Publications by authors named "Li J Chen"
Background: Whether pathophysiological factors differ between males and females with irritable bowel syndrome-diarrhea (IBS-D) remains to be tested. To better understand potential sex differences, males with IBS-D were compared to naturally cycling females and to females with IBS-D taking hormonal contraception on plasma levels of cytokines and gut microbiome characteristics.
Methods: Males and females with Rome III IBS-D completed questionnaires and kept a daily symptom diary for 28 days.
Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study.
Invest Ophthalmol Vis Sci
December 2024
Purpose: The purpose of this study was to identify serum metabolites associated with age-related macular degeneration (AMD) incidence and investigate whether metabolite profiles enhance AMD risk prediction.
Methods: In a prospective cohort study involving 240,317 UK Biobank participants, we assessed the associations of 168 metabolites with AMD incidence using Cox hazards models. Principal component analysis (PCA) captured 90% of the variance in metabolites.
Low-concentration atropine for controlling myopia onset and progression in East Asia.
Asia Pac J Ophthalmol (Phila)
December 2024
Purpose: Over the past few years, there has been a rapid accumulation of data on the use of low-concentration atropine for myopia control, especially in East Asian children, with its effectiveness varying in different studies. This review aims to evaluate the current evidence surrounding the efficacy and safety of low-concentration atropine in the management of myopia onset and progression in East Asia.
Methods: Clinical trials involving atropine for myopia control in East Asia were reviewed.
Purpose: The purpose of this study was to investigate the effects of physical activity and inactivity on the microvasculature in children, as measured from retinal photographs.
Methods: All participants were from the Hong Kong Children Eye Study, a population-based cross-sectional study of children aged 6 to 8 years. They received comprehensive ophthalmic examinations and retinal photography.
Article Synopsis
- The study examined how optic disc torsion (ODT), horizontal disc tilt (HDT) angle, and ovality index (OI) affect the thickness of retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) in healthy myopic eyes.
- Measurements were taken from fundus photographs and swept-source optical coherence tomography, with adjustments for age and axial length.
- Results showed that OI and HDT angle correlated with variations in RNFL and GCIPL thickness, indicating that optic disc morphology should be factored into developing myopic normative databases.
Purpose: To describe the clinical characteristics of choroidal metastasis (CM) in non-small cell lung carcinoma (NSCLC) patients and report treatment outcomes following targeted therapy versus conventional radiotherapy and/or chemotherapy.
Methods: A retrospective review was conducted in two hospitals in Hong Kong between 2013-2023. Outcomes included tumor response and visual function following treatment.
Purpose: To evaluate the safety, efficacy, and imaging features of a novel surgical technique without endotamponade in repairing complex macular hole (MH).
Methods: Retrospective review of consecutive cases with complex MH underwent pars plana vitrectomy with temporal internal limiting membrane flap, which was stabilized using perfluorocarbon liquid and viscoelastics. At the conclusion of surgery, perfluorocarbon liquid was removed, and no endotamponade agent would be used.
Article Synopsis
- * Researchers found that SNP rs11200647 had a significant association with myopia, particularly moderate myopia, and that other SNPs also showed nominal associations.
- * The results imply that there may be shared genetic factors between myopia and age-related macular degeneration (AMD), providing new insights into the genetics of myopia.
Article Synopsis
- - A commercial tea plantation in Menghai, Yunnan, China, experienced leaf spot issues affecting about 10% of its tea plants, with symptoms progressing to pale pink mold layers on the leaves.
- - Researchers isolated the pathogen from affected leaves and identified 15 fungal isolates that visually resembled Trichoderma roseum, characterized by distinctive colony colors and conidia shapes.
- - Genomic sequencing of the selected strain CYB5 showed a 98% similarity to known Trichoderma roseum sequences, confirming its identity through phylogenetic analysis.
Article Synopsis
- - The study aimed to understand how heart rate variability (HRV) in the high frequency (HF) range relates to EEG delta band power in women with irritable bowel syndrome (IBS) compared to healthy women.
- - Results indicated that women with IBS experienced more NREM sleep and differing HRV patterns (higher HF, lower low frequency (LF), and a decreased LF/HF ratio), but showed lower delta band power in their EEG readings.
- - The findings suggested a disrupted relationship between the heart and brain activity in IBS patients, indicated by longer lag times between cardiac signals and EEG delta power, although it remains unclear if this dysregulation affects the development of IBS.
Practice Patterns and Challenges in Managing Inherited Retinal Diseases Across Asia-Pacific: A Survey from the APIED Network.
Asia Pac J Ophthalmol (Phila)
October 2024
Article Synopsis
- The paper looks at how inherited retinal diseases (IRD) are diagnosed and treated in the Asia-Pacific region.
- They surveyed 36 centers about their practices, including how they collect patient information and provide help for low vision.
- The results showed there are important gaps, like many centers not having a database for patients, not enough genetic counselors, and a need for better support for low-vision rehabilitation.
Aims: To investigate the associations of genetic variants previously linked to axial length (AL) and spherical equivalent refraction (SE) in adults with refractive error and related endophenotypes in children, at baseline and 3-year follow-up.
