Study on the preparation and mechanism of environmentally friendly polysaccharide-xanthan gum gel dust suppressants.

In response to the dust pollution problem in open-pit mines, an environmentally friendly network structure with a dust suppressor structure was prepared by grafting acrylamide (AM) monomers onto xanthan gum (XG). The results show that the polymer produced from 1 g XG, 15 g AM, and 0.45 g trimethylolpropane triglycidyl ether (TTE) had a more orderly structured gel with a viscosity of 81.

Targeted APT8(16-34) obtained by cell-SELEX and its internalization with miR-23-5p into activated hepatic stellate cells.

Background: The activation of hepatic stellate cells play a pivotal role in the pathogenesis of hepatic fibrosis. However, the current lack of specifically identified targets on these cells poses a significant challenge in developing targeted delivery tools for effective anti-hepatic fibrosis therapeutics in clinical practice.

Methods: Cell-systematic evolution of ligands by exponential enrichment method was conducted on HSC-T6 cell line to screen out activated hepatic stellate cell-specific aptamers.

Human umbilical cord-derived mesenchymal stromal cells for the treatment of steroid refractory grades III-IV acute graft-versus-host disease with long-term follow-up.

Introduction: Mesenchymal stromal cells (MSCs) have been extensively studied as a potential treatment for steroid refractory acute graft-versus-host disease (aGVHD). However, the majority of clinical trials have focused on bone marrow-derived MSCs.

Methods: In this study, we report the outcomes of 86 patients with grade III-IV (82.

Demonstration of particle tracking with scintillating fibres read out by a SPAD array sensor and application as a neutrino active target.

Scintillating fibre detectors combine sub-mm resolution particle tracking, precise measurements of the particle stopping power and sub-ns time resolution. Typically, fibres are read out with silicon photomultipliers (SiPM). Hence, if fibres with a few hundred m diameter are used, either they are grouped together and coupled with a single SiPM, losing spatial resolution, or a very large number of electronic channels is required.

Production of a new type of cemented paste backfill with solid waste from carbide slag, soda residue, and red mud: mechanism, optimization, and its environmental effects.

To solve the disposal problems of carbide slag (CS), soda residue (SR), and red mud (RM) solid wastes, a new type of cemented paste backfill (CPB) was prepared with CS, SR, and RM solid wastes. The mixing proportion for the CPB was optimized by combining the Box‒Behnken design (BBD) response surface method and the satisfaction function method. The strength formation mechanism for the CPB was analyzed with physical and mechanical property tests, X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscopy (SEM), etc.

Numerical Simulation Research on Partial Discharge of Particle Defects at Epoxy Interface Excited by High-Frequency Sinusoidal Voltage.

In order to improve the effectiveness of partial discharge detection in attached metal particle insulators, this paper proposes a partial discharge detection method for particle defects in insulators under high-frequency sinusoidal voltage excitation. In order to study the development process of partial discharge under high-frequency electrical stress, a two-dimensional plasma simulation model of partial discharge with particle defects at the epoxy interface is established under plate-plate electrode structure, which realizes the dynamic simulation of particulate defect partial discharge. By studying the microscopic mechanism of partial discharge, the spatial and temporal distribution characteristics of microscopic parameters such as electron density, electron temperature, and surface charge density are obtained.

Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review.

Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people's life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients.

Screening of potential chemical marker with interspecific differences in wood and a spatially-resolved approach to visualize the distribution of the characteristic markers.

Profiling the spatial distributions and tissue changes of characteristic compounds with interspecific differences is critical to elucidate the complex species identification during tree species traceability, wood anti-counterfeiting verification and timber trade control. In this research, in order to visualize the spatial position of characteristic compounds in two species with similar morphology ( and ), a high coverage MALDI-TOF-MS imaging method was used to found the mass spectra fingerprints of different wood species. 2-Mercaptobenzothiazole matrix was used to spray wood tissue section to enhance the detection effect of metabolic molecules, and the mass spectrometry imaging data were obtained.

Hard-disk pressure computations-a historic perspective.

