Study on material removal of double abrasive grains in ultrasonic assisted abrasive cloth wheel of GH4169 alloy blade.

As a critical component of aero-engines, the processing quality of the blade has a significant impact on the engine's overall performance and service life. First, from the perspective of double abrasive grains, two finite element models-simultaneous and sequential scratches-are established. The interaction between the two abrasive grains affects not only the polishing force and chip formation but also the surface morphology of the processed workpiece.

A general analogy mass-spring system analytical model for sound reduction of side-branch resonators.

This study introduces a general analytical model designed to predict the sound reduction frequency of side-branch resonators, regardless of their geometric shapes. Grounded in a continuous analogy mass-spring system, we conceptualize the air within the branch cavity of the resonator as a series of infinitesimal continuous air layers. Each air layer is represented as a mass-spring unit, influenced by the pressure distribution inside the branch cavity.

Overexpression of endothelial S1pr2 promotes blood-brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both and models.

Objectives: The disruption of blood-brain barrier (BBB) is associated with poor outcomes of TBI patients. Sphingosine-1-phosphate receptor 2 (S1pr2), a member of the G protein-coupled receptor family, is involved in endothelial activation and the regulation of vascular integrity. We hypothesized that the inhibition of S1pr2 may alleviate BBB disruption and explored potential underlying molecular mechanisms.

Design, synthesis and biological evaluation of novel pyrazolinone derivatives as multifunctional ligands for the treatment of Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the depletion of cholinergic neurons and the accumulation of amyloid β (Aβ) plaques. The complexity and multifaceted nature of AD necessitate further exploration of multi-target drugs for its treatment. In this study, a series of novel pyrazolinone-based compounds were designed, synthesized, and evaluated as acetylcholinesterase (AChE) inhibitors and antioxidants.

ADAM17 promotes colorectal cancer migration and invasion by regulating the TGF-β/Smad signaling pathway.

Objective: Investigate ADAM17 expression in colorectal cancer (CRC) at molecular and cellular levels and its potential mechanism in promoting tumorigenesis by regulating CRC cell migration and invasion.

Materials And Methods: The study measured ADAM17 mRNA and protein levels in colorectal cancer cells and tissues using qPCR and immunohistochemical staining, and assessed the cells' proliferation, migration, and invasion abilities.

Results: ADAM17 expression was significantly higher in CRC tissues than in non-cancerous tissues and was linked to metastasis and poor prognosis in CRC patients.

pLM33 provides tolerance of persistent Listeria monocytogenes ST5 to various stress conditions and also enhances its virulence.

Listeria monocytogenes is a major foodborne pathogen. In our previous study, we found that L. monocytogenes ST5 and ST121 strains were dominant in two food plants of Shanghai.

Modulating the D-band center of mn and mitigating O vacancies with amino groups for enhanced long-cycle alkaline-manganese batteries.

Manganese oxide is a promising cathode material for rechargeable batteries due to its high theoretical specific capacity. However, its practical application is hindered by its poor conductivity and rapid capacity decay caused by Jahn-Teller distortion during charging and discharging. This work introduces NaEDTA during the synthesis of MnO, and the amino group is introduced by adsorption to deposit to form N-doped MnO.

Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.

The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs from avian to mammals. We find that H2 AIVs circulating in domestic poultry in China have genetic and antigenic differences compared to the A(H2N2)pdm1957.

Accurate two-dimensional simulation model and experimental demonstration in ultraviolet picosecond laser scribing ablation.

Laser patterning of copper thin films is essential for the electronics manufacturing industry. In this work, to efficiently and accurately describe the physics process of UV-ps laser ablating copper thin film, a two-temperature model (TTM) consisting of the electron-lattice system and phase explosion mechanism was proposed. The process of electron heating and electron-lattice heat transfer in single pulse ablation were revealed.

Nested hollow-core anti-resonant fiber with elliptical cladding for 2 µm laser transmission.

In this work, a nested hollow-core anti-resonant fiber (HC-ARF) with an elliptical cladding for high-power lasers for 2 µm laser transmission was proposed and theoretically investigated. The dual-layer elliptical tubes nested within the fiber enable the low-loss single-mode transmission. The finite element method (FEM) was employed to analyze and optimize the structure of fiber, with a total loss of less than 5 × 10dB/m across the wavelength range of 1920nm to 2040nm.

NiS/FeS binary nanoparticles confined in interconnected carbon framework with regulated pore structure enabled by citric acid for enhanced sodium storage properties.

Recently, pyrite iron disulfide (FeS) has emerged as a promising anode candidate for sodium-ion batteries (SIBs) due to its high theoretical capacity, affordability, non-toxicity and abundant resource in nature. However, the utilization of FeS still confronts the challenges of inferior rate capability and cycling instability for sodium storage, stemming from its low electronic conductivity and substantial volume changes during cycling. Herein, to address these obstacles, NiS/FeS binary nanoparticles encapsulated within a network of interconnected N-doped porous carbon framework (NiS/FeS@NPC) are prepared by a successive solid-state ball milling, carbonization and sulfurization strategy with coordination complex of nickel iron Prussian blue analogue (NiFe-PBA) as precursor.

Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays.

In response to an ever-increasing demand of new small molecules therapeutics, numerous chemical and genetic tools have been developed to interrogate compound mechanism of action. Owing to its ability to approximate compound-dependent changes in thermal stability, the proteome-wide thermal shift assay has emerged as a powerful tool in this arsenal. The most recent iterations have drastically improved the overall efficiency of these assays, providing an opportunity to screen compounds at a previously unprecedented rate.

Photothermal-assisted S-scheme heterojunction of NiPS nanosheets modified ZnInS microspheres for promoting photocatalytic hydrogen evolution.

