Publications by authors named "Li Jingyan"

Article Synopsis
  • Cataracts are a major cause of blindness worldwide, primarily caused by oxidative stress damaging lens epithelial cells (LECs), with aging, hypertension, and diabetes as significant risk factors.
  • The global prevalence of cataracts emphasizes the importance of developing new pharmacological treatments to complement existing surgical methods.
  • This review examines the molecular mechanisms of oxidative stress in cataract formation and discusses potential new therapeutic strategies, such as antioxidant treatments.
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Background: The limited radiosensitivity of osteosarcoma poses a challenge in applying radiotherapy, necessitating the search for effective radiosensitizing targets.

Methods: The lentiviral vectors were employed to establish CDKN2C-overexpressing (CDKN2C-OE) and CDKN2C-negative control (CDKN2C-NC) HOS and U2OS osteosarcoma cells. Cells were treated with or without irradiation (IR) to assess radiosensitization via viability, proliferation, apoptosis, and cell cycle analysis.

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The prognosis of osteosarcoma has not been improved for decades. As radioresistance is one of the major reasons, effective radiotherapy sensitization drugs need to be discovered. HOS and K7M2 osteosarcoma cell lines were treated with disulfiram (DSF) and radiation to assess cell viability, proliferation, migration ability, apoptosis level, ROS and Ca2+ level, and cell cycle in vitro.

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Background: Cancer driver genes (CDGs) have been reported as key factors influencing the progression of lung adenocarcinoma (LUAD). However, the role of CDGs in LUAD prognosis has not been fully elucidated.

Methods: LUAD transcriptome data and CDG-related data were obtained from public databases and literature.

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Compared to lithium (Li) anode, the alloy/Li-alloy anodes show more compatible with sulfide solid electrolytes (SSEs), and are promising candidates for practical SSE-based all-solid-state Li batteries (ASSLBs). In this work, a porous Li-Al alloy (LiAl-p) anode is crafted using a straightforward mechanical pressing method. Various characterizations confirm the porous nature of such anode, as well as rich oxygen species on its surface.

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Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disorder predominantly affecting preterm infants. Oxygen therapy, a common treatment for BPD, often leads to hyperoxia-induced pulmonary damage, particularly targeting alveolar epithelial cells (AECs). Crucially, disrupted lung epithelium-fibroblast interactions significantly contribute to BPD's pathogenesis.

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  • Peanut is a crucial crop for protein and oil supply, with the NCED gene playing a key role in abscisic acid biosynthesis and drought response.
  • Eight NCED-related genes were identified across peanut chromosomes, showing conservation among various plant species and containing elements responsive to ABA and drought.
  • Analysis of two peanut cultivars revealed NH5 as drought-tolerant and FH18 as drought-sensitive, with significant differences in gene expression regulation under drought stress.
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Cervical cancer seriously affects the health of women worldwide. Persistent infection of high-risk HPV (Human Papilloma Virus) can lead to cervical cancer. There is a great need for timely and efficient screening methods for cervical cancer.

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Mitochondria are the centers of energy and material metabolism, and they also serve as the storage and dispatch hubs of metal ions. Damage to mitochondrial structure and function can cause abnormal levels and distribution of metal ions, leading to cell dysfunction and even death. For a long time, mitochondrial quality control pathways such as mitochondrial dynamics and mitophagy have been considered to inhibit metal-induced cell death.

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Astaxanthin is an important ketocarotenoid widely used in industries. However, its application is limited because of its low yield. Sodium citrate (Na-citrate), one of the major carbon sources for microorganisms, can promote cell growth and product accumulation.

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Infectious diseases pose a significant threat to global health, yet traditional microbiological identification methods suffer from drawbacks, such as high costs and long processing times. Raman spectroscopy, a label-free and noninvasive technique, provides rich chemical information and has tremendous potential in fast microbial diagnoses. Here, we propose a novel Combined Mutual Learning Net that precisely identifies microbial subspecies.

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  • Chirality is a key property related to the symmetry of objects, especially important in distinguishing chiral molecules for applications in biochemistry and medicine.
  • Vibrational circular dichroism (VCD) spectroscopy is a technique that could help with this, but it often struggles with weak signals from small molecules.
  • The use of dielectric metasurfaces, particularly with achiral germanium nanoresonators, significantly enhances VCD signal sensitivity, achieving enhancements over 750 and effectively improving chiral sensing even in the presence of a chiral molecular layer.
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The increased rate of antibiotic resistance strongly limits the resolution of enterica serovar Typhimurium (S. Typhimurium) infection. Therefore, new strategies to control bacterial infections are urgently needed.