We discuss pressure computations for the hard-disk model performed since 1953 and compare them to the results that we obtain with a powerful event-chain Monte Carlo and a massively parallel Metropolis algorithm. Like other simple models in the sciences, such as the Drosophila model of biology, the hard-disk model has needed monumental efforts to be understood. In particular, we argue that the difficulty of estimating the pressure has not been fully realized in the decades-long controversy over the hard-disk phase-transition scenario.

The Efficacy of Rosuvastatin, Amlodipine, and Aspirin in the Treatment of Hypertension with Coronary Heart Disease and Its Effect on Platelet Aggregation.

Objective: This study was to study the efficacy of rosuvastatin, amlodipine, and aspirin in the treatment of hypertension with coronary heart disease and its effect on platelet aggregation.

Methods: The participants included 60 patients with hypertension and coronary heart disease who were treated at our hospital between January 2020 and May 2021 and were randomly assigned to receive either rosuvastatin, amlodipine, and Ziyin Huoxue Recipe (observation group) or rosuvastatin, amlodipine, Ziyin Huoxue Recipe, and aspirin (experimental group), with 30 patients in each. Outcome measures included clinical effectiveness, blood pressure indicators, blood lipid indices, plasma viscosity, platelet aggregation, cardiac function, and adverse responses.

Allogeneic haematopoietic stem cell transplantation with decitabine-containing preconditioning regimen in TP53-mutant myelodysplastic syndromes: A case study.

Myelodysplastic syndrome (MDS) with TP53 mutations has a poor prognosis after transplantation, and novel therapeutic means are urgently needed. Decitabine (Dec) monotherapy has demonstrated improved overall response rates in MDS and acute myeloid leukaemia, although these responses were not durable. This study aimed to preliminary evaluate the efficacy of a Dec-containing allogeneic haematopoietic stem cell transplantation (allo-HSCT) preconditioning regimen in TP53-mutant MDS.

Model Embraced Electromechanical Coupling Time for Estimation of Heart Failure in Patients With Hypertrophic Cardiomyopathy.

Objective: This study aimed to establish a model embraced electromechanical coupling time (EMC-T) and assess the value of the model for the prediction of heart failure (HF) in patients with hypertrophic cardiomyopathy (HCM).

Materials And Methods: Data on 82 patients with HCM at Shaanxi Provincial People's Hospital between February 2019 and November 2021 were collected and then formed the training dataset ( = 82). Data were used to screen predictors of HF using univariate and multivariate analyses.

Durability and life prediction of fly ash geopolymer concrete in corrosion environments caused by dry and wet circulation.

The use of tailings, waste rock, fly ash, and slag to prepare geopolymer concrete can effectively solve the problems of land resources occupied by tailings and waste rock, low utilization rate, and environmental pollution. Using a dry-wet circulation method, fly ash for a different corrosion solution to geopolymer concrete (referred to as TWGPC) was analyzed. Through an appearance change, the corrosion resistance coefficient of the compressive strength, relative dynamic elastic modulus, tensile splitting strength, relative mass, and durability were investigated, using scanning electron microscopy (SEM) analysis of the microstructure, The life of TWGPC was predicted based on the GM(1,1) prediction model of grey system theory.

Lignin Distribution on Cell Wall Micro-Morphological Regions of Fibre in Developmental Culms.

Bamboo is a natural fibre reinforced composite with excellent performance which is, to a certain extent, an alternative to the shortage of wood resources. The heterogeneous distribution and molecular structure of lignin is one of the factors that determines its performance, and it is the key and most difficult component in the basic research into the chemistry of bamboo and in bamboo processing and utilization. In this study, the distribution of lignin components and lignin content in micro-morphological regions were measured in semi-quantitative level by age and radial location by means of visible-light microspectrophotometry (VLMS) coupled with the Wiesner and Maule reaction.

Survival Cost and Diverse Molecular Mechanisms of Isolate Resistance to Epoxiconazole.

Rice blast caused by is one of the most destructive diseases on rice worldwide. Epoxiconazole is a 14α-demethylation inhibitor (DMI) with excellent control on rice blast; to date, no resistant isolates have been observed in the field. Four mutants resistant to epoxiconazole were generated from three parental isolates via fungicide adaptation.

Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by excess lipid accumulation in the liver without significant consumption of alcohol. The transmembrane 6 superfamily member 2 (TM6SF2) E167K missense variant strongly associates with NAFLD in humans. The E167K mutation destabilizes TM6SF2, resulting in hepatic lipid accumulation and low serum lipid levels.

Comparison on Reduction of VOCs Emissions from Radiata Pine ( Don) between Sodium Bicarbonate and Ozone Treatments.

Volatile organic compounds (VOCs) in wood furniture are an important factor that affects indoor air quality. In this study, radiata pine ( Don) was treated with sodium bicarbonate and ozone aqueous solution to reduce the VOC contents without sacrificing mechanical properties. The VOCs of radiata pine were identified by gas chromatography-mass spectrometry (GC-MS), and the functional group changes of wood samples were characterized by Fourier-transform infrared spectroscopy (FTIR).

Puffed Rice Inspired Porous Carbon Co-MOFs Derived Composite Electrode for Lithium Ion Batteries.

Carbon matrix metal organic frameworks (MOFs) hybrid is often used as electrode materials for lithium ion batteries (LIBs). Herein, we report three dimensional (3D) puffed rice inspired porous carbon (3DPRC) supported Co-MOFs derived composite by facile method. Co/C nanoparticles are uniformly dispersed on porous carbon sheets surface, forming unique 3D structures.

Donor-Derived CD123-Targeted CAR T Cell Serves as a RIC Regimen for Haploidentical Transplantation in a Patient With + AML.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) following chemotherapy is part of standard treatment protocol for patients with acute myeloid leukemia (AML). + AML is rare but has an extremely poor prognosis even with allo-HSCT in remission, possibly due to its a leukemia stem cell (LSC)-driven disease resulting in chemotherapy resistance and a novel therapy is urgently required. It has been reported that -positive AML expresses CD123, a marker of LSC, in some cases.

Quantitative Analysis of Thymus-Independent Donor-Derived T Cell Expansion in Transplant Patients.

Although thymus-independent donor-derived T cell expansion may determine the occurrence of graft-versus-host disease (GVHD) and relapse after transplantation, the characteristics and dynamics of the expansion process remain unclear. To address this issue, we monitored T cell receptor β repertoire at day 0, day 28, and day 61 after transplantation in 30 patients with hematologic malignancies by next-generation sequencing. The clonality index showed an increasing clonality over time (P = .

Retrospective analysis on the efficacy of sunitinib/sorafenib in combination with dendritic cells-cytokine-induced killer in metastasis renal cell carcinoma after radical nephrectomy.

Objective: Sunitinib/sorafenib (SU/SO), dendritic cells (DCs), or DC-cytokine-induced killer (CIK) could significantly prolong progression-free survival (PFS), 3-year overall survival (OS), or 5-year OS for patients with metastatic renal cell carcinoma (mRCC). We retrospectively analyzed the clinical efficacy between SU/SO combined with DC-CIK and SU/SO monotherapy in treating renal cell carcinoma (RCC) patients with metastasis after radical nephrectomy.

Materials And Methods: All patients (n = 34) with postoperative mRCC in our hospital from January 2009 to January 2014 were received either SU/SO monotherapy (Group 1, n = 15) or in combination with DC-CIK (Group 2, n = 19).

Efficacy of intracellular immune checkpoint-silenced DC vaccine.

Background: DC-based tumor vaccines have had limited clinical success thus far. SOCS1, a key inhibitor of inflammatory cytokine signaling, is an immune checkpoint regulator that limits DC immunopotency.

Methods: We generated a genetically modified DC (gmDC) vaccine to perform immunotherapy.

Recombinant canine adenovirus type 2 expressing rabbit hemorrhagic disease virus VP60 protein provided protection against RHD in rabbits.

Rabbit hemorrhagic disease virus (RHDV) is responsible for rabbit hemorrhagic disease (RHD), which is an acute, lethal and highly contagious disease in both wild and domestic rabbits. Although current vaccines are highly effective for controlling RHD, they are derived from infected rabbit livers and their use is thus associated with safety and animal-welfare concerns. In this study, we generated a recombinant lentogenic canine adenovirus type 2 (CAV2) vector expressing the RHDV vp60 gene, named rCAV2-VP60.