Publications by authors named "Li F"

A Moon-based Earth observation multispectral camera provides a unique perspective for observing large-scale Earth phenomena. This study focuses on the analysis of the field of view (FOV) for such a sensor. Unlike space-borne sensors, the analysis of the FOV for a Moon-based sensor takes into account not only Earth's maximum apparent diameter as seen from the lunar surface but also the Earth's and the solar trajectory in the lunar sky, as well as the pointing accuracy and pointing adjustment temporal intervals of the turntable.

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Predicting the remaining useful life (RUL) of mechanical bearings is crucial in the industry. Estimating the RUL enables the assessment of health bearing, maintenance planning, and significant cost reduction, thereby fostering industrial development. Existing models rely on traditional feature engineering with feature changes because operating conditions pose a major challenge to the generalization of RUL prediction models.

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This study aims to examine the variation in corrosion characteristics and tensile properties of WE43 magnesium alloy in an actual marine atmospheric environment by means of outdoor exposure tests. The macroscopic corrosion morphology, microstructure, and tensile properties were analyzed. The results indicated that WE43 alloy will corrode rapidly during exposure under marine atmospheric environmental conditions, resulting in a loose and porous Mg(OH) layer on the surface.

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This paper presents the establishment of a sensory evaluation system for purple sweet potato rice steamed sponge cake (PSPRSSC) utilizing fuzzy mathematics. Initially, eight key sensory evaluation indices were identified through expert consultations. These indices were subsequently prioritized using fuzzy binary comparison, resulting in the following order: aroma, taste, crust color, elasticity, viscosity, chewiness, hardness, and brightness.

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Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract which affects millions of individuals worldwide. Despite advancements in treatment options, there is increasing interest in exploring natural interventions with minimal side effects. Cruciferous vegetables, such as broccoli, cabbage, and radishes, contain bioactive compounds known as glucosinolates (GLSs), which have shown promising effects in alleviating IBD symptoms.

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Transcription Factors (TFs) are key regulators of how plants grow and develop. Among the diverse TF families, the Glabrous-enhancer binding protein (GeBP) family plays a key role in trichome initiation and leaf development. The specific roles of GeBP TFs in plants remain largely unexplored, although GeBP transcription factors play important roles in plants.

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Background: The global population's aging has led to an increasing demand for long-term care (LTC), especially in developing countries like China. Comprehensive assessment of LTC service demands by including the time and cost analysis is crucial to inform the planning and financing of LTC resources, yet such research is lacking in China. Our research team has developed a quantitative index system of the medical and nursing services needs of older adults (QISMNSNE) based on the framework of Time-Driven Activity-Based Costing (TDABC), providing a valuable tool for measuring LTC service needs.

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China National Health Commission issued an implementation plan for budget performance management in health projects in April 2021, which emphasizes all health projects must be evaluated in advance prior to implementation. The study aims to develop an ex-ante performance evaluation framework for health projects and formulate a self-assessment report template. The study also attempts to gain insights into the ex-ante performance of health projects in China, identify issues and explore the factors that influence the ex-ante performance of health projects and make suggestions about improvement strategies.

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Elucidation of post-translational modifications (PTMs), such as lysine acetylation (Kac), is crucial for understanding protein function and regulation. Although traditional experimental methods for identifying Kac sites are accurate, they are time-consuming and costly, leading to incomplete acetylome mapping. Computational approaches, particularly those incorporating machine learning, offer a rapid alternative, but face challenges owing to dataset imbalance, limited feature space, and the need for more effective feature-selection algorithms.

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Article Synopsis
  • Selenium-based nanoparticles (Se NPs) have antiviral properties, and this study investigates how different surface charges of these nanoparticles affect their interaction with herpes simplex virus 1 (HSV-1).
  • Three types of Se NPs (CTAB-Se, PVP-Se, and SDS-Se) were created with modified surface charges, leading to similar size and structure, but different binding capacities.
  • Among them, negatively charged SDS-Se showed the strongest antiviral activity against HSV-1, preventing viral proliferation and damaging normal cells, suggesting that surface charge engineering could enhance the effectiveness of Se NPs in fighting viral infections.
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Background: Veterans transitioning to civilian life often have chronic pain from service-related musculoskeletal disorders (MSD) with higher risk for substance misuse. Many seek VA (Department of Veterans Affairs) compensation for MSD. Use of Screening, Brief Intervention, and Referral to Treatment for Pain Management (SBIRT-PM) by VA Post-9/11 Military2VA (M2VA) case managers presents an opportunity to engage these veterans in VA pain care and address substance misuse.

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Providing self-powered energy for wearable electronic devices is currently an important research direction in the field of thermoelectric (TE) thin films. In this study, a simple dual-source magnetron sputtering method was used to prepare AgTe thin films, which exhibit good TE properties at room temperature, and the growth temperature and subsequent annealing process were optimized to obtain high-quality films. The experimental results show that films grown at a substrate temperature of 280 °C exhibit a high power factor (PF) of ~3.

