HOXD13, a member of the homeobox gene family, plays a critical role in developmental processes and has been implicated in various malignancies, including pancreatic cancer and glioma. However, its role in oral squamous cell carcinoma (OSCC) remains poorly understood. This study aimed to elucidate the potential of HOXD13 as a diagnostic biomarker and therapeutic target for OSCC.
View Article and Find Full Text PDFThe aim of the present study was to employ CELLSEARCH technology for the detection of circulating tumor cells (CTCs) in the peripheral blood of head and neck cancer (HNC) patients, and to assess the association between CTC count and patient prognosis. In this retrospective study, a cohort of 56 patients diagnosed with HNC and receiving treatment at the Department of Otolaryngology, Head and Neck Surgery (Beijing Tongren Hospital) between December 2013 and June 2018 were selected. Utilizing CELLSEARCH technology, the presence of CTCs were detected in samples of peripheral blood from patients with head and neck cancer (HNC) patients, and CTC counts were documented.
View Article and Find Full Text PDFJ Thorac Cardiovasc Surg
December 2024
Objective: The optimal hypothermic circulatory arrest temperature during total arch replacement and the impact of hypothermic circulatory arrest temperature on postoperative neurological complications are still uncertain. The aim of this study is to explore the impact of hypothermic circulatory arrest temperature on short-term postoperative outcomes, especially neurological complications, for patients who undergo total arch replacement.
Methods: We retrospectively analyzed data of 2351 patients who underwent total arch replacement at 1 of 7 selected aortic centers from January 2016 to June 2023.
Background: Colorectal cancer (CRC) poses a significant global health burden, with high incidence and mortality rates. Despite advances in diagnostic and therapeutic modalities, early diagnosis remains critical for improved outcomes. Recent research has realized the important role of gut microbiota in CRC development, highlighting the need to elucidate potential relationships.
View Article and Find Full Text PDFBiology (Basel)
October 2024
Introduction: Takayasu arteritis (TAK) is an autoimmune disease affecting the aorta and its branches. Despite anti-inflammatory treatments, some patients require surgical vascular reconstruction due to rapid disease progression. The mechanisms behind persistent inflammation are unclear due to a lack of arterial samples.
View Article and Find Full Text PDFBackground: Benign prostatic hyperplasia (BPH) is a common chronic condition in elderly men. Observational studies have identified several comorbidities associated with BPH. However, these studies are limited by various confounding factors and do not clearly explain the association between BPH and its comorbidities.
View Article and Find Full Text PDFIn the pursuit of developing an efficient artificial visual system for visual motion detection, researchers find inspiration from the visual motion-sensitive neural pathways in the insect's neural system. Although multiple proposed neural computational models exhibit significant performance aligned with those observed from insects, the mathematical basis for how these models characterize the sensitivity of visual neurons to corresponding motion patterns remains to be elucidated. To fill this research gap, this study originally proposed that the rigid propagation of visual motion is an essential mathematical property of the models for the insect's visual neural system, meaning that the dynamics of the model output remain consistent with the visual motion dynamics reflected in the input.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
November 2024
The precise control of flowering time is of utmost importance for crop adaptation to varying environmental conditions and consequently determines grain yield and plant fitness. Soybean , the homolog of Arabidopsis , is a major locus contributing to high-latitude adaptation and is involved in photoperiod sensitivity. However, due to major effects of , additional genetic loci controlling soybean flowering and adaptation have historically been masked and difficult to identify.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
October 2024
Adenanthin is a structurally unique ent-kaurane diterpenoid isolated from Rabdosia adenantha, a traditional Chinese medicinal plant with potent anti-cancer and anti-inflammatory activities. However, its anti-inflammatory molecular mechanism remains largely elusive to date. Here, we developed an affinity-based label-free protein profiling (ALFPP) to identify potential covalent targets of electrophilic natural products with ketone or aldehyde groups.
View Article and Find Full Text PDFPlant Cell Environ
October 2024
Flowering time is a key agronomic trait that directly affects soybean yield. Both APETALA1 (AP1) and SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) regulate flowering time in soybean, but their genetic and regulatory relationships have not been clarified. Here, we report that AP1c physically interacted with two SOC1 proteins, SOC1a and SOC1b, and that these SOC1s upregulated the expression of AP1c, promoting flowering.
View Article and Find Full Text PDFThe escalating need for prompt and highly sensitive on-site detection of trace-level drugs is fueling the advancement of miniature, high-performance mass spectrometers and analytical methodologies. In this study, a miniature continuous atmospheric pressure interfaced ion trap mass spectrometer integrated with thermal desorption acetone-assisted photoionization (TD-CAPI-ITMS) was developed for highly sensitive detection of nonvolatile drugs in saliva and blood. By strategically extending the sampling time of the TD-CAPI-ITMS to cover the entire desorption process, a remarkable two-order-of-magnitude enhancement in the signal intensity of individual drugs was observed.
View Article and Find Full Text PDFEnviron Sci Technol
December 2024
Saltmarsh wetlands are recognized as some of the most ecologically valuable yet vulnerable ecosystems globally. However, since the 1970s, saltmarsh wetlands in coastal China have been seriously threatened by the invasive . Although the Chinese government has initiated a nationwide removal project, the potential benefits and risks of this project remain unknown.
View Article and Find Full Text PDFBackground: While serum periostin and Krebs von den Lungen-6 (KL-6) have been acknowledged as independent markers in idiopathic pulmonary fibrosis (IPF) diagnosis, the clinical combinatory potential of these biomarkers combined with high-resolution computed tomography (HRCT) has yet to be fully explored.
Methods: This retrospective study involved 78 participants, comprising 51 UIP-IPF patients and 27 healthy controls. All subjects underwent clinical and laboratory examinations, particularly the detection of periostin and KL-6 using ELISA with innovative HRCT fibrosis score evaluations at admission and discharge during hospitalization in UIP-IPF patients.
As a common by-product during the production of alcoholic beverages, such as Chinese liquor, ethyl carbamate (EC) poses potential genotoxicity and is associated with the risk of various cancers. Hence, rapidly and accurately measuring the content of EC in liquor is critical to assess the product quality and risks of mass samples during the production process. In this study, a feasible method based on fast gas chromatography photoionization-induced chemical ionization mass spectrometry (FastGC-PICI-TOFMS) was developed for the analysis of EC in Chinese liquor.
View Article and Find Full Text PDFBackground: Lung cancer (LC), a paramount global life-threatening condition causing significant mortality, is most commonly characterized by its subtype, lung adenocarcinoma (LUAD). Concomitant with LC, pulmonary fibrosis (PF) and interstitial lung disease (ILD) contribute to an intricate landscape of respiratory diseases. Idiopathic pulmonary fibrosis (IPF) in association with LC has been explored.
View Article and Find Full Text PDFIn recent years, biomass carbon materials have received widespread attention in the field of electrochemical sensors. As a new type of renewable green energy, biomass carbon has the advantages of low cost and abundant resources. After special treatment, it can be used as an ideal electrode material.
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