The effect of modified polymer on the change rule of physical properties of different gradation coal gangue.

In this study, in order to improve the water retention of coal gangue matrix and accelerate the recovery of frozen soil layer in mining area, three different particle size gradations of coal gangue and modified polymer SAP (0.0, 0.1, 0.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

Engineering Aqueous Electrolytes with Vicinal S-based Organic Additives for Highly Reversible Zinc-Ion Batteries.

The commercial deployment of Aqueous Zinc Ion Batteries (AZIBs) is hampered by dendrites, the hydrogen evolution reaction (HER) and corrosion reactions. To tackle these challenges, we have introduced 3,3'-dithiobis-1-propanesulfonic acid disodium salt (SPS), a symmetrical sulfur-based organic salt, as an electrolyte additive for AZIBs. Unlike conventional electrolyte additives that favour (002) deposition, SPS enables dense (100) growth through a unique symmetrically aligned concentration-controlled adsorption network, affording structural uniformity and compactness to the Zn deposit layer.

Efficacy of Linaclotide in Functional Dyspepsia and Constipation-Predominant Irritable Bowel Syndrome Overlap: A Randomized Trial.

Background And Aim: Linaclotide is effective in relieving constipation-predominant irritable bowel syndrome symptoms. However, few studies focus on the efficacy of linaclotide for overlapping symptoms of functional dyspepsia among irritable bowel syndrome patients. This study aimed to assess the efficacy of linaclotide compared with lactulose in patients with functional dyspepsia and constipation-predominant irritable bowel syndrome overlap.

Artificial Intelligence Screening Tool for Obstructive Sleep Apnoea: A Study Based on Outpatients at a Sleep Medical Centre.

Purpose: Due to the lack of clear screening guidelines for different populations, identify strategies for obstructive sleep apnea (OSA) in the outpatient population are unclear, a large number of potential OSA outpatients have not been identified in time. The purpose of our study was to evaluate the applicability and accuracy of artificial intelligence sleep screening in outpatients and to provide a reference for OSA screening in different populations.

Methods: A type IV wearable artificial intelligence sleep monitoring (AISM) device was used to screen adults in the sleep clinic of the Sleep Medical Center for OSA screening, and the general demographic data of the patients were collected.

Screening for Safe and Efficient Strains with Functions of Lowering Blood Lipids, Blood Glucose, and Blood Pressure.

is a fungus widely used in food fermentation. This study employed microbial technology, combined with microscopic morphological observations and ITS sequence analysis, to isolate, purify, and identify 10 strains of red yeast mold from various products. After the HPLC detection of metabolic products, the M8 strain containing the toxic substance citrinin was excluded.

Upcycling waste commodity polymers into high-performance polyarylate materials with direct utilization of capping agent impurities.

Commodity polymers are ubiquitous in our society, having replaced many inorganic and metal-based materials due to their versatile properties. However, their functionality heavily relies on the addition of various components known as additives, making it challenging to recycle the polymer fraction of plastic materials effectively. Thus, it is crucial to develop efficient chemical recovery strategies for commodity polymers and additives to facilitate the direct utilization of recovered monomers and additives without additional purification.

Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy.

Few studies have reported an association between intrahepatic cholestasis of pregnancy (ICP) and preconception exposure to PM and sunlight duration, but there has been no in-depth analysis of the correlation between ICP and different constituents of PM. Thus, we performed this retrospective analysis among 160,544 pregnant women who delivered between 2014 and 2020, to further estimate the impact of different constituents of PM, as well as the duration of sunlight, on ICP via generalized linear models. During the three months prior to conception, the adjusted odds ratios (aORs) for ICP were 1.

PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC.

This study unveils PKM2 as a master metabolic coordinator in triple-negative breast cancer (TNBC), governing the glycolysis-lipolysis balance through the AMPK/KLF4/ACADVL axis. We demonstrate stage-specific PKM2 upregulation in TNBC, with CRISPR/Cas9 knockout inducing dual metabolic reprogramming-suppressed glycolysis and activated lipid catabolism. Mechanistically, PKM2 ablation triggers AMPK-dependent nuclear translocation of KLF4, which directly activates ACADVL (mitochondrial β-oxidation rate-limiting enzyme), explaining lipid droplet depletion.

Causal Relationship Between Intelligence, Noncognitive Education, Cognition and Urinary Tract or Kidney Infection: A Mendelian Randomization Study.