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  • HOIP is an E3 ligase essential for the NF-κB signaling pathway and is linked to cancer and immune responses, presenting a challenge for selective targeting because of its conserved RBR domain.
  • Researchers identified four compounds that bind to a unique pocket in the PUB domain of HOIP, with tolfenamic acid being a key discovery due to its significant selectivity for this pocket.
  • By chemically linking tolfenamic acid with pomalidomide, they succeeded in degrading HOIP, thereby inhibiting NF-κB activation and growth in breast cancer cells, suggesting a new approach to target HOIP's nonfunctional pocket for therapeutic benefits.
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Ceramic capacitors, known for their exceptional energy-storage performance (ESP), are crucial components in high-pulsed power systems. However, their ESP is significantly constrained by breakdown strength (E), which is influenced by interfacial polarization. This study delves into the physics, characterization, and application of interfacial polarization.

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  • The study examines the impact of Kaplan fibers (KFs) and anterolateral ligament injuries on knee stability during acute ACL injuries, particularly analyzing the pivot-shift test results in both adults and adolescents.
  • It included 540 patients with ACL tears and found that while adults’ high-grade pivot shifts were mainly linked to anterolateral ligament disruption, adolescents’ were significantly associated with KF injuries.
  • The findings suggest that KF injuries in adolescents serve as substantial indicators for increased knee instability post-ACL injury, contrasting with adults where other factors are more influential.
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  • Coronary artery disease (CAD) is the leading cause of death globally, with familial hypercholesterolemia (FH) being a significant contributor to CAD risk.
  • This study analyzed the CAD risk in patients with high levels of low-density lipoprotein cholesterol (LDL-C), comparing those with FH to those without.
  • Among 223 participants, while FH gene mutation rates were similar in CAD and non-CAD groups, individuals with triple vessel disease (TVD) showed a higher prevalence of specific FH mutations, suggesting that mutations in key FH genes are linked to increased CAD severity.
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Foxtail millet is an important minor cereal crop rich in nutrients. Due to the small size of its seeds, there is little information on the diversity of its seed structure among germplasms, limiting the identification of genes controlling seed development and germination. This paper utilized X-ray computed tomography (CT) scanning technology and deep learning models to reveal the microstructure of foxtail millet seeds, gaining insights into their internal features, distribution, and composition.

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The feruloyl oligosaccharides (FOs) produced by the decomposition of plant hemicellulose have broad potential applications in the food and biomedical areas. FOs were prepared through the specific enzymatic degradation of insoluble dietary fiber from different sources by cell-free GH10 and GH11 xylanases. The cell-free GH10 and GH11 xylanases were obtained by the heterologous expression in Escherichia coli.

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Osteoarthritis (OA), a chronic joint disease characterized by primary or secondary degeneration of articular cartilage and bone dysplasia, is associated with various risk factors and is the leading cause of musculoskeletal pain and disability, severely impacting the quality of life. Growth hormone (GH), secreted by the anterior pituitary gland, is essential in mediating the growth and development of bone and cartilage. Reportedly, osteoarthritis increases, and the growth hormone decreases with age.

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  • TNG908 is a selective inhibitor of PRMT5, entering phase I/II trials for treating non-small cell lung cancer.
  • The study developed a UPLC-MS/MS method for detecting TNG908 in dog plasma, achieving high extraction efficiency and excellent linearity.
  • After administering TNG908 to dogs, results showed low clearance and moderate oral bioavailability, indicating potential for effective treatment.
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Diabetic retinopathy (DR) is a leading cause of blindness globally. Buyang Huanwu decoction (BHD) is a traditional Chinese medicine for treating DR, but its therapeutic mechanisms are not fully understood. This study aimed to elucidate and validate the underlying mechanisms of BHD in DR treatment through network pharmacology and in vitro experiments.

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Male infertility has become an important issue of global concern. Semen analysis is the cornerstone of male fertility assessment. External quality assessment (EQA) of sperm concentration, motility, and morphology is widely recognized in the world.

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CHD1 is a chromodomain-helicase DNA-binding protein that preferentially recognizes di- and trimethylated lysine 4 on histone H3 (H3K4me2/3). Genetic studies have established CHD1 as a synthetic lethal target in phosphatase and tensin homologue (PTEN)-deficient cancers. Despite this attractive therapeutic link, no inhibitors or antagonists of CHD1 have been reported to date.

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How to obtain heteroleptic mononuclear Cu(I) halide complexes with high quantum efficiency and short decay lifetime remains a challenge. Here, seven mononuclear four-coordinate Cu(I) halide complexes [CuX(DCzDP)(PPh)] (DCzDP = 1,2-bis(9-carbazolyl)-4,5-bis(diphenylphosphino)benzene, X = Br (1), Cl (2)), [CuX(DCzDP)(CzP)] (CzP = 9-methyl-3-(diphenylphosphino)carbazole, X = I (3), Br (4), Cl (5)) and [CuX(DCzDP)(DCzP)] (DCzP = bis(9-methyl-3-carbazolyl)phenylphosphine, X = I (6), Br (7)), were synthesized and their structures and photophysical properties were characterized. At room temperature, complexes 1-7 in the powder state emit a yellowish green to yellow green delayed fluorescence ( = 531-560 nm, = 0.

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