[Construction of regional ecological security pattern based on the "sensitivity-importance-connectivity" framework: A case study of Guizhou Province].

The construction of an ecological security pattern is crucial to maintain ecosystem health and stability, with great significance for regional sustainable development. Following the research paradigm of "ecological source areas-ecological resistance surfaces-ecological corridors", based on the index framework of "sensitivity-importance-connectivity", we identified the ecological source areas, generated the ecological resistance surface through graded weighting of underlying surface factors and point of interest (POI) method, determined the ecological corridor, pinch point, and obstacle area using circuit theory, and constructed the ecological security pattern of Guizhou Pro-vince. Results showed that the areas of extremely sensitive of rocky desertification and soil erosion and the areas of extremely important areas of water resources forming, soil and water conservation and biodiversity in Guizhou Pro-vince were generally small and distributed differently, accounting for 1.

Mechanical Properties of Fully Recycled Aggregate Concrete Reinforced with Steel Fiber and Polypropylene Fiber.

The study and utilization of fully recycled aggregate concrete (FRAC), in which coarse and fine aggregates are completely replaced by recycled aggregates, are of great significance in improving the recycling rate of construction waste, reducing the carbon emission of construction materials, and alleviating the ecological degradation problems currently faced. In this paper, investigations were carried out to study the effects of steel fiber (0.5%, 1.

A fNIRS investigation of menopausal-related symptoms and brain cortical activity in menopause.

Background: This study aimed to delineate the association between menopausal-related symptoms and brain cortical hemodynamics in peri-postmenopause women.

Methods: Cross-sectional data from a total of 358 Han-Chinese women who visited the Menopause Clinic in the Shanghai Sixth People's Hospital from August 2019 to August 2022. Menopausal-related symptoms were analyzed through Kupperman index (KMI) scale and PSQI scale, while cerebral blood flow was measured using a functional near-infrared spectroscopy (fNIRS).

Insulin sensitivity, β cell function, and adverse pregnancy outcomes in women with gestational diabetes.

Background: The potential impact of β cell function and insulin sensitivity on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) remains uncertain. We aimed to investigate the association between β cell dysfunction, insulin resistance, and the composite adverse pregnancy outcomes.

Methods: This observational study included 482 women diagnosed with GDM during pregnancy.

Association of sleep characteristics with renal function in menopausal women without recognized chronic kidney disease.

Objective: To delineate the association between sleep characteristics and renal function in peri-post menopause free of Chronic kidney disease (CKD) as well as cardiometabolic and hormone indicators.

Methods: Cross-sectional data from a total of 823 Han-Chinese women aged 40-67 years who visited the Menopause Clinic in the Shanghai Sixth People's Hospital from November 2011 to November 2020 were analyzed through the Pittsburgh Sleep Quality Index (PSQI) and serum cystatin C (Cys-C). Logistic regression models were used to assess the association between cumulative/each sleep parameter and renal function after adjusting for cardiometabolic variables.

Properties of a Novel Phage L66 and Its Application Based on Electrochemical Sensor-Combined AuNPs to Detect .

is widespread in nature and poses a significant threat to human health and safety. Phage is considered as a new tool for the control of food-borne pathogens. In this study, phage L66 (phage L66) was isolated from sewage by using Typhimurium ATCC 14028 as the host bacterium, and its basic properties were obtained by biological and bioinformatics analysis.

Menopausal Symptoms and Sleep Quality in Women Aged 40-65 Years.

The study examined the relationship between menopausal symptoms and sleep disturbances and the related influencing factors. . We recruited women aged 40-65 years who attended the menopause clinic at Shanghai Jiao Tong University's Sixth People's Hospital from February 2011 to November 2019.

EIS biosensor based on a novel Myoviridae bacteriophage SEP37 for rapid and specific detection of Salmonella in food matrixes.

Recently, using bacteriophages as new molecular probes in reliable platforms for the detection of bacterial pathogens has attracted more and more increasing attentions. In this paper, a novel isolated Myoviridae bacteriophage SEP37 was covalently immobilized onto gold nanoparticles (AuNPs) modified gold disk electrode (GDE) surfaces using cysteamine (Cys) as a crosslinker. Substrates of GDE-AuNPs-Cys-Phage SEP37 and specific capture of Salmonella cells had been characterized using scanning electron microscopy (SEM) separately.

