Machine Learning-Assisted Biomass-Derived Carbon Dots as Fluorescent Sensor Array for Discrimination of Warfarin and Its Metabolites.

Warfarin (WAR), an effective oral anticoagulant, is of utmost importance in treating many diseases. Despite its significance, rapid and precise discrimination of WAR remains a formidable challenge, especially facing its structural analogs of metabolites. Here, three kinds of herb-derived N-doped carbon dots (NCDs) were greenly synthesized via a fast and simple microwave-assisted method.

Degradation of AFB in edible oil by aptamer-modified TiO composite photocatalytic materials: Selective efficiency, degradation mechanism and toxicity.

Most of the excessive aflatoxins in peanut oil are present at lower levels, and few photocatalysts have been reported for degrading low concentrations of aflatoxin B (AFB). This study employed aptamer-modified magnetic graphene oxide/titanium dioxide (MGO/TiO-aptamer) photocatalysts to degrade low concentrations of AFB in peanut oil, thoroughly investigating their selective efficiency, degradation mechanism, and product toxicity. The results indicated that the modification of aptamers on the surface of photocatalytic materials can enhance the selectivity of photocatalysts for AFB in peanut oil.

How does drivers' attention change when using a two-stage warning system? Effects of expectation and cognitive load.

The advantages of two-stage warnings have been validated. This study investigated how drivers' expectations of automated driving system capabilities and cognitive load affect their attention allocation and takeover performance when using a two-stage warning system in a Level 3 automated driving system. Thirty-two drivers participated in a driving simulation study.

ALDH1L2 drives HCC progression through TAM polarization.

Background & Aims: Dysregulation of one-carbon metabolism is considered an early hallmark of mitochondrial dysfunction and cancer metabolism. ALDH1L2 belongs to the aldehyde dehydrogenase family and plays an important role in tumor progression. However, little is known about the precise role and underlying mechanisms of ALDH1L2 in hepatocellular carcinoma (HCC).

Arterial endothelial deletion of hereditary hemorrhagic telangiectasia 2/ causes epistaxis and cerebral microhemorrhage with aberrant arteries and defective smooth muscle coverage.

Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder with manifestations including severe nose bleeding and microhemorrhage in brains. Despite being the second most common inherited bleeding disorder, the pathophysiological mechanism underlying HHT-associated hemorrhage is poorly understood. HHT pathogenesis is thought to follow a Knudsonian two-hit model, requiring a second somatic mutation for lesion formation.

In situ interfacial engineering of MnInS@InS hollow nanotubes for enhanced photocatalytic production of HO and antibiotic degradation.

Three-dimensional hollow tube-like structures have obtained considerable attention owing to their pronounced advantages in photocatalytic reactions. Herein, metal organic framework (MOF)-derived MnInS@InS with hollow tube-like structure was successfully synthesized through a facial hydrothermal combined solvothermal method. Electron spin resonance technology and radical scavengers verified that holes and superoxide anions are the primary reactive species in the photocatalytic reaction.

Milk fat globule membranes ameliorate diet-induced obesity in mice by modulating glucolipid metabolism, body inflammation, and oxidative stress.

This study aimed to explore the lipid-lowering effect and the mechanism of action of the milk fat globule membrane (MFGM) in obese mice. All findings indicated that MFGM supplementation impeded weight gain in mice with obesity. qPCR and western blot analysis further revealed that MFGM could reduce lipid deposition and improve lipid metabolism by downregulating the expression levels of Fas, Scd1, PPARγ, and Srebp-1c and increasing the expression levels of Mcad, Cpt-1c, and PPAR-α.

Interplay and long-lasting effects of maternal low-level Pb, Hg, and Cd exposures on offspring cognition.

Lead (Pb), mercury (Hg), and cadmium (Cd) are prevalent and persistent environmental contaminants, causing detrimental effects on millions of individuals worldwide. Our previous research demonstrated that early-life exposure to low-level Pb, Hg, and Cd mixtures may lead to cognitive impairments. However, the association and interaction among low levels of Pb, Hg, or Cd exposure remains unclear.

Engineering the Mechanical Stability of a Therapeutic Complex between Affibody and Programmed Death-Ligand 1 by Anchor Point Selection.

Protein-protein complexes can vary in mechanical stability depending on the direction from which force is applied. Here, we investigated the mechanical stability of a complex between a binding scaffold called Affibody and an immune checkpoint protein Programmed Death-Ligand 1 (PD-L1). We used AFM single-molecule force spectroscopy with bioorthogonal clickable peptide handles, shear stress bead adhesion assays, molecular modeling, and steered molecular dynamics (SMD) to understand the pulling point dependency of the mechanostability of the Affibody:(PD-L1) complex.

