GPS Assay Association With Long-Term Cancer Outcomes: Twenty-Year Risk of Distant Metastasis and Prostate Cancer-Specific Mortality.

Purpose: To assess the association between the Oncotype DX Genomic Prostate Score (GPS) result and long-term oncological outcomes following radical prostatectomy (RP).

Methods: We evaluated the association of the GPS result assayed from the index lesion from RP tissue with the risk of distant metastases (DM) and prostate cancer-specific mortality (PCSM) over the 20 years following RP in a stratified cohort sample of 428 patients from 2,641 treated between 1987 and 2004. Cox regression of cause-specific hazards was used to estimate the absolute risk of both end points, with death from other causes treated as a competing risk.

Characterization of the complete chloroplast genome of basswood ( maxim.).

Herein, we report the complete chloroplast genome of Maxim. from Tiliaceae. The chloroplast genome of is 162,804 bp, with a large single copy region of 91,255 bp, small single copy region of 20,355 bp, and two inverted-repeat regions of 25,597 bp.

Integrating Prostate-specific Antigen Kinetics into Contemporary Predictive Nomograms of Salvage Radiotherapy After Radical Prostatectomy.

Background: Salvage radiotherapy (SRT) is an established treatment for men with biochemical recurrence following radical prostatectomy (RP). There are several risk factors associated with adverse outcomes; however, the value of postoperative prostate-specific antigen (PSA) kinetics is less clear in the ultrasensitive PSA era.

Objective: To characterize the impact of PSA kinetics on outcomes following SRT and generate nomograms to aid in identifying patients with an increased risk of adverse clinical outcomes.

Distribution of systemically administered nanoparticles during acute pancreatitis: effects of particle size and disease severity.

Nanoparticles (NPs) promise to address current limitations for treating acute pancreatitis (AP) inflammatory cell-mediated sequestration. However, very few studies have explored the influence of NP size on their behavior in different stages of AP. The present work investigated the biodistribution of IR780 loaded mesoporous silica nanoparticles (MSNs) with sizes of 60, 150 or 300 nm after intravenous administration to rats of mild AP (MAP) or severe AP (SAP).

Three-dimensional-arterial spin labeling perfusion correlation with diabetes-associated cognitive dysfunction and vascular endothelial growth factor in type 2 diabetes mellitus rat.

Background: Type 2 diabetes mellitus (T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia. The mechanisms of diabetes-associated cognitive dysfunction (DACD) have not been fully elucidated to date. Some studies proved lower cerebral blood flow (CBF) in the hippocampus was associated with poor executive function and memory in T2DM.

SKOPE-Study of Ketorolac vs Opioid for Pain after Endoscopy: A Double-Blinded Randomized Control Trial in Patients Undergoing Ureteroscopy.

Purpose: Pain is the leading cause of unplanned emergency department visits and readmissions after ureteroscopy, making postoperative analgesic stewardship a priority given the current opioid epidemic. We conducted a double-blinded, randomized controlled trial, with noninferiority design, comparing nonsteroidal anti-inflammatory drugs to opiates for postoperative pain control in patients undergoing ureteroscopy for urolithiasis.

Materials And Methods: Patients were randomized and blinded to either oxycodone (5 mg) or ketorolac (10 mg), taken as needed, with 3 nonblinded oxycodone rescue pills for breakthrough pain.

Solar-Assisted, Fast, and Recovery of Crude Oil Spill by a Superhydrophobic and Photothermal Sponge.

Development of a functional sorbent for effective crude oil absorption is essential to address large-scale spilling incidents. Herein, we demonstrate a facile method for preparing a superhydrophobic and photothermal PDMS/CuS/PDA@MF sponge through sequential depositions of PDA, CuS nanoparticles, and a PDMS layer onto a melamine sponge. The optimized composite sponge exhibits a superhydrophobic surface property, high absorption capacity for oils, robust recycling, and excellent photothermal conversion performance.

Renewable UV-curable polyester methacrylate/cellulose nanocrystals composite resin for wood waterproof coating.

