Neurotoxicity study of cenobamate-induced zebrafish early developmental stages.

Cenobamate (CNB) is a novel anti-seizure medication with significant efficacy in treating epilepsy. However, in clinical trials, the most common adverse reactions observed in patients are central nervous system (CNS) symptoms. In animal studies, administration of CNB during pregnancy or lactation has been associated with adverse effects on neurodevelopment in offspring.

Enrichment of antioxidant peptides by interfacial modification of oat polypeptides induced by zinc ions.

The pursuit of methods to enhance the purity of food-sourced bioactive peptides continues to pose significant challenges. This study introduces an innovative approach to enrich antioxidant peptides by using zinc ion coordination to augment the foaming capabilities of oat peptides. The resulting antioxidant peptide fraction (AF) accounted for 18 % of the oat globulin hydrolysates, with a significant increase (22-47 %) in scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH), OH, and O radicals.

Effects of light intensity on the antioxidant activity, ATPases, and digestive enzymes of crimson snapper (Lutjanus erythropterus) juveniles during long-hour road transport.

The transportation of fish larvae or juveniles from hatcheries to rearing farms is a crucial process in aquaculture, as most fish farms are located far from hatcheries. Among abiotic parameters, light intensity is an important factor affecting the physiology and biochemistry of teleost fish. To date, most studies on fish transportation have focused on identifying the optimum stocking density, while little is known about the optimum light intensity for transporting hatchery-produced juvenile Crimson snapper (Lutjanus erythropterus).

Preparation of anti-leakage and salt-isolation absorbent polymer based on tragacanth gum.

Superabsorbent polymers can be used to alleviate water scarcity and improve soil salinization. In this study, a superabsorbent polymer TG-g-PAA /BTCA was prepared by grafting acrylic acid to tragacanth gum (TG) with 1,2,3, 4-butane tetracarboxylic acid (BTCA) as crosslinking agent. The polymer can also effectively improve fertilizer utilization and reduce soil surface salinity.

A preliminary study of fMRI and the relationship with depression and anxiety in Meniere's patients.

Purpose: To examine alterations in Blood Oxygen Level-Dependent (BOLD) resting-state functional magnetic resonance imaging (rs-fMRI) signals, utilizing regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF) metrics, within activated brain regions. Additionally, this study aims to explore the relationship between these neural changes and clinical characteristics, as well as emotional states, in patients diagnosed with unilateral Meniere's disease (MD).

Method: The study included 24 patients diagnosed with left Meniere's disease (L-MD), 25 patients diagnosed with right Meniere's disease (R-MD), and 23 healthy control subjects.

Patellar tendon lateral deviation angle: a new computed tomography scan measurement for evaluation of patellar instability.

Background: The tibial tuberosity-trochlear groove (TT-TG) distance is an important reference for the evaluation of patellar instability. However, measurement of the TT-TG distance has disadvantages with relatively low reproducibility. This study aimed to investigate the reliability of patellar tendon lateral deviation angle (PTLD-A) measured on a single computed tomography (CT) slice and the clinical significance for predicting patellar instability.

Lipid metabolism during seed germination of Pistacia chinensis and its response to gibberellic acid.

Lipid metabolism may play a critical role in fueling seed germination, but the knowledge of lipid metabolism during germination is still ambiguous. Here, we hypothesize that gibberellic acid (GA) promotes germination by means of enhancing lipid mobilization in Chinese pistachio (Pistacia chinensis Bunge), a species belonging to Anacardiaceae with high oil content in its seeds. A multi-omics approach has been applied to measure lipid mobilization during seed germination, and to identify the key regulators involved in GA-mediated lipid metabolism.

Generation of a BEST1 Pr-EGFP reporter human embryonic stem cell line via CRISPR/Cas9 editing.

The retinal pigment epithelium (RPE) cell, located between the neural retina and choriocapillaris, is vital for retinal maintenance and photoreceptor function. Human embryonic stem cells (hESCs) provide a limitless source of RPE cells for transplantation. Using CRISPR/Cas9, we inserted a fusion of the BEST1 promoter (an RPE-specific marker) and the EGFP gene into the AAVS1 locus to track differentiation in hESC-induced RPE (hESC-iRPE).

Translation, cross-cultural adaptation and validation of the Chinese version of the IBD-Control questionnaire: A patient-reported outcome measure in inflammatory bowel disease.

Background: A demand exists for user-friendly patient-reported outcome measures for patients with inflammatory bowel disease (IBD). The IBD-Control Questionnaire has been recently developed to assess overall disease control from the patient's view but has not been available in China.

Methods: Translation and cultural adaption of the IBD-Control into Chinese was conducted through four steps (forward translation, backward translation, expert panel, and pilot testing).

Exploring and Predicting HIV Preexposure Prophylaxis Adherence Patterns Among Men Who Have Sex With Men: Randomized Controlled Longitudinal Study of an mHealth Intervention in Western China.

Background: Preexposure prophylaxis (PrEP) is an effective strategy to reduce the risk of HIV infection. However, the efficacy of PrEP is highly dependent on adherence. Meanwhile, adherence changes over time, making it difficult to manage effectively.

