ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis.

Recent extensive studies on the genomic and molecular profiles of acute myeloid leukemia (AML) have expanded the treatment options, including, a range of compounds represented by fms-like tyrosine kinase 3 and isocitrate dehydrogenase 1/2 inhibitors. However, despite this progress, further treatments for AML are still required. Adenosine deaminase acting on RNA 1 (ADAR1) has been shown to play an important oncogenic role in many cancers, but its involvement in AML progression remains underexplored.

Phillygenin rescues impaired autophagy flux by modulating the PI3K/Akt/mToR signaling pathway in a rat model of severe acute pancreatitis.

To investigate the mechanism of pancreatic alveolar cell autophagy in rats with severe acute pancreatitis (SAP) by phillygenin (PHI) based on the PI3K/Akt/mToR pathway. Rats were randomly divided into control group (CON group), SAP model group (SAP group) and PHI treatment group (SAP+PHI group), with 10 rats in each group. 5% sodium taurocholate was injected retrogradely into the biliopancreatic duct to establish a SAP rat model, and PHI was injected intraperitoneally into the pancreas after successful establishment of the model.

Chemical Coordination of Acetic Acid to Improve Photovoltaic Performance and Long-Term Stability of Sn-Pb Perovskite Solar Cells.

Mixed Tin-Lead perovskite solar cells (Sn-Pb PSCs) with a narrow band gap (NBG) are significant for single-junction and all-perovskite tandem solar cells due to their low toxicity and ideal band gap. Nevertheless, the performance and stability of the device are adversely affected by the uncontrollable crystallization and ion migration processes. Acetic acid (HAc) is introduced into the perovskite precursor solution as a multifunctional additive to enhance the film crystallization process and restrain ion migration in the device.

The effects of fluorinated metal-organic frameworks as additives in polymer-based electrolytes for all-solid-state lithium batteries.

In this study, solid composite electrolytes (SCEs) comprising UIO-66-F(Zr) were obtained by using a simple solution casting method. By introducing fluorinated groups, the interaction between the MOF and the polymer was significantly improved, which not only stabilizes the SEI layer but also improves the ionic conductivity of the SCEs, thus advancing the practical application of solid composite electrolytes in lithium metal batteries.

Construction of a Dual-Mode Sensing Platform for Ultra-fast Detection of Bisulfite in Food and Environmental Systems.

Sulfur dioxide (SO) is widely used in food processing to extend the shelf life of food. However, excessive intake of SO and its derivatives (HSO and SO) can cause oxidative damage to the body, and result in several diseases. How to construct probes for rapid real-time detection of HSO in the field is beneficial to the developmental needs of practical applications, but it is also very challenging.

Rational design of an ultrabright quinolinium-fused rhodamine turn-on fluorescent probe for highly sensitive detection of SO derivatives: Applications in food safety and bioimaging.

Sulfur dioxide (SO) is an essential signaling molecule involved in various physiological processes within living organisms. Bisulfite (HSO) possesses antioxidant, antimicrobial, and preservative properties, making it a common food additive. However, elevated levels of SO or excessive HSO intake can lead to a range of diseases, highlighting the importance of detecting SO and its derivatives (HSO/SO).

FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS.

Myelin, along with the oligodendrocytes (OLs) that produce it, is essential for proper central nervous system (CNS) function in vertebrates. Although the accurate targeting of myelin to axons and its maintenance are critical for CNS performance, the molecular pathways that regulate these processes remain poorly understood. Through a combination of zebrafish genetics, mouse models, and primary OL cultures, we found FBXW7, a recognition subunit of an E3 ubiquitin ligase complex, is a regulator of adult myelination in the CNS.

Revisiting the sound absorption mechanisms of a finite flexible perforated panel absorber using a numerical approach.

This study investigates the sound absorption mechanisms of a finite flexible perforated panel absorber. Different from existing work where the mechanisms were often investigated by comparing the sound absorption coefficient curves of different absorber configurations, a numerical approach, called virtual impedance tube (VIT) technique, is developed and used for the analysis. One advantage of this technique is the vast dataset generated can be used to investigate the sound absorption mechanisms from an energy standpoint.

