Chiral Membrane Containing Subnanometer Channels for Enantioselective Transport Amino Acids.

The research of chiral separation technology is of great significance for understanding the origin of life and promoting the application of chiral molecules. Herein, anionic chiral pillar[6]arene and cationic pillar[6]arene were designed and synthesized, and a chiral pillar[6]arene membrane was constructed by layer-by-layer assembly through electrostatic interactions. The transport rates of l and d in this channel were 14.

PDA/PMMA Blend Membrane Utilized for the Selective Adsorption and Separation of Heavy Metal Ions.

The detrimental effects of heavy metal aqueous pollution are attracting people's attention increasingly. Membrane separation technology plays a pivotal role in the treatment of aqueous pollution due to its low energy consumption and excellent separation effect. Inspired by the strong adhesion of heavy metal ions by the dopamine in mussel protein, we have fabricated the 5 %, 10 %, 20 % and 30 % proportion of polydopamine (PDA)/Polymethyl methacrylate (PMMA) blend membranes with dopamine structure by solvent-induced phase conversion.

Gadolinium-Sensitive Artificial Nanochannel Membrane for Information Encryption.

Inspired from ion channels in the myelinated axon of found to be affected by gadolinium on axonal currents, we present a solid nanochannel membrane sensitive to gadolinium (Gd), which can be achieved via the use of the macrocyclic triacetic acid derivative in the host-guest chemistry approach. The macrocyclic nanochannel has good responsiveness toward Gd, even at the nanomolar concentration level, evidenced by discernible changes in rectification, ionic conductance, and XPS analyses. Notably, the Gd-sensitive nanochannel membrane can be switched by the addition of a diethylenetriaminepentaacetic acid (DTPA) derivative.

Controlled Release of La Ions for Enhanced Wheat Seed Germination Based on Phosphate Pillar[5]arene Nanogating.

Rare earth elements (REEs), vital and limited resources, also play a significant role in agriculture. Previous findings indicated that the proper concentration of REEs could enhance the germination process, seed germination rate, and seedling growth and development. This paper introduces designing, synthesizing, and assembling a new type of tapered nanogates for separating and detecting lanthanide ions (La).

Efficient Adsorption and Elimination of Tm for Enhanced Seed Germination Using Pillar[5]Arene Polymer.

While rare earth elements (REEs) are essential for modern technology, their production methods raise concerns for agriculture. Researchers are now exploring ways to control and recycle REEs pollution, aiming to minimize agricultural impacts and potentially even develop methods to utilize these elements for improved crop yields. Regarding this issue, a new type of pillar[5]arene polymer (Pol-P[5]-BTZP) has been designed and synthesized by click reaction to enhance the efficiency of adsorption and recovery of rare earth metals.

Therapeutic potential of the topical recombinant human interleukin-1 receptor antagonist in guinea pigs with allergic rhinitis.

Background: Recombinant human Interleukin receptor antagonist (rhIL-Ra) can bind to the IL-1 receptor on the cell membrane and reversibly blocks the proinflammatory signaling pathway. However, its effect on allergic rhinitis (AR) and the underlying mechanism remains unknown. This study aims to investigate the efficacy of recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) on AR guinea pigs.

Recent Advances of Food Hazard Detection Based on Artificial Nanochannel Sensors.

Food quality and safety are related to the health and safety of people, and food hazards are important influencing factors affecting food safety. It is strongly necessary to develop food safety rapid detection technology to ensure food safety. As a new detection technology, artificial nanochannel-based electrochemical and other methods have the advantages of being real-time, simple, and sensitive and are widely used in the detection of food hazards.

Visible Light-Gating Responsive Nanochannel for Controlled Release of the Fungicide.

Fungicides have been widely used to protect crops from the disease of pythium aphanidermatum (PA). However, excessive use of synthetic fungicides can lead to fungal pathogens developing microbicide resistance. Recently, biomimetic nano-delivery systems have been used for controlled release, reducing the overuse of fungicides, and thereby protecting the environment.

A Visible-Light Regulated ATP Transport in Retinal-Modified Pillar[6]arene Layer-by-Layer Self-Assembled Sub-Nanochannel.

Natural light-responsive rhodopsins play a critical role in visual conversion, signal transduction, energy transmission, etc., which has aroused extensive interest in the past decade. Inspired by these gorgeous works of living beings, scientists have constructed various biomimetic light-responsive nanochannels to mimic the behaviors of rhodopsins.

Recent Advances in Stimulus-Responsive Nanocarriers for Pesticide Delivery.

In an effort to make pesticide use safer, more efficient, and sustainable, micro-/nanocarriers are increasingly being utilized in agriculture to deliver pesticide-active agents, thereby reducing quantities and improving effectiveness. In the use of nanopesticides, the choice to further design and prepare pesticide stimulus-responsive nanocarriers based on changes in the plant growth environment (light, temperature, pH, enzymes, etc.) has received more and more attention from researchers.

Tailoring vanadium oxide crystal orientation for high-performance aqueous zinc-ion batteries.