Coupled intelligent prediction model for medium- to long-term runoff based on teleconnection factors selection and spatial-temporal analysis.

Accurate medium- to long-term runoff forecasting is of great significance for flood control, drought mitigation, comprehensive water resource management, and ecological restoration. However, runoff formation is a complex process influenced by various natural and anthropogenic factors, resulting in nonlinearity, nonstationarity, and long prediction periods, which complicate forecasting efforts. Traditional statistical models, which primarily focus on individual runoff sequences, struggle to integrate multi-source data, limiting their predictive accuracy.

Association of iron homeostasis-related gene polymorphisms with pregnancy and neonatal outcomes in patients with gestational diabetes mellitus.

Objective: The purpose of this study was to assess associations between iron homeostasis-related gene polymorphisms and gestational diabetes mellitus (GDM), adverse pregnancy outcomes, and neonatal outcomes.

Methods: In total, 138 patients with GDM and 74 normal pregnancy controls were recruited. Time-of-flight mass spectrometry was used to genotype single-nucleotide polymorphisms (H63D rs1799945, TMPRSS6 rs855791, GDF15 rs1059369, rs4808793, BMP2 rs173107, C282Y rs3811647, rs1800562, rs269853, TF rs8177240, TFR2 rs7385804, FADS2 rs174577, and CUBN rs10904850) in 12 candidate genes related to iron homeostasis.

Correction: Seismic response of a mid-story isolated stilted structure in mountainous areas.

[This corrects the article DOI: 10.1371/journal.pone.

Analysis of influencing factors on review efficiency of multidisciplinary scientific research projects using DEMATEL with a 5-point scale.

In the wake of advancing technology and the convergence of diverse disciplines, collaborative research across academic sectors has become instrumental in fostering innovation and tackling multifaceted challenges. The inherent complexity of such multidisciplinary endeavors, characterized by a myriad of research trajectories and a spectrum of expertise, poses significant challenges to effective review. This study aims to identify and analyze the factors influencing the review efficiency of multidisciplinary scientific research projects to ensure their smooth development and improved quality.

Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma.

Iron metabolism is a critical factor in tumorigenesis and development. Although TP53 mutations are prevalent in glioblastoma (GBM), the mechanisms by which TP53 regulates iron metabolism remain elusive. We reveal an imbalance iron homeostasis in GBM via TCGA database analysis.

Comparative Transcriptome Analyses Provide Potential Insights into Molecular Mechanisms of Anthocyanin-Rich Blueberry Extract in Rapid Intervention Against Acute Alcohol Exposure in Mice.

Alcohol-induced health damage has become an increasing global public health concern. Anthocyanins exhibit essential biological activities, including antioxidation, anti-inflammation, and lipid reduction. This study investigates the rapid intervention effects and mechanisms of anthocyanin-rich blueberry extract in mitigating acute alcohol exposure in mice, aiming to uncover its novel nutritional roles.

GsMTx4 Combined with Exercise Exerts Neuroprotective Effects by Regulating Neuronal Autophagy in Rats with Spinal Cord Injury.

A sharp increase in intramedullary pressure after spinal cord injury (SCI) can aggravate secondary injury and lead to severe neurological deficits. Unfortunately, effective treatment options are currently lacking. The mechanosensitive ion channel Piezo1 plays an important role in the pathological process of SCI by transducing mechanical stress.

Noninvasive identification of proliferative hepatocellular carcinoma on multiphase dynamic CT: quantitative and LI-RADS lexicon-based evaluation.

Objective: To identify proliferative hepatocellular carcinoma (HCC) preoperatively using quantitative measurements combined with the updated standard 2021 LI-RADS universal lexicon-based qualitative features on multiphase dynamic CT (MDCT).

Methods: We retrospectively analyzed 273 patients (102 proliferative HCCs) who underwent preoperative MDCT with surgically confirmed HCC in two medical centers. Imaging features were evaluated according to the updated 2021 LI-RADS universal lexicon, and quantitative measurements were analyzed.

Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity.

Aerobic exercise facilitates synaptic plasticity, thereby improving cognitive functions such as learning and memory. The 5-hydroxytryptamine system has been indicated in these processes. 5-Hydroxytryptamine type 3 receptors are necessary for exercise-induced hippocampal neurogenesis.

Ultrafast Charge Transfer in Lithium-Ion and Water-Intercalated MoS/WS Heterostructures.

Heterostructures of monolayer transition metal dichalcogenides such as MoS and WS are promising for applications in optoelectronics and photocatalysis. However, the strong interlayer coupling in MoS/WS heterostructures results in indirect bandgaps that significantly hinder their performance and efficiency in practical applications. Here, we use first-principles calculations to demonstrate an effective method to weaken interlayer coupling in MoS/WS heterostructures by intercalating lithium ions with water molecules.

Increased perfluorooctanoic acid accumulation facilitates the migration and invasion of lung cancer cells via remodeling cell mechanics.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely used in industrial and household products, raising serious concerns due to their environmental persistence and mobility. Epidemiological studies have reported potential carcinogenic risks of PFAS based on their widespread occurrence and population exposure. In this study, we observed that perfluorooctanoic acid (PFOA), a common PFAS, functions as a mechanical regulator in lung cancer cells.