Biobased Sulfur- and Phosphate-Containing High-Refractive-Index Polymers: Substituent Effects on Optical Properties of Polymers.

Four biobased phosphate-containing aryl monomers with methoxy, allyl, and vinyl groups as substituents have been successfully synthesized. Copolymerizing these monomers with thiophenol or mercaptans via the photoclick thiol-ene reaction gives the polymers with refractive indices () of 1.63-1.

Design and Modulation of Negative Thermal Expansion for Epoxy Polymers.

Modulating the coefficient of thermal expansion (CTE) and realizing low or negative thermal expansion (NTE) for epoxy polymers are challenging issues. In this study, we developed an effective strategy to prepare epoxy polymers with an NTE performance. A novel motif DBCOD-NH based on the dibenzocyclooctadiene (DBCOD) was designed, synthesized, and utilized as a curing agent for several commercial epoxy resins.

Cementocyte-derived extracellular vesicles regulate osteoclastogenesis and osteoblastogenesis.

Background/purpose: Cementum shares many properties with bone; however, in contrast to bone, it is not innervated or vascularized and has a limited capacity for remodeling. Osteocytes located in the lacunae-canalicular system of bone tissue play a central role in bone remodeling by communicating with osteoblasts and osteoclasts. Although cementocytes are present in cellular cementum and are morphologically similar to osteocytes, it remains unclear whether they are involved in the dynamic functional regulation of metabolism in cementum.

A Subunit-Based Concept for Preoperative Design of the Cauliflower Ear.

Purpose: Cauliflower ear is an ear deformity caused by a closed ear injury with varying severity. Several studies on the systematic reconstruction of cauliflower ear have been reported. Here, the authors aim to introduce a simplified subunit-based reconstruction concept for the cauliflower ear.

Concurrent sensing of vector magnetic field based on diamond nitrogen-vacancy ensemble using a time-divided hardware-synchronized protocol.

A diamond nitrogen-vacancy (NV) ensemble has been developed as a vector magnetometry platform for sensing external time-varying magnetic fields. However, due to the complexity of manipulating electron spins along different directions, a current vector NV magnetometer often needs a large amount of supporting equipment, preventing its applications in a compact circumstance. Here, we develop a hardware-level protocol to realize a multi-axis NV magnetometer using only a single channel of microwave generation and signal detection resources.

Artificial intelligence in individualized retinal disease management.

Owing to the rapid development of modern computer technologies, artificial intelligence (AI) has emerged as an essential instrument for intelligent analysis across a range of fields. AI has been proven to be highly effective in ophthalmology, where it is frequently used for identifying, diagnosing, and typing retinal diseases. An increasing number of researchers have begun to comprehensively map patients' retinal diseases using AI, which has made individualized clinical prediction and treatment possible.

NCME-Net: Nuclear cataract mask encoder network for intelligent grading using self-supervised learning from anterior segment photographs.

Cataracts are a leading cause of blindness worldwide, making accurate diagnosis and effective surgical planning critical. However, grading the severity of the lens nucleus is challenging because deep learning (DL) models pretrained using ImageNet perform poorly when applied directly to medical data due to the limited availability of labeled medical images and high interclass similarity. Self-supervised pretraining offers a solution by circumventing the need for cost-intensive data annotations and bridging domain disparities.

Improving the Oxidation Resistance of Phenolic Resin Pyrolytic Carbons by In Situ Catalytic Formation of Carbon Nanofibers via Copper Nitrate.

Phenolic resin pyrolytic carbons were obtained by catalytic pyrolysis of phenolic resin at 500 °C, 600 °C, 700 °C, and 800 °C for 3 h in an argon atmosphere using copper nitrate as a catalyst precursor. The effects of copper salts on the pyrolysis process of phenolic resin as well as the structural evolution and oxidation resistance of phenolic resin pyrolytic carbons were studied. The results showed that copper oxide (CuO) generated from the thermal decomposition of copper nitrate was reduced to copper (Cu) by the gas generated from the thermal decomposition of the phenolic resin.

[Corrigendum] Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis.

Following the publication of the above article, the authors drew to the attention of the Editorial Office that, after having reviewed all the figures and the data of their drawing software, they discovered that the pictures in the 'Control' and 'DEX' groups of Fig. 4D on p. 904 had been incorrectly imported into Fig.

Cell fate decision by a morphogen-transcription factor-chromatin modifier axis.

Cell fate decisions remain poorly understood at the molecular level. Embryogenesis provides a unique opportunity to analyze molecular details associated with cell fate decisions. Works based on model organisms have provided a conceptual framework of genes that specify cell fate control, for example, transcription factors (TFs) controlling processes from pluripotency to immunity.