Background: The occurrence of urinary tract or kidney infection is correlated with intelligence, noncognitive education and cognition, but the causal relationship between them remains uncertain, and which risk factors mediate this causal relationship remains unknown.

Methods: The intelligence (n=269,867), noncognitive education (n=510,795) and cognition data (n=257,700) were obtained from genome-wide association studies (GWAS) conducted in individuals of European ethnicities. The genetic associations between these factors and urinary tract or kidney infection (UK Biobank, n=397,867) were analyzed using linkage disequilibrium score regression.

Revisiting the Treatment Algorithm for Atlantoaxial Dislocation after 10 Years: A Multi-center Study with Mid-to-long-term Follow-up.

Study Design: A multi-center retrospective cohort study.

Objective: To overcome the limitations of former single-center strategy studies, an updated classification guiding surgical management of Atlantoaxial dislocation (AAD) is proposed in this study based on a large multi-center retrospective cohort study with mid-to-long-term follow-up.

Summary Of Background Data: AAD is the most prevalent disorder affecting the cranio-vertebral junction, often leading to myelopathy and impairment of cranial nerve function, which can result in significant morbidity or even mortality.

A label-free colorimetric assay for sensitive screening of T4 polynucleotide kinase activity and inhibition based on enzyme-aided cyclic strand displacement amplification and PNA-gold nanoparticle platform.

The phosphorylation of nucleic acids mediated by 5'-polynucleotide kinase (PNK) exerts a crucial regulatory function in a wide range of significant cellular activities. Nevertheless, the current approaches for detecting PNK require expensive labeled probes and complex instrumentation, making it impossible to achieve real-time, on-site, and rapid analysis. Here, we take T4 PNK as a model and establish a novel colorimetric strategy for the detection of PNK activity and its inhibition by means of a coupled enzyme-assisted cyclic strand displacement amplification (SDA) and peptide nucleic acid (PNA)-gold nanoparticle (AuNP) based platform.

Prognostic analysis of esophageal cancer patients after neoadjuvant therapy.

Background: Neoadjuvant therapy is widely used for esophageal cancer (EC), but optimal treatment regimens and predictive factors for outcomes remain unclear. This study retrospectively analyzed data from EC patients who underwent neoadjuvant therapy.

Methods: The or was utilized to examine differences in general clinicopathological data between treatment benefit groups.

Improving dietary energy and antioxidative properties benefit early maternal BMI and further manage adverse pregnancy outcomes with better weight gain.

Dietary characteristics affect maternal status in early pregnancy, which is important for later outcomes. However, Chinese dietary guidelines for pregnant women are not specific to obesity, overweight, and underweight. Moreover, since pregnancy is a prolonged process, an intermediate factor is needed to connect early maternal BMI with pregnancy outcomes.

Effective mechanism of polysaccharides from Erxian herbal pair in promoting bone repair in traumatic osteomyelitis by activating osteoblast GPR41 and inhibiting the MEK/ERK/MAPK signalling axis.

Polysaccharides are the key components of natural products; however, their effects on bone repair haven't been fully evaluated. This study aimed to assess the efficacy and mechanism of polysaccharides in promoting bone repair. The Erxian herb pair polysaccharide (EHP) was isolated and purified using water extraction (1:20 (w/v); 100 ± 2 °C; 5 h) and alcohol precipitation (80 ± 2 %).

Effect of different natural antioxidants on the quality promotion of pork chip snacks during storage as revealed by lipid profiles and volatile flavor compounds.

This study primarily investigated the effects of different natural antioxidants (ascorbic acid, rosemary extract, PostbioYDFF-3®, and NatuProtec®) on changes in the lipid profiles and volatile flavors of pork chip snacks (PCS) during storage via lipidomic techniques and SPME-GC-MS. Compared with the control, the PCS containing different natural antioxidants exhibited obvious reductions in TBARS, peroxide, and acid values after 90-day storage (P < 0.05).

Online PGC-LC-MS analysis of colonic mucin O-glycans in ovalbumin-induced food allergy in Balb/c mice by treatment with sea cucumber chondroitin sulfate polysaccharide.

The highly sulfated polysaccharide sea cucumber chondroitin sulfate (SCCS) can alleviate intestinal damage and display strong anti-food-allergic activity. The O-glycopattern levels in colonic mucin are closely related to the its protective effect on function of the intestinal barrier. However, the effect of the SCCS on colonic mucin O-glycan has not been investigated.

