adopted a -rich helix structure when the -proline oligopeptide chain length was longer, according to the optical activities and 2D-NMR analysis. The helical structure could be maintained and significantly influenced the polymers' helical conformation by introducing the -proline oligopeptide to the pendants.

The anoikis-related gene signature predicts survival and correlates with immune infiltration in osteosarcoma.

Anoikis is essential for the progression of many malignant tumors. However, the understanding of anoikis' roles in osteosarcoma remains scarce. This study conducted an extensive bioinformatics analysis to identify anoikis-related genes (ARGs), developed ARGs modeles for predicting OS and RFS, and evaluated the effect of these ARGs on osteosarcoma cell migration and invasion.

Bioinspired Zn-MOF doped radial porous chitosan-based sponge with antibacterial and antioxidant properties for rapid hemostasis and wound healing.

Herein, a novel bioinspired radial porous zinc-based metal-organic framework (Zn-MOF) doped sodium alginate/chitosan derivatives/pullulan-based SA/PSCS/Pul/Zn-MOF (SPCP/Zn) composites sponge with excellent antioxidant and antibacterial properties was fabricated by the ice-templating method. Boric acid (BA) and Ca, which were respectively used as hydrogen- and ionic- bonding cross-linkers, provided strong mechanical properties for sponge matrix composed of SA, PSCS, and Pul. The obtained SPCP/Zn sponge exhibited uniform porous morphology, proper hydrophilicity, and admirable biocompatibility.

Development and internal validation of a clinical prediction model for spontaneous abortion risk in early pregnancy.

Objective: This study aimed to develop and internally validate a prediction model for estimating the risk of spontaneous abortion in early pregnancy.

Methods: This prospective cohort study included 9,895 pregnant women who received prenatal care at a maternal health facility in China from January 2021 to December 2022. Data on demographics, medical history, lifestyle factors, and mental health were collected.

The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis B.

Background: Accompanied by the growing prevalence of nonalcoholic fatty liver disease (NAFLD), the coexistence of chronic hepatitis B (CHB) and NAFLD has increased. In the context of CHB, there is limited understanding of the factors that influence the development of NASH.

Methods: We enrolled CHB combined NAFLD patients who had liver biopsy and divided them to NASH vs.

Unidirectional asymmetry transmission based on quasi-accidental bound states in the continuum.

The unidirectional asymmetry transmission is demonstrated based on quasi-accidental bound states in the continuum by a one-dimensional chiral photonic crystal slab (CPhCs) composed of tilted silicon nano-pillars. The chirality breaks symmetries on the far field polarization and radiation -factor between the upward and downward radiation channels. Accordingly, the CPhCs only supports the unidirectional maximal asymmetry transmission at fixed incident and conical angles.

Analyzing the epidemic situation and influencing factors of childhood pneumonia during the COVID-19 epidemic period in Laiwu, China.

This study aimed to analyze the trends of childhood pneumonia before and after the corona virus disease 2019 (COVID-19) pandemic in Laiwu, China, and explore the associated risk factors to provide a reference for the prevention, control, and treatment of childhood pneumonia. In this cross-sectional study, data were collected from 11,716 children aged 3 to 12 years who underwent chest radiography/computed tomography from January 2018 to December 2021 in Laiwu, China. The generalized estimating equation model was used to analyze the time trend of the pneumonia detection rate.