Publications by authors named "Leyi Hu"
Article Synopsis
- - The study aimed to explore the relationship between retinal nerve fiber layer (RNFL) thickness and high-density lipoprotein cholesterol (HDL-C) levels in a healthy population of 31,738 UK Biobank participants, using advanced imaging techniques.
- - Results showed that high HDL-C levels were linked to thinner RNFL thickness in both men and women, while moderate HDL-C levels were positively associated with thicker RNFL in women, indicating a complex relationship between cholesterol and eye health.
- - The findings suggest that elevated HDL-C could be a potential risk factor for neurodegenerative diseases, highlighting its importance for preventive healthcare strategies.
Article Synopsis
- The study aims to classify congenital cataracts to improve individualized treatment and predict visual outcomes for affected individuals.
- Researchers analyzed data from 164 children with congenital cataracts, identifying two distinct clusters based on their ocular features and visual results.
- Cluster 1 had better visual outcomes and fewer ocular complications compared to Cluster 2, paving the way for personalized early interventions in congenital cataracts treatment.
Pediatric cataract, including congenital and developmental cataract, is a kind of pediatric vision-threatening disease with extensive phenotypic heterogeneity and multiple mechanisms. We aimed to investigate the metabolite profile of aqueous humor (AH) in patients with pediatric cataracts, and identify underlying mutual correlations between differential metabolites. Metabolomic profiles of AH were analyzed and compared between pediatric cataract patients (n = 33) and age-related cataract patients without metabolic diseases (n = 29), using global untargeted metabolomics with ultra-high-performance liquid chromatography tandem mass spectrometry.
View Article and Find Full Text PDFAim: To explore the hotspots and frontiers of genetic research on pediatric cataracts.
Methods: Global publications from 2013 to 2022 related to genes in pediatric cataracts were extracted from the Web of Science Core Collection, and were analyzed in terms of the publication counts, countries, journals, authors, keywords, cited references, subject categories, and the underlying hotspots and frontiers.
Results: Totally 699 publications were included in the final analysis.
Generating Retinas through Guided Pluripotent Stem Cell Differentiation and Direct Somatic Cell Reprogramming.
Curr Stem Cell Res Ther
September 2024
Retinal degeneration diseases affect millions of people worldwide but are among the most difficult eye diseases to cure. Studying the mechanisms and developing new therapies for these blinding diseases requires researchers to have access to many retinal cells. In recent years there has been substantial advances in the field of biotechnology in generating retinal cells and even tissues , either through programmed sequential stem cell differentiation or direct somatic cell lineage reprogramming.
View Article and Find Full Text PDFIntroduction: This study aimed to evaluate the publication delays and correlative factors of peer-reviewed ophthalmology journals.
Methods: The ophthalmology journals listed in the Journal Citation Report 2020 were retrieved from the Web of Science database. The first original research article of each journal issue from January to December 2020 was extracted, and its submission, final revision, acceptance, and publication dates were obtained.
The crystalline lens is a transparent and refractive biconvex structure formed by lens epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading cause of blindness in the world. LECs are the principal cells of lens throughout human life, exhibiting different physiological properties and functions.
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