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  • - The study investigates the role of N-methyladenosine (m6A) RNA methylation regulators in the development of bronchopulmonary dysplasia (BPD), a condition affecting premature infants, as its relationship with gene expression is not well understood.
  • - Researchers identified and compared differentially expressed m6A regulators in BPD patients through transcriptome data analysis, revealing significant changes in molecules like IGF2BP1/2/3 and classifying BPD into two subsets based on severity.
  • - Functional analysis indicated a disrupted immune-related signaling pathway in one subset of BPD, suggesting that understanding m6A regulation could offer new insights into diagnosing and treating this condition.
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Nuclear receptor coactive 4 (NCOA4), which functions as a selective cargo receptor, is a critical regulator of the particularly autophagic degradation of ferritin, a process known as ferritinophagy. Mechanistically, NCOA4-mediated ferritinophagy performs an increasingly vital role in the maintenance of intracellular iron homeostasis by promoting ferritin transport and iron release as needed. Ferritinophagy is not only involved in iron-dependent responses but also in the pathogenesis and progression of various human diseases, including metabolism-related, neurodegenerative, cardiovascular and infectious diseases.

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In patients with diabetic wounds, wound healing is impaired due to the presence of persistent oxidative stress, an altered inflammatory response, and impaired angiogenesis and epithelization. Salvianolic acid B (SAB), which is derived from the Chinese medicinal plant Salvia miltiorrhiza, has been found to exhibit antioxidant, anti-inflammatory, and proangiogenic effects. Previous studies have used 3D bioprinting technology incorporating sodium alginate (SA) and gelatin (Gel) as basic biomaterials to successfully produce artificial skin.

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  • The study aimed to create a juvenile mouse model of asthma using postnatal exposure to high oxygen levels (hyperoxia) along with early sensitization to ovalbumin (OVA).
  • The researchers exposed newborn mice to 95% oxygen and administered OVA injections, followed by inhalation challenges, then measured various asthma-related symptoms and immune responses.
  • Results showed that the combination of hyperoxia and OVA significantly increased asthma-like symptoms, airway sensitivity, and certain immune markers compared to either treatment alone, suggesting the model effectively mimics juvenile asthma.
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Nanoattapulgite (nano-ATP), a magnesium-aluminum silicate clay, can absorb substances and is a suitable material for bone repair and regeneration. In this study, using three-dimensional printing technology, a nano-ATP/polycaprolactone (PCL) scaffold was fabricated and modified using NaOH to form a rough surface. Biomimetic hydroxyapatite (HA) on nano-ATP/PCL scaffolds was fabricated using a biomineralized approach.

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Due to their appealing physiochemical properties, metal-organic frameworks (MOFs) have been widely employed in biomedical fields. In this study, we utilize ferric ions and fluorine-containing organic ligands as both structural and functional units to develop a stimulus-responsive nanoagent, FIMOF-TA nanoparticles, for activatable F magnetic resonance imaging (MRI) and synergistic therapy of tumors. This nanoagent could respond to excess GSH in a tumor microenvironment, discharging fluorinated organic ligands and reduced ferrous ions.

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Conventional electrospinning produces nanofibers with smooth surfaces that limit biomineralization ability. To overcome this disadvantage, we fabricated a tetramethylpyrazine (TMP)-loaded matrix-mimicking biomineralization in PCL/Gelatin composite electrospun membranes with bubble-shaped nanofibrous structures. PCL/Gelatin membranes (PG), PCL/Gelatin membranes containing biomineralized hydroxyapatite (HA) (PGH), and PCL/Gelatin membranes containing biomineralized HA and loaded TMP (PGHT) were tested.

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Article Synopsis
  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting preterm infants, and oxygen therapy used to treat BPD can inadvertently cause lung damage due to high oxygen levels.
  • A study identified the PVT1/IL-33 axis's role in BPD; hyperoxia exposure increased RNA levels of IL-33 and PVT1, leading to lung cell apoptosis.
  • Silencing PVT1 was found to reduce apoptosis and improve lung function, suggesting that targeting the PVT1/IL-33 pathway could be a potential treatment strategy for lung injuries in BPD.
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Bronchial asthma is not considered a singular disease, but rather a collection of syndromes with multiple phenotypes and mechanisms that involve various signaling pathways. It typically emerges during the preschool years, and its etiology is intricate and diverse. In recent years, the advancement of high-throughput sequencing technology has revealed that early alterations in lung microbiota may be associated with asthma incidence and progression.

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  • Polystyrene nanoplastics (PS-NPs) have been detected in human blood and kidneys, but their effects on renal health have not been fully understood.
  • Research showed that PS-NPs can lead to cell death (apoptosis) in human kidney cells, influenced by the size and concentration of the particles.
  • The study identified that PS-NPs increase reactive oxygen species (ROS) production and alter cell structures, with the MAPK signaling pathway playing a crucial role in the apoptosis process.
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