Uremic toxin indoxyl sulfate induces dysfunction of vascular smooth muscle cells via integrin-β1/ERK signaling pathway.

Background: Protein-bound uremic toxins (PBUTs) are reported to be one of the major culprits in chronic kidney disease-cardiovascular disease (CKD-CVD) development, yet its mechanism is not fully clear. Our previous study confirmed elevated expression of integrin-β1 (ITGβ1) in vascular smooth muscle cells of uremic patients. Thus, this study aimed to explore the relationship between PBUTs and ITGβ1 in uremic vasculature injury.

Nitrogen addition, rather than altered precipitation, stimulates nitrous oxide emissions in an alpine steppe.

Anthropogenic-driven global change, including changes in atmospheric nitrogen (N) deposition and precipitation patterns, is dramatically altering N cycling in soil. How long-term N deposition, precipitation changes, and their interaction influence nitrous oxide (NO) emissions remains unknown, especially in the alpine steppes of the Qinghai-Tibetan Plateau (QTP). To fill this knowledge gap, a platform of N addition (10 g m year) and altered precipitation (±50% precipitation) experiments was established in an alpine steppe of the QTP in 2013.

Correlation between menopausal symptoms and everyday cognition in Chinese (peri)menopausal women.

Objective: The aim of this study was to evaluate the relationship between the severity of menopausal symptoms and everyday cognitive decline in Chinese peri and postmenopausal women.

Methods: The peri and postmenopausal Chinese Han female who first visited the menopausal clinic of Shanghai Jiao Tong University Affiliated Sixth People's Hospital was selected as the study participants. The general questionnaire was used to obtain the sociodemographic characteristics of the study participants.

The complete chloroplast genome of Tibetan medicine .

(Mum.) Ma is an important species in Tibetan folk medicine, but its wild populations are shrinking roughly due to the increasing demand for it. is presently at risk of over-exploitation, so it needs urgent conservation.

Soil Fungal Community Composition, Not Assembly Process, Was Altered by Nitrogen Addition and Precipitation Changes at an Alpine Steppe.

Global climate change and nitrogen deposition have been having broad impacts on microorganisms. On the Qinghai-Tibetan Plateau (QTP), the responses of soil microbial community assemblage and diversity to nitrogen deposition and changes in precipitation are poorly understood, especially in the alpine steppe. In this study, we conducted a field manipulative experiment of nitrogen deposition and precipitation amount in an alpine steppe on the northeastern QTP and investigated the responses of community composition, diversity, and community assemblage of soil fungi.

A retrospective analysis reveals a predictor of survival for the patient with paraquat intoxication.

Feasible and accurate predictors are urgently needed to evaluate the survival for patients with paraquat poisoning since the high mortality of paraquat poisoning always resulted in the loss of both life and money. Multiple predictors have been developed to predict prognosis of the patients with PQ poisoning, which however heavily depend on the time of admission to hospitals. Here we reported a feasible and accurate prognosis predictor for patients with paraquat poisoning that is independent of the time of admission to hospitals.

Association of snoring and body composition in (peri-post) menopausal women.

Background: Little attention has been paid to whether snoring frequency is associated with body composition in menopausal women, particularly in China. This study objected to investigate the association between self-reported snoring and body composition in (peri-post) menopausal Chinese women as well as metabolic indicators.

Methods: This cross-sectional study enrolled 715 participants aged 40-67 years from the Menopause Clinic in the Shanghai Sixth People's Hospital.

Examining differences in phylogenetic composition enhances understanding of the phylogenetic structure of the shrub community in the northeastern Qinghai-Tibetan Plateau.

Periodic climatic oscillations and species dispersal during the postglacial period are two important causes of plant assemblage and distribution on the Qinghai-Tibet Plateau (QTP). To improve our understanding of the bio-geological histories of shrub communities on the QTP, we tested two hypotheses. First, the intensity of climatic oscillations played a filtering role during community structuring.

The impact of increasing land productivity on groundwater dynamics: a case study of an oasis located at the edge of the Gobi Desert.

