Publications by authors named "Li Ben-Fu"

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  • * Researchers developed a novel class of compounds called PROTACs, specifically targeting CDK9 for degradation, which showed strong effectiveness in laboratory tests against TNBC cells.
  • * One of these compounds, referred to as compound 29, demonstrated high potency in degrading CDK9, favorable oral bioavailability in mice, and the ability to inhibit tumor growth in TNBC models, suggesting its potential as a future treatment option.
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  • Echinococcosis is widespread in Western and Northern China, particularly in Yunnan Province, where cases were documented in epidemiological surveys conducted in 2012 and 2016.
  • The study aimed to assess the spatial distribution and characteristics of echinococcosis cases in Yunnan, collected through reports from hospitals and disease control centers between 2021-2022.
  • Findings revealed 397 analyzed cases across 89 counties in Yunnan, with the highest incidences in Dali, Diqing, and Kunming, highlighting significant regional differences and a low overall case reporting rate.
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Background: Implementing effective interventions remain a lot of difficulties along all border regions. The emergence of artemisinin resistance of Plasmodium falciparum strains in the Greater Mekong Subregion is a matter of great concern. China has effectively controlled cross-border transmission of malaria and artemisinin resistance of P.

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  • The study aimed to assess the prevalence of soil-transmitted nematode infections in Xiding Township, Menghai County, to help shape control strategies.
  • It utilized the Kato-Katz and cellophane tape methods to detect nematode eggs in feces and soil samples from local crop fields, finding a 20.06% infection rate among 1,002 residents.
  • Results indicated a high infection rate but mostly light infections, highlighting the need for improved monitoring and control measures in the area.
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The malaria epidemics in Laza city of Myanmar and Yingjiang county in Yunnan province of China in 2012 and 2013 was reviewed retrospectively, and a survey on malaria infection was conducted in residents in the border areas. A total of 179 malaria cases were reported in Yingjiang county from 2012 to 2013, with an average annual incidence of 2.9 per 10,000.

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Objective: To observe whether there was difference between the head-chest leads electrocardiogram (HCECGs) and routine lead electrocardiogram (RLECGs) in the manifest accessory pathways in patients with Wolff-Parkinson-White syndrome.

Methods: HCECGs and RLECGs were recorded simultaneously in patients with Wolff-Parkinson-White syndrome, whose manifest accessory pathways had been confirmed by radiofrequency catheter ablation and intra-cardiac electrophysiology according to the same standard set beforehand. The diagnosis of pathways location was made by analysis of each HCECG and RLECG by two senior physicians in clinical electrophysiology.

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Objective: To explore the effect of reference point on the potential distribution of normal cardioeleclric field of healthy individuals.

Methods: Two different reference points including central terminal and right forehead were applied to record electrocardiogram simultaneously from 15 testing points (V(1)-V(6), V(7)-V(9), V(3R)-V(8R)) of Wilson lead (RL) and the same testing points (HV(1)-HV(9), HV(3R)-HV(8R)) of head-chest (HC) lead around the torso of healthy individuals. Chi-square test was performed to observe statistical difference between the HCECGs and RLECGs according to different shapes of QRS and T waves.

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Objective: To evaluate the possibility of resultant cardiac vector of ex vivo guinea pig heart.

Methods: ECGs were recorded in 4 directions on every plane, and in each direction 4 points at different distances from the anterior, posterior, right and left of isolated guinea pig ventricles immersed in normal saline and distilled water.

Results: Main upward waves of ECGs were recorded at all points in 4 directions at 3 levels in the two media.

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Objective: To compare the value of head-chest lead electrocardiogram (HCECG) and routine lead electrocardiogram (RLECG) in diagnosis of acute positive posterior myocardial infarction.

Methods: HCECGs and RLECGs were recorded simultaneously in 68 normal individuals and 32 patients with acute posterior wall myocardial infarction confirmed by coronary angiography and echocardiography. Each HCECG and RLECG was analyzed by two senior physicians specialized in clinical electrophysiology who were blinded to the results.

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Conventional medical experiments can hardly simulate cardiac excitation propagation and observe the evolvement of cardiac electrical activities firsthand as is possible with computer simulation. Based on the anatomic structure of the heart, simulation of cardiac electrical activity mainly consists of the emulation of the excitation process among the cardiac cells and calculation of the electrical activities of individual cardiac cells. In this study we establish a geometric ventricular structure model demonstrating the direction of the cardiac muscle fibers and the layers of the ventricular cells, and endow different action potential models to the ventricular cells of different layers, and observe the activation process of the ventricular parts in view of the three-dimensional anatomy.

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The interference by 50-Hz noise arising from the power supply cables is common in PC-based application system, often considerably affecting the detection of useful signals. On the basis of self-adapting correlation method, we attempt to address the problem of fast elimination of 50-Hz noise from the useful signals in PC-based application system such as digital ECG recording system.

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