Highly efficient determination of metal ion in cosmetic samples by reversed-phase liquid-liquid microextraction based on green hydrophobic deep eutectic solvent.

In this paper, a green hydrophobic deep eutectic solvent (HDES) composed of menthol and hexanoic acid was employed to dissolve cosmetics containing Cd and Cd was extracted using an EDTA-2Na saturated solution, analyzed by FAAS. The study found that HDES-1 can be recycled and reused well; the stability constants of Cd EDTA chelates play an important role in the extracting process; the optimum conditions were: the solubility of HDES-1 was 20 mL/g for cosmetic sample at an indoor temperature of around 10 °C; the dissolver-extractant ratio was 2:1; the LOD was 0.037 mg/kg; the RSD was 3.

MBP-activated autoimmunity plays a role in arsenic-induced peripheral neuropathy and the potential protective effect of mecobalamin.

Intake excessive arsenic (As) is related to the occurrence of peripheral neuropathy. However, both the underlying mechanism and the preventive approach remain largely unknown. In the present study, As treatment significantly decreased the mechanical withdrawal threshold and increased the titer of anti-myelin basic protein antibody in rats, accompanied with damaged BNB.