Publications by authors named "Li Hailiang"
Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.
Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.
[Curcumol Mediates the Programmed Cell Death in Acute Myeloid Leukemia through PI3K/AKT Signaling Pathway].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Objective: To investigate the effects of Curcumol on the malignant biological characteristics of acute myeloid leukemia (AML) cells and its molecular mechanism, and to provide theoretical and experimental evidence for the anti-leukemia treatment of traditional Chinese medicine.
Methods: After the AML cell lines HL-60 and KG-1 cells were treated different concentrations of with Curcumol. The proliferation activity of cells was detected by CCK-8 method, and the expression changes of apoptotic proteins and PI3K/AKT signaling pathway proteins were detected by Western blot.
Article Synopsis
- The study explores the prognostic significance of lipoprotein-associated phospholipase A2 (Lp-PLA2) and lipoprotein(a) (Lp(a)) in predicting long-term stroke recurrence in patients with acute ischemic stroke (AIS).
- A total of 580 AIS patients were monitored over two years, with results showing that 17.41% experienced stroke recurrence, highlighting key risk factors such as age, diabetes, and levels of Lp-PLA2 and Lp(a).
- The results suggest that using both Lp-PLA2 and Lp(a) together offers a more effective and cost-efficient method for assessing stroke recurrence risk than looking at these factors individually.
Organisms detect temperature signals through peripheral neurons, which relay them to central circadian networks to drive adaptive behaviors. Despite recent advances in Drosophila research, how circadian circuits integrate temperature cues with circadian signals to regulate sleep/wake patterns remains unclear. In this study, we used the FlyWire brain electron microscopy connectome to map neuronal connections, identifying lateral posterior neurons LPNs as key nodes for integrating temperature information into the circadian network.
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- The study investigates the impact of cancer cachexia in patients with hepatocellular carcinoma (HCC), focusing on how body composition changes over time can help identify cachexia.
- It utilizes a cohort of unresectable HCC patients treated with specific therapies, analyzing body composition through CT scans to categorize patients into different cachexia phases based on their skeletal muscle mass and total adipose tissue.
- Findings reveal that patients experiencing significant declines in muscle and tissue mass have worse overall survival outcomes, highlighting the importance of monitoring body composition in HCC treatment plans.
Gastric cancer (GC) is a common malignant tumour with high incidence and mortality rates worldwide. Despite current treatment modalities, including surgical resection and chemotherapy, challenges such as postoperative recurrence, metastasis and drug resistance persist. Therefore, investigating the feasibility and mechanism of traditional Chinese medicine in treating gastric cancer is crucial for discovering new anti-gastric cancer drugs or adjuvant therapies.
View Article and Find Full Text PDF[Mechanism of Huayu Jiedu Decoction in Inhibiting Malignant Biological Characteristics of Multiple Myeloma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2024
Objective: To analyze and explore the effects of Huayu Jiedu Decoction on the malignant biological characteristics of multiple myeloma (MM) cells and its molecular mechanism, so as to provide experimental basis and theoretical basis for the alternative therapy of anti-MM in traditional Chinese medicine.
Methods: Different concentrations of Huayu Jiedu Decoction were used to intervene myeloma U266 cells. The changes of cell proliferation activity were detected by CCK-8 assay, apoptosis was detected by Annexin V/PI double staining flow cytometry, and apoptosis and protein expression of related signaling pathways were detected by Western blot.
Article Synopsis
- This study investigates the progression of advanced hepatocellular carcinoma (HCC) in patients receiving a combination of local therapies, targeted drugs, and PD-1/PD-L1 inhibitors.
- It analyzed data from 86 patients treated between 2018 and 2022, focusing on disease progression through imaging and immune cell analysis.
- Results show that intrahepatic and extrahepatic progression occurred at specific median times, with lymph nodes and lungs being the most affected areas, and notable changes in PD-1+ immune cell percentages were observed post-treatment.
Article Synopsis
- Chemical derivatization boosts liquid chromatography-mass spectrometry for analyzing complex mixtures but lacks enough reference spectra for derived molecules, creating challenges in practical applications.
- A deep learning model called DeepCDM is introduced to predict mass spectra for chemically derived molecules by adapting an existing spectrum model, enhancing its accuracy significantly.
- DeepCDM was successfully applied to dansylated molecules, leading to the creation of DnsBank, a spectral library that improves identification rates, aiding in the detection of hazardous pollutants from leather industry wastewater.
Article Synopsis
- The study examined how physical activity, sleep duration, and daily sitting time impact bone mineral density (BMD) using data from NHANES 2007-2018.
- Findings revealed that low and high-intensity physical activities help reduce the risk of low BMD, while both short and long sleep durations, along with excessive sitting, increase that risk.
- The research concluded that increasing physical activity can help counteract the negative effects of poor sleep patterns and long periods of sitting on BMD, highlighting the importance of lifestyle changes for bone health.
Background And Objectives: Transarterial chemoembolization (TACE) and I seed implantation are methods used to treat hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT), PVTT often associated with arterioportal shunts(APS), there are few reports on the combined use of TACE and I seed implantation for such patients. This study aimed to evaluate the efficacy and safety of TACE combined with PVTT I seed implantation in the treatment of HCC patients with APS.
Methods: Forty-two patients diagnosed with HCC combined with PVTT and APS between January 2020 and December 2021 were included.
