Residue Behavior and Risk Assessment of Diazepam and Its Metabolites in Crucian Carp (Carassius auratus) After Oral Administration.

Diazepam (DZP), a benzodiazepine medication, is extensively utilized in both human and veterinary medicine and has been frequently detected in fish populations. The use of DZP-laced bait is identified as a predominant contributor to drug residue contamination in fish. Nonetheless, our understanding of the residue profile of DZP in fish and its potential implications for human health remains constrained.

A Feature Fusion Attention-based Deep Learning Algorithm for Mammographic Architectural Distortion Classification.

Architectural Distortion (AD) is a common abnormality in digital mammograms, alongside masses and microcalcifications. Detecting AD in dense breast tissue is particularly challenging due to its heterogeneous asymmetries and subtle presentation. Factors such as location, size, shape, texture, and variability in patterns contribute to reduced sensitivity.

Skin cancer detection using dermoscopic images with convolutional neural network.

Skin malignant melanoma is a high-risk tumor with low incidence but high mortality rates. Early detection and treatment are crucial for a cure. Machine learning studies have focused on classifying melanoma tumors, but these methods are cumbersome and fail to extract deeper features.

Latitudinal variations in incubation behaviour among uniparental incubating birds.

Uniparental incubating birds must resolve the trade-off between self-maintenance and incubation. This balance manifests through diverse incubation behaviours that vary significantly among species and geographic regions. However, limited research has examined the variability of incubation behaviours across species and regions.

Sustainable pest management using plant secondary metabolites regulated azadirachtin nano-assemblies.

Biopesticides have emerged as a global trend to minimize the risks associated with synthetic agrochemicals. However, their stability and efficacies remain challenges for widespread application. Herein, co-assembled nanoparticles (AT NPs or AP NPs) based on azadirachtin (AZA) and tannic acid (TA) or phenylalanine (PA) are constructed in aqueous solution through self-assembly technology.

Except for environmental protection, promoting income: An analysis of the role of outsourcing livestock manure on promoting farmers' incomes.

To realize the harmless treatment and complete resource utilization of livestock manure, the Chinese government continues to promote the outsourcing livestock manure (OLM) services. Exploring OLM's impacts on farmers' incomes is of great significance to evaluate and improve the socialized service system. However, the economic effects of OLM still lack empirical support.

Successful resuscitation of acute type A aortic dissection with pulmonary embolism using long-term venoarterial extracorporeal membrane oxygenation: a case report.

Acute aortic dissection (AAD) and pulmonary embolism (PE) are two critical and potentially fatal causes of chest pain. The simultaneous occurrence of these conditions is exceptionally rare; however, when they co-occur, the conflicting therapeutic strategies required significantly elevate mortality rates. While venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been extensively reported as a life-saving intervention for high-risk pulmonary embolism, its application in the management of AAD remains highly debated.

Nasolacrimal Metastasis from Parotid Ductal Carcinoma Detected by F-FDG PET/CT.

A 39-year-old woman presented with left neck masses for 4 months and epiphora of the left eye for 3 weeks. Ultrasonography revealed a mass in the left parotid gland and multiple cervical lymph nodes. Biopsy of the mass in the left parotid gland revealed infiltrating ductal carcinoma.

Clinical efficacy and safety of sintilimab plus oral vinorelbine as first-line treatment for newly diagnosed stage IIIB-IV nonsmall cell lung cancer patients with performance status 2 or age ≥75 years.

This study aimed to evaluate the efficacy and safety of sintilimab combined with oral vinorelbine in newly diagnosed patients with stage IIIb to IV nonsmall cell lung cancer (NSCLC) who had an Eastern Cooperative Oncology Group performance status (PS) of 2 or over 75 years of age during the initial treatment. This prospective single-center single-arm study enrolled patients with histologically confirmed NSCLC. Eligible patients were administered sintilimab and vinorelbine.

Reinforcement learning based route optimization model to enhance energy efficiency in internet of vehicles.

The Internet of Vehicles (IoV) transforms the automobile industry through connected vehicles with communication infrastructure that improves traffic control, safety and information, and entertainment services. However, some issues remain, like data protection, privacy, compatibility with other protocols and systems, and the availability of stable and continuous connections. Specific problems are related to energy consumption for transmitting information, distributing energy loads across the vehicle's sensors and communication units, and designing energy-efficient approaches to processing received data and making decisions in the context of the IoV environment.

Study on structure, properties and formation mechanism of cassava starch-faba bean protein heat-induced gel.

In this experiment, the effects of different concentrations of cassava starch (CS) on the gel behavior of faba bean protein (FBP) were studied, focusing on the structural characteristics, gel characteristics and physical and chemical characteristics of the gel system. Specifically, with the increase of CS concentration from 4 % to 12 %, the morphology of the sample changed from fluid to gel solid. From the molecular structure, different concentrations of CS affected the secondary and tertiary structures of FBP protein, which made aromatic amino acids move to the surface of protein and promoted the transformation from α-helix to β-sheet.

Prodrug Self-Assemblies Based on Plant Volatile Aldehydes with Improved Stability and Antimicrobial Activity Against Plant Pathogens.