Low-viscosity UV-curable resins are widely used in industry as they allow for UV curing materials with reduced amounts of reactive diluents to adjust the viscosity. But their mechanical properties and waterproof performance after curing as UV coatings still need to be improved. Here, a series of low-viscosity bio-based UV-curable polyester methacrylates were synthesized through L-lactide (LA) and-caprolactone (CL) monomers.

[Annual progress in critical care medicine in 2020].

The epidemic of coronavirus disease 2019 (COVID-19) puts higher demands on critical care medicine. Lots of studies have been conducted to solve COVID-19-related problems. Therefore, we reviewed the annual progress for COVID-19-related issues including antivirals threapies, respiratory support and immunomodulatory therapies and other critical issues, including the effect of antibiotic on mitochondrial damage and its relationship with sepsis, the goal and direction of antimicrobial de-escalation, drug prophylaxis of constipation, bleeding in gastrointestinal disorders and management of critical illness in the informalization era and so on.

TMT-based proteomics analysis of the effects of Qianjinweijing Tang on lung cancer.

Qianjinweijing Tang (QJWJ) is a classic traditional Chinese formula that is often used in the treatment of treat lung cancer (LC). However, the underlying cellular mechanisms of the anticancer effects of QJWJ remain unclear. Cell viability was determined by MTS assay and levels of apoptosis measured by flow cytometry.

Multimodal Gait Recognition for Neurodegenerative Diseases.

In recent years, single modality-based gait recognition has been extensively explored in the analysis of medical images or other sensory data, and it is recognized that each of the established approaches has different strengths and weaknesses. As an important motor symptom, gait disturbance is usually used for diagnosis and evaluation of diseases; moreover, the use of multimodality analysis of the patient's walking pattern compensates for the one-sidedness of single modality gait recognition methods that only learn gait changes in a single measurement dimension. The fusion of multiple measurement resources has demonstrated promising performance in the identification of gait patterns associated with individual diseases.

Dielectric Properties of Human Active Liver, Kidney and Spleen Compared to Those of Respective Inactive Tissues, Porcine Tissues and the Data Provided by a Database in the Frequency Range of 10 Hz to 100 MHz.

Objective: The purpose of this work is to study whether the active state and species of biological tissues can influence changes in their dielectric properties.

Methods: In this paper, the dielectric properties of liver, kidney and spleen tissues from human active, human inactive and animal tissues are measured in the frequency range of 10 Hz to 100 MHz. The four- and two-electrode methods are used to measure dielectric properties at different frequencies.

Perovskite Solar Cells toward Eco-Friendly Printing.

Eco-friendly printing is important for mass manufacturing of thin-film photovoltaic (PV) devices to preserve human safety and the environment and to reduce energy consumption and capital expense. However, it is challenging for perovskite PVs due to the lack of eco-friendly solvents for ambient fast printing. In this study, we demonstrate for the first time an eco-friendly printing concept for high-performance perovskite solar cells.

Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice.

The protein leverage hypothesis predicts that low dietary protein should increase energy intake and cause adiposity. We designed 10 diets varying from 1% to 20% protein combined with either 60% or 20% fat. Contrasting the expectation, very low protein did not cause increased food intake.

Designing nanofibrous membrane with biomimetic caterpillar-like structured for highly-efficient and simultaneous removal of insoluble emulsified oils and soluble dyes towards sewage remediation.

Purification of insoluble emulsified oils and soluble organic pollutants from sewage has attracted tremendous attention in today's society. Herein, a stable and environmentally friendly nanofibrous membrane with hierarchical caterpillar-like structure was fabricated via in-situ hydrothermal growing the nickel-cobalt layered double hydroxides (NiCo-LDHs) on tche polyacrylonitrile (PAN) electrospun nanofibers. The wrapped hydrophilic NiCo-LDHs constructed the hierarchical structure and endowed the membrane attractive superhydrophilicity (≈ 0°)/underwater superoleophobicity (≈ 161°) and enhanced oil-repellency performance.

[Impact of mild hypothermia therapy on hemodynamics during the induction stage in neonates with moderate to severe hypoxic-ischemic encephalopathy].

