Ellagic Acid Protects against Alcohol-Related Liver Disease by Modulating the Hepatic Circadian Rhythm Signaling through the Gut Microbiota-NPAS2 Axis.

Alcohol-related liver disease (ALD) encompasses a spectrum of hepatic disorders resulting from alcohol abuse, which constitutes the predominant etiology of morbidity and mortality associated with hepatic pathologies globally. Excessive alcohol consumption disrupts the integrity of the intestinal barrier and perturbs the balance of gut microbiota, thereby facilitating the progression of ALD. Ellagic acid (EA) has been extensively reported to be an effective intervention for alleviating liver symptoms.

Formation and evolution of thermokarst landslides in the Qinghai-Tibet Plateau, China.

Thermokarst landslide (TL) activity in the Qinghai-Tibet Plateau (QTP) is intensifying due to climate warming-induced permafrost degradation. However, the mechanisms driving landslide formation and evolution remain poorly understood. This study investigates the spatial distribution, annual frequency, and monthly dynamics of TLs along the Qinghai-Tibet engineering corridor (QTEC), in conjunction with in-situ temperature and rainfall observations, to elucidate the interplay between warming, permafrost degradation, and landslide activity.

Evaluating the impact of soil erosion on soil quality in an agricultural land, northeastern China.

The impact of soil erosion on soil quality is still not systematically understood. The purpose of this study was thus to quantify the impact of soil erosion on soil quality and its change with slope morphology in an agricultural field, northeastern China based on radionuclide Cs, unmanned aerial vehicle derived high resolution digital elevation model, and soil sampling. Cs method yielded an average soil erosion rate of - 275 t km yr ranging from - 1870 to 1557 t km yr.

MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis.

Alcohol-related liver disease (ALD) is recognized as a global health crisis, contributing to approximately 20% of liver cancer-associated fatalities. Dysbiosis of the gut microbiome is associated with the development of ALD, with the gut microbial metabolite urolithin A (UA) exhibiting a potential for alleviating liver symptoms. However, the protective efficacy of UA against ALD and its underlying mechanism mediated by microbiota remain elusive.

Vascular architecture characters and risk factors analysis of unstable moyamoya disease.

Background: In some MMD patients, the digital subtraction angiography (DSA) examination found, occlusion in the ipsilateral internal carotid artery or middle cerebral artery, accompanied by the formation of numerous moyamoya vessels. Conversely, the contralateral internal carotid artery or middle cerebral artery shows signs of stenosis without the presence of moyamoya vessels. Notably, cerebral perfusion studies reveal a similar or even more severe reduction in perfusion on the occluded side compared to the stenotic side.

A Green Synthesis of Au-Ag Alloy Nanoparticles using Polydopamine Chemistry: Evaluation of their Anticancer Potency Towards Both MCF-7 Cells and their Cancer Stem Cells Subgroup.

Background: Limited chemotherapy efficacy and cancer stem cells (CSCs)-induced therapeutic resistance are major difficulties for tumour treatment. Adopting more efficient therapies to eliminate bulk-sensitive cancer cells and resistant CSCs is urgently needed.

Methods: Based on the potential and functional complementarity of gold and silver nanoparticles (AuNPs or AgNPs) on tumour treatment, bimetallic NPs (alloy) have been synthesized to obtain improved or even newly emerging bioactivity from a combination effect.

Differences of serum glucose and lipid metabolism and immune parameters and blood metabolomics regarding the transition cows in the antepartum and postpartum period.

This study aims to investigate differences in metabolism regarding the transition cows. Eight cows were selected for the test. Serum was collected on antepartum days 14th (ap14) and 7th (ap7) and postpartum days 1st (pp1), 7th (pp7), and 14th (pp14) to detect biochemical parameters.

Recent decreasing precipitation and snowmelt reduce the floods around the Chinese Tianshan Mountains.

Understanding and managing mountain floods has become increasingly urgent, with global climate change and human activities exacerbating flood risk. However, flood research in Tianshan Mountains, a typical flood-prone mountainous region in China, is still insufficient. Here, we customized a set of flood research methods based on rainstorms and extreme snowmelt events, including a new flood counting method that comprehensively considered the frequency and magnitude of floods and the methods of flood classification and change attribution.

High-Impact Performance and Thermal Properties of Polyimine Nanocomposites Reinforced by Silicon Carbide Nano-Whiskers.

Polymer nanocomposites, which combine the advantages of polymers and fillers, are widely used in the field of automobile and aviation. Polyimine (PI) is an emerging thermoset material with remarkable properties, such as malleability, recyclability, and self-healing. Silicon carbide nano-whiskers (SiCw), as a cheap and high-hardness filler material, are chosen to enhance the properties of polyimine matrix.

Flattened Gaussian focal spot with uniform phase produced by photon sieve.

The equivalent pupil and the point spread function constitute the Fourier-Bessel transform relation. Based on this, we established the equivalent pupil function theory of rotating symmetric photon sieve and derived the Fourier transform of the flattened Gaussian function. The focal spot produced by this type of photon sieve exhibits a uniform intensity and phase distribution.

Arterial spin labeling for moyamoya angiopathy: A preoperative and postoperative evaluation method.

Objectives: Studies have shown that arterial spin labeling (ASL) effectively replaces traditional MRI perfusion imaging for detecting cerebral blood flow (CBF) in patients with Moyamoya angiopathy (MMA). However, there are few reports on the relationship between neovascularization and cerebral perfusion in patients with MMA. The aim of this study is to investigate the effects of neovascularization on cerebral perfusion with MMA after bypass surgery.

Safety and efficacy of aspirin after combined cerebral revascularization for ischemic moyamoya disease: A prospective study.

