[Association between chronic diseases and possible sarcopenia in middle-aged and older Chinese men: A prospective cohort study].

Objective: To investigate the association between chronic diseases and the risk of possible sarcopenia among middle-aged and older Chinese males.

Methods: This prospective cohort study included the data collected from the China Health and Retirement Longitudinal Study on 4 878 males aged over 45 years without possible sarcopenia as the baseline population in 2011 and 2013, and all were followed up until 2015. Possible sarcopenia was determined by measuring the grip strength and the time of five successive sit-ups.

[Interactive effect of chemical fertilizer exposure and drinking untreated water on the risk of birth defects].

Objective: To explore the interactive effect of chemical fertilizer exposure and drinking untreated water during pregnancy on the risk of birth defects.

Methods: The data were collected from a population-based birth surveillance system in Pingding County, Shanxi Province, from 2007 to 2012. Totally, 157 cases of birth defects were followed up and 204 healthy newborns taken as controls.

Positive association between triglyceride glucose index and central systolic blood pressure among hypertensive adults.

Background: While studies have suggested the association between triglyceride-glucose (TyG) index, a reliable surrogate for insulin resistance and hypertension data are limited to the correlation of TyG and central blood pressure. This study aims to test the hypothesis that a higher TyG index is associated with elevated central systolic blood pressure (cSBP).

Methods: A total of 9249 Chinese hypertensive adults from the H-type Hypertension and Stroke Prevention and Control Project were analyzed in this study.

Individual and joint effects of borderline ankle-brachial index and high plasma total homocysteine on all-cause death in hypertensive adults.

Background: The cardiovascular hazards of total homocysteine (tHcy) are long known. In addition, despite the acknowledgment on the importance of low ankle-brachial index (ABI) (< 0.9), borderline ABI (0.

Bioinformatics analysis of candidate genes and potential therapeutic drugs targeting adipose tissue in obesity.

Obesity is a complex medical condition that affects multiple organs in the body. However, the underlying of obesity, as well as its treatment, . The focus of this research was to use bioinformatics to discover possible treatment targets for obesity.

Hsp22 ameliorates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidative stress, and apoptosis.

Sepsis-induced myocardial dysfunction (SIMD) is ubiquitous in septic shock patients and is associated with high morbidity and mortality rates. Heat shock protein 22 (Hsp22), which belongs to the small HSP family of proteins, is involved in several biological functions. However, the function of Hsp22 in lipopolysaccharide (LPS)-induced myocardial injury is not yet established.

Effect of the icariin on endothelial microparticles, endothelial progenitor cells, platelets, and erectile function in spontaneously hypertensive rats.

Objectives: To investigate the effect of icariin on endothelial microparticles, endothelial progenitor cells, platelets, and erectile function in spontaneously hypertensive rats.

Materials And Methods: Twelve 8-week-old healthy male Wistar-Kyoto rats and 12 spontaneously hypertensive rats were randomly divided into four following groups: Wistar-Kyoto control group (normal saline 1 ml/d given by gavage), Wistar-Kyoto + icariin group (icariin 10 mg/kg × d dissolved in 1 ml normal saline and given by gavage), spontaneously hypertensive rats control group (normal saline 1 ml/d given by gavage), and spontaneously hypertensive rats + icariin group (icariin 10 mg/kg × d dissolved in 1 ml normal saline and given by gavage). Four weeks later, the maximum intracavernous pressure/mean arterial pressure, platelet count, mean platelet volume, platelet distribution width, endothelial microparticles, endothelial progenitor cells, and vitronectin receptor were measured in each group.

Potential therapeutic target genes for systemic lupus erythematosus: a bioinformatics analysis.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs. However, the underlying etiology and mechanisms remain unclear. This study was performed to identify potential therapeutic targets for SLE using bioinformatics methods.

LINC00963 targeting miR-128-3p promotes acute kidney injury process by activating JAK2/STAT1 pathway.

The role of long non-coding RNAs (lncRNAs) in kidney diseases has been gradually discovered in recent years. LINC00963, as an lncRNA, was found to be involved in chronic renal failure. However, the role and molecular mechanisms of LINC00963 engaged in acute kidney injury (AKI) were still unclear.

[Association between contraceptive choice and the risk of induced abortion among floating married women of childbearing age].

Objective: To find the association between factors related to contraception, reproductive health and the risk of induced abortion among floating married women of childbearing age, so as to provide basis for improving the access to health services for floating women of childbearing age.

Methods: Using data from the reproductive health survey on floating population from five cities in 2005, factors as demographic characteristics, contraceptive choice, settings and access to health services, induced abortion among the floating married women of childbearing age were described. Multivariate logistic regression was used to investigate the association the factors relative to contraception, reproductive health and the risk of induced abortion between 543 cases and 1796 controls.

[Study on the risk factors of induced abortion among floating women of childbearing age in 5 cities of China].

Objective: To understand the status of abortion and risk factors among floating women of childbearing age and to provide reference for further improvement of induced abortion services in this population.

Methods: Data on demography, working, and living conditions as well as the use of contraceptive among 4687 persons from a reproductive health survey regarding floating population in five cities in 2005, were involved, while multivariate logistic regression model was used to find out the relationship.

Results: The risks of abortion among the younger than 30 age group and the 30 - 39 age groups were 2.

Impact of periconceptional multi-micronutrient supplementation on gestation: a population-based study.

Objective: To examine the effect of periconceptional multi-micronutrient supplementation on gestation and birth outcomes.