Objective: To study the changes in hemodynamics during the induction stage of systemic mild hypothermia therapy in neonates with moderate to severe hypoxic-ischemic encephalopathy (HIE).

Methods: A total of 21 neonates with HIE who underwent systemic mild hypothermia therapy in the Department of Neonatology, Dongguan Children's Hospital Affiliated to Guangdong Medical University, from July 2017 to April 2020 were enrolled. The rectal temperature of the neonates was lowered to 34℃ after 1-2 hours of induction and maintained at this level for 72 hours using a hypothermia blanket.

Expression profile of Fc receptor-like molecules in patients with IgA nephropathy.

Background: Fc receptor-like (FCRL) molecules were considered to play a role in the pathogenesis of certain autoimmune diseases. Nonetheless, the clinical significance of FCRLs in IgA nephropathy (IgAN) remains unclear.

Objective: This study is aimed at investigating the expression levels of FCRLs molecules in IgAN patients and determining its relevance to disease activity.

Plasma periostin as a biomarker of osteoporosis in postmenopausal women with type 2 diabetes.

Introduction: Periostin, as an emerging biomarker, is involved in multiple steps in bone metabolism. This study aimed to investigate the correlation between periostin levels and bone mineral density as well as bone turnover markers in postmenopausal women with type 2 diabetes (T2DM).

Materials And Methods: This study was a cross-sectional study that included 164 postmenopausal women with T2DM as study subjects and 32 age-matched nondiabetic postmenopausal women with normal bone mineral density (BMD) as healthy control subjects.

Comparison of Associations Between Glucocorticoids Treatment and Mortality in COVID-19 Patients and SARS Patients: A Systematic Review and Meta-Analysis.

Background: The response to glucocorticoids treatment may be different between coronavirus disease 2019 (Covid-19) and severe acute respiratory syndrome (SARS).

Methods: In this systematic review and meta-analysis, we searched studies on Medline, Embase, EBSCO, ScienceDirect, Web of Science, Cochrane Library, ClinicalTrials.gov, International Clinical Trials Registry Platform from 2002 to October 7, 2020.

Novel Lytic Phages Protect Cells and Mice against Infection.

With the fast emergence of serious antibiotic resistance and the lagged discovery of novel antibacterial drugs, phage therapy for pathogenic bacterial infections has acquired great attention in the clinics. However, development of therapeutic phages also faces tough challenges, such as laborious screening and time to generate effective phage drugs since each phage may only lyse a narrow scope of bacterial strains. Identifying highly effective phages with broad host ranges is crucial for improving phage therapy.

A NOVEL SCORING SYSTEM FOR THE RISK OF PAPILLARY THYROID CANCER METASTASES IN LYMPH NODES POSTERIOR TO THE RIGHT OF THE RECURRENT LARYNGEAL NERVE.

Objective: Some surgeons believe that dissection posterior to the right recurrent laryngeal nerve lymph node (PRRLN-LN) is unnecessary for the low metastasis rate and high complication risk. However, persistent metastatic lymph nodes may have a higher recurrence rate, surgical risk, and complications. Thus, it is important to distinguish patients who require PRRLN-LN dissection.

Risk factors and outcomes of cardiovascular disease readmission within the first year after dialysis in peritoneal dialysis patients.

Background: In the first year of dialysis, patients are vulnerable to cardiovascular disease (CVD) hospitalization, but knowledge regarding the risk factors and long-term outcomes of cardiovascular readmission within the first year after dialysis in incident continuous ambulatory peritoneal dialysis (CAPD) patients is limited.

Methods: This retrospective cohort study was conducted in incident CAPD patients. The demographic characteristics, laboratory parameters, and CVD readmission were collected and analyzed.

Prevalence, risk factors and impact on outcomes of 30-day unexpected rehospitalization in incident peritoneal dialysis patients.

Background: Rehospitalization is a major problem for end stage renal disease (ESRD) populations. However, researches on 30-day unexpected rehospitalzation of incident peritoneal dialysis (PD) patients were limited. This study aimed to investigate the prevalence, risk factors and impact on outcomes of 30-day unexpected rehospitalization in incident PD patients.