Case Report: Treatment of a complex hand disfigurement injury by fully shaped reconstruction of a severed finger combined with ectopic banking.

One of the primary challenges in hand microsurgical reconstruction lies in addressing severe hand injuries, particularly those involving multiple finger amputations, as autologous replantation might not fully restore hand functionality. In such scenarios, fully shaped reconstruction of a severed finger combined with Ectopic banking could yield superior reconstructive outcomes and enhance the amputated limb's function. This case report presents a unique approach that combines ectopic replantation of an amputated finger with interphalangeal reconstruction methods to restore both the form and function of the hand.

[Simultaneous determination and toxicokinetic study of six compounds from Zhachong Shisanwei Pills in plasma of chronic cerebral ischemia rats by LC-MS/MS].

A liquid chromatography-tandem mass spectrometry method was established and validated for determining the concentrations of costunolide(CO), piperine(PI), agarotetrol(AG), glycyrrhizic acid(GL), vanillic acid(VA), and glycyrrhetinic acid(GA) in rat plasma. This method was then applied to the toxicokinetic study of these six compounds in rats with chronic cerebral ischemia(CCI) following multiple oral doses of Zhachong Shisanwei Pills. Finally, the effects of continuous multiple-dose administration of Zhachong Shisanwei Pills on the liver of CCI rats were investigated.

Dietary inflammatory index and its associations with cardiovascular diseases and cancer: Evidence form NHANES 2017-2018 and Mendelian randomization analysis.

Objective: Cardiovascular diseases (CVDs) and cancer are significant global causes of mortality. However, the link between diets that promote inflammation and various subtypes of CVDs and cancers remains unclear.

Methods: Utilizing the dataset from the 2017-2018 National Health and Nutrition Examination Survey (NHANES) data release cycle, our study encompassed 3538 adult participants within the age range of 20 to 80 years.

Efficacy and safety of the combination of envafolimab and lenvatinib in unresectable hepatocellular carcinoma: a single-arm, multicentre, exploratory phase II clinical study.

Currently, therapeutic combinations of immune checkpoint inhibitors (ICIs) with anti-angiogenic agents have shown promising outcomes and have the potential to establish a new standard of care. The efficacy and safety of the first-line combination of envafolimab (an ICI) and lenvatinib (an anti-tumor angiogenesis drug) for the treatment of patients with inoperable hepatocellular carcinoma (HCC) have not been demonstrated. Unresectable HCC patients with an Eastern Cooperative Oncology Group (ECOG) physical status score ≤ 1 and a Child-Pugh score ≤ 7 who had not received systemic therapy were included in this single-arm, exploratory, multicentre phase II clinical study.

A Large-Scale Building Unsupervised Extraction Method Leveraging Airborne LiDAR Point Clouds and Remote Sensing Images Based on a Dual P-Snake Model.

Automatic large-scale building extraction from the LiDAR point clouds and remote sensing images is a growing focus in the fields of the sensor applications and remote sensing. However, this building extraction task remains highly challenging due to the complexity of building sizes, shapes, and surrounding environments. In addition, the discreteness, sparsity, and irregular distribution of point clouds, lighting, and shadows, as well as occlusions of the images, also seriously affect the accuracy of building extraction.

3D Ordered Macroporous Mn, Zr-Doped CaCO Nanomaterials for Stable Thermochemical Energy Storage.

Developing high-performance Ca-based materials that can work for long-term heat transfer and storage in concentrated solar power plants is crucial to achieve the large-scale conversion of solar photon fluxes to dispatchable electricity. This work demonstrates that a series of Mn, Zr co-doped CaCO nanomaterials with the 3D ordered macroporous (3DOM) skeletons are successfully prepared by a novel strategy of templated metal salt co-precipitation. The characterization results indicate that a majority of Zr and Mn are atomically dispersed into the highly-crystallized CaCO framework, whereas a minor amount of Mn is present in the form of CaMnO nanoparticles (NPs).

Nomogram model based on γ-glutamyl transferase to albumin ratio predicts survival in hepatocellular carcinoma patients with transarterial chemoembolization treatment.

Background: The development of tumor is closely linked to inflammation. Therefore, targeting molecules involved in inflammation may be effective in predicting cancer prognosis. Transarterial chemoembolization (TACE) holds significant therapeutic significance in addressing hepatocellular carcinoma (HCC).

Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4.

Recent studies have revealed a structural role for DNA ligase 4 (Lig4) in the maintenance of a repair complex during non-homologous end joining (NHEJ) of DNA double-strand breaks. In cultured cell lines, catalytically inactive Lig4 can partially alleviate the severe DNA repair phenotypes observed in cells lacking Lig4. To study the structural role of Lig4 in vivo, a mouse strain harboring a point mutation to Lig4's catalytic site was generated.

Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis.

Aryl hydrocarbon Receptor (AhR), an essential host regulator, has been observed to be significantly upregulated in patients with Metabolic dysfunction-associated steatohepatitis (MASH). However, the underlying mechanism remains unclear. The specific AhR antagonist CH223191 and siRNAs were employed to investigated the role of AhR and its potential as a therapeutic target for MASH in mice and hepatocytes model.

Spectrum analysis of inborn errors of metabolism for expanded newborn screening in Xinjiang, China.

To determine the disease spectrum and genetic characteristics of inborn errors of metabolism (IEM) in Xinjiang province in the northwest of China, 41,690 newborn babies were screening by tandem mass spectrometry from November 2018 to December 2021. Of these, 57 newborn babies were referred for genetic analysis by next-generation sequencing, which was validated by Sanger sequencing. A total of 36 newborn babies and one relative were diagnosed with IEM, and the overall positive predictive value was 29.