Background: Intensification of agricultural systems may result in overexploitation of water resources in arid regions because enhanced productivity of crops is often associated with increased actual evapotranspiration (AET). The aim of this study was to quantify the effect of increased regional AET on the groundwater level in a case study of the oasis located within the Shiyang River Basin near the edge of the Gobi Desert.

Result: The results of the study show that regional AET increased during the period from 1981 to 2010 due to increasing oasis area and air temperature.

Nitrogen Fertilizer Levels Affect the Growth and Quality Parameters of .

Owing to overexploitation, wild resources of , a Chinese herbal plant that is widely distributed in the arid and semi-arid areas of Northern China, have gradually become exhausted, and therefore, commercial cultivation is increasingly important to meet the growing demand for astragalus and reduce the pressure on wild populations. Nitrogen level is an important factor that affects the yield and quality of . However, uniform standards for fertilization among production areas have not yet been determined.

Precipitation and nitrogen addition enhance biomass allocation to aboveground in an alpine steppe.

There are two important allocation hypotheses in plant biomass allocation: allometric and isometric. We tested these two hypotheses in an alpine steppe using plant biomass allocation under nitrogen (N) addition and precipitation (Precip) changes at a community level. An in situ field manipulation experiment was conducted to examine the two hypotheses and the responses of the biomass to N addition (10 g N m y) and altered Precip (±50% precipitation) in an alpine steppe on the Qinghai-Tibetan Plateau from 2013 to 2016.

Maternal glycemic parameters and adverse pregnancy outcomes among high-risk pregnant women.

Objective: We aimed to investigate the association between maternal glycemic parameters and adverse pregnancy outcomes among high-risk pregnant women.

Research Design And Methods: A total of 1976 high-risk pregnant women were enrolled between 2015 and 2017. All participants received a 75 g oral glucose tolerance test during the 24-30 gestational weeks and complete birth and delivery information was collected.

Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells.

Autophagy has been demonstrated to be vital for kidney homeostasis and is centrally implicated in the pathogenesis of cisplatin-induced acute kidney injury (AKI). Lithium is a potent autophagy inducer in a number of cell types. However, it remains uncertain whether its autophagic activity is associated with a beneficial effect on renal tubular cells in AKI.

Histopathological and proteomic analyses identify integrin-β1 as a potential mediator of phlebosclerosis in uremic patients.

Background: Patients with uremia have an excessive mortality from cardiovascular disease (CVD). Arterial remodeling is mainly responsible for uremia-induced CVD and has been well studied, yet venous remodeling is poorly understood. Here we investigate the histopathology and proteomic profiles of venous remodeling in uremic patients.

Oxylipin profiling of human plasma reflects the renal dysfunction in uremic patients.

Introduction: Nearly all the enzymes that mediate the metabolism of polyunsaturated fatty acids (PUFAs) are present in the kidney. However, the correlation of renal dysfunction with PUFAs metabolism in uremic patients remains unknown.

Objectives: To test whether the alterations in the metabolism of PUFAs reflect the renal dysfunction in uremic patients.

Differential responses of heterotrophic and autotrophic respiration to nitrogen addition and precipitation changes in a Tibetan alpine steppe.

Soil respiration (Rs) is an important source of atmospheric CO flux and is sensitive to changes in soil nutrient and water contents. Despite extensive studies on the effects of enhanced atmospheric nitrogen (N) deposition and changes in precipitation (P) on Rs, few studies have taken into account the effects of interactions between these factors on Rs of alpine grasslands. To address these questions, we investigated the effects of N addition (10 g N m yr), changes in precipitation (±50% precipitation), and their interaction on soil respiration and its components, including heterotrophic respiration (Rh) and autotrophic respiration (Ra),in a Tibetan alpine steppe during three consecutive growing seasons.

Prevalence and predictors of sexual function in midlife partnered Chinese women assessed by two simple indicators: Sexual frequency and sexual desire.

Aim: To investigate the prevalence and predictors of sexual frequency, sexual desire in midlife partnered Chinese women.

Methods: Sexual frequency, sexual desire over the past 3 months, menopausal symptoms and other socioeconomic information were assessed for women aged 40-65 years in the Shanghai Sixth People's Hospital.

Results: Among 3485 eligible partnered participants, the prevalence of low sexual frequency (less than once per week) and low sexual desire (less than 5 scores) were 72.