Publications by authors named "Li Bai"

Introduction: A novel recombinant antigen-based capture enzyme immunoassay (RAg-CEIA) was optimized and used to determine technical parameters for estimating human immunodeficiency virus type 1 (HIV-1) incidence in China.

Methods: We employed orthogonal experimental design to optimize RAg-CEIA by adjusting raw material dilution ratios. The assay was used to measure normalized optical density (ODn) values in 171 longitudinal plasma specimens from 51 HIV-1 seroconverting individuals, plotted against estimated days post-seroconversion.

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Objective: To investigate the intervention of melatonin (MT) in the expression of circadian genes in patients with pulmonary fibrosis and to analyze the mechanism by which it alleviates the progression of pulmonary fibrosis.

Methods: By utilizing the Gene Expression Omnibus (GEO) database, we identified differentially expressed circadian genes between patients with pulmonary fibrosis and controls. We analyzed the correlation between circadian genes and pulmonary function as well as genes related to pulmonary fibrosis.

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: Renal anemia is linked to a decreased lifespan of red blood cells. The factors influencing red blood cell lifespan (RBCLS) in peritoneal dialysis patients, particularly the connection between inflammation and RBCLS, are still not well understood. This cross-sectional study was conducted to investigate these relationships.

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Photocatalytic CO reduction is considered a sustainable method to address energy and environmental issues by converting CO into fuels and chemicals, yet the performance is still unsatisfactory. Single atom catalysts hold promising potential in photocatalysis, but the selection of metal species is still limited, especially in early transition metals. Herein, inspired by the structure of anatase TiO, single Ti sites were successfully incorporated into a metal hydroxide support for the first time cationic defects, significantly enhancing the photocatalytic performance by more than 30 times (from 0.

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This study aims to investigate the effect of promethazine (PMZ) on hippocampal neuronal injury through network pharmacology and in vivo experiments. Network pharmacology: The intersection genes of PMZ and Alzheimer Disease (AD) were obtained, and the core genes of PMZ in AD were screened. The intersection genes were enriched by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses.

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  • * The study investigated the impact of fecal microbiota transplantation (FMT) on rats poisoned with MeHg over a 14-day treatment period, analyzing neurological behaviors, weight changes, and levels of MeHg and dopamine.
  • * Results showed that FMT significantly improved weight gain, reduced neurological problems, increased mercury excretion, restored gut microbiota, and boosted beneficial metabolites, suggesting potential applications for treating neurological conditions like Parkinson's Disease.
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A series of x Cu-TiO obtained from the sol-gel method were tested for NH selective catalytic oxidation (NH-SCO). Its performance was higher than that of supported Cu/TiO-Im and solvent-free Cu/TiO-SF. The catalyst exhibits better water resistance at 300 °C.

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  • Co-combustion of municipal solid waste (MSW) with industrial solid waste (ISW) is increasingly common, but its impact on harmful pollutants remains unclear, complicating control efforts.
  • An incineration study using a 650 t/d capacity tested various ISW blends and developed a new model to understand the relationship between waste components and their toxic byproducts, including PCDD/Fs and dl-PCBs.
  • Results showed co-combustion led to a significant increase in the generation of these contaminants, particularly from plastics like PET and PVC, indicating a need for stricter regulations on blending certain waste types to minimize toxic emissions.
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Objective: This study aimed to assess the risk of foodborne outbreaks associated with household food handling practices in China and identify the consumer groups that are at higher risk for foodborne outbreaks.

Methods: A national survey of household pork handling practices was conducted in China. The risk of foodborne outbreaks stemming from consumers' improper handling practices was assessed utilizing the Weighted Harmonic Outbreak Prevention Index (WHOPI).

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Purpose: Primary care access is a key health system metric, but little research has compared models to provide primary care access when one's regular physician is not available. We compared health system use after a visit with a patient's own family physician group (ie, within-group physician who was not the patient's primary physician) vs a visit with a walk-in clinic physician who was not part of the patient's family physician group.

Methods: We conducted a population-based, retrospective cohort study using administrative data from Ontario, Canada, including all individuals formally enrolled with a family physician, from April 1, 2019 to March 31, 2020.

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Cholinergic projection neurons of the nucleus basalis and substantia innominata (NBM/SI) densely innervate the basolateral amygdala (BLA) and have been shown to contribute to the encoding of fundamental and life-threatening experiences. Given the vital importance of these circuits in the acquisition and retention of memories that are essential for survival in a changing environment, it is not surprising that the basic anatomical organization of the NBM/SI is well conserved across animal classes as diverse as teleost and mammal. What is not known is the extent to which the physiology and morphology of NBM/SI neurons have also been conserved.

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Chiral nanophotonic materials have emerged as ideal candidates for biosensing applications due to their exceptional sensitivity. However, the inability to directly visualize chiral signals limits their broader application, particularly in disease diagnosis and treatment. In this study, we introduce a chiral nanocomposite based on upconversion nanoparticles (UCNPs), denoted UCNPs@L-POM, that exhibits both upconversion luminescence (UCL) and circular dichroism (CD) signals.

