Voriconazole: a review of adjustment programs guided by therapeutic drug monitoring.

Objectives: Exploring adjustments to the voriconazole dosing program based on therapeutic drug monitoring results to implement individualized therapy.

Methods: PubMed and Embase were systematically searched to obtain study about voriconazole dose adjustment program guided by therapeutic drug monitoring. Quality evaluation and summarization of the obtained studies were performed to obtain program adjustments for voriconazole under therapeutic drug monitoring.

Clostridium butyricum, a future star in sepsis treatment.

Sepsis is a systemic inflammatory response syndrome of multiorgan failure caused by dysregulation of the host response to infection and is a major cause of death in critically ill patients. In recent years, with the continuous development of sequencing technology, the intestinal microecology of this disease has been increasingly studied. The gut microbiota plays a host-protective role mainly through the maintenance of normal immune function and the intestinal barrier.

Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis.

Background: Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions. Tryptophan metabolism has been believed as a significant factor in UC pathogenesis, with specific metabolites influencing immune modulation and gut microbiota interactions. However, the precise regulatory mechanisms and key genes involved remain unclear.

Targeted thermosensitive liposomes loaded with gold nanoparticles and temozolomide hexadecanoate for the synergistic photothermal-chemotherapy treatment of glioblastoma.

Glioblastoma (GBM) is a highly aggressive malignant brain tumour which presents a significant challenge due to the limited effectiveness of current surgical and chemotherapeutic approaches. In this study, we have developed TMZ16e and gold nanoparticles coencapsulated thermosensitive liposomes modified with anti-EphA3 (anti-EphA3-TMZ16e-GNPs-TSL) delivered via the intranasal route to achieve photothermal chemotherapy (PCT) for improving the therapeutic effects of GBM. The prepared anti-EphA3-TMZ16e-GNPs-TSL were spherical with a particle size of 173.

Multi-level Hierarchical Structure Analysis of Influencing Factors of Coal Mine Managers' Blame Avoidance Behavior.

Background: In the Chinese coal industry, widespread blame avoidance behavior (BAB) greatly impacts coal mine accidents. Therefore, it is necessary to stop the BAB of coal mine managers and raise the management level of coal mine enterprises for the safe development of Chinese coal industry.

Methods: Based on the semi-structured interviews and questionnaire surveys (20 middle-level managers in coal mines), this paper used the Grounded Theory and Nvivo Software qualitative research methodology to open, spindle, and selectively encode the interview data.

Pembrolizumab alone or combined with chemotherapy versus chemotherapy for the treatment of metastatic cancer: A meta-analysis of randomized clinical trials.

Background: Whether pembrolizumab alone or in combination with chemotherapy is superior to chemotherapy in metastatic cancer remains controversial. The study aims to give the effectiveness and safety of pembrolizumab-related interventions compared to chemotherapy in metastatic cancer.

Methods: Electronic databases were systematically searched until November 20, 2023, for all randomized controlled trials comparing Pembrolizumab alone or in combination with chemotherapy versus chemotherapy for metastatic cancer.

Highly Efficient Methods with a Generalized Linear Mixed Model for the Quantitative Trait Locus Mapping of Resistance to Columnaris Disease in Rainbow Trout ().

Linear mixed models (LMMs) are commonly used in genome-wide association studies (GWASs) to evaluate population structures and relatedness. However, LMMs have been shown to be ineffective in controlling false positive errors for the analysis of resistance to Columnaris disease in Rainbow Trout. To solve this problem, we conducted a series of studies using generalized linear mixed-model association software such as GMMAT (v1.

Changes in Biochemical Composition and Nutrient Materials in Honey During Storage.

() honey is rich in effective ingredients including flavonoids, terpenes, and alkaloids that are beneficial to human health. In this study, widely targeted metabolomics were used to detect the plant-derived secondary metabolites of the same batch of honey from 2022 to 2024, in order to explore whether storage time changes the quality of honey, especially the content of plant-derived secondary metabolites with important health benefits. The results showed that storage time had no significant effect on the content of sugars, proteins, and other major components in honey.

Different trend of muscle wasting extracted from computed tomography in patients with severe acute pancreatitis.

Purpose: The trend of muscle wasting in patients with acute severe and moderately severe pancreatitis (AP) remains unclear. This retrospective study aimed to investigate the trend of skeletal muscle area (SMA) changes and its impact on patients with severe and moderately severe AP.

Methods: Patients diagnosed with AP who had repeated CT scans after intensive care unit (ICU) admission were included.

Risk Factor Analysis and Prediction of Para-Aortic Lymph Node Metastases in Locally Advanced Cervical Cancer.

Background And Purpose: The indications of prophylactic extended-field radiotherapy (EFRT) remain uncertain. This study aims to identify the risk factors for para-aortic lymph node (PALN) metastases in locally advanced cervical cancer (LACC) and determine which part of patients may benefit from prophylactic EFRT.

Materials And Methods: Between January 2015 and July 2023, a single-center retrospective analysis was performed on patients with stages IB3 and IIA2-IVA cervical cancer.

Progressive osseous heteroplasia in a five-month-old boy with a mutation in exon 9 of : a case report.

