Publications by authors named "Li Gaofeng"
Background: Our goal is to develop a nomogram model to predict overall survival (OS) for elderly esophageal squamous cell carcinoma (ESCC) patients receiving definitive radiotherapy (RT) or concurrent chemoradiotherapy (CRT), aiding clinicians in personalized treatment planning with a risk stratification system.
Methods: A retrospective study was conducted on 718 elderly ESCC patients treated with RT or CRT at 10 medical centers (3JECROG) from January 2004 to November 2016. We identified independent prognostic factors using univariate and multifactorial Cox regression to construct a nomogram model.
Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer and poses a serious threat to human health. Due to the advances in lung cancer screening, more and more clinical T1 NSCLC defined as a tumor with a maximum diameter of 3cm surrounded by lung tissue or visceral pleura have been detected and have achieved favorable treatment outcomes, greatly improving the prognosis of NSCLC patients. However, the preoperative lymph node staging and intraoperative lymph node dissection patterns of operable clinical T1 NSCLC are still subject to much disagreement, as well as the heterogeneity between primary tumors and metastatic lymph nodes poses a challenge in designing effective treatment strategies.
View Article and Find Full Text PDFPurpose: This study aimed to compare the efficacy of anlotinib plus whole-brain radiotherapy (WBRT) with that of WBRT alone in non-small cell lung cancer (NSCLC) patients with multiple brain metastases (BMs).
Methods: The clinical data of patients with NSCLC and multiple BMs who received WBRT between 2019 and 2022 were collected. The patients were assigned to anlotinib plus WBRT group and WBRT group according to the treatment used.
Background: This study aimed to explore a novel and effective modified technique for the improvement in labia minora hypertrophy.
Methods: From January 2020 to December 2022, 25 patients with labia minora hypertrophy underwent surgical treatment using a modified mucosal advancement flap combined with a de-epithelialized mucosal flap for labia minora reduction. Postoperative follow-up ranged from 3 to 12 months.
carbon-coated CoS micro/nano-spheres were successfully prepared by sulfuric calcination using the solvothermal method with glycerol as the carbon source without introducing extraneous carbon. This method prevents carbon agglomeration and avoids the cumbersome steps of the current technology. The composite demonstrates excellent sodium storage capacity as an anode material for sodium-ion batteries.
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- The study investigates the effects of adding oxaliplatin to capecitabine-based chemoradiotherapy (CRT) in patients with postoperative pathological stage N2 rectal cancer, highlighting previous concerns about increased toxicity without survival benefits.
- A total of 180 patients were analyzed, with 85 receiving capecitabine with radiotherapy and 95 getting capecitabine plus oxaliplatin; results showed improved three-year disease-free survival in the experimental group.
- Overall survival rates and significant toxicities were similar between both groups, but those who survived beyond three years had better conditional overall survival when treated with oxaliplatin.
Article Synopsis
- Air pollution, particularly from coal smoke in the Xuanwei area, has been linked to a specific subtype of lung adenocarcinoma (LUAD) that affects never-smokers, revealing distinct genetic characteristics.
- The analysis showed that Benzo[a]pyrene (BaP) is a major risk factor, with a significant mutation (EGFR-G719X) found in 20% of cases, leading to worse outcomes and increased activation of the MAPK pathway.
- Four distinct clinical subtypes of this lung cancer were identified, each with unique biological processes and potential new therapeutic targets, providing important insights for future treatment strategies.
Ear Reconstruction for Auricle Defects Using an Expanded Neck Flap: A Case Report.
Ear Nose Throat J
October 2024
Article Synopsis
- - A patient with a left ear deformity from a flame burn received a 3-stage reconstruction using an expanded neck flap and rib cartilage as the framework for the ear.
- - The reconstruction involved implanting tissue expanders, excising scar tissue, and using the expanded flap to cover the ear framework, followed by final shaping and scar removal.
- - After one year, the reconstruction healed well with minor complications, resulting in a realistic ear shape and improved appearance, suggesting that expanded neck flaps can be an effective solution for burn patients with limited flap options.
Article Synopsis
- Zorifertinib is an experimental cancer drug that targets mutations in the EGFR gene and has shown effectiveness in patients with lung cancer that has spread to the brain.
- A phase 3 trial compared zorifertinib to standard treatments and found that it significantly extended the time patients lived without the disease worsening (progression-free survival).
- Results indicate that zorifertinib may be a better first-line treatment option for non-small cell lung cancer due to its ability to improve survival and manage side effects effectively.
BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer.
J Exp Clin Cancer Res
September 2024
Background: The vast majority of pancreatic cancers have been shown to be insensitive to single-agent immunotherapy. Exploring the mechanisms of immune resistance and implementing combination therapeutic strategies are crucial for PDAC patients to derive benefits from immunotherapy. Deletion of BAP1 occurs in approximately 27% of PDAC patients and is significantly correlated with poor prognosis, but the mechanism how BAP1-deletion compromises survival of patients with PDAC remain a puzzle.
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- The study aimed to investigate how the quality of multidisciplinary teams (MDTs) affects the survival rates of patients with locally advanced rectal cancer who underwent surgery.
- It analyzed data from the STELLAR trial, revealing that fewer specialized disciplines, infrequent meetings, and lower annual discussion volumes in MDTs were linked to poorer disease-free survival (DFS) and overall survival (OS).
- Patients treated in hospitals with high-quality MDTs demonstrated significantly better 3-year OS compared to those in general quality hospitals, indicating that strong MDT frameworks can enhance patient outcomes.
Article Synopsis
- SCT510 is a biosimilar to bevacizumab (Avastin) and was tested for its effectiveness, safety, and other factors in patients with advanced non-squamous non-small cell lung cancer (NSCLC).