TBAPy-based metal-organic frameworks with phosphate-induced fluorescence for detecting gossypol.

How to achieve good dispersion of MOFs (metal-organic frameworks) is the key to its application in many fields. In our work, a novel MOF nanocomposite TBAPy-Yb was synthesized by solvothermal approach with TBAPy [1,3,6,8-tetrakis(p-benzoic acid)pyrene)] as the organic ligand and lanthanide metal ions as the metal ion source. Due to the coordination between phosphate and TBAPy-Yb, TBAPy-Yb had excellent dispersion in phosphate buffer and induced strong fluorescence emission in 435 nm.

Ultrafast detection of bisulfite by a unique quinolinium-based fluorescent probe and its applications in smartphone-assisted food detection and bioimaging.

Sulfur dioxide (SO) is one of the major pollutants in the atmosphere, which is highly susceptible to inhalation by the human body and is converted into its derivatives (HSO/SO), which is hazardous to both human health and the ecological environment. Therefore the detection of SO derivatives (HSO/SO) is very important. In this work, we have prepared ID-QL, a water-soluble fluorescent probe based on the intramolecular charge transfer (ICT) mechanism, it exhibits colorimetric and fluorescent dual-channel response to HSO with ultrafast, highly selective and sensitive detection.

Steric Influences on Chain Microstructure in Palladium-Catalyzed α-Olefin (Co)polymerization: Unveiling the Steric-Deficient Effect.

This study addresses the challenge of controlling branching density and branch-type distribution in late-transition-metal-catalyzed chain walking polymerizations. We explored α-diimine Pd(II) complexes with incrementally increased -aryl sterics for long-chain α-olefin (co)polymerization. - catalysts, which feature gradually increased -aryl sterics and at least one small CH substituent, exhibited similar 2,1-insertion fractions (44-50%), polymer branching densities (55-63/1000C), and melting temperatures (26-28 °C).

The applications of Keggin-based metal-organic compounds in sensing and catalysis.

Environmental pollution and energy problems caused by excessive use of fossil fuels deviate from the theme of green and sustainable development. It is very promising to detect small molecules or catalyze the conversion of pollutants to obtain renewable energy by using photoelectric technology. Therefore, there is an urgent requirement to develop materials with low detection limits and high catalytic performance.

The mechanism exploration of different colored rice for immunomodulation based on UPLC-Q-TOF, network pharmacology, and cell experiments.

Rice has a long history as a staple food consumed by half of the world's population. Compared with white rice (WR), colored rice (CR) has more nutritional value because it contains rich active ingredients. In this study, the potential mechanism of CR (red rice (RR), green rice (GR), black rice (BR), and purple rice (PR)) for immunomodulation was explored by UPLC-Q-TOF, network pharmacology, and cell experiment.

Overexpression of MtIPT gene enhanced drought tolerance and delayed leaf senescence of creeping bentgrass (Agrostis stolonifera L.).

Background: Isopentenyltransferases (IPT) serve as crucial rate-limiting enzyme in cytokinin synthesis, playing a vital role in plant growth, development, and resistance to abiotic stress.

Results: Compared to the wild type, transgenic creeping bentgrass exhibited a slower growth rate, heightened drought tolerance, and improved shade tolerance attributed to delayed leaf senescence. Additionally, transgenic plants showed significant increases in antioxidant enzyme levels, chlorophyll content, and soluble sugars.

A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin.

Gephyrin is thought to play a critical role in clustering glycine receptors at synapses within the central nervous system (CNS). The main in vivo evidence for this comes from Gephyrin (Gphn)-null mice, where glycine receptors are depleted from synaptic regions. However, these mice die at birth, possibly due to impaired molybdenum cofactor (MoCo) synthesis, an essential role Gephyrin assumes throughout an animal.