Publications by authors named "Li'na Sang"
HLA-DPA1*02:117 differs from HLA-DPA1*02:02:02:01 by one nucleotide in exon 2.
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- Risk stratification for normal karyotype acute myeloid leukemia (NK-AML) is currently inadequate, leading to a high rate of leukemia relapses among patients.
- The study assessed the impact of gene mutations and clinical characteristics on predicting relapses, developing a new prognostic system using a genomics-based nomogram model.
- Results showed that patients with higher genomic mutation signatures (GMS-high) experienced significantly more relapses and lower survival rates than those with lower signatures, suggesting the GMSN model's effectiveness as a relapse predictor for NK-AML.
Objectives: This study retrospectively investigated in which cycle measurable residual disease (MRD) is associated with prognosis in patients in first complete remission (CR1) of intermediate-risk acute myeloid leukemia (AML).
Methods: The study enrolled 235 younger patients with intermediate-risk AML. MRD was evaluated by multiparameter flow cytometry after the 1st, 2nd, and 3rd chemotherapy cycles (MRD1-3, respectively).
Intestinal microbiota is an important prognostic factor for allogeneic hematopoietic stem cell transplantation (allo-HSCT), but its role in predicting survival has not been determined. Here, stool samples at day 15 ± 1 posttransplant were obtained from 209 patients at two centers. Microbiota was examined using 16S rRNA sequencing.
View Article and Find Full Text PDFBackground: The occurrence in drug resistance of chronic myeloid leukemia (CML) was accompanied by autophagy activation. Abnormal circular RNAs (circRNAs) participated in this progression. This study attempted to investigate the potential role of circ_0009910 in imatinib resistance of CML cells.
View Article and Find Full Text PDFObjective: To investigate the expression of cystic fibrosis transmembrane conductance regulator (CFTR) protein in patients with acute leukemia and its relationship to clinical features and prognosis of acute leukemia.
Methods: A total of115 patients with acute leukemia were enrolled in the experimental group and 20 healthy individuals were used as control. Peripheral blood or bone marrow samples were collected, and mononuclear cells were isolated.