Objective: To analyze the safety and efficacy of regular aspirin use after combined cerebral revascularization in patients with ischemic moyamoya disease.

Methods: From December 2020 to October 2021, a total of 326 patients diagnosed with ischemic moyamoya disease by global cerebral angiography and undergoing first-time combined cerebral revascularization at the Moyamoya Disease Diagnosis and Treatment Research Center of our hospital were selected. Combined cerebral revascularization: superficial temporal artery-middle cerebral artery (STA-MCA) +encephalo-duro-myo-synangiosis (EDMS).

High-efficiency square-hole single-mode waveguide photon sieves for THz waves.

The photon sieve has had the problem of low diffraction efficiency since it was proposed. Dispersion from different waveguide modes in the pinholes also reduces the quality of focusing. To overcome the above drawbacks, we propose a kind of photon sieve working in the terahertz band.

Case Report: Curative effect of OA-PICA protected bypass in severe PICA-complicated vertebral artery stenosis treatment: Results in 3 cases.

Objectives: We aimed to explore the results of OA-PICA-protected bypass grafting in patients with severe stenosis of the vertebral artery combined with PICA.

Methods: Three patients with vertebral artery stenosis involving the posterior inferior cerebellar artery, treated by the Department of Neurosurgery of Henan Provincial People's Hospital from January 2018 to December 2021, were retrospectively analyzed. All the patients underwent Occipital Artery-Posterior Inferior Cerebellar Artery (OA-PICA) bypass surgery followed by elective vertebral artery stenting.

Correction: Hybrid cellulose nanocrystal/alginate/gelatin scaffold with improved mechanical properties and guided wound healing.

[This corrects the article DOI: 10.1039/C9RA04026A.].

Influence of Autologous Bone Marrow Stem Cell Therapy on the Levels of Inflammatory Factors and Conexin43 of Patients with Moyamoya Disease.

Moyamoya disease is a medical condition that shows the typical characteristics like continuous and chronic thickening of the walls and the contraction of the internal carotid artery; as a result, the internal diameter of the artery gets narrowed. There are six phases of the disease ranging from I to VI (moyamoya vessels completely disappear, followed by the complete blockage of the arteries). Surgery is a commonly recommended treatment for the moyamoya disease.

Gain-Phase Error-Calibrated Piezoelectric Sensor Array-Based Impact Localization on Stiffened Curved Composite Structures.

Stiffened structure-induced gain-phase errors degrade the performance of the high-resolution two-dimensional multiple signal classification (2D-MUSIC) algorithm, which makes it impossible to ensure the high accuracy of impact localization results. To eliminate the localization bias caused by these errors, a calibrated 2D-MUSIC-based impact localization method is first introduced. Firstly, time-frequency characteristics of the non-stationary impact signals are evaluated by experiment to obtain a clear first wave packet or a wave packet that purely corresponds to a single mode through continuous wavelet transform (CWT).

Angiographic Characteristics of Cerebral Perfusion and Hemodynamics of the Bridging Artery After Surgical Treatment of Unilateral Moyamoya Disease.

Purpose: To investigate the characteristics of cerebral perfusion and hemodynamics of bypass grafting in the treatment of moyamoya disease (MMD) using the iFlow color-coded flow map in comparison with magnetic resonance imaging-perfusion-weighted imaging (MRI-PWI) and computational fluid dynamic (CFD) analysis.

Materials And Methods: Patients with MMD treated with bypass grafting who had undergone MRI PWI and digital subtraction angiography for iFlow color-coded map was retrospectively enrolled and CFD was performed for calculating the hemodynamic stresses around the bypass grafting.

Results: Forty-five patients with unilateral MMD treated with bypass surgery were enrolled.

Acute recurrent cerebral infarction caused by moyamoya disease complicated with adenomyosis: A case report.

Background: Moyamoya disease is essentially an ischemic cerebrovascular disease. Here, we describe a case of acute recurrent cerebral infarction caused by moyamoya disease with concurrent adenomyosis which, to our knowledge, is the first in the literature. A literature review is also presented.

Case Report: The Different Fates of Three Aneurysms: Diagnosis and Treatment Strategies for Unruptured Intracranial Aneurysms With Other Intracranial Diseases.

Intracranial aneurysms are vascular diseases characterized by local aneurysms of intracranial arteries. Their etiology involves a variety of environmental and genetic factors. Unruptured intracranial aneurysms (UIAs) are more common in intracranial aneurysms, but once an aneurysm is ruptured, the fatality rate and disability rate are extremely high.

Solubilities of CO, O and N in rocket propellant 5 under low pressure.

The static method of isochoric saturation was used to measure the solubilities of CO, O and N in rocket propellant 5 (RP5) at temperatures ranging from 253.15 to 323.15 K in 10 K intervals and pressures ranging from 0 to 120 kPa.

Environmental Effects on Piezoelectric Sensors Array Signals and a Compensated Damage Imaging Method.

Piezoelectric sensors array based damage imaging method as a high resolution source localization algorithm is becoming a promising method in structural health monitoring (SHM) technology. However, the environmental variations could affect the gain-phase of array signal. This paper experimentally evaluates the environmental effects on piezoelectric sensors array, and presents a compensated 2D-MUSIC based damage imaging method for composite structures.

Gas-liquid mass transfer characteristics of aviation fuel scrubbing in an aircraft fuel tank.

Dissolved oxygen evolving from aviation fuel leads to an increase in the oxygen concentration in an inert aircraft fuel tank ullage that may increase the flammability of the tank. Aviation fuel scrubbing with nitrogen-enriched air (NEA) can largely reduce the amount of dissolved oxygen and counteract the adverse effect of oxygen evolution. The gas-liquid mass transfer characteristics of aviation fuel scrubbing are investigated using the computational fluid dynamics method, which is verified experimentally.