Methods: 15 candidate single-nucleotide polymorphisms (SNPs), selected from previous Genome-Wide Association Studies and meta-analyses, were genotyped in 2819 Chinese children, who had undergone baseline and 3-year follow-up cycloplegic refraction, ocular biometry and ocular health examinations. Linear regression analyses were conducted to assess the associations of the SNPs with baseline measurements and longitudinal changes in SE, spherical power (SPH), AL, corneal radius of curvature (CR) and AL/CR ratio.
To investigate the impact of intravitreal injection of conbercept, a recombinant fusion protein with decoy receptors for the vascular endothelial growth factor (VEGF) family, on intraocular concentrations of angiogenic and inflammatory mediators in patients with proliferative diabetic retinopathy (PDR), analyzed its potential impact on surgical outcomes. Forty eyes from 40 patients with PDR were included in this prospective study. Patients received intravitreal injection of conbercept followed by vitrectomy or phacovitrectomy in 1 week.
View Article and Find Full Text PDFPurpose: To systematically review and meta-analyze all reported heritability studies of refractive astigmatism (RA), corneal astigmatism (CA) and corneal curvature (CC), and evaluate the existing genetic associations of RA, CA and CC.
Design: Systematic review and meta-analysis (PROSPERO ID: CRD42023447370).
Methods: Studies that reported the heritability and genetic associations of RA, CA and/or CC were identified from PubMed, Web of Science and EMBASE (from inception to October 1, 2023).
Article Synopsis
- Primary diabetes care and diabetic retinopathy (DR) screening face challenges due to a lack of trained primary care physicians, especially in low-resource areas.
- The integrated image-language system, DeepDR-LLM, combines a language model and deep learning to help PCPs provide tailored diabetes management recommendations, showing comparable or better accuracy than PCPs in diagnosing DR.
- In a study, patients assisted by DeepDR-LLM demonstrated improved self-management and adherence to referral recommendations, indicating that the system enhances both care quality and patient outcomes.
Retinoblastoma (RB), originating from the developing retina, is an aggressive intraocular malignant neoplasm in childhood. Biallelic loss of RB1 is conventionally considered a prerequisite for initiating RB development in most RB cases. Additional genetic mutations arising from genome instability following RB1 mutations are proposed to be required to promote RB development.
View Article and Find Full Text PDFMyopia has long been a global threat to public health. Timely interventions are likely to reduce the risk of vision-threatening complications. There are both established and rapidly evolving therapeutic approaches to slow myopia progression and/or delay its onset.
View Article and Find Full Text PDFGenetic association of TIE2 with diabetic retinopathy and diabetic macular edema.
Asia Pac J Ophthalmol (Phila)
June 2024
Purpose: To evaluate the associations of the TIE2 gene with diabetic retinopathy (DR) and diabetic macular edema (DME).
Methods: This study included a Chinese cohort of 285 non-proliferative DR patients and 433 healthy controls. The DR patients were classified further into those with or without DME.
Background/aims: To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD OCT) combined with OCT angiography (OCTA) for myopic myopic macular neovascularisation (MNV) activity.
Methods: Both eyes of patients with myopic MNV diagnosed with fluorescein angiography (FA), SD OCT and OCTA were assessed by unmasked investigators. The images were deidentified and randomised before graded by masked investigators, who determined the presence of active myopic MNV by using SD OCT together with OCTA without FA and by FA alone, respectively.
Article Synopsis
- Genetic variants may influence primary angle-closure diseases, including types like glaucoma and suspects for the disease, but their specific effects have been unclear.
- A systematic review analyzed data from multiple studies and databases to find common and rare single-nucleotide variants (SNVs) linked to these diseases.
- The analysis showed that 17 SNVs were significantly associated with primary angle-closure diseases and 15 with primary angle-closure glaucoma, identifying specific variants tied to different disease subtypes.
Purpose: To evaluate (1) the long-term efficacy of low-concentration atropine over 5 years, (2) the proportion of children requiring re-treatment and associated factors, and (3) the efficacy of pro re nata (PRN) re-treatment using 0.05% atropine from years 3 to 5.
Design: Randomized, double-masked extended trial.
Introduction: The objective of this study was to compare the outcome of submacular hemorrhage (SMH) displacement using pneumatic displacement with intravitreal expansile gas versus pars plana vitrectomy (PPV) with subretinal injection of tissue plasminogen activator (tPA), anti-vascular endothelial growth factor (VEGF) agent, and air as primary surgery.
Methods: Retrospective interventional case series of 63 patients who underwent surgical displacement of SMH secondary to neovascular age-related macular degeneration (nAMD) or polypoidal choroidal vasculopathy (PCV) from May 1, 2015, to October 31, 2022. Medical records were reviewed for diagnosis, logMAR visual acuity (VA), central subfield thickness (CST), and postoperative displacement rates and complications up to 12 months after operation.
Purpose: To evaluate the genetic associations of different subtypes of central serous chorioretinopathy (CSCR), neovascular age-related macular degeneration (nAMD), and polypoidal choroidal vasculopathy (PCV).
Design: A case-control genetic association study.
Methods: This study enrolled 217 CSCR, 341 nAMD, 288 PCV patients, and 1380 controls.