- The study included 567 eligible patients who were randomly assigned to receive either SCT510 or bevacizumab, showing similar objective response rates and no significant differences in other secondary endpoints regarding efficacy or safety.
- Results indicate that SCT510 is equivalent to the reference product bevacizumab, which suggests it can be a viable alternative treatment option for patients with advanced NSCLC.
Article Synopsis
- Grass damage limits foxtail millet production, and while chemical weeding is one solution, specific herbicides are still needed.
- The study tested penoxsulam at five concentrations on Jingu 21 during its three-five leaf stage to evaluate its effects on growth and antioxidant capacity.
- Results indicated that penoxsulam effectively controls certain weeds but negatively impacts millet growth as spraying amounts increase, suggesting 1/2X and 1X dosages are beneficial for weed management without harming the crop.
Background: In ORIENT-15 study, sintilimab plus chemotherapy demonstrated significant improvement on overall survival (OS) versus placebo plus chemotherapy in first-line treatment of advanced esophageal squamous cell carcinoma (ESCC). Here, we report effect of sintilimab plus chemotherapy on health-related quality of life (HRQoL) in patients with advanced ESCC.
Methods: From December 14, 2018 to August 28, 2022, HRQoL was evaluated in all randomized patients using European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 items (QLQ-C30), EORTC Quality of Life Questionnaire Oesophageal Cancer Module 18 items (QLQ-OES18), and visual analogue scale (VAS) of the EuroQol five-dimensional five-level questionnaire (EQ-5D-5L).
Surface chemistry and bulk structure jointly play crucial roles in achieving high-performance supercapacitors. Here, the synergistic effect of surface chemistry properties (vacancy and phosphorization) and structure-derived properties (hollow hydrangea-like structure) on energy storage is explored by the surface treatment and architecture design of the nanostructures. The theoretical calculations and experiments prove that surface chemistry modulation is capable of improving electronic conductivity and electrolyte wettability.
View Article and Find Full Text PDFBackground: Immunotherapy has changed the treatment landscape for lung cancer. This study aims to construct a tumor mutation-related model that combines long non-coding RNA (lncRNA) expression levels and tumor mutation levels in tumor genomes to detect the possibilities of the lncRNA signature as an indicator for predicting the prognosis and response to immunotherapy in lung adenocarcinoma (LUAD).
Methods: We downloaded the tumor mutation profiles and RNA-seq expression database of LUAD from The Cancer Genome Atlas (TCGA).
Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with limited treatment options, especially for extensive-stage (ES) patients. We present a case of a 70-year-old male with ES-SCLC and asymptomatic brain metastasis who opted for immune monotherapy with serplulimab (an anti-PD-1 antibody). After four cycles, the patient achieved a confirmed partial response and a progression-free survival of over 1 year.
View Article and Find Full Text PDFBackground: Research on the risk factors for cervical cancer in Yunnan Province's four characteristic ethnic groups (Han, Bai, Dai, and Hani) is lacking.
Objective: To study the risk factors of cervical cancer in four ethnic women in Yunnan Province, and to provide evidence for its prevention.
Methods: The cervical cancer patients of Han, Bai, Dai and Hani ethnic groups in Yunnan Province who were first diagnosed in the Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center) from January 2011 to December 2020 were selected as the research objects.
Background: The initial phase II stuty (NCT03215693) demonstrated that ensartinib has shown clinical activity in patients with advanced crizotinib-refractory, anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). Herein, we reported the updated data on overall survival (OS) and molecular profiling from the initial phase II study.
Methods: In this study, 180 patients received 225 mg of ensartinib orally once daily until disease progression, death or withdrawal.
Introduction: In Chinese patients with NSCLC, prevalence of EGFR-mutated (EGFRm) disease is high. In the global phase 3 ADAURA study (NCT02511106), adjuvant osimertinib was found to have a statistically significant and clinically meaningful improvement in disease-free survival (DFS) versus placebo in resected stage IB to IIIA EGFRm NSCLC. We present efficacy and safety data from a subgroup analysis of 159 Chinese patients enrolled in the People's Republic of China from ADAURA.
View Article and Find Full Text PDFBackground: The biological function of distal-less homeobox 1 (DLX1) in lung adenocarcinoma (LUAD) remains unclear, despite a growing body of evidence that DLX1 is involved in the initiation and progression of various tumors.
Methods: This study explored and confirmed the prognostic and immunologic roles of DLX1 in LUAD bioinformatic analysis and cellular functional validation. MethSurv was used to analyze the DNA methylation levels of DLX1 and the prognostic value of CpG islands.
Lung cancer is a prevalent malignancy, and fatalities of the disease exceed 400,000 cases worldwide. Lung squamous cell carcinoma (LUSC) has been recognized as the most common pathological form of lung cancer. The comprehensive understanding of molecular features related to LUSC progression has great significance in LUSC prognosis assessment and clinical management.
View Article and Find Full Text PDFThis study aims to analyze the RNA expression and alternative polyadenylation (APA) events and identify APA tuned genes with prognostic significance in lung adenocarcinoma (LUAD). Genome-wide RNA expression profile and APA events were acquired in LUAD cancer and normal samples in GSE197346. Comparative analysis screened common deregulated genes and transcripts.
View Article and Find Full Text PDFObjective: To investigate the clinical effect of asymmetric Z-plasty with central axis inward displacement and stallard Z-plasty in the correction of epicanthus.
Methods: We retrospectively analyzed 193 patients who underwent epicanthal plasty in the Department of Plastic and Laser Cosmetology of Hunan Provincial People's Hospital from 2009 to 2019. The patients were divided into two groups according to different surgical methods: group A (n = 125) received the asymmetric Z-plasty with central axis inward displacement method and group B (n = 68) received the stallard Z-plasty method.