The peroxisome proliferator-activated receptor agonist rosiglitazone specifically represses tumour metastatic potential in chromatin inaccessibility-mediated FABP4-deficient gastric cancer.

Efforts to prevent recurrence in gastric cancer (GC) patients are limited by current incomplete understanding of the pathological mechanisms. The present study aimed to identify novel tumour metastasis-associated genes and investigate potential value of these genes in clinical diagnosis and therapy. RNA sequencing was performed to identify differentially expressed genes related to GC metastasis.

An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer.

Immunosuppressive molecules are extremely valuable prognostic biomarkers across different cancer types. However, the diversity of different immunosuppressive molecules makes it very difficult to accurately predict clinical outcomes based only on a single immunosuppressive molecule. Here, we establish a comprehensive immune scoring system (ISS) based on 6 immunosuppressive ligands (NECTIN2, CEACAM1, HMGB1, SIGLEC6, CD44, and CD155) using the LASSO method to improve prognostic accuracy and provide an additional selection strategy for adjuvant chemotherapy of gastric cancer (GC).

mA modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling.

Background: BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive.

Methods: We obtained GC tissues and corresponding normal tissues from 8 patients and identified BATF2 as a downregulated gene via RNA-seq.

CDK5RAP3 Inhibits the Translocation of MCM6 to Influence the Prognosis in Gastric Cancer.

Cyclin-dependent kinase 5 regulatory subunit-associated protein 3 (CDK5RAP3) was identified as a tumor suppressor in gastric cancer, while, minichromosome maintenance complex component 6 (MCM6), which is closely related to the initiation of DNA replication, was reported to be upregulated in multiple malignancies. However, the interaction between these two proteins has not been investigated in gastric cancer. Here, we evaluate the connection between CDK5RAP3 and MCM6 using mass spectrometry and immunoprecipitation.

Vital contribution of residential emissions to atmospheric fine particles (PM) during the severe wintertime pollution episodes in Western China.

To mitigate severe wintertime pollution events in Western China, identifying the source of atmospheric fine particles with an aerodynamic diameter of ≤2.5 μm (PM) is a crucial step. In this study, we first analyzed the meteorological and emission factors that caused a considerable increase in the PM concentration in December 2016.

CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer.

Background: CDK5RAP3 was initially isolated as a binding protein of the CDK5 activator p35. Although CDK5RAP3 has been shown to negatively regulate the Wnt/β-catenin signaling pathway in gastric cancer by repressing GSK-3β phosphorylation, its in-depth mechanism has not been determined.

Methods: Following CDK5RAP3 overexpression or knock down, CDK5RAP3 signaling pathways were investigated in gastric cancer cells by Western Blotting.

[Analysis of water sources of plants in artificial sand-fixation vegetation area based on large rainfall events.].

Water is a major limiting factor for plant growth in arid and semi-arid regions. To find out the main sources of water for two artificial sand-fixation plants (Caragana korshinskii and Artemisia ordosica), we analyzed the characteristics of hydrogen and oxygen stable isotopes in water molecules of rainfall, soil water and xylem water. To analyze water sources of these two plants, we used a direct comparison method and a multi-variate mixed linear model.

[Concentration and Source of Dissolved Organic Carbon in Snowpits of the Tibetan Plateau].

Snowpit samples of three glaciers (Laohugou NO. 12 Glacier (LHG), Small Dongkemadi Glacier on Mount Tanggula (TGL) and East Ronghuk Glacier on Mount Everest (ZF)) in the Tibetan Plateau were collected. Concentrations of DOC and major ions were analyzed.

[Chemical speciation and risk assessment of heavy metals in the middle part of Yarlung Zangbo surface sediments].

Nine heavy metals (Cd, Co, Ni, Cu, Zn, Pb, Cs, As, Cr) of surface sediments collected from the Middle Part of the Yarlung Zangbo River were analyzed by BCR sequential extraction procedure. Based on speciation distributions of these metals, ecological risk of heavy metals was assessed with methods of risk assessment code (RAC) and sediment quality guideline quotient (SQG-Q). The results show that: (1) Large part of Cr and As belong to residual fraction(87%-96%).

[Study on soil element background values of the Hoh Xil area in north Tibet].

Hoh Xil locates at northern part of the Tibetan Plateau. Twenty five surface soil samples were collected from this area in 2007 and 32 elements were analyzed and compared to the element contents of Yarlung Zangbo river sediment, background element value of the Tibetan surface soil and the Chinese Continental crust contents. The results showed that the element contents of the < 20 microm fraction were higher than those of bulk samples; Contents of many elements of this study were similar to those of the Tibetan soil.

Ecological restoration and recovery in the wind-blown sand hazard areas of northern China: relationship between soil water and carrying capacity for vegetation in the Tengger Desert.

The main prevention and control area for wind-blown sand hazards in northern China is about 320000 km(2) in size and includes sandlands to the east of the Helan Mountain and sandy deserts and desert-steppe transitional regions to the west of the Helan Mountain. Vegetation recovery and restoration is an important and effective approach for constraining wind-blown sand hazards in these areas. After more than 50 years of long-term ecological studies in the Shapotou region of the Tengger Desert, we found that revegetation changed the hydrological processes of the original sand dune system through the utilization and space-time redistribution of soil water.

The effect of the structure of polychlorinated biphenyls on their hydroxylation, oxidation, and glutathionyl conjugation reactions.

Objective: To compare the nature of the metabolites formed from the phase I metabolism (hydroxylation and oxidation) and phase II metabolism (glutathionyl conjugation) of PCBs that have different chlorine substitution patterns. To discuss the structure-activity relationships and metabolic mechanisms of PCBs.

Methods: 4-Cl-biphenyl (PCB3), 4,4'-Cl-biphenyl (PCB15), 3,4,3',4'-Cl-biphenyl (PCB77) were used for in vitro metabolic study.

[Indoor air pollution in the Nam Co and Ando Regions in the Tibetan Plateau].

Concentrations and variations of fine particulate matter (PM2.5) and carbon monoxide (CO) within tents from the Nam Co and Ando regions were observed at summer 2009, in order to understand the concentrations and variations of PM2.5 and CO in these tents (or in rooms) and their main affect factors, as well as the exposure of different residents.

[Composition and seasonal variations of carbon isotopes in aerosols of Lhasa, Tibet].

A total of 30 samples of total suspended particles were collected at an urban site in western of Lhasa city, Tibet from August 2006 to July 2007 for investigating carbonaceous aerosol features. 14C was taken as a reference to quantitatively distinguish the fossil and biogenic-derived origins along with the characteristics of seasonal variations of all carbonaceous materials in Lhasa are discussed. The results showed that the f(c) values in Lhasa ranged from 0.

Distribution, biomass, and dynamics of roots in a revegetated stand of Caragana korshinskii in the Tengger Desert, northwestern China.

A field experiment was conducted to investigate root distribution, biomass, and seasonal dynamics in a revegetated stand of Caragana korshinskii Kom. in the Tengger Desert. We used soil profile trenches, soil core sampling, and minirhizotron measurements to measure root dynamics.