Virtual Reality Portable Perimetry and Home Monitoring of Glaucoma: Retention and Compliance over a 2-year Period.

Purpose: To evaluate long-term retention, compliance, and performance of glaucoma patients using a virtual reality portable perimeter to monitor visual fields (VFs) at home.

Design: Prospective, longitudinal, cohort study.

Subjects: Twenty-five glaucoma patients with stable and reliable VFs (average age 67.

Generalization analysis of adversarial pairwise learning.

Adversarial pairwise learning has become the predominant method to enhance the discrimination ability of models against adversarial attacks, achieving tremendous success in various application fields. Despite excellent empirical performance, adversarial robustness and generalization of adversarial pairwise learning remain poorly understood from the theoretical perspective. This paper moves towards this by establishing the high-probability generalization bounds.

Construction and validation of an immune gene-based model for diagnosis and risk prediction of severe asthma.

Objective: Severe asthma (SA) is a serious disease with limited treatment options, which is closely linked to immune dysfunction. Therefore, immune-associated biomarkers may diagnose SA and offer therapeutic targets for SA.

Methods: The gene expression profiles of SA patients and matched controls were from the National Center for Biotechnology Information database.

Clinical characteristics and early identification of augmented renal clearance in PICU patients with severe sepsis associated with MRSA infection.

Objectives: To investigate the epidemiological characteristics of Augmented Renal Clearance (ARC) in severe sepsis children with MRSA infection and find risk factors to establish a model predicting ARC onset in PICU.

Design: Retrospective study, in which ARC was defined by estimated glomerular filtration rate (eGFR) measured by the modified Schwartz formula above 130 ml/min/1.73 m.

Molecular Mechanisms of Solvation Force for Aqueous Systems.

Solvation force, stemming from the interfacial liquid structure, dominates the short-range interfacial interaction within a few nanometers across broad fields such as battery, lubrication, and colloid. However, achieving a quantitative understanding of solvation force for an aqueous system has remained elusive for decades, with the widely used contact value theory underestimating solvation force due to inherent assumptions. In this work, inspired by the flow field of liquid when two confining surfaces approach each other, we proposed a parameter-free expression for the solvation force acting on atomically smooth surfaces, quantitatively related to the energy barrier when liquid molecules are squeezed out from confinement.

ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells.

Fibroblast growth factor 21 (FGF21) is a key regulator of metabolism and cardiovascular health. However, its upregulation in aging and age-related disorders suggests the presence of FGF21 resistance. This study aimed to elucidate the mechanisms underlying senescence-associated FGF21 resistance in human umbilical vein endothelial cells (HUVECs) and to explore potential therapeutic interventions.

High inflammatory indices are significant predictors of disease severity in maintenance hemodialysis patients with COVID-19: A cross-sectional study.

Background: The patients with kidney failure who undergo maintenance hemodialysis (MHD) at high risk of morbidity and mortality from COVID-19. Previous studies showed that inflammation plays an important role in the progression of COVID-19. This study aimed to evaluate the prognostic value of the inflammatory indices in MHD patients with COVID-19.

Polythiophene side chain chemistry and its impact on advanced composite anodes for lithium-ion batteries.

In the development of high-performance lithium-ion batteries (LIBs), the design of polymer binders, particularly through manipulation of side-chain chemistry, plays a pivotal role in optimizing electrode stability, ion transport, and adaptability to the volume changes during cycling. In particular, poly[3-(potassium-4-butanoate)thiophene-2,5-diyl] (P3KBT) increases magnetite and silicon capacity and cycling stability. This work explores the impact of polythiophene alkyl sidechain length on anode characteristics, aiming to enhance performance in LIBs.

Classification and epidemiologic analysis of 86 diseases in .

Following the release of in May 2018, the Chinese government officially published in September 2023. To date, there is no unified standard and international consensus for rare diseases, and epidemiologic data for most rare diseases in China are lacking. We investigated 86 rare diseases on the second list using Orphanet and other databases to clarify the classification, nomenclature, and epidemiologic data for these diseases, and we summarized the genotype and phenotype of hereditary diseases.

Controlling Ion Uptake in Carboxylated Mixed Conductors.

Organic mixed ionic-electronic conductors (OMIECs) have garnered significant attention due to their capacity to transport both ions and electrons, making them ideal for applications in energy storage, neuromorphics, and bioelectronics. However, charge compensation mechanisms during the polymer redox process remain poorly understood, and are often oversimplified as single-ion injection with little attention to counterion effects. To advance understanding and design strategies toward next-generation OMIEC systems, a series of p-channel carboxylated mixed conductors is investigated.

A composite dressing combining ultralong hydroxyapatite nanowire bio-paper and a calcium alginate hydrogel accelerates wound healing.

An acute wound is the most common type of skin injury. Developing wound dressings with excellent mechanical properties, wound protection, comfort, angiogenic capacity and therapeutic effects is significant for effective treatments, yet remains challenging. Herein, we have designed a novel HAP-Alg composite dressing comprising a complementary ultralong hydroxyapatite (HAP) nanowire bio-paper and calcium alginate hydrogel.

Efficacy and Safety of Transcatheter Arterial Chemoembolization Combined with Lenvatinib Plus Anti-PD-1 Inhibitors for Hepatocellular Carcinoma Patients with Extrahepatic Metastases: A Multicenter Retrospective Study.

Purpose: The prognosis of hepatocellular carcinoma (HCC) with extrahepatic metastases (EM) is poor. The efficacy and safety of transcatheter arterial chemoembolization combined with lenvatinib plus anti-programmed cell death 1 inhibitors (triple therapy) for HCC with EM remains unclear. In this study, we aimed to determine the efficacy and safety of triple therapy in HCC patients with EM.