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  • The study developed an intranasal COVID-19 vaccine called RBD-HR, which consists of a receptor binding domain-derived protein and a special oil-in-water adjuvant for enhanced immune response.
  • Testing in mice and rats showed that the vaccine generated strong and long-lasting immune responses, producing high levels of neutralizing antibodies against specific SARS-CoV-2 variants for at least six months.
  • Additionally, the intranasal administration of the vaccine resulted in effective mucosal and systemic immunity, and when used as a booster after mRNA vaccines, it provided better immune responses and protection against live virus challenges.
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Atom-centered neural network (ANN) potentials have shown high accuracy and computational efficiency in modeling atomic systems. A crucial step in developing reliable ANN potentials is the proper selection of atom-centered symmetry functions (ACSFs), also known as atomic features, to describe atomic environments. Inappropriate selection of ACSFs can lead to poor-quality ANN potentials.

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Background And Objective: Predicting post-operative flow is essential for assessing the risk of adverse events in cerebrovascular stenosis patients following endovascular treatment (EVT). This study aimed to evaluate the accuracy of the CFD simulation model in predicting post-operative velocity, flow and pressure distal to a stenosis, based on cerebrovascular microcirculatory resistance.

Methods: The patient-specific models of the extracranial and intracranial arteries were reconstructed.

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  • The study investigates the prevalence of reproductive tract infections (RTIs) among women aged 18 to 65 in Lueyang, Shaanxi, revealing that 42.04% reported symptoms, with older women particularly affected.
  • A comprehensive survey, conducted from May to September 2022, included over 20,000 women and highlighted a concerning gap in gynecological examination behavior, with only 9.88% of symptomatic women seeking checkups.
  • The findings indicate that while common symptoms like vulvar itching and abnormal discharge were prevalent, significant barriers such as perceived symptom severity and time constraints hindered women from obtaining necessary healthcare.
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Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge and evade immunity, resulting in breakthrough infections in vaccinated populations. There is an urgent need for the development of vaccines with broad protective effects. In this study, we selected hotspot mutations in the receptor-binding domain (RBD) that contribute to immune escape properties and integrated them into the original RBD protein to obtain a complex RBD protein (cRBD), and we found cRBDs have broad protective effects against SARS-CoV-2 variants.

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  • Researchers created a framework to segment and model lenticulostriate arteries using advanced MRI techniques, specifically targeting patients with CADASIL and comparing them to healthy controls.
  • The framework involves a small-patch convolutional neural network for accurate segmentation, supported by a random forest model for further analysis, with performance evaluated against manual segmentation methods.
  • Results showed that the framework achieved high accuracy in artery measurements, demonstrating better reliability than manual methods, suggesting it could be beneficial for diagnosing and studying CADASIL.
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Objectives: To explore the current application of high-throughput drug sensitivity (HDS) testing in children with relapsed and refractory acute leukemia (RR-AL) and analyze the feasibility of salvage treatment plans.

Methods: A retrospective collection of clinical data from children with RR-AL who underwent HDS testing at the Department of Children's Hematology and Oncology of the First Affiliated Hospital of Zhengzhou University from November 2021 to October 2023 was conducted, followed by an analysis of drug sensitivity results and treatment outcomes.

Results: A total of 17 children with RR-AL underwent HDS testing, including 7 cases of relapsed refractory acute myeloid leukemia and 10 cases of relapsed refractory acute lymphoblastic leukemia.

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  • Clostridium perfringens is a foodborne pathogen that causes intestinal diseases in humans and animals, especially affecting infants and young children due to its variety of toxins, including the newly identified BEC toxin.
  • Recent studies identified two strains of C. perfringens carrying becAB genes in China, indicating that these strains can spread across different regions through a specific plasmid.
  • This research highlights the need for continued surveillance of becAB-carrying strains due to their potential health impact and the importance of monitoring their antimicrobial resistance.
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  • Foodborne transmission of Hepatitis E virus (HEV) is a growing public health issue in China, with pig liver identified as a potential source of contamination.
  • A study tested 787 pig liver samples from various markets in 7 provinces and found an overall HEV positive rate of 8.13%, with Inner Mongolia and Hebei showing the highest rates.
  • Different market types (wholesale, supermarket, butcher's shop) had varying positive rates, but no significant differences were found between them; specific genotypes of HEV were identified in several samples.
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Siglec-9 is a promising immune checkpoint molecule, and therapeutics targeting Siglec-9 have the potential to augment anti-tumor immunity. Here, we generated a bispecific antibody, named as aSE4-1-Fc, by fusing two distinct alpaca derived nanobodies, which can simultaneously target the extracellular Ig variable (V)-set domain and C2-set domains of murine Siglec-9 (also known as Siglec-E) with high affinity. In vivo studies showed that aSE4-1-Fc was better than its component antibodies in inhibiting tumor growth/metastasis, and Siglec-E blockade using aSE4-1-Fc generated protective anti-tumor T cell memory.

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  • The study aimed to compare family physicians working in walk-in clinics with those providing long-term care in Ontario, focusing on their characteristics and patient demographics.
  • The research linked a 2019 physician survey with health care data, revealing differences such as a higher percentage of male physicians and a diverse language background among walk-in clinic practitioners.
  • Results showed that walk-in clinic physicians typically served younger, less frequently seeking patients, many of whom were from diverse backgrounds and often attached to other family physicians.
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