Protocadherin 17 weakens the lenvatinib resistance of liver cancer through inducing ferroptosis.

Lenvatinib has been employed in the treatment of advanced liver cancer; however, its clinical application is significantly impeded by frequent drug resistance. Recent studies have revealed that lenvatinib treatment triggers ferroptosis in liver cancer cells, providing a novel approach to addressing lenvatinib resistance. In this study, we initially validated the induction of ferroptosis by lenvatinib in liver cancer cells.

Prediction of pulmonary function decline in fibrous interstitial lung abnormalities based on quantitative chest CT parameters.

Background: Interstitial lung abnormalities (ILA) are a proposed imaging concept. Fibrous ILA have a higher risk of progression and death. Clinically, computed tomography (CT) examination is a frequently used and convenient method compared with pulmonary function tests.

Preparation of amorphous silicon-doped YO aerogel enabling nonlinear optical features for ultrafast photonics.

Amorphous aerogels with the microscopic nanoscale three-dimensional meshes provide superb platforms for investigating unique physicochemical properties. In order to enhance the physical, thermal and mechanical performances, one efficient and common approach is integrating diverse functional materials. Herein, we report a simple strategy to fabricate the amorphous silicon doped YO aerogels with the post-gelation method under the N/EtOH supercritical atmosphere.

Polarized, broadly tunable, 2.3 µm continuous-wave laser operation of Tm-vanadate crystals.

We report for the first time the polarized, broadly tunable, continuous-wave laser operation on the H → H transition in Tm-vanadate (Tm:REVO, RE = Gd, Y, Lu) crystals. Continuous wavelength tunings with tuning widths of about 200 nm were achieved in π-polarization for both the Tm:GdVO and Tm:YVO crystals. To the best of our knowledge, these tuning widths are broader than most previously reported values for wavelength tunable 2.

Sonodynamic therapy for intestinal obstruction caused by intestinal metastasis of bladder cancer: A case report.

This paper presents a case report of a patient with intestinal obstruction caused by intestinal metastasis of bladder cancer treated with sonodynamic therapy. Sonodynamic therapy is a novel anti-tumor therapy that is safe, effi- cacious, and has minimal side effects. After treatment, the patient's intestinal obstruction was effectively relieved.

Copper Functionalized SnSe Nanoflakes Enabling Nonlinear Optical Features for Ultrafast Photonics.

This study enhances the ultrafast photonics application of tin selenide (SnSe) nanoflakes via copper (Cu) functionalization to overcome challenges such as low conductivity and weak near-infrared (NIR) absorption. Cu functionalization enhances concentration, induces strain, and reduces the bandgap through Sn substitution and Sn vacancy filling with Cu ions. Demonstrated by density functional theory calculations and experimental analyses, Cu-functionalized SnSe exhibits improved NIR optical absorption and superior third-order nonlinear optical properties.

One-Step Fabrication of 0D CsPbBr Perovskite with Nonlinear Optical Properties for Ultrafast Pulse Generation.

Low-dimensional lead halide perovskites demonstrate remarkable nonlinear optical characteristics attributed to their distinctive physical structures and electronic properties. Nevertheless, the investigation into their nonlinear optical properties remains in its incipient stages. This study addresses this gap by precisely controlling solvent volumes to synthesize both 0D CsPbBr and CsPbBr/CsPbBr perovskites.

Ultrafast nonlinear optical response of layered violet phosphorus for femtosecond noise-like pulse generation.

As a new member of two-dimensional (2D) phosphorene, 2D layered violet phosphorus (VP) has unique optoelectronic properties and good environmental stability, showing its huge advantages in optoelectronic applications. In this paper, the ultrafast nonlinear optical (NLO) properties of layered VP nanosheets at 1 µm band were explored, which exhibit an obvious saturable absorption response with a modulation depth of ∼1.97%.

Crystal growth, polarized spectral properties, and 2.3 µm laser performance of Tm:LuVO crystal.

We report on the Czochralski crystal growth, polarized optical spectroscopy, and the first continuous-wave laser operation of 1.5 at.% Tm:LuVO crystal on the H → H transition.

Polarized spectral properties and 2.3 µm laser performance of the Tm:YVO crystal.

The polarized spectral properties and ∼2.3 µm high-power continuous-wave laser operation of Tm-doped yttrium orthovanadate crystal (Tm:YVO) are reported. For the H → H transition, the stimulated-emission cross-section σ is 1.

