Publications by authors named "Li'an Shen"

Article Synopsis
  • Aberrant activation of the Wnt/β-catenin signaling pathway is linked to tumor development, and targeting the β-catenin/BCL9 interaction could be an effective anti-cancer strategy.
  • The study introduces two new variations of β-catenin and analyzes how their structural changes at the BCL9 binding site affect potential drug binding.
  • A class of novel compounds was identified that show strong inhibition of β-catenin/BCL9 interactions and improve immune responses in cancer, potentially overcoming resistance to immunotherapy.
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The β-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction (PPI) is a potential target for aberrantly active Wnt/β-catenin signaling which actively participates in initiating and progressing of many cancers. Herein, we discovered novel 8-substituted quercetin derivatives with potential inhibitory activities targeting β-catenin/BCL9 PPI. Among all the derivatives, compound B4 displayed the most promising PPI inhibitory activity with an IC value of 2.

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Article Synopsis
  • Researchers are exploring the disruption of the β-catenin/BCL9 protein interaction as a promising strategy for treating colorectal cancer by inhibiting Wnt signaling.
  • A series of synthesized compounds showed one particular compound effectively inhibited CRC cell growth and Wnt signaling, achieving an IC value of 0.72 μM.
  • In animal studies, this compound enhanced anti-tumor activity and improved the function of immune cells when combined with an anti-PD-1 antibody, highlighting its potential as a novel treatment approach.
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The β-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction (PPI) is a potential target for the suppression of hyperactive Wnt/β-catenin signaling that is vigorously involved in cancer initiation and development. Herein, we first described quercetin and its derivatives had potential inhibitory effects on β-catenin/BCL9 PPI. The most potent compound, quercetin-3'-O-(4-methylpiperazine-1-yl) propyl (C1), directly binded with β-catenin and disrupted the β-catenin/BCL9 interaction in both the protein level and the cellular context.

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Low tensile strength, poor elastic modulus, and complex concrete cracking work condition are almost unavoidable due to the intrinsic brittleness. To deal with concrete maintenance and durability, microbial self-healing concretes have been rapidly developed and widely applied recently. The microbial self-healing can specifically patch fractures as well as boost the concrete structure's capacity, durability, and permeability.

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To date, the overall response rate to checkpoint blockade remains unsatisfactory, partially due to the limited understanding of the tumor immune microenvironment. The retinoic acid-related orphan receptor γt (RORγt) is the key transcription factor of T helper cell 17 (Th17) cells and plays an essential role in tumor immunity. In this study, we used JG-1, a potent and selective small-molecule RORγt agonist to evaluate the therapeutic potential and mechanism of action of targeting RORγt in tumor immunity.

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