The effect of pressure on the mechanical properties of hydroxyl-terminated polybutadiene-based propellants.

Context: In order to estimate the mechanical behavior of the propellant under working pressures, the effect of pressure on the mechanical properties of hydroxyl-terminated polybutadiene (HTPB) propellants was studied by analyzing the uniaxial tensile strength and maximum strain master curves under the test conditions of - 20 ~ 70 °C, 0.5 mm/min ~ 500 mm/min with different pressures from 0 to 10 MPa. The results show that the master curves for tensile strength are obviously affected by the pressure in the range of 0.

The role of the PKCζ/JNK signaling pathway in regulating the development of femoral head necrosis.

Osteonecrosis of the femoral head (ONFH) is a debilitating condition characterized by the death of bone cells in the hip joint, resulting in profound disability. This condition has a significant global prevalence. Glucocorticoid (GC)-induced apoptosis of bone cells serves as a crucial cellular mechanism underlying ONFH.

Steric Inhibition by Butyryl Groups on Gut Microbial Amylases Significantly Impacts Fecal Fermentation of Butyrylated Starch.

Colonic starch fermentation requires the assistance of gut microbial amylases (GMAs). However, it remains unknown whether chemically substituted butyryl groups induce a steric inhibitory effect on GMAs analogous to that observed with pancreatic amylase during the intestinal digestion of butyrylated starch. In this study, we investigated the fermentation and enzymatic hydrolysis performance of three types of butyrylated starch.

Microbial adhesion behavior and participation of adhered and planktonic microorganisms in anaerobic digestion of leaf, epidermis, pith from corn stalk.

This study presents deep insights into the microbial adhesion and community dynamics of adhered and planktonic microorganisms during the anaerobic digestion (AD) of leaf, epidermis, and pith of corn stalk (CS). Microbial adhesion regularity varied with the part of CS. Overall, hydrolytic bacteria (Ruminofilibacter xylanolyticus, uncultured Bacteroidetes bacteria RII-AN097, uncultured Prolixibacteriaceae bacteria, Proteiniphilum sp.

Importance of starch chain-length distribution in determining starch digestibility through affecting short- and long-range intermolecular interactions during retrogradation.

Starch retrogradation involves both short- and long-range intermolecular interactions, while their relations with starch chain-length distribution (CLD) and digestibility are less clear. To address this, 9 types of starches with distinct CLDs were analyzed for intermolecular interactions and digestibility over 7 days of retrogradation. Wheat starch exhibited a higher ratio of long-range intermolecular interactions, while pea, mung bean, potato, sweet potato, lentil, and corn starch formed more short-range intermolecular interactions.

Spontaneous Anionic Double Capture/Displacement to Trigger Single-Ion Conducting Interpenetrating Polymer Networks with Desired Ionic Conductivity for Durable Zn Metal Batteries.

The engineering of single-ion conductors (SICs) is a promising strategy to stabilize the anode/electrolyte interface in zinc-ion batteries. However, the commonly employed single-ion conductive solid or quasi-solid electrolytes often lead to a significant reduction in overall ionic conductivity, thereby impeding ion diffusion kinetics. Here, we propose a compromise strategy that effectively balances ionic conductivity and ion transference number.

EEG-based Emotion Recognition using Graph Attention Network with Dual-Branch Attention Module.

EEG reveals human brain activities for emotion and becomes an important aspect of affective computing. In this study, we developed a novel approach, namely DAM-GAT, which incorporated a dual-branch attention module (DAM) into a graph attention network (GAT) for EEG-based emotion recognition. This method used the GAT to capture the local features of emotional EEG signals.

3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression.

Colorectal carcinoma (CRC) is a deadly cancer with an aggressive nature, and how CRC tumor cells manage to translocate and proliferate in a new tissue environment remains not fully understood. Recently, higher-order chromatin structures and spatial genome organization are increasingly implicated in diseases including cancer, but in-depth studies of three-dimensional genome (3D genome) of metastatic cancer are currently lacking, preventing the understanding of the roles of genome organization during metastasis. Here we perform multi-omics profiling of matched normal colon, primary tumor, lymph node metastasis, liver metastasis and normal liver tissue from CRC patients using Hi-C, ATAC-seq and RNA-seq technologies.