Methods: A population-based community intervention program was conducted in 18 counties in China. Participants were divided into an intervention group, who received multi-micronutrient supplementation from at least 3 months before pregnancy throughout the first trimester, and a control group.

2,3,6-Trichloro-5-(trichloro-meth-yl)pyridine.

The title compound, C(6)HCl(6)N, lies on a mirror plane, the asymmetric unit conataining a half-mol-ecule. Weak intra-molecular C-H⋯Cl contacts are observed.

Cesarean delivery on maternal request and childhood intelligence: a cohort study.

Background: Cesarean section births have been steadily increasing over the past decade and have become an epidemic in China. Cesarean delivery on maternal request is a major contributor to this upward trend, and there has been of much concern about its impact on maternal and child health. Most of mothers believe that cesarean delivery on maternal request can improve the child's intelligence, but direct evidence is sparse.

Maternal periconceptional consumption of pickled vegetables and risk of neural tube defects in offspring.

Background: Maternal exposure to nitrate, nitrite, and N-nitroso compounds from drinking water or diet has been associated with an increased risk of neural tube defects (NTDs) in some studies. Pickled vegetables contain relatively large amounts of nitrite and N-nitroso compounds. We examined the association between maternal periconceptional consumption of pickled vegetables and NTDs in Shanxi Province of northern China.

[Sexual dysfunction in diabetic women].

Diabetes mellitus is a common problem, and female sexual dysfunction is one of its complications in diabetic women. Recent studies show that the major risk factors of sexual dysfunction in diabetic women are diabetes-induced vascular disease, neuropathy, endocrine abnormalities and psychological problems and so on. This article outlines the advances in the recent studies of female sexual dysfunction in diabetic women.

Effect of pathoanatomic diagnosis on the quality of birth defects surveillance in China.

Objective: To provide evidence for more accurate diagnosis of birth defects based on the pathoanatomy of congenital malformations.

Methods: Data used in this study were obtained from Luliang City Hospital and three county hospitals of Shanxi province between February 2004 and March 2006. Autopsy and pathological examination of 160 dead fetuses and stillbirths were performed.

Unusual patterns of neural tube defects in a high risk region of northern China.

Objective: To study the prevalence of different types of neural tube defects (NTDs) in Luliang Prefecture, Shanxi province, where the prevalence of NTDs is unusually high and the correlation between NTDs prevalence and patterns.

Methods: A surveillance population-based birth defects was performed in Luliang Prefecture, Shanxi province.

Results: The results of our study showed that the prevalence of NTDs was 2-fold higher in Luliang Prefecture than in other areas of Shanxi province.

[Application of 'Family-Based Association Test' in studying genetic epidemiology].

To introduce the application of Family-Based Association Test (FBAT) in detecting the association or linkage between marker alleles and phenotype or traits in genetic epidemiology. A brief overview on basic steps involved in design, implementation, principles of application, available software as well as the use and feature of FBAT method, were explained based on data from nuclear family. Advantages of FBAT were compared to conventional genetic statistics approaches.

[Prevalence of visual, hearing, speech, physical, intellectual and mental disabilities in China, 2006].

Objective: To explore the prevalence of visual, hearing, speech, physical, intellectual and mental disabilities in China, 2006.

Methods: The reference time of the Second National Sample Survey on Disability was zero hour, April 1, 2006, and 2,526,145 individuals were investigated from 31 provinces autonomous regions or municipalities under the "Disability Classification and Standards for the Second National Sampling Survey on Disability". The classified prevalence rates of 6 types of disability was analyzed.

[Study on the differences of exposure levels to the environmental risk factors during periconceptional period between intended and unintended pregnancies].

Objective: This paper was to analyze the difference of exposure levels of the environmental risk factors on birth defects during peri-conceptional period between intended and unintended pregnancies, and to estimate the role of intended pregnancies in reducing exposure of environmental risk factors.

Methods: Data used in this paper were from a retrospective survey of maternal women from 2002 through 2004 conducted in Wuxi city. The total number of women under study was 1628.

[The relationships between exposure of periconceptional environmental risk factors and risks of common, structural birth defects].

Objective: This paper is to explore the relationships between the occurrence of structural birth defects and environmental risk factors on birth defects.

Methods: A survey was conducted by using a population-based case control study. A total number of 388 structural birth defects, which were detected after 28 weeks' gestational age to 7th day after birth in various hospitals were recruited in Wuxi from 2002 to 2004.

[Association between parental transforming growth factor alpha gene TaqI variant, paternal smoking and the cleft lip with or without cleft palate].

Objective: To study the association between transforming growth factor alpha gene (TGFalpha) TaqI variant and nonsyndromic cleft lip with or without cleft palate (nsCL/P) in Chinese population, and the interaction with parental smoking.

Methods: TGFalpha TaqI variant was detected using RFLP-PCR for DNA samples of the 170 triads with nsCL/P affected child. We performed the transmission/disequilibrium test (TDT) and the family-based association study (FBAT) to test the associations between this variant and risk of nsCL/P.

[Study on the association between transforming growth factor alpha gene TaqI variant and cleft lip with or without cleft palate].

Objective: To study the association between transforming growth factor alpha gene (TGFalpha) TaqI variant and nonsyndromic cleft lip with or without cleft palate (nsCL/P) in Chinese population.

Methods: TGFalpha TaqI variant was detected using polymerase chain reaction-restriction fragment length polymorphism for DNA samples of the 149 triads with nsCL/P affected child. We performed the Transmission/disequilibrium test and the family-based association study (FBAT) to identify the associations between this variant and risk of nsCL/P.