Progressive osseous heteroplasia (POH) is an ultrarare hereditary disease that begins with cutaneous ossification, and progressive heterotopic ossification involves subcutaneous and deep connective tissues. We reported a case of POH in a five-month-old boy with clinical, pathological, and genetic features of POH. Most POH cases are caused by GNAS inactivating mutations, and the mutation of GNAS is also found in some other related heterotopic ossification conditions.

Melatonin treatment delayed fruit softening by regulating postharvest carbohydrate metabolism of hami melon.

Melatonin (MT) treatment has been proven to improve fruit quality. Herein, the efficacy of 0.5 mmol L MT treatment on carbohydrate metabolism, fruit softening, and their relationship during storage of harvested Hami melons was investigated.

Noise induces Ca2+ signaling waves and Chop/S-Xbp1 expression in the hearing cochlea.

Exposure to loud noise is a common cause of acquired hearing loss. Disruption of subcellular calcium homeostasis and downstream stress pathways in the endoplasmic reticulum and mitochondria, including the unfolded protein response, have been implicated in the pathophysiology of noise-induced hearing loss. However, studies on the association between calcium homeostasis and stress pathways have been limited due to limited ability to measure calcium dynamics in mature-hearing, noise-exposed mice.

MdHY5 positively regulates cold tolerance in apple by integrating the auxin and abscisic acid pathways.

Low-temperature stress causes various types of physiological and biochemical damage to plants. The basic leucine zipper (bZIP) family transcription factor HY5 plays a significant role in multiple stress responses in plants. Here, cold stress was found to induce the upregulation of MdHY5 expression, which, in turn, positively regulates the cold tolerance of apple (Malus domestica).

Simultaneous removal of organic matter and inorganic nitrogen in Baijiu wastewater by methanotrophic denitrification.

Methanotroph could facilitate nitrogen removal during methane oxidation, and promote conversion of organic compounds by producing methane monooxygenase. Co-metabolic effect and mechanism of aerobic methane oxidation on the removal of nitrogen and organic matter from Baijiu wastewater were investigated using an improved denitrifying biological filter. It was found that the average removal efficiency of chemical oxygen demand (COD), total nitrogen (TN) and chroma increased by 17 %, 22 % and 10 % in reactor B with methane compared to reactor A with air only.

Microbiome and metabolomics reveal the effect of gut microbiota on liver regeneration of fatty liver disease.

Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with impaired regenerative capacity and poor postoperative prognosis following hepatectomy. Previous research has highlighted the importance of the gut-liver axis in the physiological and pathological processes of the liver. However, the contribution of gut bacteria to the regeneration of livers with MAFLD and its metabolic regulatory mechanisms remain elusive.

Enhancing patient experience in the surgical ICU through virtual reality: A pre-post mixed-methods study.

Background: Patients in the Surgical Intensive Care Unit (SICU) often experience psychological stress.

Objectives: To evaluate the feasibility, acceptability, and potential outcomes of virtual reality (VR) interventions for enhancing patient experience during SICU stay.

Methods: This mixed-method study employed a pre-post-test design complemented by a sequential explanatory approach, conducted from January to December 2023 in the SICU of a hospital in China.

Serine related gene CCT6A promotes metastasis of hepatocellular carcinoma via interacting with RPS3.

Metastasis is responsible for approximately 90% of lethality from solid tumors. Metabolic abnormalities are one of the key characteristics of tumor cells, closely associated with tumorigenesis and progression. The de novo synthesis pathway of serine is a key metabolic bypass in glycolysis, which could provide material and energy basis for the rapid proliferation of tumor cells by mediating one-carbon metabolism.

[Method for Dynamic Updating of Source Emission Inventories Based on the Response Relationship Between Anthropogenic Source Emissions and Air Quality].

Pollution source emission inventories are the basis for analyzing the causes of pollution, identifying the contribution of pollution sources, and scientifically formulating air pollution prevention strategies. The current inventory construction methods mainly focus on improving the accuracy and spatial and temporal resolution of the inventory, and there is an urgent need to look into dynamic updating methods to address the problem of lagging source emission inventories. In order to develop an effective and versatile method for the dynamic updating of source emission inventories, a meteorological normalization method based on random forests was chosen to capture the response relationship between pollutants and anthropogenic emissions.

The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken.

Intensification of poultry industry has led to a surge in animal product output, but this has also revealed issues with environmental management in poultry houses, particularly the harmful effects of high hydrogen sulfide (HS) levels on poultry health. The study aimed to assess the therapeutic impact of tea tree oil (TTO) on HS-induced spleen and intestinal injuries in chickens. A total of 240 one-day-old Lohmann Brown chicks were randomly divided into three groups: the control group (CON), the HS exposure group (AVG), and the TTO treatment group (TTG), with four replicates, each consisting of 20 chicks.

Effects of sucrose and 1-MCP on enzymatic and nonenzymatic antioxidants in postharvest Gynura bicolor DC.

After harvesting, Gynura bicolor DC (G. bicolor) undergoes rapid quality deterioration, including decay, nutrient loss, and reactive oxygen species (ROS) burst, greatly limiting its shelf life. This study was performed to evaluate the effects of treatment with sucrose and 1-methylcyclopropene (1-MCP) on indices of quality deterioration, ROS metabolism, and phenylpropanoid metabolism, with the goals of resisting oxidative stress and improving the postharvest quality of G.