Background: The aim of this research is to prospectively investigate the diagnostic performance of intravoxel incoherent motion (IVIM) using the integrated slice-specific dynamic shimming (iShim) technique in staging primary esophageal squamous cell carcinoma (ESCC) and predicting presence of lymph node metastases from ESCC.
Methods: Sixty-three patients with ESCC were prospectively enrolled from April 2016 to April 2019. MR and IVIM using iShim technique (b = 0, 25, 50, 75, 100, 200, 400, 600, 800 s/mm) were performed on 3.
Article Synopsis
- This expert consensus outlines guidelines for diagnosing and treating lung cancer that appears as multiple ground glass nodules.
- Key topics include strategies for monitoring patients, how to differentiate between types of nodules, methods for accurate diagnosis and staging, treatment options, and follow-up care after treatment.
- The review emphasizes the importance of informed clinical practices based on the latest literature.
Article Synopsis
- A study assessed the effectiveness and safety of iodine-125 brachytherapy for patients with right lower paratracheal lymph node metastasis after prior treatments failed.
- Out of 24 patients, the treatment achieved an objective response rate of 87.5%, with significant reduction in lymph node size and improved clinical symptoms.
- The median overall survival was 14.70 months, and complications were manageable, suggesting iodine-125 brachytherapy is a promising alternative treatment option.
Background: The combination of transcatheter arterial chemoembolization (TACE) and tyrosine kinase inhibitors (TKIs) has shown broad prospects in prolonging the survival of patients with hepatocellular carcinoma (HCC). TACE and TKIs can affect the immune microenvironment in patients with HCC.
Aim: To determine the overall effects and differences between TACE and different TKIs combinations on the immune microenvironment.
Article Synopsis
- Patients with emphysema have a higher risk of pneumothorax when undergoing lung biopsies, but needle embolization might help reduce this risk.
- This study examined two groups of emphysema patients: one group had no embolization, while the other had tract embolization during their biopsies, with over 1,000 patients analyzed in total.
- Results showed that embolization led to a significantly lower rate of pneumothorax and the need for chest tubes, suggesting it is an effective preventive measure in high-risk patients.
Spinal cord injury (SCI) is a severe neurological condition that involves a lengthy pathological process. This process leads to the upregulation of chondroitin sulfate proteoglycans (CSPGs) by reactive glia, which impedes repair and regeneration in the spinal cord. The role of the CSPG-specific receptor protein tyrosine phosphatase-sigma (PTP-σ) in post-SCI remains largely unexplored.
View Article and Find Full Text PDFBackground: The role of transarterial chemoembolization (TACE) in the treatment of advanced hepatocellular carcinoma (HCC) is unconfirmed. This study aimed to assess the efficacy and safety of immune checkpoint inhibitors (ICIs) plus anti-vascular endothelial growth factor (anti-VEGF) antibody/tyrosine kinase inhibitors (TKIs) with or without TACE as first-line treatment for advanced HCC.
Methods: This nationwide, multicenter, retrospective cohort study included advanced HCC patients receiving either TACE with ICIs plus anti-VEGF antibody/TKIs (TACE-ICI-VEGF) or only ICIs plus anti-VEGF antibody/TKIs (ICI-VEGF) from January 2018 to December 2022.
Objective: High-grade glioma (HGG) patients frequently encounter treatment resistance and relapse, despite numerous interventions seeking enhanced survival outcomes yielding limited success. Consequently, this study, rooted in our prior research, aimed to ascertain whether leveraging circadian rhythm phase attributes could optimize radiotherapy results.
Methods: In this retrospective analysis, we meticulously selected 121 HGG cases with synchronized rhythms through Cosinor analysis.
Natural polysaccharides are important active biomolecules. However, the analysis and structural characterization of polysaccharides are challenging tasks that often require multiple techniques and maps to reflect their structural features. This study aimed to propose a new heart-cutting two-dimensional liquid chromatography (2D-LC) method for separating and analyzing polysaccharides to explore the multidimensional information of polysaccharide structure in a single map.
View Article and Find Full Text PDFObjective: To evaluate the value of a nomogram combined MRI Diffusion Weighted Imaging (DWI) and clinical features to predict the treatment response of Neoadjuvant Chemotherapy (NAC) in patients with osteosarcoma.
Methods: A retrospective analysis was conducted on 209 osteosarcoma patients admitted into two bone cancer treatment centers (133 males, 76females; mean age 16.31 ± 11.
Article Synopsis
- - The circadian clock influences animal physiological activities, but how temperature affects this relationship is not well understood.
- - Researchers used advanced imaging techniques to study how temperature changes affect the central circadian circuit in fruit flies (Drosophila), specifically noting the crucial role of DN1a neurons as temperature sensors.
- - Their findings show that DN1a neurons interact with other circadian neurons to regulate both activity in response to cold temperatures and sleep patterns during warmer conditions, highlighting the complex integration of temperature and light in managing daily behavioral rhythms.
Article Synopsis
- The study investigates the effectiveness and safety of using small-sized (≤ 100 μm) drug-eluting beads loaded with epirubicin in transarterial chemoembolization (DEB-TACE) for treating hepatocellular carcinoma (HCC).
- A total of 108 patients were enrolled across ten centers, showing a 6-month objective response rate of 73.3% based on EASL criteria, with positive outcomes in various follow-up measures including overall survival rates.
- The trial concluded that DEB-TACE with these small microspheres presents a promising approach for local tumor control in HCC with manageable safety concerns.