Exploring high-efficiency photocatalysts for solar hydrogen (H) generation through water splitting is of great significance for addressing both energy shortage and environmental contamination. In this work, a facile self-assembly strategy was developed to couple NiPS nanosheets (NPS NSs) with ZnInS (ZIS) microspheres to synthesize NPS NSs/ZIS (NPS/ZIS) composites, featuring a characteristic of S-scheme charge transfer mechanism. The NPS/ZIS composites possess broad-spectrum light absorption property, improved photothermal effect and efficient charge transfer, showcasing exceptional solar-to-chemical energy conversion capability for visible-light-driven photocatalytic hydrogen evolution (PHE).

Origin, Evolution, and Diversification of the Expansin Family in Plants.

The cell wall is a crucial feature that allows ancestral streptophyte green algae to colonize land. Expansin, an extracellular protein that mediates cell wall loosening in a pH-dependent manner, could be a powerful tool for studying cell wall evolution. However, the evolutionary trajectory of the expansin family remains largely unknown.

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging.

To systematically characterize the loss of tissue integrity and organ dysfunction resulting from aging, we produced an in-depth spatial transcriptomic profile of nine tissues in male mice during aging. We showed that senescence-sensitive spots (SSSs) colocalized with elevated entropy in organizational structure and that the aggregation of immunoglobulin-expressing cells is a characteristic feature of the microenvironment surrounding SSSs. Immunoglobulin G (IgG) accumulated across the aged tissues in both male and female mice, and a similar phenomenon was observed in human tissues, suggesting the potential of the abnormal elevation of immunoglobulins as an evolutionarily conserved feature in aging.

OffsetNet: Towards Efficient Multiple Object Tracking, Detection, and Segmentation.

Offset-based representation has emerged as a promising approach for modeling semantic relations between pixels and object motion, demonstrating efficacy across various computer vision tasks. In this paper, we introduce a novel one-stage multi-tasking network tailored to extend the offset-based approach to MOTS. Our proposed framework, named OffsetNet, is designed to concurrently address amodal bounding box detection, instance segmentation, and tracking.

Near-infrared responsive photocatalysts for environmental remediation and energy conversion: A review.

Photocatalytic technology provides a vital pathway for the sustainable and efficient removal of environmental pollutants and energy conversion. However, enhancing the near-infrared (NIR) light absorption and utilization capabilities of photocatalysts has remained a significant challenge in this field. This paper presents a comprehensive review of recent developments in NIR-responsive photocatalysts.

Multifactorial analysis of factors influencing premolar mobility in stage III/IV grade C periodontitis patients ≤ 35 years of age: a cross-sectional study.

Background: Previous studies have suggested a potential link between the crown-to-root ratio (CRR) and root morphology in patients with mild chronic periodontitis, which may be associated with tooth mobility. However, these findings have not been thoroughly investigated. Our previous study found that 76% of patients with aggressive periodontitis, particularly those with premolar involvement, exhibited abnormal root morphology, severe alveolar bone loss, and increased tooth mobility, leading to poor clinical outcomes.

Fabrication of a Partial Encapsulation Architecture on S-Scheme Heterojunctions toward Durable Selective Photocatalytic CO Reduction.

It remains a challenging issue to achieve durably stable photocatalytic CO reduction over heterojunctions owing to their inherent structural assembly features. Herein, a unique partial encapsulation architecture is fabricated on the 3D/2D CoWO/CN heterojunction by embedding CoWO microspheres on CN nanosheets, which achieves efficient, durable, stable, and selective photocatalytic CO reduction. For the optimal 5%-CoWO/CN heterojunction, the yield of selective CO reduction to CO is 7.

Identification of 3-methyl-1-(3-methylpyridin-2-yl)-1H-pyrazol-5-ol as promising neuroprotective agent.

Pyrazolol derivatives are gaining significant attention for their diverse pharmacological effects, such as analgesic, anti-inflammatory, antioxidant, and anticancer activities. In this study, 20 pyrazolol derivatives were designed and synthesized to develop an anti-ischemic stroke formulation with free radical scavenging activity. Most of these synthesized compounds demonstrated antioxidant capabilities in DPPH, ABTS radical scavenging, and ORAC assays.

Quantification of silica nanoparticle uptake at environmentally relevant concentrations by gold-core embedding.

The increasing use of silica nanoparticles (SiO NPs) has raised concerns about potential human exposure. Assessing the health risks associated with SiO NPs necessitates understanding their cellular uptake, yet measuring this uptake at low, environmentally relevant concentrations presents a significant challenge. In this study, we synthesized core-shell structured Au@SiO NPs with diameters ranging from 50 to 200 nm and quantified their cellular uptake by analyzing the concentrations of Si and Au in A549 human lung carcinoma cells.

Low-Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption.

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching, adjusting dielectric/magnetic resonance and promoting electromagnetic (EM) wave absorption, but still exist a significant challenging in regulating local phase evolution. Herein, accordion-shaped Co/CoO@N-doped carbon nanosheets (Co/CoO@NC) with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and low-temperature oxidation process. The results indicate that the surface epitaxial growth of crystal CoO domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components, which are beneficial for optimizing impedance matching and interfacial polarization.

Whole genome sequences of 135 "Candidatus Liberibacter asiaticus" strains from China.

"Candidatus Liberibacter asiaticus" (CLas) is a phloem-limited alpha-proteobacteria causing Citrus Huanglongbing, the destructive disease currently threatening global citrus industry. Genomic analyses of CLas provide insights into its evolution and biology. Here, we sequenced and assembled whole genomes of 135 CLas strains originally from 20 citrus cultivars collected at ten citrus-growing provinces in China.