Enhanced Nonradiative Charge Recombination in Microfiber-Based Bismuthene.

After the first report of a graphene-based passive mode-locking ultrafast fiber laser, two-dimensional materials as efficient saturable absorbers offer a new horizon in ultrafast fiber laser. However, the interactions on atomic scale between these two-dimensional materials and fiber and the fiber effect on the carrier dynamics have not been realized. To figure out the exact role of fiber and the carrier dynamics affected by the fiber substrate related to ultrafast photonics, bismuthene, a newly reported 2D quantum material used in a passive mode-locking fiber laser, deposited on α-quartz has been investigated.

Diode-pumped Tm:YAP laser operating at 2.3 µm with enhanced performance through cascade lasing.

The laser diode (LD)-pumped Tm:YAP (a-cut, 3.5 at.%) laser generated a maximum ∼2.

Chinese expert consensus on imaging diagnosis of drug-resistant pulmonary tuberculosis.

Tuberculosis (TB) remains one of the major infectious diseases in the world with a high incidence rate. Drug-resistant tuberculosis (DR-TB) is a key and difficult challenge in the prevention and treatment of TB. Early, rapid, and accurate diagnosis of DR-TB is essential for selecting appropriate and personalized treatment and is an important means of reducing disease transmission and mortality.

Interobserver Agreement in Automatic Segmentation Annotation of Prostate Magnetic Resonance Imaging.

We aimed to compare the performance and interobserver agreement of radiologists manually segmenting images or those assisted by automatic segmentation. We further aimed to reduce interobserver variability and improve the consistency of radiomics features. This retrospective study included 327 patients diagnosed with prostate cancer from September 2016 to June 2018; images from 228 patients were used for automatic segmentation construction, and images from the remaining 99 were used for testing.

Six-watt diode-pumped Tm:GdVO laser at 2.29 µm.

A compact Tm:GdVO laser pumped by a 794 nm laser diode generated 6.09 W at 2.29 µm (H → H Tm transition) with a high slope efficiency of 30.

Determining rib fracture age from CT scans with a radiomics-based combined model: a multicenter retrospective study.

Objectives: We aimed to develop a combined model based on clinical and radiomic features to classify fracture age.

Methods: We included 1219 rib fractures from 239 patients from our center between March 2016 and September 2022. We created an external dataset using 120 rib fractures from 32 patients from another center between October 2019 and August 2023.

Diode-pumped efficient high-power cascade Tm:GdVO laser simultaneously operating at ∼2 μm and ∼2.3 μm.

The laser diode (LD)-pumped efficient high-power cascade Tm:GdVO laser simultaneously operating on the F → H (at ∼2 μm) and H → H (at ∼2.3 μm) Tm transition was first reported in this paper. The cascade Tm:GdVO laser generated a maximum total continuous-wave (CW) laser output power of 8.

Optical absorption of bismuthene with a single vacancy: first-principle calculations.

The exceptional mechanical, electronic, topological, and optical properties, make bismuthene an ideal candidate for various applications in ultrafast saturation absorption and spintronics. Despite the extensive research efforts devoted to synthesizing this material, the introduction of defects, which can significantly affect its properties, remains a substantial obstacle. In this study, we investigate the transition dipole moment and joint density of states of bismuthene with/without single vacancy defect via energy band theory and interband transition theory.

Tm:CALGO lasers at 2.32 µm: cascade lasing and upconversion pumping.

We report on the first laser operation of a disordered Tm:CaGdAlO crystal on the H → H transition. Under direct pumping at 0.79 µm, it generates 264 mW at 2.

To Assess the Role of microRNA-451 in the Progression and Metastasis of Colorectal Cancer.

The study aimed to determine the expression of miR451 in colorectal cancer (CRC) subjects with CRC cells, and the role of miR451 in colorectal cancer cells. In October 2020, ATC purchased CRC and normal mucosal cell lines of CRC and implanted them in DMEM with 10% fetal serum. The suitability of the HT29 cell line is verified using the STR profile.

Watt-level diode-pumped Tm:YVO laser at 2.3 µm.

In this Letter, a watt-level laser diode (LD)-pumped ∼2.3-µm (on the H→H quasi-four-level transition) laser is reported based on a 1.5 at.