Due to the increasing demand for higher security and low-cost energy storage systems, the main research focus has been developing a suitable substitute for lithium-ion batteries. Aqueous zinc ion batteries (AZIBs) are considered the best alternative to lithium-ion batteries in large-scale energy storage devices. Owing to its high capacity, vanadate is a promising cathode material for AZIBs.

pH-Stimulated Response Gating for Mimic Cytochrome C Transport on Biomimetic Asymmetric Nanochannels.

Proteins are vital components in cells, biological tissues, and organs, playing a pivotal role in growth and developmental processes in living organisms. Cytochrome C (Cyt C) is a class of heme proteins found in almost all life and is involved in cellular energy metabolic processes such as respiration, mainly as electron carriers or terminal reductases. It binds cardiolipin in the inner mitochondrial membrane, leading to apoptosis.

Selectively Transport and Removal of Fluoride Ion by Pillar[5]Arene Polymer-Filled Nanochannel Membrane.

Excess fluoride ions in groundwater accumulate through the roots of crops, affecting photosynthesis and inhibiting their growth. Long-term bioaccumulation also threatens human health because it is poorly degradable and toxic. Currently, one of the biggest challenges is developing a unique material that can efficiently remove fluoride ions from the environment.

The Specific Removal of Perfluorooctanoic Acid Based on Pillar[5]arene-Polymer-Packed Nanochannel Membrane.

The conspicuous surface activity and exceptional chemical stability of perfluorooctanoic acid, commonly referred to as PFOA, have led to its extensive utilization across a broad spectrum of industrial and commercial products. Nonetheless, significant concerns have arisen regarding the environmental presence of PFOAs, driven by their recognized persistence, bioaccumulative nature, and potential human health risks. In the realm of sustainable agriculture, a pivotal challenge revolves around the development of specialized materials capable of effectively and selectively eliminating PFOA from the environment.

Metformin Ameliorates Postoperative Cognitive Dysfunction through Regulation of the AMPK/SIRT1 Pathway.

Background: Postoperative cognitive dysfunction (POCD) is a common postoperative complication in elderly patients. The purpose of this study was to investigate the mechanism through which metformin improves postoperative cognitive function.

Methods: In the experiment, 18-month-old Sprague-Dawley (SD) rats were randomly divided into four groups (n = 12 in each group): the control, metformin, operation, and operation plus metformin groups.

L-ribose specific recognition surface constructed by pillar[5]arene-based host-guest interaction.

In living organisms, chiral molecules have specific chiral conformations that produce different physiological effects. Ribose is one of the components of RNA, which mainly plays a role in regulating biological activity. Inspired by the biological recognition of sugars, functional chiral surfaces for recognizing L-ribose through non-covalent interactions were constructed.

Feasibility analysis of intrathecal administration strategy of nusinersen based on Cobb angle in children with spinal muscular atrophy.

Aim: This retro-prospective observational study described the experience in lumbar puncture procedures in children with spinal muscular atrophy (SMA) with and without neuromuscular scoliosis in a single center. The technical feasibility of intrathecal nusinersen administration was the main limiting factor.

Study Design: A total of 457 technically successful intrathecal injections based on a hierarchical strategy in Cobb angle were reviewed in 81 SMA children aged 0.

Highly Selective Transport and Enrichment of Lithium Ions through Bionic Ion Pair Receptor Nanochannels.

Inspired by ion pair cotransport channels in biological systems, a bionic nanochannel modified with lithium ion pair receptors is constructed for selective transport and enrichment of lithium ions (Li). NH-pillar[5]arene (NP5) is chosen as ion pair receptors, and the theoretical simulation and NMR titration experiments illustrate that NP5 has good affinity for the ion pair of LiCl through a strong host-guest interaction at the molecular level. Due to the confinement effect and ion pair cooperation recognition, an NP5-based receptor was introduced into an artificial PET nanochannel.

Imaging changes in the polarity of lipid droplets during NAFLD-Induced ferroptosis via a red-emitting fluorescent probe with a large Stokes shift.

Cell death resulting from ferroptosis is a consequence of the accumulation of lipid peroxides that are produced when lipids and reactive oxygen species (ROS) interact. This process is dependent on iron and alters the structure and polarity of lipid droplets (LDs). Unlike reactive fluorescent probes, environment-sensitive fluorescent probes can accurately monitor metabolic activities by sensing the intracellular environment of living organisms.

Precise Printing of Microfiber Scaffold with Gelatin Methacryloyl (GelMA)/Polyethylene Oxide (PEO) Bioink.

Gelatin methacryloyl scaffolds with microscale fiber structures own great significance because they can effectively mimic the extracellular matrix environment. Compared with extruding bioprinting, electrospinning technology is more suitable for establishing accurate hydrogel microfibers. However, electrospinning accurate gelatin methacryloyl microfiber remains a big challenge restricted by its bad spinnability.

Clinical observation of different dosages of dexmedetomidine combined with a target-controlled infusion of propofol in hysteroscopic submucosal myomectomy.

Objective: This study aimed to explore the clinical effects of different dosages of dexmedetomidine (Dex) combined with a target-controlled infusion of propofol in hysteroscopic submucosal myomectomy.

Methods: Ninety patients who underwent hysteroscopic submucosal myomectomy between September 2021 and March 2022 were enrolled and randomly divided into three groups, with 30 patients in each group. Patients in Groups A, B, and C received injections of 0.