Plant volatile aldehydes (PVAs) such as cinnamaldehyde (Cin), citral (Cit), citronellal (Citr), and perillaldehyde (Per) have broad-spectrum antimicrobial activity and show great potential in agricultural sustainable production. However, most PVAs not only have very high volatility but also are easily degradable in environment, which seriously restricts their wide application. To address the inherent problems with PVAs, four prodrugs based on PVAs are fabricated by conjugating individually Cin, Cit, Citr, and Per to sodium bisulfite (Sod) through a simple addition reaction and subsequently self-assembled into nanoparticles (prodrug self-assemblies) in aqueous solutions.

TG-CDDPM: text-guided antimicrobial peptides generation based on conditional denoising diffusion probabilistic model.

Antimicrobial peptides (AMPs) have emerged as a promising substitution to antibiotics thanks to their boarder range of activities, less likelihood of drug resistance, and low toxicity. Traditional biochemical methods for AMP discovery are costly and inefficient. Deep generative models, including the long-short term memory model, variational autoencoder model, and generative adversarial model, have been widely introduced to expedite AMP discovery.

Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone.

Rotenone remains an efficient pesticide used extensively in agriculture, leading to neurotoxicity and the increase of the prevalence of Parkinson's disease (PD). Previous studies indicated that Parkin, a neurohomeostasis regulatory factor, and NOD-like receptor protein 3 (NLRP3), a core factor driving the inflammatory response, interacted with each other, which affected neuroinflammation occurrence. However, whether rotenone accelerated PD progression via Parkin-NLRP3 loop and the specific mechanisms were still unclear.

LHPre: Phage Host Prediction with VAE-based Class Imbalance Correction and Lyase Sequence Embedding.

The escalation of antibiotic resistance underscores the need for innovative approaches to combat bacterial infections. Phage therapy has emerged as a promising solution, wherein host determination plays an important role. Phage lysins, characterized by their specificity in targeting and cleaving corresponding host bacteria, serve as key players in this paradigm.

Naturally selected CD7-directed CAR-T bridging allo-HSCT in refractory acute myeloid leukemia: a case report and review.

Relapsed/refractory acute myeloid leukemia (R/R-AML) has a poor prognosis. CD7 is expressed in leukemic cells in 30% of patients with AML but not in normal myeloid cells. Therefore, it can be a potential target for immunotherapy in patients with R/R-AML.

Construction of cationic covalent organic framework for efficient gold extraction.

In this work, we report a rare ionic covalent organic framework (named as ECUT-iCOF-5) synthesized by the Knoevenagel reaction using an ionic liquid monomer. ECUT-iCOF-5 is found to show a promising potential for gold extraction with a high extraction ability towards gold, including a high extraction capacity (3260 mg g), good selectivity over both cations and anions, and good recycle use (at least six times).

Tea saponin-Zein binary complex as a quercetin delivery vehicle: preparation, characterization, and functional evaluation.

In this study, in order to solve the application problems of poor water solubility and low bioavailability of quercetin, we prepared a nano-delivery system with core-shell structure by anti-solvent method, including a hydrophilic shell composed of tea saponin and a hydrophobic core composed of Zein, which was used to improve the delivery efficiency and biological activity of quercetin. Through the optimal experiments, the loading rate and encapsulation rate of nanoparticles reached 89.41 % and 7.

Mining software insights: uncovering the frequently occurring issues in low-rating software applications.

In today's digital world, app stores have become an essential part of software distribution, providing customers with a wide range of applications and opportunities for software developers to showcase their work. This study elaborates on the importance of end-user feedback for software evolution. However, in the literature, more emphasis has been given to high-rating & popular software apps while ignoring comparatively low-rating apps.

The complete mitochondrial genome of : using HiFi reads to investigate genome recombination and gene transfer from chloroplast genome.

Water hyacinth ( Mart.) is a monocotyledonous aquatic plant renowned for its rapid growth, extensive proliferation, biological invasiveness, and ecological resilience to variations in pH, nutrients, and temperature. The International Union for Conservation of Nature (IUCN) has listed among the top 100 invasive species.

Complete mitochondrial genome of Melia azedarach L., reveals two conformations generated by the repeat sequence mediated recombination.

Melia azedarach is a species of enormous value of pharmaceutical industries. Although the chloroplast genome of M. azedarach has been explored, the information of mitochondrial genome (Mt genome) remains surprisingly limited.

OMGMed: Advanced System for Ocular Myasthenia Gravis Diagnosis via Eye Image Segmentation.

This paper presents an eye image segmentation-based computer-aided system for automatic diagnosis of ocular myasthenia gravis (OMG), called OMGMed. It provides great potential to effectively liberate the diagnostic efficiency of expert doctors (the scarce resources) and reduces the cost of healthcare treatment for diagnosed patients, making it possible to disseminate high-quality myasthenia gravis healthcare to under-developed areas. The system is composed of data pre-processing, indicator calculation, and automatic OMG scoring.

Identification and Pathogenicity of Pestalotioid Species on in Hainan Province, China.

is a traditional Chinese medicinal plant with a medicinal history of more than 1700 years. Ring leaf blight (RLB) disease, caused by pestalotioid species, is an important disease of , seriously affecting the yield and quality of its fruits. The causal agent of RLB disease has not been systematically identified or characterized yet.