Publications by authors named "Li Chun-Yu"

Ethnopharmacological Relevance: The Bu Shen Yi Sui capsule (BSYS), a modified version of the classical Chinese medicine formula Liu Wei Di Huang pill, has demonstrated therapeutic efficacy in the treatment of multiple sclerosis (MS). Nevertheless, the precise mechanism through which BSYS facilitates remyelination remains to be elucidated.

Aim Of The Study: This research investigates the role and potential mechanisms of BSYS-modified exosomes (exos) derived from bone marrow mesenchymal stem cells (BMSCs) in promoting remyelination in a cuprizone (CPZ)-induced demyelination model in mice.

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  • Mismatch repair (MMR) deficiency can lead to diseases like constitutional mismatch repair deficiency (CMMRD) syndrome and Lynch syndrome (LS), both linked to various tumors, including brain cancers, mainly affecting adults but with some pediatric cases.
  • A study from hospitals in Hong Kong identified five patients with MMR gene mutations, revealing that four had CMMRD syndrome with various brain tumors and one had LS associated with a medulloblastoma at age 10.
  • The study noted that all CMMRD patients had café-au-lait macules (CALMs) since birth, and highlighted the challenges in diagnosing CMMRD due to similarities with other syndromes, emphasizing the need for better clinical differentiation of CALM-related genetic
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Gut microbial bile salt hydrolases (gmBSHs), an important class of bacteria-produced cysteine hydrolases, play a crucial role in bile acid metabolism. Modulating the total gmBSH activity is a feasible way for ameliorating some metabolic diseases including colorectal cancer, type 2 diabetes, and obesity. This study reported the discovery and characterization of a botanical compound as a covalent -inhibitor of gmBSHs.

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This study compares how a modified distributed Bragg reflector (DBR) and yellow color filter (Y-CF) increase the color purity, viewing angle, and brightness of the quantum dot color conversion layer (QDCC) for micro-LED displays. We designed and built a 53-layer high-performance modified DBR with almost total blue leakage filtering (T %: 0.16 %) and very high G/R band transmittance (T %: 96.

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As China strives to balance rapid urbanization with environmental conservation, increasing attention is being paid to the pursuit of green production efficiency (GPE) in the real estate industry. The undesirable super-SBM model was used to calculate the GPE of China's real estate industry from 2001 to 2020. Additionally, GPE spatial distribution characteristics in China's real estate industry were analyzed using the standard deviation ellipse (SDE), Moran's index, Theil index, random kernel density estimation (RKDA), and spatial Markov chain (SMC) methods.

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  • Chinese patent medicines with Epimedii Folium and Psoraleae Fructus have been linked to idiosyncratic drug-induced liver injury (IDILI), but the specific toxic biomarkers and mechanisms are not well understood.
  • The study focused on the effects of bavachin and epimedin B from these plants on liver injury models induced by TNF-α, using both in vitro (cell cultures) and in vivo (mice) methods to measure liver damage.
  • Results indicated that combining bavachin and epimedin B exacerbated liver injury in TNF-α treated mice, shown by increased liver enzyme levels (ALT and AST) and inflammation, along with distinctive metabolites identified through metabolomics analysis.
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The oxygen saturation index (OSI), defined by FO/SO multiplied by the mean airway pressure, has been reported to exceed the Berlin definition in predicting the mortality of acute respiratory distress syndrome (ARDS). The OSI has served as an alternative to the Berlin definition in categorizing pediatric ARDS. However, the use of the OSI for the stratification of adult ARDS has not been reported.

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Background And Aim: Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG repeats expansion. Cognitive decline contributes to the loss of daily activity in manifest HD. We aimed to examine the cognition status in a Chinese HD cohort and explore factors influencing the diverse cognitive domains.

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Perilla (Perilla frutescens) is a potential specific oilseed crop with an extremely high α-linolenic acid (ALA) content in its seeds. AP2/ERF transcription factors (TFs) play important roles in multiple biological processes. However, limited information is known about the regulatory mechanism of the AP2/ERF family in perilla's oil accumulation.

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The global economic growth is hindered by resources shortage, energy demand, air pollution and climate. Energy efficiency can reduce some pollutants while potentially increase others. This study refers to sulfur dioxide (SO), nitrogen oxides (NO), and dust and smoke (DS) as primary pollutants to distinguish it from secondary ones.

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Cytochrome P450 3A4 (CYP3A4) is a key xenobiotic-metabolizing enzyme-mediated drug metabolism and drug-drug interaction (DDI). Herein, an effective strategy was used to rationally construct a practical two-photon fluorogenic substrate for hCYP3A4. Following two-round structure-based substrate discovery and optimization, we have successfully constructed a hCYP3A4 fluorogenic substrate () with desirable features, including high binding affinity, rapid response, excellent isoform specificity, and low cytotoxicity.

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Orbital angular momentum (OAM) conservation plays an important role in shaping and controlling structured light with nonlinear optics. The OAM of a beam originating from three-wave mixing should be the sum or difference of the other two inputs because no light-matter OAM exchange occurs in parametric nonlinear interactions. Here, we report anomalous OAM transfer in parametric upconversion, in which a Hermite-Gauss mode signal interacts with a specially engineered pump capable of astigmatic transformation, resulting in Laguerre-Gaussian mode sum-frequency generation (SFG).

