Polar Magnetism Above 600 K with High Adaptability in Perovskite Oxides.

High magnetic order temperature, sustainable polar insulating state, and tolerance to device integrations are substantial advantages for applications in next-generation spintronics. However, engineering such functionality in a single-phase system remains a challenge owing to the contradicted chemical and electronic requirements for polar nature and magnetism, especially with an ordering state highly above room temperature. Perovskite-related oxides with unique flexibility allow electron-unpaired subsystems to merge into the polar lattice to induce magnetic interactions, combined with their inherent asymmetry, thereby promising polar magnet design.

Self super-resolution autostereoscopic 3D measuring system using deep convolutional neural networks.

Autostereoscopy technology can provide a rapid and accurate three-dimensional (3D) measurement solution for micro-structured surfaces. Elemental images (EIs) are recorded within one snapshot and the measurement accuracy can be quantified from the disparities existing in the 3D information. However, a trade-off between the spatial and the angular resolution of the EIs is a major obstacle to the improvement on the measurement results.

PTEN is recognized as a prognostic-related biomarker and inhibits proliferation and invasiveness of skull base chordoma cells.

Objective: This work aimed to examine the function of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) in skull base chordoma (SBC) at the clinical and cellular levels.

Methods: Totally 65 paraffin-embedded and 86 frozen specimens from 96 patients administered surgery were analyzed. Immunohistochemical staining and quantitative real-time polymerase chain reaction were performed, and the associations of PTEN expression with clinical features were assessed.

A novel hollow microsphere composite MnOx/PAA: effective catalyst for ozone decomposition at high humidity.

Ozone air pollution poses a serious threat to human health and ecological environment. Manganese oxide (MnOx) is a popular material for ozone decomposition with excellent catalytic performance. However, the catalytic activity may be reduced under high-humidity conditions because of oxygen vacancy of MnOx from the water evaporation.

Surface-enhanced Raman spectroscopy for environmental monitoring using gold clusters anchored on reduced graphene oxide.

Surface-enhanced Raman spectroscopy is a strong and sensitive analysis tool that can realize single-molecule level detection and provide the fingerprint information of molecules, which has been widely applied in analysing chemistry and biomolecules and monitoring environment. However, it is still a challenge to design and prepare SERS substrates with high enhancement factor, simple synthesis, stability and reproducibility. Here, we synthesized gold clusters anchored on reduced graphene oxide (Au clusters@rGO) using co-reduction method to achieve high SERS enhancement.

Enteral nutrition for children with acute leukemia-related pancreatitis.

Objective: Pancreatitis in children with acute lymphoblastic leukemia and acute myeloid leukemia may cause discontinuation of chemotherapy, thus adversely affecting treatment outcomes. Enteral nutrition (EN) is recommended for acute pancreatitis. The optimal use of EN for leukemia-related pancreatitis is under debate.

Nomogram for predicting an individual prospective hemorrhage risk in untreated brainstem cavernous malformations.

Objective: In this study, the authors aimed to create a nomogram for precisely predicting the 5-year prospective hemorrhage risk in brainstem cavernous malformations (BSCMs).

Methods: Patients with confirmed BSCMs in a single-center prospective observational series from January 2012 to December 2016 were included in the present study for nomogram building and validation. The concordance index (C-index), calibration curves, and decision curve analysis were used to evaluate the predictive accuracy, discriminative ability, and clinical usefulness of the nomogram.

Applying the Properties of Neurons in Machine Learning: A Brain-like Neural Model with Interactive Stimulation for Data Classification.

Some neural models achieve outstanding results in image recognition, semantic segmentation and natural language processing. However, their classification performance on structured and small-scale datasets that do not involve feature extraction is worse than that of traditional algorithms, although they require more time to train. In this paper, we propose a brain-like neural model with interactive stimulation (NMIS) that focuses on data classification.

Acute exercise in ozone-polluted air induces apoptosis in rat quadriceps femoris muscle cells via mitochondrial pathway.

Ozone (O) pollution can decrease sport performance and induce respiratory toxicity, but relatively few studies have investigated its effects on skeletal muscles. We randomly assigned rats to the following groups based on a 2 ​× ​4 two-factor factorial design: Air+0, Air+10, Air+15, and Air+20, O+0, O+10, O+15, and O+20. The rats in the +0 groups rested, whereas those in the +10, +15, and +20 groups ran on a treadmill (in clean air for Air groups and in air polluted with 0.

Effects of Bacillus subtilis natto JLCC513 on gut microbiota and intestinal barrier function in obese rats.

Aims: This study aimed to investigate the effects of Bacillus subtilis natto JLCC513 (JLCC513) on gut microbiota, inflammation and intestinal barrier function in high-fat-diet (HFD) rats.

Methods And Results: Sprague-Dawley (SD) rats were fed HFD for 16 weeks, and treated with JLCC513 in 9th week. The oral administration of JLCC513 decreased body weight and reduced the inflammation level in HFD rats.

Indoor Positioning System with UWB Based on a Digital Twin.

Ultra-wideband (UWB) technology is used for indoor positioning, but its positioning accuracy is usually degenerated by various obstacles in the indoor environment because of non-line-of-sight (NLOS). Facing the complex and changeable indoor environment, an indoor positioning system with UWB based on a digital twin is presented in this paper. The indoor positioning accuracy is improved with a perception-prediction feedback of cyber-physics space in this indoor positioning system.

RING-finger E3 ligases regulatory network in PI3K/AKT-mediated glucose metabolism.

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway plays an essential role in glucose metabolism, promoting glycolysis and resisting gluconeogenesis. PI3K/AKT signaling can directly alter glucose metabolism by phosphorylating several metabolic enzymes or regulators of nutrient transport. It can indirectly promote sustained aerobic glycolysis by increasing glucose transporters and glycolytic enzymes, which are mediated by downstream transcription factors.

Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of pancreatic cancer.

Pancreatic cancer is one of the leading causes of cancer-related mortality in both developed and developing countries. The incidence of pancreatic cancer in China accounts for about a quater of the global incidence, and the epidemiological characteristics and therapeutic strategies differ due to social, economic, cultural, environmental, and public health factors. Non-domestic guidelines do not reflect the clinicopathologic characteristics and treatment patterns of Chinese patients.

Organo/Silver Dual Catalytic (3 + 2)/Conia-Ene Type Cyclization: Asymmetric Synthesis of Indane-Fused Spirocyclopenteneoxindoles.

Developing efficient strategies to synthesize spirocyclopenteneoxindoles is an attractive target due to their potential biological activity. This work described the thiourea/silver dual catalytic (3 + 2)/Conia-ene type reaction of 2-(2-oxoindolin-3-yl)malononitrile with -ethynyl substituted nitrostyrene. The reaction features mild conditions and good atom- and step-economy.

Membrane-camouflaged supramolecular nanoparticles for co-delivery of chemotherapeutic and molecular-targeted drugs with siRNA against patient-derived pancreatic carcinoma.

Pancreatic cancer remains one of the most lethal malignancies worldwide. The combination of the first-line standard agent gemcitabine (GEM) with the molecular-targeted drug erlotinib (Er) has emerged as a promising strategy for pancreatic cancer treatment. However, the clinical benefit from this combination is still far from satisfactory due to the unfavorable drug antagonism and the fibrotic tumor microenvironment.

Enclosure in Combination with Mowing Simultaneously Promoted Grassland Biodiversity and Biomass Productivity.

Grassland is the primary land use in China, which has experienced extensive degradation in recent decades due to overexploitation. Here, we conducted field experiments to quantify the degraded grassland's recovery rate in Northeast Inner Mongolia in response to restoration measures, including fallow + enclosure (FE) and mowing + enclosure (ME) in comparison to livestock grazing (LG), since 2005. Plant community properties were surveyed and aboveground biomass (AGB) sampled in summer 2013.

Screening of Prognostic Markers for Hepatocellular Carcinoma Patients Based on Multichip Combined Analysis.

Methods: GSE (14520, 36376, 57957, 76427) datasets were accessed from GEO database. 55 differential mRNAs (DEGs) were obtained by differential analysis based on the datasets. GO and KEGG analysis results indicated that the DEGs were enriched in xenobiotic metabolic process and other pathways.

Identification of a Seven-Differentially Expressed Gene-Based Recurrence-Free Survival Model for Melanoma Patients.

Melanoma is a malignant tumor that originates in melanocytes of the skin or mucous membrane, which has a high mortality rate and worse prognosis. Therefore, perspective prognosis evaluation seems more important for patients' treatment. Gene expression profiles of melanoma were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, respectively.

Molecular characteristics, sources and environmental risk of aromatic compounds in particulate matter during COVID-2019: Nontarget screening by ultra-high resolution mass spectrometry and comprehensive two-dimensional gas chromatography.

Aromatic compounds, including many polycyclic aromatic hydrocarbons (PAHs), are suspected carcinogens and may originate from different sources. To investigate the impact of anthropogenic emission reductions on unknown aromatic compounds in particulate matter, we collected samples during the pre-COVID period in 2020, the COVID-19 lockdown period in 2020, and the same period as the lockdown in 2019. Besides the 16 PAHs, other aromatic compounds were analyzed by Fourier transform ion cyclotron resonance mass spectrometry and comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry.

Ovarian reserve and IVF outcomes in patients with inflammatory bowel disease: A systematic review and meta-analysis.

Background: Inflammatory bowel disease (IBD) mainly affects people during reproductive age. However, it is unclear whether IBD might be associated with impaired ovarian reserve in female patients or with in vitro fertilization (IVF) outcomes.

Methods: This systematic review and meta-analysis included articles from inception to May, 2022.

China rheumatoid arthritis registry of patients with Chinese medicine (CERTAIN): Rationale, design, and baseline characteristics of the first 11,764 enrollees.

Background: Chinese medicine (CM) has become a popular interventional treatment for rheumatoid arthritis (RA). However, limited knowledge about general characteristics and long-term clinical outcomes hampers the development of CM for RA.

Purpose: The main objectives of the China Rheumatoid Arthritis Registry of Patients with Chinese Medicine (CERTAIN) were to describe the population of RA patients receiving CM treatment in multiple centers in China using different variables and compare these findings with internationally reported data.

Identification of novel candidate biomarkers and immune infiltration in polycystic ovary syndrome.

Background: In this study, we aimed to identify novel biomarkers for polycystic ovary syndrome (PCOS) and analyze their potential roles in immune infiltration during PCOS pathogenesis.

Methods: Five datasets, namely GSE137684, GSE80432, GSE114419, GSE138518, and GSE155489, were obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were selected from the train datasets.

Effects of different bypass surgeries on LSA revascularization in patients with left subclavian occlusion.

Introduction: Left subclavian artery (LSA) bypass surgery is mainly carried out for patients with severe left subclavian occlusion. This article aimed to evaluate the hemodynamic effects of different surgical bypass modes on LSA revascularization.

Methods: Three-dimensional models of the aorta were reconstructed from CTA images of a patient with LSA occlusion, a patient with type B aortic dissection with LSA coverage during thoracic endovascular aortic repair, and a healthy 74-year-old man, resulting in six modes for each person: healthy LSA mode, LSA occlusion mode and four bypass modes.

Dynamic Instance Domain Adaptation.

Most existing studies on unsupervised domain adaptation (UDA) assume that each domain's training samples come with domain labels (e.g., painting, photo).