Efficacy and safety of oral and vaginal administration of misoprostol for induction of labor in high-risk obese pregnant women with hypertension or diabetes mellitus.

Objective: This study aims to compare the safety and efficacy of misoprostol administered orally and vaginally in obese pregnant women at term with either gestational hypertension or diabetes.

Methods: A total of 264 pregnant women were enrolled and categorized into two groups based on their primary condition: hypertension (134 cases) or diabetes mellitus (130 cases) and were further divided into subgroups for misoprostol administration: orally (Oral group) or vaginally (Vaginal group). The primary outcomes measured were changes in the Bishop score following treatment, induction of labor (IOL) success rates, requirement for oxytocin augmentation, duration of labor, mode of delivery, and cesarean section rates.

A new C polyacetylene and seven isoprenylated pterocarpans from .

A new C polyacetylene, erysectol A (), and seven isoprenylated pterocarpans, phaseollin (), phaseollidin (), cristacarpin (), (3')-erythribyssin D/(3'S)-erythribyssin D () and dolichina A/dolichina B () were isolated from the twigs and leaves of Their structures were determined based on their NMR spectral data. Except for -, all the other compounds were isolated from this plant for the first time. Erysectol A was the first reported C polyacetylene from plants.

Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats.

Background And Aims: Hydrotalcite plays an important role in the therapy of gastric ulcer induced by nonsteroidal anti-inflammatory drugs (NSAIDs), but little is known about the mechanism. We designed two experiments to study the preventive and curative effects of hydrotalcite on NSAIDs-related gastric injury in rats and to investigate the relationship between the protective and curative mechanism of hydrotalcite and the secretion of epidermal growth factor (EGF)/prostaglandin E2 (PGE2).

Methods: Two experiments were separately designed to evaluate the preventive and curative effects of hydrotalcite.

Small intestinal hemolymphangioma with bleeding: a case report.

Small intestinal hemolymphangioma is a very rare benign tumor. There was only one report of a hemolymphangioma of the pancreas invading to the duodenum until March 2011. Here we describe the first case of small intestinal hemolymphangioma with bleeding in a 57-year-old woman.

Fragile X syndrome and epilepsy.

Fragile X syndrome (FXS) is one of the most prevalent mental retardations. It is mainly caused by the loss of fragile X mental retardation protein (FMRP). FMRP is an RNA binding protein and can regulate the translation of its binding RNA, thus regulate several signaling pathways.

Limbic epileptogenesis in a mouse model of fragile X syndrome.

Fragile X syndrome (FXS), caused by silencing of the Fmr1 gene, is the most common form of inherited mental retardation. Epilepsy is reported to occur in 20-25% of individuals with FXS. However, no overall increased excitability has been reported in Fmr1 knockout (KO) mice, except for increased sensitivity to auditory stimulation.