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Objectives: To study the early clinical efficacy of combined therapy of stage 4 neuroblastoma.

Methods: A retrospective analysis was performed on the medical data and follow-up data of 14 children with stage 4 neuroblastoma who were diagnosed in Hong Kong University-Shenzhen Hospital from January 2016 to June 2021.

Results: The median age of onset was 3 years and 7.

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Background: The current surveillance system only focuses on notifiable infectious diseases in China. The arrival of the big-data era provides us a chance to elaborate on the full spectrum of infectious diseases.

Methods: In this population-based observational study, we used multiple health-related data extracted from the Shandong Multi-Center Healthcare Big Data Platform from January 2013 to June 2017 to estimate the incidence density and describe the epidemiological characteristics and dynamics of various infectious diseases in a population of 3,987,573 individuals in Shandong province, China.

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Bile salt hydrolases (BSHs), a group of cysteine-hydrolases produced by gut microbes, play a crucial role in the hydrolysis of glycine- or taurine-conjugated bile acids and have been validated as key targets to modulate bile acid metabolism. This study aims to discover one or more efficacious inhibitors against a BSH produced by (lsBSH) from natural products and to characterize the mechanism of the newly identified BSH inhibitor(s). Following screening of the inhibition potentials of more than 100 natural compounds against lsBSH, amentoflavone (AMF), a naturally occurring biflavone isolated from various medicinal plants, was discovered to be an efficacious BSH inhibitor (IC = 0.

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A total of 33 pesticides have been banned from Chinese medicinal materials and decoction pieces(plants) according to Chinese Pharmacopoeia(2020 edition). According to the chemical structures, they are mainly divided into seven categories: organophosphorus compounds, organochlorines, carbamates, amidines, sulfonylureas, phenylpyrazoles, and ethers. These banned pesticides exhibit neurotoxicity, reproductive toxicity, immune system toxicity, teratogenicity, carcinogenesis, and mutagenesis, seriously damaging human and animal health.

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Human activity recognition without equipment plays a vital role in smart home applications, freeing humans from the shackles of wearable devices. In this paper, by using the channel state information (CSI) of the WiFi signal, semi-supervised transfer learning with dynamic associate domain adaptation is proposed for human activity recognition. In order to improve the CSI quality and denoising of CSI, we carried out missing packet filling, burst noise removal, background estimation, feature extraction, feature enhancement, and data augmentation in the data pre-processing stage.

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  • * The research identified 155 patients with rare pathogenic variants linked to ALS, with specific genes showing a higher mutation frequency and certain variants associated with increased disease risk and poor prognosis.
  • * Findings indicate that understanding ALS genetics in diverse populations, like those in China, can inform genetic testing strategies and enhance the evaluation of disease outcomes.
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  • The study investigates the connection between TRIM family proteins and Parkinson's disease, particularly focusing on early-onset cases in a Chinese cohort.
  • Researchers identified 123 rare genetic variants across multiple TRIM proteins, linking some variants to an increased risk of Parkinson's disease.
  • The findings highlight TRIM24 as a potential risk gene, enhancing the understanding of genetic factors in early-onset Parkinson's disease and expanding the spectrum of known mutations.
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Objective: To observe the effect of electroacupuncture(EA) at "Zusanli"(ST36), "Yinlingquan" (SP9) or "Yingu"(KI10) on the expression of 5-hydroxytryptamine type 7 receptor (5-HT7R) in the gastric antrum and colon tissues in functional diarrhea (FD) model rats, so as to explore its mechanisms underlying improving FD.

Methods: Forty male SD rats were randomly divided into control, model, ST36, SP9 and KI10 groups,with 8 rats in each group. The FD model was established by combined administration of restriction (four-limbs' banding) + abdominal cold stimulation + feeding every other day, for 14 days.

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The worldwide prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, and this metabolic disorder has been recognized as a severe threat to human health. A variety of chemical drugs have been approved for treating NAFLD, however, they always has serious side effects. Chinese herbal medicines (CHMs) have been widely used for preventing and treating a range of metabolic diseases with satisfactory safety and effective performance in clinical treatment of NAFLD.

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Three new flavonoid glycosides, embeliaflavosides A-C (), together with eight known flavonoid glycosides (), were isolated from the fruits of . Their structures were established based on the analyses of spectroscopic data. Compounds were evaluated for antioxidant and -glucosidase inhibitory activities.

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The aim of this study was to explore the clinical features, pathological characteristics, and the prognosis of children with microscopic polyangiitis (MPA). Ten children with MPA that were hospitalized in our hospital were included in this study. The children's pre-diagnosis status, clinical manifestations, renal pathology, treatment, and prognosis data were analyzed retrospectively.

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  • Yolk sac tumors in adults are extremely rare, with only six documented cases in the nasal cavity and paranasal sinuses, often linked to other cancers.
  • A case study of a 55-year-old man showed a nasal tumor with characteristics of pure YST, but further testing revealed a diagnosis of INI-1-deficient carcinoma with YST features.
  • The patient had surgery and radiotherapy, displaying no signs of recurrence at the 6-month follow-up, highlighting the diagnostic complexity of similar tumors in adults.
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